Robert Silbergleit

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Lessons from the RAMPART study--and which is the best route of administration of benzodiazepines in status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, U S A
    Epilepsia 54:74-7. 2013
  2. pmc Intramuscular versus intravenous therapy for prehospital status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48105, USA
    N Engl J Med 366:591-600. 2012
  3. pmc Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 19:448-54. 2012
  4. pmc Lack of association between hyperglycaemia at arrival and clinical outcomes in acute stroke patients treated with tissue plasminogen activator
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Int J Stroke 5:163-6. 2010
  5. pmc RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, U S A
    Epilepsia 52:45-7. 2011
  6. doi request reprint A multilevel intervention to increase community hospital use of alteplase for acute stroke (INSTINCT): a cluster-randomised controlled trial
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Lancet Neurol 12:139-48. 2013
  7. pmc Lack of association between pretreatment neurology consultation and subsequent protocol deviation in tissue plasminogen activator-treated patients with stroke
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Mich, USA
    Stroke 41:2098-101. 2010
  8. pmc Safety of intravenous thrombolytic use in four emergency departments without acute stroke teams
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 17:1062-71. 2010
  9. ncbi request reprint Preconditioning with hyperbaric oxygen attenuates brain edema after experimental intracerebral hemorrhage
    Zhiyong Qin
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Neurosurg Focus 22:E13. 2007
  10. doi request reprint Emergency treatment of status epilepticus: current thinking
    Dan Millikan
    Department of Emergency Medicine, University of Michigan Neuro Emergencies Research, Ann Arbor, MI 48106, USA
    Emerg Med Clin North Am 27:101-13, ix. 2009

Collaborators

Detail Information

Publications24

  1. pmc Lessons from the RAMPART study--and which is the best route of administration of benzodiazepines in status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, U S A
    Epilepsia 54:74-7. 2013
    ..Lessons from the RAMPART study's findings and potential implications on clinical practice, on the potential role of other routes of administration, on the effect of timing of interventions, and on future clinical trials are discussed. ..
  2. pmc Intramuscular versus intravenous therapy for prehospital status epilepticus
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48105, USA
    N Engl J Med 366:591-600. 2012
    ..Early termination of prolonged seizures with intravenous administration of benzodiazepines improves outcomes. For faster and more reliable administration, paramedics increasingly use an intramuscular route...
  3. pmc Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 19:448-54. 2012
    ..The NETT model used in RAMPART demonstrates how EFIC may be effectively performed in established clinical trial networks...
  4. pmc Lack of association between hyperglycaemia at arrival and clinical outcomes in acute stroke patients treated with tissue plasminogen activator
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Int J Stroke 5:163-6. 2010
    ..Hyperglycaemia is associated with adverse outcomes in some studies of acute ischaemic stroke...
  5. pmc RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics
    Robert Silbergleit
    Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, U S A
    Epilepsia 52:45-7. 2011
    ..Secondary outcomes include timing of treatment and initial seizure cessation. At the time of writing this communication, enrollment of all subjects is near completion and the study data will soon be analyzed...
  6. doi request reprint A multilevel intervention to increase community hospital use of alteplase for acute stroke (INSTINCT): a cluster-randomised controlled trial
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Lancet Neurol 12:139-48. 2013
    ..Several types of barrier frequently prevent its use. We assessed whether a standardised, barrier-assessment, multicomponent intervention could increase alteplase use in community hospitals in Michigan, USA...
  7. pmc Lack of association between pretreatment neurology consultation and subsequent protocol deviation in tissue plasminogen activator-treated patients with stroke
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Mich, USA
    Stroke 41:2098-101. 2010
    ..We evaluated the hypothesis that consultation with neurology would be associated with fewer protocol deviations in tissue plasminogen activator-treated patients with stroke...
  8. pmc Safety of intravenous thrombolytic use in four emergency departments without acute stroke teams
    Phillip A Scott
    Department of Emergency Medicine, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 17:1062-71. 2010
    ..The objective was to evaluate safety of intravenous (IV) tissue plasminogen activator (tPA) delivered without dedicated thrombolytic stroke teams...
  9. ncbi request reprint Preconditioning with hyperbaric oxygen attenuates brain edema after experimental intracerebral hemorrhage
    Zhiyong Qin
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Neurosurg Focus 22:E13. 2007
    ..This study investigated if preconditioning with HBO2 protects against intracerebral hemorrhage (ICH)-induced brain edema formation and examined the role of p44/42 MAPK in such protection...
  10. doi request reprint Emergency treatment of status epilepticus: current thinking
    Dan Millikan
    Department of Emergency Medicine, University of Michigan Neuro Emergencies Research, Ann Arbor, MI 48106, USA
    Emerg Med Clin North Am 27:101-13, ix. 2009
    ....
  11. doi request reprint The 60-day temperature-dependent degradation of midazolam and Lorazepam in the prehospital environment
    Jason T McMullan
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267 0769, USA
    Prehosp Emerg Care 17:1-7. 2013
    ..Lorazepam is preferred in the emergency department, but concerns about nonrefrigerated storage limits emergency medical services (EMS) use. Midazolam is increasingly popular, but its heat stability is undocumented...
  12. pmc The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial
    Arthur M Pancioli
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
    Stroke 39:3268-76. 2008
    ....
  13. doi request reprint Empirical hospital and professional charges for patient care associated with out of hospital cardiac arrest before and after implementation of therapeutic hypothermia for comatose survivors
    Michael J Paulsen
    University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Resuscitation 83:1265-70. 2012
    ..The objectives of this study are to characterize the total hospital and professional charges for patients with out of hospital cardiac arrest both with and without therapeutic hypothermia treatment...
  14. ncbi request reprint Determining intravenous rt-PA eligibility in the Emergency Department
    Amy C Mecozzi
    Stroke Program, University of Michigan Medical School, TC 1920 0316, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Neurocrit Care 7:103-8. 2007
    ..The purpose of this study was to assess the agreement of Emergency Department (ED) attendings, ED residents, and neurology residents compared with stroke neurologists in the assessment of intravenous rt-PA eligibility...
  15. ncbi request reprint Response to Food and Drug Administration draft guidance statement on research into the treatment of life-threatening emergency conditions using exception from informed consent: testimony of the neurological emergencies treatment trials
    Robert Silbergleit
    Neurological Emergencies Treatment Trials, Clinical Coordinating Center, Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 14:e63-8. 2007
  16. doi request reprint Critical care transport of patients who have acute neurological emergencies
    Bradley Uren
    Department of Emergency Medicine and Survival Flight, University of Michigan, Ann Arbor, MI, USA
    Emerg Med Clin North Am 27:17-26, vii. 2009
    ..Finally, the cost of critical care transport of patients who have neurologic emergencies is considered...
  17. doi request reprint Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis
    Jason McMullan
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Acad Emerg Med 17:575-82. 2010
    ..Rapid treatment of status epilepticus (SE) is associated with better outcomes. Diazepam and midazolam are commonly used, but the optimal agent and administration route is unclear...
  18. doi request reprint NIH Roundtable on Emergency Trauma Research
    Charles B Cairns
    Department of Emergency Medicine, University of North Carolina, 170 Manning Dr, Chapel Hill, NC 27599, USA
    Ann Emerg Med 56:538-50. 2010
    ....
  19. pmc Resource utilization and outcome at a university versus a community teaching hospital in tPA treated stroke patients: a retrospective cohort study
    Angela F Caveney
    Department of Psychiatry, University of Michigan, Commonwealth Blvd, Ann Arbor, MI, USA
    BMC Health Serv Res 10:44. 2010
    ....
  20. ncbi request reprint What treatments are "satisfactory?" divining regulatory intent and an ethical basis for exception to informed consent for emergency research
    Robert Silbergleit
    University of Michigan, USA
    Am J Bioeth 6:24-6; discussion W49-50. 2006
  21. ncbi request reprint Research conditions that qualify for emergency exception from informed consent
    Drew Watters
    Department of Emergency Medicine, University of Arizona, Tucson, AZ 85724, USA
    Acad Emerg Med 12:1040-4. 2005
    ..6) Further study should also address variability among institutional review boards, the goals of community involvement, and how best to engage and educate the public in research efforts using emergency exception from informed consent...
  22. pmc An overview of the adaptive designs accelerating promising trials into treatments (ADAPT-IT) project
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Ann Emerg Med 60:451-7. 2012
    ....
  23. ncbi request reprint Rapid endovascular warming for profound hypothermia
    Megan Laniewicz
    Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    Ann Emerg Med 51:160-3. 2008
    ..Rapid warming from profound hypothermia can be accomplished with endovascular systems, and these may be an effective alternative to more invasive extracorporeal methods...
  24. ncbi request reprint Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia
    Zhiyong Qin
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Stroke 38:1362-7. 2007
    ....