Debra Silberg

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Cdx1 and cdx2 expression during intestinal development
    D G Silberg
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 119:961-71. 2000
  2. ncbi request reprint Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice
    Debra G Silberg
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 122:689-96. 2002
  3. ncbi request reprint Cellular and molecular mechanisms responsible for progression of Barrett's metaplasia to esophageal carcinoma
    Michelle Beilstein
    Division of Gastroenterology, Hospital of the University of Pennsylvania, 3rd Floor Ravdin, 2400 Spruce Street, Philadelphia, PA 10104, USA
    Gastroenterol Clin North Am 31:461-79, ix. 2002
  4. ncbi request reprint Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice
    Fang Xiao
    Gastroenterology Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 4:669-75. 2005
  5. ncbi request reprint Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6145, USA
    Gastroenterology 128:935-45. 2005
  6. ncbi request reprint Regulation of RELM/FIZZ isoform expression by Cdx2 in response to innate and adaptive immune stimulation in the intestine
    Mei Lun Wang
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1074-83. 2005
  7. ncbi request reprint The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice
    Felix H Brembeck
    Gastrointestinal Unit, Abramson Cancer Center and Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19014, USA
    Cancer Res 63:2005-9. 2003
  8. ncbi request reprint Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas
    Raquel Almeida
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, 4200 Porto, Portugal
    J Pathol 199:36-40. 2003
  9. ncbi request reprint To differentiate or proliferate? The interaction between PI3K/PTEN and Cdx2
    John P Lynch
    Gastroenterology 123:1395-7. 2002
  10. pmc A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP
    Francois Boudreau
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 22:5467-78. 2002

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Cdx1 and cdx2 expression during intestinal development
    D G Silberg
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 119:961-71. 2000
    ..This study focused on the complex patterns of expression of Cdx1 and Cdx2 during mouse gastrointestinal development...
  2. ncbi request reprint Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice
    Debra G Silberg
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 122:689-96. 2002
    ..Cdx2 induces differentiation of intestinal epithelial cells in vitro; therefore, we sought to establish whether a causal relationship exists between Cdx2 activation and intestinal metaplasia...
  3. ncbi request reprint Cellular and molecular mechanisms responsible for progression of Barrett's metaplasia to esophageal carcinoma
    Michelle Beilstein
    Division of Gastroenterology, Hospital of the University of Pennsylvania, 3rd Floor Ravdin, 2400 Spruce Street, Philadelphia, PA 10104, USA
    Gastroenterol Clin North Am 31:461-79, ix. 2002
    ..This knowledge will lead to better biomarkers to diagnose and assess cancer risk...
  4. ncbi request reprint Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice
    Fang Xiao
    Gastroenterology Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 4:669-75. 2005
    ..Alteration in the composition of the gastric epithelium may play a role in influencing the microenvironment to engender susceptibility to carcinogens...
  5. ncbi request reprint Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6145, USA
    Gastroenterology 128:935-45. 2005
    ..The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon...
  6. ncbi request reprint Regulation of RELM/FIZZ isoform expression by Cdx2 in response to innate and adaptive immune stimulation in the intestine
    Mei Lun Wang
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1074-83. 2005
    ....
  7. ncbi request reprint The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice
    Felix H Brembeck
    Gastrointestinal Unit, Abramson Cancer Center and Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19014, USA
    Cancer Res 63:2005-9. 2003
    ..Taken together, we have defined how mutant K-ras signaling modulates important molecular events in the initiating events of pancreatic and gastric carcinogenesis...
  8. ncbi request reprint Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas
    Raquel Almeida
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, 4200 Porto, Portugal
    J Pathol 199:36-40. 2003
    ....
  9. ncbi request reprint To differentiate or proliferate? The interaction between PI3K/PTEN and Cdx2
    John P Lynch
    Gastroenterology 123:1395-7. 2002
  10. pmc A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP
    Francois Boudreau
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 22:5467-78. 2002
    ..Our results demonstrate that an intestinal gene can be repressed in the distal gut and identify Cux/CDP as a regulator of this repression during development...
  11. pmc The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine
    Mary Ann S Crissey
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 600 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 USA
    Neoplasia 10:8-19. 2008
    ..Our results therefore suggest that Cdx1 is not an oncogene in normal intestinal epithelium...
  12. ncbi request reprint Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine
    Erinn B Rankin
    Gastroenterology Div, Dept of Medicine, Univ of Pennsylvania, Ste 600, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Gastrointest Liver Physiol 286:G872-80. 2004
    ..8 and -6.8 kb upstream of the CDX1 gene, respectively, which may function as potential intestine-specific enhancers...

Research Grants7

  1. Molecular Mechanisms Underlying Barrett's Esophagus
    Debra Silberg; Fiscal Year: 2003
    ....
  2. Cdx in GI Differentiation and Transdifferentiation
    Debra Silberg; Fiscal Year: 2005
    ..In summary, the overall goal of this project is to elucidate the biological roles of Cdxl and Cdx2 in intestinal metaplasia and the molecular mechanisms of the transdifferentiation program induced by Cdxl and Cdx2. ..