Linmarie Sikich

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Olanzapine approved for the acute treatment of schizophrenia or manic/mixed episodes associated with bipolar I disorder in adolescent patients
    Ann E Maloney
    Maine Medical Center Research Institute, Scarborough, ME, USA
    Neuropsychiatr Dis Treat 6:749-66. 2010
  2. doi request reprint Diagnosis and evaluation of hallucinations and other psychotic symptoms in children and adolescents
    Linmarie Sikich
    ASPIRE Program, University of North Carolina at Chapel Hill, CB 7167 UNC CH, 2218 Nelson Highway, Suite 1, Chapel Hill, NC 27599 7167, USA Electronic address
    Child Adolesc Psychiatr Clin N Am 22:655-73. 2013
  3. ncbi request reprint A pilot study of risperidone, olanzapine, and haloperidol in psychotic youth: a double-blind, randomized, 8-week trial
    Linmarie Sikich
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 29:133-45. 2004
  4. ncbi request reprint Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study
    Linmarie Sikich
    University of North Carolina at Chapel Hill, NC 27514, USA
    Am J Psychiatry 165:1420-31. 2008
  5. ncbi request reprint Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders
    Linmarie Sikich
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7160, USA
    J Clin Psychiatry 69:21-5. 2008
  6. ncbi request reprint Neurocognition in early-onset schizophrenia and schizoaffective disorders
    Stephen R Hooper
    The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7255, USA
    J Am Acad Child Adolesc Psychiatry 49:52-60. 2010
  7. pmc Brain volumes in psychotic youth with schizophrenia and mood disorders
    Mohamed El-Sayed
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7160, USA
    J Psychiatry Neurosci 35:229-36. 2010
  8. pmc Mapping social target detection with functional magnetic resonance imaging
    Gabriel S Dichter
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7160, USA
    Soc Cogn Affect Neurosci 4:59-69. 2009
  9. doi request reprint Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations
    Gabriel S Dichter
    Department of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599 7255, USA
    Int J Neurosci 122:483-93. 2012
  10. doi request reprint A pilot of a video game (DDR) to promote physical activity and decrease sedentary screen time
    Ann E Maloney
    Department of Psychiatry, Center for Psychiatric Research, Maine Medical Center Research Institute, Scarborough, Maine, USA
    Obesity (Silver Spring) 16:2074-80. 2008

Collaborators

Detail Information

Publications16

  1. pmc Olanzapine approved for the acute treatment of schizophrenia or manic/mixed episodes associated with bipolar I disorder in adolescent patients
    Ann E Maloney
    Maine Medical Center Research Institute, Scarborough, ME, USA
    Neuropsychiatr Dis Treat 6:749-66. 2010
    ..Enduring response to current medications appears limited. Recently, olanzapine was approved for the treatment of adolescents with schizophrenia or acute manic/mixed episodes in pedBP...
  2. doi request reprint Diagnosis and evaluation of hallucinations and other psychotic symptoms in children and adolescents
    Linmarie Sikich
    ASPIRE Program, University of North Carolina at Chapel Hill, CB 7167 UNC CH, 2218 Nelson Highway, Suite 1, Chapel Hill, NC 27599 7167, USA Electronic address
    Child Adolesc Psychiatr Clin N Am 22:655-73. 2013
    ..Strategies for optimizing the clinical diagnostic interview, appropriate laboratory tests, indications for psychological testing, and rating scales are reviewed. ..
  3. ncbi request reprint A pilot study of risperidone, olanzapine, and haloperidol in psychotic youth: a double-blind, randomized, 8-week trial
    Linmarie Sikich
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 29:133-45. 2004
    ..However, youth treated with risperidone and olanzapine experienced weight gain and extrapyramidal effects that appear more prevalent and severe than reported in adults...
  4. ncbi request reprint Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study
    Linmarie Sikich
    University of North Carolina at Chapel Hill, NC 27514, USA
    Am J Psychiatry 165:1420-31. 2008
    ....
  5. ncbi request reprint Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders
    Linmarie Sikich
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7160, USA
    J Clin Psychiatry 69:21-5. 2008
    ..Over the past 5 years, several studies have been initiated to address these questions. The results of the studies completed to date are reviewed...
  6. ncbi request reprint Neurocognition in early-onset schizophrenia and schizoaffective disorders
    Stephen R Hooper
    The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7255, USA
    J Am Acad Child Adolesc Psychiatry 49:52-60. 2010
    ....
  7. pmc Brain volumes in psychotic youth with schizophrenia and mood disorders
    Mohamed El-Sayed
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7160, USA
    J Psychiatry Neurosci 35:229-36. 2010
    ..We sought to test the hypothesis that deficits in grey matter volume are characteristic of psychotic youth with early-onset schizophrenia-spectrum disorders (EOSS) but not of psychotic youth with early-onset mood disorders (EOMD)...
  8. pmc Mapping social target detection with functional magnetic resonance imaging
    Gabriel S Dichter
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7160, USA
    Soc Cogn Affect Neurosci 4:59-69. 2009
    ..Clinical cognitive neuroscience research of disorders characterized by cognitive dysfunction and impaired social processing would benefit from the use of tasks that evaluate the combined effects of deficits in these two domains...
  9. doi request reprint Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations
    Gabriel S Dichter
    Department of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599 7255, USA
    Int J Neurosci 122:483-93. 2012
    ..We review these methodological considerations and provide recommendations for best practices for each of these topics...
  10. doi request reprint A pilot of a video game (DDR) to promote physical activity and decrease sedentary screen time
    Ann E Maloney
    Department of Psychiatry, Center for Psychiatric Research, Maine Medical Center Research Institute, Scarborough, Maine, USA
    Obesity (Silver Spring) 16:2074-80. 2008
    ..We examined the feasibility of Dance Dance Revolution (DDR), a dance video game, in participants' homes, to increase physical activity (PA) and to decrease sedentary screen time (SST)...
  11. pmc fMRI tracks reductions in repetitive behaviors in autism: two case studies
    Gabriel S Dichter
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 3366, USA
    Neurocase 16:307-16. 2010
    ..These findings suggest that fMRI may elucidate potential mechanisms of action of targeted autism interventions...
  12. pmc Early pharmacological treatment of autism: a rationale for developmental treatment
    Terrence C Bethea
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biol Psychiatry 61:521-37. 2007
    ..Finally, we discuss the importance of exploring early pharmacologic interventions within multiple experimental settings in order to develop effective treatments as quickly as possible while minimizing risks...
  13. ncbi request reprint Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods
    Jon McClellan
    University of Washington, Seattle, USA
    J Am Acad Child Adolesc Psychiatry 46:969-78. 2007
    ..The rationale, design, and methods of the Treatment of Early Onset Schizophrenia Spectrum Disorders Study are described...
  14. ncbi request reprint Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
    ..We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders...
  15. pmc Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia
    Sanjiv Kumra
    Division of Child and Adolescent Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454, USA
    Schizophr Bull 34:60-71. 2008
    ..Such a substantial risk points to the urgent need to develop therapeutic strategies to prevent and/or mitigate weight gain and diabetes early in the course of treatment in this population...
  16. doi request reprint Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Science 320:539-43. 2008
    ..These results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia...

Research Grants3

  1. 2/3-Improving Metabolic Parameters of Antipsychotic Child Treatment
    Linmarie Sikich; Fiscal Year: 2009
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
  2. 2/3-Improving Metabolic Parameters of Antipsychotic Child Treatment
    Linmarie Sikich; Fiscal Year: 2010
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..