Alexander B Sigalov

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Novel mechanistic concept of platelet inhibition
    Alexander B Sigalov
    University of Massachusetts Medical School, Department of Pathology, 55 Lake Avenue North, Worcester, MA 01655, USA
    Expert Opin Ther Targets 12:677-92. 2008
  2. ncbi request reprint Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I
    Alexander B Sigalov
    Biomedical Department, AMW Biomed, 22 1 11 Tarusskaya Street, Moscow 117588, Russia
    Antioxid Redox Signal 4:553-7. 2002
  3. ncbi request reprint Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif
    Alexander Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Biochemistry 43:2049-61. 2004
  4. pmc Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Biochemistry 45:15731-9. 2006
  5. pmc Membrane binding mode of intrinsically disordered cytoplasmic domains of T cell receptor signaling subunits depends on lipid composition
    Alexander B Sigalov
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Biochem Biophys Res Commun 389:388-93. 2009
  6. doi request reprint SCHOOL model and new targeting strategies
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655, Massachusetts, USA
    Adv Exp Med Biol 640:268-311. 2008
  7. pmc The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Biochemistry 47:12942-4. 2008
  8. ncbi request reprint Transmembrane interactions as immunotherapeutic targets: lessons from viral pathogenesis
    Alexander B Sigalov
    University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA
    Adv Exp Med Biol 601:335-44. 2007
  9. doi request reprint Protein intrinsic disorder and oligomericity in cell signaling
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Biosyst 6:451-61. 2010
  10. pmc Binding of intrinsically disordered proteins is not necessarily accompanied by a structural transition to a folded form
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Biochimie 89:419-21. 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Novel mechanistic concept of platelet inhibition
    Alexander B Sigalov
    University of Massachusetts Medical School, Department of Pathology, 55 Lake Avenue North, Worcester, MA 01655, USA
    Expert Opin Ther Targets 12:677-92. 2008
    ..However, despite intensive research efforts in antithrombotic drug discovery and development, uncontrolled hemorrhage still remains the most common side effect associated with antithrombotic drugs that are currently in use...
  2. ncbi request reprint Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I
    Alexander B Sigalov
    Biomedical Department, AMW Biomed, 22 1 11 Tarusskaya Street, Moscow 117588, Russia
    Antioxid Redox Signal 4:553-7. 2002
    ....
  3. ncbi request reprint Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif
    Alexander Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Biochemistry 43:2049-61. 2004
    ..Phosphorylation of zeta(cyt) and FcepsilonRIgamma(cyt) does not significantly alter their oligomerization behavior. The implications of these results for transmembrane signaling and cellular activation by immune receptors are discussed...
  4. pmc Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Biochemistry 45:15731-9. 2006
    ..Phosphorylation of zetacyt and FcepsilonRIgammacyt does not alter their random-coil conformation but weakens binding to membranes. The implications of these results for transmembrane signal transduction by immune receptors are discussed...
  5. pmc Membrane binding mode of intrinsically disordered cytoplasmic domains of T cell receptor signaling subunits depends on lipid composition
    Alexander B Sigalov
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Biochem Biophys Res Commun 389:388-93. 2009
    ..These findings explain the long-standing puzzle in the literature and highlight the importance of the choice of an appropriate membrane model for protein-lipid interactions studies...
  6. doi request reprint SCHOOL model and new targeting strategies
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655, Massachusetts, USA
    Adv Exp Med Biol 640:268-311. 2008
    ....
  7. pmc The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Biochemistry 47:12942-4. 2008
    ..Thus, our findings oppose the generally accepted view of the behavior of intrinsically disordered proteins and provide new evidence of the existence of specific interactions for unfolded protein molecules...
  8. ncbi request reprint Transmembrane interactions as immunotherapeutic targets: lessons from viral pathogenesis
    Alexander B Sigalov
    University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA
    Adv Exp Med Biol 601:335-44. 2007
    ....
  9. doi request reprint Protein intrinsic disorder and oligomericity in cell signaling
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Biosyst 6:451-61. 2010
    ....
  10. pmc Binding of intrinsically disordered proteins is not necessarily accompanied by a structural transition to a folded form
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Biochimie 89:419-21. 2007
    ....
  11. ncbi request reprint Immune cell signaling: a novel mechanistic model reveals new therapeutic targets
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Trends Pharmacol Sci 27:518-24. 2006
    ....
  12. ncbi request reprint Multi-chain immune recognition receptors: spatial organization and signal transduction
    Alexander Sigalov
    Department of Pathology, S2 302, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Immunol 17:51-64. 2005
    ..Here, the current progress in studying this important aspect of cellular signaling is reviewed...
  13. ncbi request reprint Multichain immune recognition receptor signaling: different players, same game?
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Trends Immunol 25:583-9. 2004
  14. doi request reprint Signaling chain homooligomerization (SCHOOL) model
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Adv Exp Med Biol 640:121-63. 2008
    ..Important applications of the SCHOOL model in clinical immunology, molecular pharmacology and virology are described in the Chapters 20 and 22 of this book...
  15. pmc Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments
    Walter M Kim
    University of Massachusetts Medical School, USA
    Acta Crystallogr D Biol Crystallogr 66:163-75. 2010
    ..The combination of NCS rotations that were nearly parallel to the twin operation (k, h, -l) and a and b unit-cell parameters that were nearly identical predisposed the P2(1)2(1)2(1) crystal form to pseudo-merohedral twinning...
  16. doi request reprint Interplay between protein order, disorder and oligomericity in receptor signaling
    Alexander B Sigalov
    SignaBlok, Inc, Shrewsbury, Massachusetts, USA
    Adv Exp Med Biol 725:50-73. 2012
    ....
  17. pmc New therapeutic strategies targeting transmembrane signal transduction in the immune system
    Alexander B Sigalov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA
    Cell Adh Migr 4:255-67. 2010
    ....
  18. doi request reprint Viral pathogenesis, modulation of immune receptor signaling and treatment
    Walter M Kim
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Adv Exp Med Biol 640:325-49. 2008
    ..This suggests that it is very likely that similar general mechanisms can be or are used by other viral and possibly nonviral pathogens...
  19. pmc Bi-specific MHC heterodimers for characterization of cross-reactive T cells
    Zu T Shen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 285:33144-53. 2010
    ..A similar strategy could be used to develop reagents to analyze cross-reactive T cell responses in humans...
  20. doi request reprint Evolution of immunity: no development without risk
    Alexander B Sigalov
    SignaBlok, Inc, P O Box 4064, Shrewsbury, MA, 01545, USA
    Immunol Res 52:176-81. 2012
    ..Not only does this phenomenon serve as the molecular basis for the development and evolution of the immune and other complex biological systems, but it fits closely to Darwinian evolutionary biology...
  21. ncbi request reprint Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy
    Elke Duchardt
    Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University Frankfurt, 60439 Frankfurt, Germany
    Chembiochem 8:820-7. 2007
    ..Regions around the ITAM2 and ITAM3 sequences are involved in a highly dynamic binding of the free zeta-chain to a detergent micelle formed by the acidic lipid LMPG...