Genomes and Genes

Species

P A Sieving

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. Sieving P, Chaudhry P, Kondo M, Provenzano M, Wu D, Carlson T, et al. Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. Proc Natl Acad Sci U S A. 2001;98:1835-40 pubmed
    ..Isotretinoin was also found to protect rat photoreceptors from light-induced damage, suggesting that strategies of altering retinoid cycling may have therapeutic implications for some forms of retinal and macular degeneration. ..
  2. request reprint
    Sieving P, Fowler M, Bush R, Machida S, Calvert P, Green D, et al. Constitutive "light" adaptation in rods from G90D rhodopsin: a mechanism for human congenital nightblindness without rod cell loss. J Neurosci. 2001;21:5449-60 pubmed
    ..We conclude that G90D is constitutively active in mouse rods in vivo but that it does not cause significant rod degeneration. Instead, G90D desensitizes rods by a process equivalent to light adaptation. ..