Genomes and Genes


P A Sieving


Affiliation: University of Michigan
Country: USA


  1. Sieving P, Chaudhry P, Kondo M, Provenzano M, Wu D, Carlson T, et al. Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. Proc Natl Acad Sci U S A. 2001;98:1835-40 pubmed
    ..Isotretinoin was also found to protect rat photoreceptors from light-induced damage, suggesting that strategies of altering retinoid cycling may have therapeutic implications for some forms of retinal and macular degeneration. ..
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    Sieving P, Fowler M, Bush R, Machida S, Calvert P, Green D, et al. Constitutive "light" adaptation in rods from G90D rhodopsin: a mechanism for human congenital nightblindness without rod cell loss. J Neurosci. 2001;21:5449-60 pubmed
    ..We conclude that G90D is constitutively active in mouse rods in vivo but that it does not cause significant rod degeneration. Instead, G90D desensitizes rods by a process equivalent to light adaptation. ..