PETER SIELING

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions
    P A Sieling
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 164:4790-6. 2000
  2. ncbi request reprint Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c
    P A Sieling
    Division of Dermatology and Rheumatology, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 165:5338-44. 2000
  3. pmc Regulation of human T-cell homing receptor expression in cutaneous bacterial infection
    Peter A Sieling
    Division of Dermatology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunology 120:518-25. 2007
  4. ncbi request reprint Toll-like receptor 2 ligands as adjuvants for human Th1 responses
    Peter A Sieling
    Department of Medicine, Division of Dermatology, David Gefffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:194-200. 2003
  5. ncbi request reprint A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Joshua R Bleharski
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:3812-8. 2003
  6. pmc TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
    Stephan R Krutzik
    Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
    Nat Med 11:653-60. 2005
  7. pmc Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses
    Motoyuki Tanaka
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 183:2349-55. 2009
  8. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
  9. ncbi request reprint Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders
    Peter A Sieling
    Division of Dermatology, Department of Medicine, Molecular Biology Institute, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Curr Opin Microbiol 5:70-5. 2002
  10. ncbi request reprint Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1535-41. 2002

Research Grants

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions
    P A Sieling
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 164:4790-6. 2000
    ..The existence of CD4+ CD1-restricted T cells that produce a Th1 cytokine pattern suggests a contributory role in immunity to mycobacterial infection...
  2. ncbi request reprint Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c
    P A Sieling
    Division of Dermatology and Rheumatology, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 165:5338-44. 2000
    ..The data suggest that CD1c-restricted T cells from SLE patients can provide help to CD1c(+) B cells for IgG production and could therefore promote pathogenic autoantibody responses in SLE...
  3. pmc Regulation of human T-cell homing receptor expression in cutaneous bacterial infection
    Peter A Sieling
    Division of Dermatology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunology 120:518-25. 2007
    ..6-3.4, n = 3). Our data indicate that CLA expression is regulated during the course of leprosy infection and suggest that T-cell responsiveness to a microbial antigen directs antigen-specific T cells to the site of infection...
  4. ncbi request reprint Toll-like receptor 2 ligands as adjuvants for human Th1 responses
    Peter A Sieling
    Department of Medicine, Division of Dermatology, David Gefffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:194-200. 2003
    ..Our data suggest that bLPs adjuvant adaptive Th1 responses by enhancing Ag presentation of endogenous peptides...
  5. ncbi request reprint A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Joshua R Bleharski
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:3812-8. 2003
    ..Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges...
  6. pmc TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
    Stephan R Krutzik
    Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
    Nat Med 11:653-60. 2005
    ..Thus, TLR-induced differentiation of monocytes into either macrophages or dendritic cells seems to crucially influence effective host defenses in human infectious disease...
  7. pmc Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses
    Motoyuki Tanaka
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 183:2349-55. 2009
    ..Therefore, activation of FcgammaRI on monocytes triggers differentiation into specialized iDC with the capacity to expand autoreactive T cells that may contribute to the pathogenesis of immune complex-mediated tissue injury...
  8. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
    ..LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease...
  9. ncbi request reprint Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders
    Peter A Sieling
    Division of Dermatology, Department of Medicine, Molecular Biology Institute, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Curr Opin Microbiol 5:70-5. 2002
    ..These findings have also provided a framework for determining how TLRs may by used to therapeutically modulate immune responses to infection...
  10. ncbi request reprint Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1535-41. 2002
    ..These data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2. As such, TLR2 may provide a novel target for treatment of this common skin disease...
  11. ncbi request reprint Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
    Stephan R Krutzik
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
    Nat Med 9:525-32. 2003
    ..These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens...
  12. pmc LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 179:8128-36. 2007
    ....
  13. ncbi request reprint The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens
    Peter A Sieling
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 174:2637-44. 2005
    ..In comparison with the MHC class II-restricted T cell repertoire, the CD1-restricted T cell repertoire is limited to recognition of cross-reactive Ags, imparting a distinct role in the host response to immunologically related pathogens...
  14. ncbi request reprint Immunology. Now presenting: gammadelta T cells
    Robert L Modlin
    Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Science 309:252-3. 2005
  15. pmc Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy
    Rosane B Oliveira
    Division of Dermatology, Department of Microbiology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Infect Immun 71:1427-33. 2003
    ..The ability of M. leprae ligands to induce the apoptosis of Schwann cells through TLR2 provides a mechanism by which activation of the innate immune response contributes to nerve injury in leprosy...
  16. pmc Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue
    Maria Teresa Ochoa
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Immunology 108:10-5. 2003
    ..The co-expression of TLR1 and TLR2 on myeloid cells in lymphoid tissue provides the host with the ability to respond to a variety of microbial ligands at sites conducive to the generation of an immune response...
  17. ncbi request reprint TGF-alpha regulates TLR expression and function on epidermal keratinocytes
    Lloyd S Miller
    Division of Dermatology, Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 174:6137-43. 2005
    ..These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces...
  18. pmc Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy
    Daniel Cruz
    Division of Cardiology, Molecular Biology Institute, Department of Microbiology, Immunology, and Molecular Genetics, UCLA David Geffen School of Medicine, Howard Hughes Medical Institute, Los Angeles, California 90095, USA
    J Clin Invest 118:2917-28. 2008
    ....
  19. pmc Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation
    Peter A Sieling
    Division of Dermatology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:5833-42. 2008
    ..This study demonstrates that the universe of bacterial T cell Ags includes lipoglycoproteins, which act as TLR2 ligands but also require glycosylation for MHC class II-restricted T cell activation in vivo...
  20. ncbi request reprint TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response
    Claudia N Renn
    Division of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 177:298-305. 2006
    ..Finally, CXCL9 colocalized with LCs in skin biopsy specimens from viral infections. Together, our data suggest that LCs exhibit a direct antiviral activity that is dependent on type I IFN as part of the innate immune system...
  21. pmc Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion
    Shereen Sabet
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunology 120:354-61. 2007
    ..leprae-pulsed antigen-presenting cells by the granule exocytosis pathway, and expressed the antimicrobial protein granulysin. BV6(+) T cells may therefore functionally contribute to the cell-mediated immune response against M. leprae...
  22. ncbi request reprint Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
    Ulrich E Schaible
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Med 9:1039-46. 2003
    ....
  23. pmc Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences
    Kayvan R Niazi
    Discovery Translation Unit, Buck Institute, Novato, CA, USA
    Immunology 122:522-31. 2007
    ..These findings may have implications in designing DNA vaccines, providing a greater variety of tools to generate T-cell responses against microbial pathogens or tumours...
  24. ncbi request reprint Expression of signaling lymphocytic activation molecule-associated protein interrupts IFN-gamma production in human tuberculosis
    Virginia Pasquinelli
    Department of Microbiology, Parasitology and Immunology, University of Buenos Aires School of Medicine, Paraguay 2155 12th Floor, Capital Federal, 1121 Buenos Aires, Argentina
    J Immunol 172:1177-85. 2004
    ..The study further suggests that SAP and SLAM might be focal points for therapeutic modulation of T cell cytokine responses in tuberculosis...
  25. ncbi request reprint Ito cells are liver-resident antigen-presenting cells for activating T cell responses
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 26:117-29. 2007
    ....
  26. ncbi request reprint Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection
    Maria F Quiroga
    Department of Microbiology, Parasitology, and Immunology, University of Buenos Aires School of Medicine, Buenos Aires, Argentina
    J Immunol 173:4120-9. 2004
    ....
  27. ncbi request reprint Saposin C is required for lipid presentation by human CD1b
    Florian Winau
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Immunol 5:169-74. 2004
    ..We propose a model in which SAP-C exposes lipid antigens from intralysosomal membranes for loading onto CD1b. Thus, SAP-C represents a missing link in antigen presentation of lipids through CD1b to human T cells...
  28. ncbi request reprint Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis
    Jordi B Torrelles
    Department of Microbiology, Colorado Stae University, Fort Collins 80523, USA
    J Biol Chem 279:41227-39. 2004
    ....
  29. ncbi request reprint Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells
    Jin S Im
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 177:5226-35. 2006
    ....
  30. ncbi request reprint Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis
    Maria F Quiroga
    Department of Microbiology, Parasitology and Immunology, University of Buenos Aires School of Medicine, Paraguay 2155 P 12, Capital Federal, 1121 Buenos Aires, Argentina
    J Immunol 176:5965-74. 2006
    ..tuberculosis-specific T cells modulates ICOS levels, and accordingly, ICOS ligation induces IFN-gamma secretion. Thus, ICOS activation may promote the induction of protective Th1 cytokine responses to intracellular bacterial pathogens...

Research Grants6

  1. CD1 RESTRICTED T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS
    PETER SIELING; Fiscal Year: 2003
    ..Finally, we anticipate that our findings will be useful in establishing new mains of treating autoimmune disease. ..
  2. CD1-RESTRICTED T CELLS AGAINST THE TULAREMIA PATHOGEN
    PETER SIELING; Fiscal Year: 2005
    ..From these studies we hope to expand the diversity of lipid antigens known to activate CDl-restricted T cells with the future goal to design lipid-based vaccines against tularemia infection. ..