B Siegmund

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13249-54. 2001
  2. ncbi Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001
  3. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
  4. pmc Interferon-alpha induces interleukin-18 binding protein in chronic hepatitis C patients
    A Kaser
    Division of Gastroenterology and Hepatology, Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria
    Clin Exp Immunol 129:332-8. 2002
  5. pmc Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice
    B Siegmund
    Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik I, Hindenburgdamm 30, 12200 Berlin, Germany
    Gut 53:965-72. 2004
  6. pmc Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
    O Ludwiczek
    Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria
    Clin Exp Immunol 138:323-9. 2004
  7. ncbi Therapeutic approaches in inflammatory bowel disease based on the immunopathogenesis
    B Siegmund
    Department of Medicine I, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Rocz Akad Med Bialymst 49:22-30. 2004
  8. pmc Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice
    G Fantuzzi
    Department of Medicine I, Charite, Campus Benjamin Franklin, Berlin, Germany
    Clin Exp Immunol 142:31-8. 2005
  9. doi Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice
    R Glauben
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Medicine I, Hindenburgdamm 30, D 12200 Berlin, Germany
    Gut 57:613-22. 2008

Collaborators

Detail Information

Publications9

  1. pmc IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13249-54. 2001
    ..We conclude that inhibition of ICE represents a novel anti-inflammatory strategy for intestinal inflammation...
  2. ncbi Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001
    ..The stimulation of lamina propria mononuclear cells by IL-18 and IL-12 resulted in a synergistic increase in IFN-gamma synthesis. These findings suggest that IL-18 is a pivotal mediator in experimental colitis...
  3. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
  4. pmc Interferon-alpha induces interleukin-18 binding protein in chronic hepatitis C patients
    A Kaser
    Division of Gastroenterology and Hepatology, Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria
    Clin Exp Immunol 129:332-8. 2002
    ..These anti-inflammatory properties might account - together with its antiviral action - for its clinical efficacy in chronic hepatitis C...
  5. pmc Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice
    B Siegmund
    Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik I, Hindenburgdamm 30, 12200 Berlin, Germany
    Gut 53:965-72. 2004
    ..Leptin regulates appetite through the long isoform of its receptor in the hypothalamus. Although leptin regulates immune responses, it is still unknown whether a direct effect of leptin on lymphocytes is required...
  6. pmc Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
    O Ludwiczek
    Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria
    Clin Exp Immunol 138:323-9. 2004
    ....
  7. ncbi Therapeutic approaches in inflammatory bowel disease based on the immunopathogenesis
    B Siegmund
    Department of Medicine I, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Rocz Akad Med Bialymst 49:22-30. 2004
    ..In summary, with regard to this review, treatments, which intervene as early as possible in the initiation of the pathological immune reaction and simultaneously have a favorable side-effect profile, must be the focus of future research...
  8. pmc Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice
    G Fantuzzi
    Department of Medicine I, Charite, Campus Benjamin Franklin, Berlin, Germany
    Clin Exp Immunol 142:31-8. 2005
    ....
  9. doi Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice
    R Glauben
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Medicine I, Hindenburgdamm 30, D 12200 Berlin, Germany
    Gut 57:613-22. 2008
    ..Since inflammatory bowel disease is associated with an increased risk of developing colon cancer, here the combined anti-inflammatory and proapoptotic efficacy of histone deacetylase inhibitors was studied in mouse models...