Affiliation: University of Pittsburgh
- Pupillary assessment and computational modeling of the Stroop task in depressionGreg J Siegle
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
Int J Psychophysiol 52:63-76. 2004..Computational neural network modeling further suggested that observed effects were consistent with decreased prefrontal cortex activity, associated with decreased cognitive control...
- Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI dataGreg J Siegle
University of Pittsburgh, Pittsburgh, PA, USA
Neuroimage 20:114-24. 2003....
- MATLAB toolbox for functional connectivityDongli Zhou
Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuroimage 47:1590-607. 2009..Though all implemented measures demonstrate functional connectivity between dACC and DLPFC activity during event-related tasks, different participants appeared to display qualitatively different relationships...
- Relationships between affect, vigilance, and sleepiness following sleep deprivationPeter L Franzen
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Sleep Res 17:34-41. 2008..By including affective outcomes in experimental sleep deprivation research, the impact of sleep loss on affective function and their relationship to other neurobehavioral domains can be assessed...
- Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responsesGreg J Siegle
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
Psychophysiology 45:679-87. 2008..Together these indices provide a rich picture of the time course of information processing, from early reactivity through sustained cognition, and after stimulus-related cognition ends...
- Cognitive therapy versus medication for depression: treatment outcomes and neural mechanismsRobert J Derubeis
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Neurosci 9:788-96. 2008..A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes...
- Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measuresJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1873-80. 2007....
- Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinicGreg J Siegle
Am J Psychiatry 164:1776-9. 2007
- Reward-related decision-making in pediatric major depressive disorder: an fMRI studyErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
J Child Psychol Psychiatry 47:1031-40. 2006..Depression is postulated to involve decreased activity in reward-related affective systems...
- Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent featuresGreg J Siegle
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 61:198-209. 2007..These mechanisms have been hypothesized to interact in depression. This study explored relationships between amygdala and DLPFC activity during emotional and cognitive information processing in unipolar depression...
- Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuliChristine L Larson
Department of Psychology, Michigan State University, East Lansing, Michigan 48824 1116, USA
Biol Psychiatry 60:410-7. 2006..We hypothesized that activation of the amygdala early in the presentation of fear-relevant visual stimuli would distinguish phobics from nonphobics...
- Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapyGreg J Siegle
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 163:735-8. 2006..In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation...
- Anterior cingulate activity correlates with blood pressure during stressPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Psychophysiology 42:627-35. 2005..These results support the hypothesis that the anterior cingulate cortex regulates blood pressure reactions to behavioral stressors in humans...
- Is there a functional neural correlate of individual differences in cardiovascular reactivity?Peter J Gianaros
Cardiovascular Behavioral Medicine Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Psychosom Med 67:31-9. 2005..The present study tested whether individuals who differ in the magnitude of their blood pressure reactions to a behavioral stressor also differ in their stressor-induced patterns of functional neural activation...
- Opiate addicts lack error-dependent activation of rostral anterior cingulateSteven D Forman
Department of Psychology TSB, DMB, Washington University, St Louis, Missouri, USA
Biol Psychiatry 55:531-7. 2004..Fundamental questions include whether this error-related activation provides a signal contributing to behavioral control and, given generally poorer performance on such tasks by addicts, whether this signal is disrupted in addiction...
- Sympathetic and parasympathetic innervation of pupillary dilation during sustained processingStuart R Steinhauer
Biometrics Research Program, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
Int J Psychophysiol 52:77-86. 2004..Moreover, modulation of both ambient light intensity and pharmacological blockade of the final pupillary musculature were observed to provide converging approaches for quantifying the activity of identifiable central autonomic pathways...
- Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigationGreg J Siegle
University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Ann N Y Acad Sci 985:481-4. 2003
- Using connectionist models to guide assessment of psychological disorderGreg J Siegle
Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
Psychol Assess 14:263-78. 2002..Two extended examples are given based on the authors' research on cognitive aspects of depression and Alzheimer's disease...
- Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individualsGreg J Siegle
University of Pittsburgh Medical School and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 51:693-707. 2002..This study examined whether brain activity in response to emotional stimuli was sustained in depressed individuals, even following subsequent distracting stimuli...
- Neurovisceral integration in cardiac and emotional regulationJulian F Thayer
LPC GRC National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
IEEE Eng Med Biol Mag 21:24-9. 2002
- Cognitive and Affective Neurosciences of DepressionGreg Siegle; Fiscal Year: 2006..The applicant, Dr. Greg Siegle, Ph.D...
- Functional Neuroanatomy of Recovery from DepressionGreg J Siegle; Fiscal Year: 2010..This project will be executed in conjunction with an ongoing clinical trial through which the intervention will be provided. ..