Greg Siegle

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Pupillary assessment and computational modeling of the Stroop task in depression
    Greg J Siegle
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 52:63-76. 2004
  2. ncbi request reprint Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI data
    Greg J Siegle
    University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 20:114-24. 2003
  3. pmc MATLAB toolbox for functional connectivity
    Dongli Zhou
    Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroimage 47:1590-607. 2009
  4. pmc Relationships between affect, vigilance, and sleepiness following sleep deprivation
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Sleep Res 17:34-41. 2008
  5. doi request reprint Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responses
    Greg J Siegle
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Psychophysiology 45:679-87. 2008
  6. pmc Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms
    Robert J Derubeis
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Neurosci 9:788-96. 2008
  7. pmc Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measures
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1873-80. 2007
  8. ncbi request reprint Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinic
    Greg J Siegle
    Am J Psychiatry 164:1776-9. 2007
  9. pmc Reward-related decision-making in pediatric major depressive disorder: an fMRI study
    Erika E Forbes
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
    J Child Psychol Psychiatry 47:1031-40. 2006
  10. ncbi request reprint Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 61:198-209. 2007

Research Grants

Detail Information

Publications20

  1. ncbi request reprint Pupillary assessment and computational modeling of the Stroop task in depression
    Greg J Siegle
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 52:63-76. 2004
    ..Computational neural network modeling further suggested that observed effects were consistent with decreased prefrontal cortex activity, associated with decreased cognitive control...
  2. ncbi request reprint Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI data
    Greg J Siegle
    University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 20:114-24. 2003
    ....
  3. pmc MATLAB toolbox for functional connectivity
    Dongli Zhou
    Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroimage 47:1590-607. 2009
    ..Though all implemented measures demonstrate functional connectivity between dACC and DLPFC activity during event-related tasks, different participants appeared to display qualitatively different relationships...
  4. pmc Relationships between affect, vigilance, and sleepiness following sleep deprivation
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Sleep Res 17:34-41. 2008
    ..By including affective outcomes in experimental sleep deprivation research, the impact of sleep loss on affective function and their relationship to other neurobehavioral domains can be assessed...
  5. doi request reprint Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responses
    Greg J Siegle
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Psychophysiology 45:679-87. 2008
    ..Together these indices provide a rich picture of the time course of information processing, from early reactivity through sustained cognition, and after stimulus-related cognition ends...
  6. pmc Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms
    Robert J Derubeis
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Neurosci 9:788-96. 2008
    ..A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes...
  7. pmc Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measures
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1873-80. 2007
    ....
  8. ncbi request reprint Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinic
    Greg J Siegle
    Am J Psychiatry 164:1776-9. 2007
  9. pmc Reward-related decision-making in pediatric major depressive disorder: an fMRI study
    Erika E Forbes
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
    J Child Psychol Psychiatry 47:1031-40. 2006
    ..Depression is postulated to involve decreased activity in reward-related affective systems...
  10. ncbi request reprint Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 61:198-209. 2007
    ..These mechanisms have been hypothesized to interact in depression. This study explored relationships between amygdala and DLPFC activity during emotional and cognitive information processing in unipolar depression...
  11. ncbi request reprint Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuli
    Christine L Larson
    Department of Psychology, Michigan State University, East Lansing, Michigan 48824 1116, USA
    Biol Psychiatry 60:410-7. 2006
    ..We hypothesized that activation of the amygdala early in the presentation of fear-relevant visual stimuli would distinguish phobics from nonphobics...
  12. ncbi request reprint Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy
    Greg J Siegle
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 163:735-8. 2006
    ..In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation...
  13. pmc Anterior cingulate activity correlates with blood pressure during stress
    Peter J Gianaros
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Psychophysiology 42:627-35. 2005
    ..These results support the hypothesis that the anterior cingulate cortex regulates blood pressure reactions to behavioral stressors in humans...
  14. ncbi request reprint Is there a functional neural correlate of individual differences in cardiovascular reactivity?
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychosom Med 67:31-9. 2005
    ..The present study tested whether individuals who differ in the magnitude of their blood pressure reactions to a behavioral stressor also differ in their stressor-induced patterns of functional neural activation...
  15. ncbi request reprint Opiate addicts lack error-dependent activation of rostral anterior cingulate
    Steven D Forman
    Department of Psychology TSB, DMB, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 55:531-7. 2004
    ..Fundamental questions include whether this error-related activation provides a signal contributing to behavioral control and, given generally poorer performance on such tasks by addicts, whether this signal is disrupted in addiction...
  16. ncbi request reprint Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing
    Stuart R Steinhauer
    Biometrics Research Program, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Int J Psychophysiol 52:77-86. 2004
    ..Moreover, modulation of both ambient light intensity and pharmacological blockade of the final pupillary musculature were observed to provide converging approaches for quantifying the activity of identifiable central autonomic pathways...
  17. ncbi request reprint Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigation
    Greg J Siegle
    University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Ann N Y Acad Sci 985:481-4. 2003
  18. ncbi request reprint Using connectionist models to guide assessment of psychological disorder
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Psychol Assess 14:263-78. 2002
    ..Two extended examples are given based on the authors' research on cognitive aspects of depression and Alzheimer's disease...
  19. ncbi request reprint Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
    Greg J Siegle
    University of Pittsburgh Medical School and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 51:693-707. 2002
    ..This study examined whether brain activity in response to emotional stimuli was sustained in depressed individuals, even following subsequent distracting stimuli...
  20. ncbi request reprint Neurovisceral integration in cardiac and emotional regulation
    Julian F Thayer
    LPC GRC National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    IEEE Eng Med Biol Mag 21:24-9. 2002

Research Grants8

  1. Cognitive and Affective Neurosciences of Depression
    Greg Siegle; Fiscal Year: 2006
    ..The applicant, Dr. Greg Siegle, Ph.D...
  2. Functional Neuroanatomy of Recovery from Depression
    Greg Siegle; Fiscal Year: 2009
    ..This project will be executed in conjunction with an ongoing clinical trial through which the intervention will be provided. ..
  3. Functional Neuroanatomy of Recovery from Depression
    Greg J Siegle; Fiscal Year: 2010
    ..This project will be executed in conjunction with an ongoing clinical trial through which the intervention will be provided. ..