Research Topics
| Greg SiegleSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Pupillary assessment and computational modeling of the Stroop task in depressionGreg J Siegle
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
Int J Psychophysiol 52:63-76. 2004..Computational neural network modeling further suggested that observed effects were consistent with decreased prefrontal cortex activity, associated with decreased cognitive control...- Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI dataGreg J Siegle
University of Pittsburgh, Pittsburgh, PA, USA
Neuroimage 20:114-24. 2003.... 
MATLAB toolbox for functional connectivityDongli Zhou
Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuroimage 47:1590-607. 2009..Though all implemented measures demonstrate functional connectivity between dACC and DLPFC activity during event-related tasks, different participants appeared to display qualitatively different relationships...- Relationships between affect, vigilance, and sleepiness following sleep deprivationPeter L Franzen
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Sleep Res 17:34-41. 2008..By including affective outcomes in experimental sleep deprivation research, the impact of sleep loss on affective function and their relationship to other neurobehavioral domains can be assessed... 
Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responsesGreg J Siegle
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
Psychophysiology 45:679-87. 2008..Together these indices provide a rich picture of the time course of information processing, from early reactivity through sustained cognition, and after stimulus-related cognition ends...- Cognitive therapy versus medication for depression: treatment outcomes and neural mechanismsRobert J Derubeis
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Neurosci 9:788-96. 2008..A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes... - Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measuresJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1873-80. 2007.... - Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinicGreg J Siegle
Am J Psychiatry 164:1776-9. 2007 - Reward-related decision-making in pediatric major depressive disorder: an fMRI studyErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
J Child Psychol Psychiatry 47:1031-40. 2006..Depression is postulated to involve decreased activity in reward-related affective systems... - Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent featuresGreg J Siegle
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 61:198-209. 2007..These mechanisms have been hypothesized to interact in depression. This study explored relationships between amygdala and DLPFC activity during emotional and cognitive information processing in unipolar depression... - Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuliChristine L Larson
Department of Psychology, Michigan State University, East Lansing, Michigan 48824 1116, USA
Biol Psychiatry 60:410-7. 2006..We hypothesized that activation of the amygdala early in the presentation of fear-relevant visual stimuli would distinguish phobics from nonphobics... - Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapyGreg J Siegle
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 163:735-8. 2006..In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation... - Anterior cingulate activity correlates with blood pressure during stressPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Psychophysiology 42:627-35. 2005..These results support the hypothesis that the anterior cingulate cortex regulates blood pressure reactions to behavioral stressors in humans... - Is there a functional neural correlate of individual differences in cardiovascular reactivity?Peter J Gianaros
Cardiovascular Behavioral Medicine Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Psychosom Med 67:31-9. 2005..The present study tested whether individuals who differ in the magnitude of their blood pressure reactions to a behavioral stressor also differ in their stressor-induced patterns of functional neural activation... - Opiate addicts lack error-dependent activation of rostral anterior cingulateSteven D Forman
Department of Psychology (TSB, DMB, Washington University, St. Louis, Missouri, USA
Biol Psychiatry 55:531-7. 2004..CONCLUSIONS: The attenuation of this error signal in anterior cingulate cortex may play a role in loss of control in addiction and other forms of impulsive behavior... - Sympathetic and parasympathetic innervation of pupillary dilation during sustained processingStuart R Steinhauer
Biometrics Research Program, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
Int J Psychophysiol 52:77-86. 2004..Moreover, modulation of both ambient light intensity and pharmacological blockade of the final pupillary musculature were observed to provide converging approaches for quantifying the activity of identifiable central autonomic pathways... - Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigationGreg J Siegle
University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Ann N Y Acad Sci 985:481-4. 2003 - Using connectionist models to guide assessment of psychological disorderGreg J Siegle
Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
Psychol Assess 14:263-78. 2002..Two extended examples are given based on the authors' research on cognitive aspects of depression and Alzheimer's disease... - Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individualsGreg J Siegle
University of Pittsburgh Medical School and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 51:693-707. 2002..CONCLUSIONS: Results suggest that depression is associated with sustained activity in brain areas responsible for coding emotional features... - Neurovisceral integration in cardiac and emotional regulationJulian F Thayer
LPC/GRC/National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
IEEE Eng Med Biol Mag 21:24-9. 2002
Research Grants
- Cognitive and Affective Neurosciences of DepressionGreg Siegle; Fiscal Year: 2006..The applicant, Dr. Greg Siegle, Ph.D...
- Functional Neuroanatomy of Recovery from DepressionGreg Siegle; Fiscal Year: 2009..This project will be executed in conjunction with an ongoing clinical trial through which the intervention will be provided. ..
- Functional Neuroanatomy of Recovery from DepressionGreg J Siegle; Fiscal Year: 2010..This project will be executed in conjunction with an ongoing clinical trial through which the intervention will be provided. ..