Research Topics
| Greg J SiegleSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Toward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristicsGreg J Siegle
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 69:913-24. 2012..Subgenual anterior cingulate activity, in particular, may reflect processes that interfere with treatment (eg, emotion generation) in addition to its putative regulatory role; alternately, its absence may facilitate treatment response...
Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapyGreg J Siegle
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 163:735-8. 2006..In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation...- Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent featuresGreg J Siegle
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 61:198-209. 2007..These mechanisms have been hypothesized to interact in depression. This study explored relationships between amygdala and DLPFC activity during emotional and cognitive information processing in unipolar depression... - Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlatesGreg J Siegle
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 69:726-33. 2011..This study examined 1) whether pretreatment assessment of pupillary responses to negative information were associated with remission in CT and 2) their associated brain mechanisms... - Sustained gamma-band EEG following negative words in depression and schizophreniaGreg J Siegle
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Psychophysiol 75:107-18. 2010..This study examined whether there were group differences in baseline and sustained gamma-band EEG following emotional stimuli in healthy adults as well as adults with depression and schizophrenia... - Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responsesGreg J Siegle
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
Psychophysiology 45:679-87. 2008..Together these indices provide a rich picture of the time course of information processing, from early reactivity through sustained cognition, and after stimulus-related cognition ends... - Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigationGreg J Siegle
University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Ann N Y Acad Sci 985:481-4. 2003 - Using connectionist models to guide assessment of psychological disorderGreg J Siegle
Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
Psychol Assess 14:263-78. 2002..Two extended examples are given based on the authors' research on cognitive aspects of depression and Alzheimer's disease... 
Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measuresJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1873-80. 2007....- Pediatric functional magnetic resonance neuroimaging: tactics for encouraging task complianceMichael W Schlund
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
Behav Brain Funct 7:10. 2011.... - Pubertal changes in emotional information processing: pupillary, behavioral, and subjective evidence during emotional word identificationJennifer S Silk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Dev Psychopathol 21:7-26. 2009..These results provide physiological, behavioral, and subjective evidence consistent with a model of puberty-specific changes in neurobehavioral systems underpinning emotional reactivity... - Sleep deprivation alters pupillary reactivity to emotional stimuli in healthy young adultsPeter L Franzen
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Biol Psychol 80:300-5. 2009..Such responses may have important implications for psychiatric disorders, which may be triggered or characterized by sleep disturbances... - Reward/Punishment reversal learning in older suicide attemptersAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
Am J Psychiatry 167:699-707. 2010..The authors further hypothesized that this impairment could be dissociated from executive abilities, such as forward planning... - Nothing to fear? Neural systems supporting avoidance behavior in healthy youthsMichael W Schlund
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
Neuroimage 52:710-9. 2010..The present approach may offer developmental affective neuroscience a conceptual and methodological framework for investigating avoidance in childhood anxiety... - Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson diseaseSamay Jain
Movement Disorders Division, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3232, USA
Mov Disord 26:1344-7. 2011..Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease... - Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI dataGreg J Siegle
University of Pittsburgh, Pittsburgh, PA, USA
Neuroimage 20:114-24. 2003.... - Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortexNaho Ichikawa
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Cogn Affect Behav Neurosci 11:354-71. 2011..These data may suggest that responses to errors are affected by emotion and that aspects of emotion and cognition are inextricably linked, even during a nominally cognitive task... - Effects of word frequency on semantic memory in schizophrenia: electrophysiological evidence for a deficit in linguistic accessRuth Condray
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Psychophysiol 75:141-56. 2010..g., cholinergic system). Electrophysiological responding may be informative regarding the storage-access distinction for schizophrenia... - Anterior cingulate activity correlates with blood pressure during stressPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Psychophysiology 42:627-35. 2005..These results support the hypothesis that the anterior cingulate cortex regulates blood pressure reactions to behavioral stressors in humans... - Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individualsGreg J Siegle
University of Pittsburgh Medical School and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 51:693-707. 2002..CONCLUSIONS: Results suggest that depression is associated with sustained activity in brain areas responsible for coding emotional features... - Emotional reactivity and regulation in anxious and nonanxious youth: a cell-phone ecological momentary assessment studyPATRICIA Z TAN
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
J Child Psychol Psychiatry 53:197-206. 2012..However, no study has examined anxious youth's emotional reactivity and regulation in real-world contexts... - Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact taskJennifer S Silk
Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15260, USA
Soc Cogn Affect Neurosci 7:93-105. 2012..Furthermore, the salience of social rejection and acceptance feedback appears to increase during adolescence... - Lethal forethought: delayed reward discounting differentiates high- and low-lethality suicide attempts in old ageAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 70:138-44. 2011..Can the willingness to postpone future gratification differentiate between individuals prone to serious, premeditated and less serious, unplanned suicidal acts?.. - Cardiovascular reactivity to acute psychological stress following sleep deprivationPeter L Franzen
Department of Psychiatry, School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA
Psychosom Med 73:679-82. 2011.... - Impact of inflammatory bowel disease and high-dose steroid exposure on pupillary responses to negative information in pediatric depressionNeil P Jones
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
Psychosom Med 73:151-7. 2011..In systemic inflammation, proinflammatory cytokines have been implicated in altering activity in brain regions known to affect emotion processing and emotion regulation in depression... - Common and distinct brain networks underlying explicit emotional evaluation: a meta-analytic studyKyung Hwa Lee
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Soc Cogn Affect Neurosci 7:521-34. 2012..These findings suggest that different types of explicit emotional evaluation may involve common and distinct networks and provide new insights on multiple mechanisms underlying explicit emotional evaluation... - Affective functioning among early adolescents at high and low familial risk for depression and their mothers: a focus on individual and transactional processes across contextsDana L McMakin
School of Medicine, Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, 322 Loeffler Building, Pittsburgh, PA 15213, USA
J Abnorm Child Psychol 39:1213-25. 2011..transactional processes (e.g., negative escalation). Findings are discussed in concert with attention to affect flexibility, contextual and transactional factors... - Pupillary assessment and computational modeling of the Stroop task in depressionGreg J Siegle
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
Int J Psychophysiol 52:63-76. 2004..Computational neural network modeling further suggested that observed effects were consistent with decreased prefrontal cortex activity, associated with decreased cognitive control... - Poor performance on cognitive tasks in depression: Doing too much or not enough?Neil P Jones
Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
Cogn Affect Behav Neurosci 10:129-40. 2010..These findings support the hypothesis that allocating cognitive resources to intrinsic processing contributes to observed cognitive deficits in depression... - Sympathetic and parasympathetic innervation of pupillary dilation during sustained processingStuart R Steinhauer
Biometrics Research Program, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
Int J Psychophysiol 52:77-86. 2004..Moreover, modulation of both ambient light intensity and pharmacological blockade of the final pupillary musculature were observed to provide converging approaches for quantifying the activity of identifiable central autonomic pathways... - Is there a functional neural correlate of individual differences in cardiovascular reactivity?Peter J Gianaros
Cardiovascular Behavioral Medicine Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Psychosom Med 67:31-9. 2005..The present study tested whether individuals who differ in the magnitude of their blood pressure reactions to a behavioral stressor also differ in their stressor-induced patterns of functional neural activation... - Reward-related decision-making in pediatric major depressive disorder: an fMRI studyErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
J Child Psychol Psychiatry 47:1031-40. 2006..Depression is postulated to involve decreased activity in reward-related affective systems... - Sustained neural alterations in anxious youth performing an attentional bias task: a pupilometry studyRebecca B Price
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Depress Anxiety 30:22-30. 2013..We investigated early, intermediate, and sustained forms of bias using behavioral measures and pupillary reactivity, an index of cognitive and affective load, to gain insight into potential neurocognitive targets for early intervention... - Mom-it helps when you're right here! Attenuation of neural stress markers in anxious youths whose caregivers are present during fMRIOlivia L Conner
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
PLoS ONE 7:e50680. 2012..Capitalizing on the ability of anxious youths to manifest low levels of anxiety-like information processing in the presence of a caregiver could help in modeling adaptive function in behavioral treatments... - Autonomic insufficiency in pupillary and cardiovascular systems in Parkinson's diseaseSamay Jain
University of Pittsburgh School of Medicine, PA, USA
Parkinsonism Relat Disord 17:119-22. 2011..In Parkinson's disease (PD), neurodegenerative changes have been observed in autonomic pathways involving multiple organ systems. We explore pupillary and cardiac autonomic measures as physiological manifestations of PD neurodegeneration... - Automatic activation of the semantic network in schizophrenia: evidence from event-related brain potentialsRuth Condray
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 54:1134-48. 2003..Pharmacologic agents, such as haloperidol, might enhance automatic activation of the semantic network in this patient population, as indexed by the N400 component of the ERP... - Amygdalae morphometry in late-life depressionRobert J Tamburo
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:837-46. 2009.... - Relationships between affect, vigilance, and sleepiness following sleep deprivationPeter L Franzen
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Sleep Res 17:34-41. 2008..By including affective outcomes in experimental sleep deprivation research, the impact of sleep loss on affective function and their relationship to other neurobehavioral domains can be assessed... - When the solution is part of the problem: problem solving in elderly suicide attemptersLawrence M Gibbs
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:1396-404. 2009..Thus, those with perceived deficits in problem-solving ability may be predisposed to suicidal behavior. To test this hypothesis, we investigated whether elderly suicide attempters perceived their problem solving as deficient... - Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women's Health InitiativeHilary A Tindle
University of Pittsburgh, PA, USA
Circulation 120:656-62. 2009..Trait optimism (positive future expectations) and cynical, hostile attitudes toward others have not been studied together in relation to incident coronary heart disease (CHD) and mortality in postmenopausal women... - Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuliChristine L Larson
Department of Psychology, Michigan State University, East Lansing, Michigan 48824 1116, USA
Biol Psychiatry 60:410-7. 2006..We hypothesized that activation of the amygdala early in the presentation of fear-relevant visual stimuli would distinguish phobics from nonphobics... - Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinicGreg J Siegle
Am J Psychiatry 164:1776-9. 2007 - Opiate addicts lack error-dependent activation of rostral anterior cingulateSteven D Forman
Department of Psychology (TSB, DMB, Washington University, St. Louis, Missouri, USA
Biol Psychiatry 55:531-7. 2004..CONCLUSIONS: The attenuation of this error signal in anterior cingulate cortex may play a role in loss of control in addiction and other forms of impulsive behavior... - Cognitive therapy versus medication for depression: treatment outcomes and neural mechanismsRobert J Derubeis
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Neurosci 9:788-96. 2008..A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes... - Neurovisceral integration in cardiac and emotional regulationJulian F Thayer
LPC/GRC/National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
IEEE Eng Med Biol Mag 21:24-9. 2002