Greg J Siegle

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Toward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristics
    Greg J Siegle
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 69:913-24. 2012
  2. ncbi request reprint Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy
    Greg J Siegle
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 163:735-8. 2006
  3. ncbi request reprint Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 61:198-209. 2007
  4. doi request reprint Sustained gamma-band EEG following negative words in depression and schizophrenia
    Greg J Siegle
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Psychophysiol 75:107-18. 2010
  5. doi request reprint Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responses
    Greg J Siegle
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Psychophysiology 45:679-87. 2008
  6. ncbi request reprint Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigation
    Greg J Siegle
    University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Ann N Y Acad Sci 985:481-4. 2003
  7. ncbi request reprint Using connectionist models to guide assessment of psychological disorder
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Psychol Assess 14:263-78. 2002
  8. doi request reprint Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlates
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 69:726-33. 2011
  9. pmc Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measures
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1873-80. 2007
  10. pmc Pediatric functional magnetic resonance neuroimaging: tactics for encouraging task compliance
    Michael W Schlund
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    Behav Brain Funct 7:10. 2011

Detail Information

Publications48

  1. doi request reprint Toward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristics
    Greg J Siegle
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 69:913-24. 2012
    ..Subgenual anterior cingulate activity, in particular, may reflect processes that interfere with treatment (eg, emotion generation) in addition to its putative regulatory role; alternately, its absence may facilitate treatment response...
  2. ncbi request reprint Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy
    Greg J Siegle
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 163:735-8. 2006
    ..In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation...
  3. ncbi request reprint Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 61:198-209. 2007
    ..These mechanisms have been hypothesized to interact in depression. This study explored relationships between amygdala and DLPFC activity during emotional and cognitive information processing in unipolar depression...
  4. doi request reprint Sustained gamma-band EEG following negative words in depression and schizophrenia
    Greg J Siegle
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Psychophysiol 75:107-18. 2010
    ..This study examined whether there were group differences in baseline and sustained gamma-band EEG following emotional stimuli in healthy adults as well as adults with depression and schizophrenia...
  5. doi request reprint Blink before and after you think: blinks occur prior to and following cognitive load indexed by pupillary responses
    Greg J Siegle
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Psychophysiology 45:679-87. 2008
    ..Together these indices provide a rich picture of the time course of information processing, from early reactivity through sustained cognition, and after stimulus-related cognition ends...
  6. ncbi request reprint Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigation
    Greg J Siegle
    University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Ann N Y Acad Sci 985:481-4. 2003
  7. ncbi request reprint Using connectionist models to guide assessment of psychological disorder
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Psychol Assess 14:263-78. 2002
    ..Two extended examples are given based on the authors' research on cognitive aspects of depression and Alzheimer's disease...
  8. doi request reprint Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlates
    Greg J Siegle
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 69:726-33. 2011
    ..This study examined 1) whether pretreatment assessment of pupillary responses to negative information were associated with remission in CT and 2) their associated brain mechanisms...
  9. pmc Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measures
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1873-80. 2007
    ....
  10. pmc Pediatric functional magnetic resonance neuroimaging: tactics for encouraging task compliance
    Michael W Schlund
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    Behav Brain Funct 7:10. 2011
    ....
  11. pmc Sustained neural alterations in anxious youth performing an attentional bias task: a pupilometry study
    Rebecca B Price
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Depress Anxiety 30:22-30. 2013
    ..We investigated early, intermediate, and sustained forms of bias using behavioral measures and pupillary reactivity, an index of cognitive and affective load, to gain insight into potential neurocognitive targets for early intervention...
  12. pmc Sleep deprivation alters pupillary reactivity to emotional stimuli in healthy young adults
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychol 80:300-5. 2009
    ..Such responses may have important implications for psychiatric disorders, which may be triggered or characterized by sleep disturbances...
  13. pmc Pubertal changes in emotional information processing: pupillary, behavioral, and subjective evidence during emotional word identification
    Jennifer S Silk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Dev Psychopathol 21:7-26. 2009
    ..These results provide physiological, behavioral, and subjective evidence consistent with a model of puberty-specific changes in neurobehavioral systems underpinning emotional reactivity...
  14. ncbi request reprint Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI data
    Greg J Siegle
    University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 20:114-24. 2003
    ....
  15. pmc Reward/Punishment reversal learning in older suicide attempters
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Am J Psychiatry 167:699-707. 2010
    ..The authors further hypothesized that this impairment could be dissociated from executive abilities, such as forward planning...
  16. pmc Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease
    Samay Jain
    Movement Disorders Division, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3232, USA
    Mov Disord 26:1344-7. 2011
    ..Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease...
  17. pmc Nothing to fear? Neural systems supporting avoidance behavior in healthy youths
    Michael W Schlund
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    Neuroimage 52:710-9. 2010
    ..The present approach may offer developmental affective neuroscience a conceptual and methodological framework for investigating avoidance in childhood anxiety...
  18. doi request reprint Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortex
    Naho Ichikawa
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Cogn Affect Behav Neurosci 11:354-71. 2011
    ..These data may suggest that responses to errors are affected by emotion and that aspects of emotion and cognition are inextricably linked, even during a nominally cognitive task...
  19. doi request reprint Effects of word frequency on semantic memory in schizophrenia: electrophysiological evidence for a deficit in linguistic access
    Ruth Condray
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 75:141-56. 2010
    ..g., cholinergic system). Electrophysiological responding may be informative regarding the storage-access distinction for schizophrenia...
  20. pmc Anterior cingulate activity correlates with blood pressure during stress
    Peter J Gianaros
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Psychophysiology 42:627-35. 2005
    ..These results support the hypothesis that the anterior cingulate cortex regulates blood pressure reactions to behavioral stressors in humans...
  21. ncbi request reprint Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
    Greg J Siegle
    University of Pittsburgh Medical School and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 51:693-707. 2002
    ..This study examined whether brain activity in response to emotional stimuli was sustained in depressed individuals, even following subsequent distracting stimuli...
  22. pmc Emotional reactivity and regulation in anxious and nonanxious youth: a cell-phone ecological momentary assessment study
    PATRICIA Z TAN
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Child Psychol Psychiatry 53:197-206. 2012
    ..However, no study has examined anxious youth's emotional reactivity and regulation in real-world contexts...
  23. pmc Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task
    Jennifer S Silk
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15260, USA
    Soc Cogn Affect Neurosci 7:93-105. 2012
    ..Furthermore, the salience of social rejection and acceptance feedback appears to increase during adolescence...
  24. pmc Lethal forethought: delayed reward discounting differentiates high- and low-lethality suicide attempts in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 70:138-44. 2011
    ..Can the willingness to postpone future gratification differentiate between individuals prone to serious, premeditated and less serious, unplanned suicidal acts?..
  25. doi request reprint Looking under the hood of the dot-probe task: an fMRI study in anxious youth
    Rebecca B Price
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Depress Anxiety 31:178-87. 2014
    ..In particular, neural mechanisms of threat disengagement, a clinically relevant construct, have been inadequately explored...
  26. pmc "You can do it!": The role of parental encouragement of bravery in child anxiety treatment
    Jennifer S Silk
    University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Anxiety Disord 27:439-46. 2013
    ..Encouragement of bravery increased from pre- to post-treatment for youth who received CBT but not CCT, and pre-treatment encouragement of bravery predicted a better response to treatment, particularly for youth receiving CBT. ..
  27. pmc Mom-it helps when you're right here! Attenuation of neural stress markers in anxious youths whose caregivers are present during fMRI
    Olivia L Conner
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    PLoS ONE 7:e50680. 2012
    ..Capitalizing on the ability of anxious youths to manifest low levels of anxiety-like information processing in the presence of a caregiver could help in modeling adaptive function in behavioral treatments...
  28. pmc Cardiovascular reactivity to acute psychological stress following sleep deprivation
    Peter L Franzen
    Department of Psychiatry, School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Psychosom Med 73:679-82. 2011
    ....
  29. pmc Impact of inflammatory bowel disease and high-dose steroid exposure on pupillary responses to negative information in pediatric depression
    Neil P Jones
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Psychosom Med 73:151-7. 2011
    ..In systemic inflammation, proinflammatory cytokines have been implicated in altering activity in brain regions known to affect emotion processing and emotion regulation in depression...
  30. doi request reprint Associations between maternal negative affect and adolescent's neural response to peer evaluation
    PATRICIA Z TAN
    University of Pittsburgh, Western Psychiatric Institute and Clinic, USA Electronic address
    Dev Cogn Neurosci 8:28-39. 2014
    ..Findings also suggest that maternal negative affect could contribute to alterations in affective processing, specifically, dampening the saliency and/or reward of peer interactions during adolescence. ..
  31. pmc Common and distinct brain networks underlying explicit emotional evaluation: a meta-analytic study
    Kyung Hwa Lee
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Soc Cogn Affect Neurosci 7:521-34. 2012
    ..These findings suggest that different types of explicit emotional evaluation may involve common and distinct networks and provide new insights on multiple mechanisms underlying explicit emotional evaluation...
  32. pmc Affective functioning among early adolescents at high and low familial risk for depression and their mothers: a focus on individual and transactional processes across contexts
    Dana L McMakin
    School of Medicine, Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, 322 Loeffler Building, Pittsburgh, PA 15213, USA
    J Abnorm Child Psychol 39:1213-25. 2011
    ..transactional processes (e.g., negative escalation). Findings are discussed in concert with attention to affect flexibility, contextual and transactional factors...
  33. ncbi request reprint Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing
    Stuart R Steinhauer
    Biometrics Research Program, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Int J Psychophysiol 52:77-86. 2004
    ..Moreover, modulation of both ambient light intensity and pharmacological blockade of the final pupillary musculature were observed to provide converging approaches for quantifying the activity of identifiable central autonomic pathways...
  34. ncbi request reprint Pupillary assessment and computational modeling of the Stroop task in depression
    Greg J Siegle
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 52:63-76. 2004
    ..Computational neural network modeling further suggested that observed effects were consistent with decreased prefrontal cortex activity, associated with decreased cognitive control...
  35. ncbi request reprint Is there a functional neural correlate of individual differences in cardiovascular reactivity?
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychosom Med 67:31-9. 2005
    ..The present study tested whether individuals who differ in the magnitude of their blood pressure reactions to a behavioral stressor also differ in their stressor-induced patterns of functional neural activation...
  36. pmc Poor performance on cognitive tasks in depression: Doing too much or not enough?
    Neil P Jones
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Cogn Affect Behav Neurosci 10:129-40. 2010
    ..These findings support the hypothesis that allocating cognitive resources to intrinsic processing contributes to observed cognitive deficits in depression...
  37. pmc Reward-related decision-making in pediatric major depressive disorder: an fMRI study
    Erika E Forbes
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
    J Child Psychol Psychiatry 47:1031-40. 2006
    ..Depression is postulated to involve decreased activity in reward-related affective systems...
  38. pmc Autonomic insufficiency in pupillary and cardiovascular systems in Parkinson's disease
    Samay Jain
    University of Pittsburgh School of Medicine, PA, USA
    Parkinsonism Relat Disord 17:119-22. 2011
    ..In Parkinson's disease (PD), neurodegenerative changes have been observed in autonomic pathways involving multiple organ systems. We explore pupillary and cardiac autonomic measures as physiological manifestations of PD neurodegeneration...
  39. ncbi request reprint Automatic activation of the semantic network in schizophrenia: evidence from event-related brain potentials
    Ruth Condray
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 54:1134-48. 2003
    ....
  40. pmc Amygdalae morphometry in late-life depression
    Robert J Tamburo
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:837-46. 2009
    ....
  41. pmc Relationships between affect, vigilance, and sleepiness following sleep deprivation
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Sleep Res 17:34-41. 2008
    ..By including affective outcomes in experimental sleep deprivation research, the impact of sleep loss on affective function and their relationship to other neurobehavioral domains can be assessed...
  42. pmc When the solution is part of the problem: problem solving in elderly suicide attempters
    Lawrence M Gibbs
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:1396-404. 2009
    ..Thus, those with perceived deficits in problem-solving ability may be predisposed to suicidal behavior. To test this hypothesis, we investigated whether elderly suicide attempters perceived their problem solving as deficient...
  43. pmc Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women's Health Initiative
    Hilary A Tindle
    University of Pittsburgh, PA, USA
    Circulation 120:656-62. 2009
    ..Trait optimism (positive future expectations) and cynical, hostile attitudes toward others have not been studied together in relation to incident coronary heart disease (CHD) and mortality in postmenopausal women...
  44. pmc Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms
    Robert J Derubeis
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Neurosci 9:788-96. 2008
    ..A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes...
  45. ncbi request reprint Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinic
    Greg J Siegle
    Am J Psychiatry 164:1776-9. 2007
  46. ncbi request reprint Opiate addicts lack error-dependent activation of rostral anterior cingulate
    Steven D Forman
    Department of Psychology TSB, DMB, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 55:531-7. 2004
    ..Fundamental questions include whether this error-related activation provides a signal contributing to behavioral control and, given generally poorer performance on such tasks by addicts, whether this signal is disrupted in addiction...
  47. ncbi request reprint Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuli
    Christine L Larson
    Department of Psychology, Michigan State University, East Lansing, Michigan 48824 1116, USA
    Biol Psychiatry 60:410-7. 2006
    ..We hypothesized that activation of the amygdala early in the presentation of fear-relevant visual stimuli would distinguish phobics from nonphobics...
  48. ncbi request reprint Neurovisceral integration in cardiac and emotional regulation
    Julian F Thayer
    LPC GRC National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    IEEE Eng Med Biol Mag 21:24-9. 2002