Steven Siegel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc In vitro and in vivo demonstration of risperidone implants in mice
    C Rabin
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, United States
    Schizophr Res 98:66-78. 2008
  2. doi request reprint Deviance-elicited changes in event-related potentials are attenuated by ketamine in mice
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cogn Neurosci 20:1403-14. 2008
  3. pmc GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction
    M J Gandal
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Transl Psychiatry 2:e142. 2012
  4. ncbi request reprint Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials
    S J Siegel
    Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 133:729-38. 2005
  5. ncbi request reprint Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, Laboratory of Molecular Neuropsychopharmacolgy, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Gates Building 10th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 26:817-23. 2002
  6. ncbi request reprint Effects of strain, novelty, and NMDA blockade on auditory-evoked potentials in mice
    Steven J Siegel
    Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 28:675-82. 2003
  7. ncbi request reprint A unique iontophoretic patch for optimal transdermal delivery of sumatriptan
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st St Rm 2223, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 24:1919-26. 2007
  8. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006
  9. ncbi request reprint Brain activity and emotional processing in smokers treated with varenicline
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Biol 18:732-8. 2013
  10. ncbi request reprint Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010

Collaborators

Detail Information

Publications60

  1. pmc In vitro and in vivo demonstration of risperidone implants in mice
    C Rabin
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, United States
    Schizophr Res 98:66-78. 2008
    ..The goal of this study was to provide in vitro and in vivo proof of concept for a long-term implantable risperidone delivery system in mice...
  2. doi request reprint Deviance-elicited changes in event-related potentials are attenuated by ketamine in mice
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cogn Neurosci 20:1403-14. 2008
    ..This study examines a novel rodent model of impaired pitch deviance detection in mice using the NMDA receptor antagonist ketamine...
  3. pmc GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction
    M J Gandal
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Transl Psychiatry 2:e142. 2012
    ....
  4. ncbi request reprint Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials
    S J Siegel
    Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 133:729-38. 2005
    ....
  5. ncbi request reprint Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, Laboratory of Molecular Neuropsychopharmacolgy, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Gates Building 10th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 26:817-23. 2002
    ..Surgically-implantable formulations are a viable approach to provide long-term delivery of antipsychotic medications to patients with psychotic disorders...
  6. ncbi request reprint Effects of strain, novelty, and NMDA blockade on auditory-evoked potentials in mice
    Steven J Siegel
    Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 28:675-82. 2003
    ..The ability to model novelty detection deficits in mice will aid in identifying genetic contributions to abnormal neuronal organization in people with schizophrenia...
  7. ncbi request reprint A unique iontophoretic patch for optimal transdermal delivery of sumatriptan
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st St Rm 2223, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 24:1919-26. 2007
    ..Four unique prototype iontophoretic sumatriptan patch conditions were compared to a 6 mg subcutaneous injection and an oral 50 mg tablet of sumatriptan succinate...
  8. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006
    ..This study assessed the relationship between symptoms and cognitive measures at intake and functional outcome 2-8 years later (average 3 years) in first-episode and previously treated schizophrenia patients...
  9. ncbi request reprint Brain activity and emotional processing in smokers treated with varenicline
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Biol 18:732-8. 2013
    ..Taken together, these results suggest that observed drug effects on brain activity do not reflect affective changes but rather enhanced early processing of perceptual features of facial stimuli. ..
  10. ncbi request reprint Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010
    ..In rodents and humans, cognitive deficits can be reversed by treatment with the alpha4beta2 nicotinic receptor partial agonist varenicline. This neuroimaging study examined the neural mechanisms that underlie these effects...
  11. pmc Working memory deficits predict short-term smoking resumption following brief abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 106:61-4. 2010
    ....
  12. pmc Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma
    J M Phillips
    Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, Room 2223, 125 South 31st Street, Philadelphia, PA 19104, USA
    Neuroscience 144:1314-23. 2007
    ..The results also support the hypothesis that nicotine may be beneficial to individuals with deficits in neurocognitive functions, such as those suffering from schizophrenia...
  13. pmc A placebo-controlled trial of modafinil for nicotine dependence
    Robert A Schnoll
    Department of Psychiatry, Abramson Cancer Center, and Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, United States
    Drug Alcohol Depend 98:86-93. 2008
    ..Modafinil (Provigil), a wakefulness medication shown to have efficacy for the treatment of cocaine addiction, was tested as a novel therapy for nicotine dependence in a double-blind placebo-controlled trial...
  14. ncbi request reprint N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia
    R S Ehrlichman
    Stanley Center for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 158:705-12. 2009
    ..5 Hz) and gamma (31-61 Hz) bands in the context of N-methyl-d-aspartic acid receptor (NMDAR) hypofunction and dopaminergic hyperactivity, both of which are thought to serve as pharmacological models of schizophrenia...
  15. ncbi request reprint Computerized neurocognitive scanning: I. Methodology and validation in healthy people
    R C Gur
    Brain Behavior Laboratory, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 25:766-76. 2001
    ..Therefore, the computerized scan has favorable reliability and construct validity and can be applied efficiently to study healthy variability related to age and gender...
  16. pmc Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients
    C R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, Room 2223, 125 South 31st Street, Philadelphia, PA 19104, USA
    Neuroscience 141:1257-64. 2006
    ..This transgenic model of sensory encoding deficits provides a foundation for identifying biochemical contributions to sensory processing impairments associated with schizophrenia...
  17. ncbi request reprint Computerized neurocognitive scanning: II. The profile of schizophrenia
    R C Gur
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, The University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 25:777-88. 2001
    ..We conclude that the computerized neurocognitive scan can be applied reliably in people with schizophrenia, yielding data that support its construct and criterion validity...
  18. ncbi request reprint Phosphodiesterase inhibitors: a novel mechanism for receptor-independent antipsychotic medications
    C R Maxwell
    Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 129:101-7. 2004
    ..The current study examines the potential of using non-receptor-based agents that modify intracellular signal transduction as potential antipsychotic medications...
  19. pmc Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity
    S J Kanes
    Department of Psychiatry and Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 144:239-46. 2007
    ..Given previous reports showing rolipram improves cognition, we conclude that PDE4 represents an important novel target for further antipsychotic drug development...
  20. pmc Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia
    T B Halene
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Brain Behav 8:661-75. 2009
    ..The behavioral signature in NR1(neo)-/- mice supports the impact of impaired NMDAR function in a mouse model with possible relevance to negative symptoms in schizophrenia...
  21. pmc Varenicline improves mood and cognition during smoking abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:144-9. 2009
    ..Varenicline, a partial agonist at the alpha4beta2 nAChRs, is a new, efficacious medication for nicotine dependence. Its effects on the affective and cognitive dimensions of nicotine withdrawal have yet to be well characterized...
  22. pmc A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice
    M J Gandal
    Medical Scientist Training Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 157:95-104. 2008
    ..We report an electrophysiological model of chemotherapy-induced cognitive deficits using a sensory gating paradigm, to correspond with performance in two behavioral tasks...
  23. ncbi request reprint Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content
    Avinash Budhian
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 3231 Walnut St, Philadelphia, PA 19104 6272, United States
    Int J Pharm 336:367-75. 2007
    ..When optimized, the drug-loaded PLGA/PLA nanoparticles contain as much as 2.5% haloperidol...
  24. ncbi request reprint Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, Translational Research Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 190:201-11. 2007
    ..Non-adherence with medication remains the major correctable cause of poor outcome in schizophrenia. However, few treatments have addressed this major determinant of outcome with novel long-term delivery systems...
  25. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  26. ncbi request reprint Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  27. ncbi request reprint Evaluation of in vitro release and in vivo efficacy of mPEG-PLA-haloperidol conjugate micelle-like structures
    Meredith L Hans
    Department of Chemical and Biological Engineering, Biomaterials and Drug Delivery Laboratory, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res B Appl Biomater 83:422-30. 2007
    ..Furthermore, results indicate that the sedative side effects of haloperidol were reduced with the micelle delivery systems as compared to the acute haloperidol injection...
  28. ncbi request reprint Controlling the in vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles
    Avinash Budhian
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA
    Int J Pharm 346:151-9. 2008
    ..The average value of drug diffusivities for PLGA and PLA nanoparticles was calculated and its variation with particle size was established...
  29. ncbi request reprint Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....
  30. pmc Ketamine exposure in adult mice leads to increased cell death in C3H, DBA2 and FVB inbred mouse strains
    Chalon R Majewski-Tiedeken
    Department of Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 92:217-27. 2008
    ..We previously demonstrated that ketamine exposure results in lasting physiological abnormalities in mice. However, the extent to which these deficits reflect neuropathologic changes is not known...
  31. pmc Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 15:75-83. 2008
    ..Our results imply that chronically stimulating targets upstream of cAMP may detrimentally affect cognition...
  32. ncbi request reprint Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 992:85-95. 2003
    ..Future studies will attempt to determine the cause of these differences in sensory and sensorimotor processing between these two closely related inbred mouse strains...
  33. ncbi request reprint Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives
    Farzin Irani
    Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    Schizophr Res 88:151-60. 2006
    ....
  34. ncbi request reprint Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
    ....
  35. ncbi request reprint Effect of drug type on the degradation rate of PLGA matrices
    Steven J Siegel
    Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Eur J Pharm Biopharm 64:287-93. 2006
    ..We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate...
  36. ncbi request reprint The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurochem Res 29:1179-88. 2004
    ..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems...
  37. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..Such changes may contribute to the cognitive deficits common in schizophrenia...
  38. ncbi request reprint A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Schizophrenia Research Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 55:512-7. 2004
    ..Although gender differences in schizophrenia are evident clinically and correlate with neuroanatomic measures, their relationship to OAR has not been examined...
  39. ncbi request reprint Symptom and demographic profiles in first-episode schizophrenia
    Edward I Gelber
    Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Schizophr Res 67:185-94. 2004
    ..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients...
  40. ncbi request reprint Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:739-46. 2004
    ..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not...
  41. pmc Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha
    Thomas J Gould
    Department of Psychology, Temple University, Weiss Hall, Philadelphia, PA, USA
    Neuropsychopharmacology 29:494-501. 2004
    ....
  42. ncbi request reprint Levels-of-processing effect on word recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 54:1154-61. 2003
    ..By requiring participants to classify and encode words on either a shallow (e.g., uppercase/lowercase) or deep level (e.g., concrete/abstract), the levels-of-processing paradigm eliminates the need to generate organizational strategies...
  43. ncbi request reprint Facial emotion recognition in schizophrenia: intensity effects and error pattern
    Christian G Kohler
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1768-74. 2003
    ..The authors used color photographs of emotional and neutral expressions to investigate recognition patterns of five universal emotions in schizophrenia...
  44. ncbi request reprint Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia
    Raquel E Gur
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:2029-36. 2003
    ..These results suggest that some effects of olanzapine may impact both symptoms and cognitive performance...
  45. ncbi request reprint Development of an abbreviated schizophrenia quality of life scale using a new method
    Warren B Bilker
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neuropsychopharmacology 28:773-7. 2003
    ..This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments...
  46. ncbi request reprint Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice
    Wayne N Frankel
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 25:3452-8. 2005
    ..Because C3H/He mice have no other brain abnormalities, they are an attractive alternative for studying idiopathic absence epilepsy...
  47. pmc Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:577-88. 2007
    ..We conclude that expression of Galphas(*) within forebrain neurons causes PPI deficits because of a PKA-dependent decrease in cAMP and suggest that cAMP PDE inhibitors may exhibit antipsychotic-like therapeutic effects...
  48. ncbi request reprint Effects of nicotine vary across two auditory evoked potentials in the mouse
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 61:23-30. 2007
    ..We evaluated the effects of acute and chronic nicotine, using an animal model that incorporates genetic variation for sensory processing and nicotine sensitivity...
  49. pmc Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
    Schizophr Bull 32:279-87. 2006
    ..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness...
  50. ncbi request reprint Ketamine produces lasting disruptions in encoding of sensory stimuli
    Christina R Maxwell
    Division of Neuropsychiatry and Stanley Center for Experimental Therapeutics in Psychiatry, Clinical Research Bldg, Rm 145a, 415 Ci Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 316:315-24. 2006
    ..This lasting deficit in information processing occurred in the absence of acute changes among the FVB/Hsd mice. Implications for both ketamine abuse and N-methyl-D-aspartate hypofunction models of schizophrenia are discussed...
  51. ncbi request reprint Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol
    Avinash Budhian
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104 6272, USA
    J Microencapsul 22:773-85. 2005
    ..By varying other processing and materials parameters, the size, haloperidol incorporation and haloperidol release of the haloperidol-loaded PLGA nanoparticles were controlled...
  52. ncbi request reprint Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition
    J Daniel Ragland
    Department of Psychiatry, 10th Floor Gates Bldg HUP, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1840-8. 2005
    ..Patients with schizophrenia improve episodic memory accuracy when given organizational strategies through levels-of-processing paradigms. This study tested if improvement is accompanied by normalized frontotemporal function...
  53. pmc Withdrawal from chronic nicotine administration impairs contextual fear conditioning in C57BL/6 mice
    Jennifer A Davis
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Neurosci 25:8708-13. 2005
    ..These findings provide a model of how the effects of nicotine on learning may contribute to the development and maintenance of nicotine addiction...
  54. ncbi request reprint Synthesis and characterization of mPEG-PLA prodrug micelles
    Meredith Hans
    Biomaterials and Drug Delivery Laboratory, Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 6:2708-17. 2005
    ..Drug incorporation could be increased from 3% to 20% (w/w) using the different formulations...
  55. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  56. ncbi request reprint Corticosterone modulates auditory gating in mouse
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:897-903. 2006
    ..These data highlight the need to consider serum glucocorticoid levels when assessing human disease states associated with aberrations of information processing such as schizophrenia and depression...
  57. ncbi request reprint Patient and family attitudes toward schizophrenia treatment
    Farzin Irani
    Division of Neuropsychiatry, University of Pennsylvania, Clinical Research Building, Room 145a, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 6:283-8. 2004
    ..The important contribution of family members in caring for their loved ones is also emphasized. Patient participation in biomedical research is also discussed in the context of guiding the treatment of schizophrenia...
  58. ncbi request reprint Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  59. doi request reprint Translating basic science to improve pharmacotherapy for nicotine dependence
    Jennifer M Phillips
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nicotine Tob Res 9:S583-98. 2007
    ....
  60. ncbi request reprint PDE inhibitors in psychiatry--future options for dementia, depression and schizophrenia?
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st Street, Philadelphia, PA 19104, United States
    Drug Discov Today 12:870-8. 2007
    ..Adverse effects are a major impediment for clinical approval. It is therefore necessary to search for more specific inhibitors at the level of different PDE sub-families and isoforms...

Research Grants8

  1. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2004
    ..abstract_text> ..
  2. An implantable semiannual antipsychotic delivery system
    Steven Siegel; Fiscal Year: 2007
    ..Completion of the proposed studies would foster future industrial investment in long-term delivery systems for multiple agents, leading to dramatically improved patient care in the future. ..
  3. Long-term neurobehavioral effects of ketamine exposure in adolescent mice
    Steven Siegel; Fiscal Year: 2009
    ....
  4. Long-term neurobehavioral effects of ketamine exposure in adolescent mice
    Steven J Siegel; Fiscal Year: 2010
    ....
  5. An implantable semiannual antipsychotic delivery system
    Steven J Siegel; Fiscal Year: 2010
    ..We will also determine how constant infusion of antipsychotic medication from implants improves behavior and brain function in comparison to oral administration rodents. ..
  6. An implantable semiannual antipsychotic delivery system
    Steven J Siegel; Fiscal Year: 2011
    ..We will also determine how constant infusion of antipsychotic medication from implants improves behavior and brain function in comparison to oral administration rodents. ..