Steven J Siegel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism
    Mili V Mehta
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e26077. 2011
  2. pmc Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials
    Robert E Featherstone
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39775. 2012
  3. pmc Animal models and measures of perceptual processing in schizophrenia
    Steven J Siegel
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, United States Electronic address
    Neurosci Biobehav Rev 37:2092-8. 2013
  4. ncbi request reprint Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, Translational Research Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 190:201-11. 2007
  5. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006
  6. pmc Profile of auditory information-processing deficits in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychiatry Res 165:27-37. 2009
  7. pmc Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 15:75-83. 2008
  8. pmc Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1294:116-27. 2009
  9. ncbi request reprint Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:739-46. 2004
  10. pmc Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 35:311-7. 2009

Detail Information

Publications64

  1. pmc mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism
    Mili V Mehta
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e26077. 2011
    ..These results are consistent with emerging preclinical literature that mGluR5-antagonists may have therapeutic efficacy for core symptoms of autism...
  2. pmc Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials
    Robert E Featherstone
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e39775. 2012
    ..Although the role of nicotine receptor subtypes in augmentation of ERPs has received some attention, less is known about how these receptor subtypes regulate the effect of nicotine on evoked gamma activity...
  3. pmc Animal models and measures of perceptual processing in schizophrenia
    Steven J Siegel
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, United States Electronic address
    Neurosci Biobehav Rev 37:2092-8. 2013
    ....
  4. ncbi request reprint Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, Translational Research Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 190:201-11. 2007
    ..Non-adherence with medication remains the major correctable cause of poor outcome in schizophrenia. However, few treatments have addressed this major determinant of outcome with novel long-term delivery systems...
  5. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006
    ..This study assessed the relationship between symptoms and cognitive measures at intake and functional outcome 2-8 years later (average 3 years) in first-episode and previously treated schizophrenia patients...
  6. pmc Profile of auditory information-processing deficits in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychiatry Res 165:27-37. 2009
    ..Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia...
  7. pmc Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 15:75-83. 2008
    ..Our results imply that chronically stimulating targets upstream of cAMP may detrimentally affect cognition...
  8. pmc Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Brain Res 1294:116-27. 2009
    ..Using mutant mice heterozygous for Nrg1 (Nrg1(+/-)) we studied the effects of Nrg1 signaling on behavioral and electrophysiological measures relevant to schizophrenia...
  9. ncbi request reprint Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:739-46. 2004
    ..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not...
  10. pmc Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 35:311-7. 2009
    ..Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli...
  11. ncbi request reprint Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  12. ncbi request reprint Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
    ..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
  13. ncbi request reprint Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition
    J Daniel Ragland
    Department of Psychiatry, 10th Floor Gates Bldg HUP, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1840-8. 2005
    ..Patients with schizophrenia improve episodic memory accuracy when given organizational strategies through levels-of-processing paradigms. This study tested if improvement is accompanied by normalized frontotemporal function...
  14. doi request reprint Deviance-elicited changes in event-related potentials are attenuated by ketamine in mice
    Richard S Ehrlichman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cogn Neurosci 20:1403-14. 2008
    ..This study examines a novel rodent model of impaired pitch deviance detection in mice using the NMDA receptor antagonist ketamine...
  15. doi request reprint Attitudes of patients and family members towards implantable psychiatric medication
    Mary E Dankert
    Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:279-86. 2008
    ..The devastating consequences of nonadherence have motivated the development of novel therapeutic strategies, including a new long-term implantable medication delivery system...
  16. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  17. doi request reprint Male and female mice differ for baseline and nicotine-induced event related potentials
    Laura C Amann
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, PA, USA
    Behav Neurosci 122:982-90. 2008
    ..Whether this electrophysiological sexual dimorphism has functional consequences for sensory or cognitive abilities requires additional research. (PsycINFO Database Record (c) 2008 APA, all rights reserved)...
  18. ncbi request reprint Ketamine produces lasting disruptions in encoding of sensory stimuli
    Christina R Maxwell
    Division of Neuropsychiatry and Stanley Center for Experimental Therapeutics in Psychiatry, Clinical Research Bldg, Rm 145a, 415 Ci Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 316:315-24. 2006
    ..This lasting deficit in information processing occurred in the absence of acute changes among the FVB/Hsd mice. Implications for both ketamine abuse and N-methyl-D-aspartate hypofunction models of schizophrenia are discussed...
  19. ncbi request reprint Symptom and demographic profiles in first-episode schizophrenia
    Edward I Gelber
    Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Schizophr Res 67:185-94. 2004
    ..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients...
  20. ncbi request reprint Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content
    Avinash Budhian
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 3231 Walnut St, Philadelphia, PA 19104 6272, United States
    Int J Pharm 336:367-75. 2007
    ..When optimized, the drug-loaded PLGA/PLA nanoparticles contain as much as 2.5% haloperidol...
  21. pmc Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice
    Christina L Bodarky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Pharmacol Exp Ther 331:308-18. 2009
    ..In addition, NR1 reduction decreased GABA(A) receptor-mediated effects on ERPs while causing increased GABA(B) receptor-mediated effects. Future studies will examine changes in GABA receptor subunits after reductions in NR1 expression...
  22. doi request reprint Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice
    Robert E Featherstone
    Department of Psychiatry, Translational Neuroscience Program, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 47:338-46. 2012
    ....
  23. ncbi request reprint Effect of drug type on the degradation rate of PLGA matrices
    Steven J Siegel
    Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Eur J Pharm Biopharm 64:287-93. 2006
    ..We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate...
  24. ncbi request reprint Effects of nicotine vary across two auditory evoked potentials in the mouse
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 61:23-30. 2007
    ..We evaluated the effects of acute and chronic nicotine, using an animal model that incorporates genetic variation for sensory processing and nicotine sensitivity...
  25. ncbi request reprint The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurochem Res 29:1179-88. 2004
    ..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems...
  26. ncbi request reprint Controlling the in vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles
    Avinash Budhian
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA
    Int J Pharm 346:151-9. 2008
    ..The average value of drug diffusivities for PLGA and PLA nanoparticles was calculated and its variation with particle size was established...
  27. doi request reprint Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density
    Yufei A Cao
    ranslational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, PA, USA
    Behav Neurosci 126:332-43. 2012
    ..Nicotine restored normal event-related activity among COMT-Val-tg mice, suggesting one mechanism through which nicotine may normalize cognitive function among people with the high-activity allele...
  28. pmc Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
    Schizophr Bull 32:279-87. 2006
    ..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness...
  29. pmc Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression
    Robert E Featherstone
    Department of Psychiatry, Translational Neuroscience Program, School of Medicine, University of Pennsylvania, 125 South 31st Street, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 227:639-49. 2013
    ....
  30. ncbi request reprint Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
    ....
  31. pmc Mouse model predicts effects of smoking and varenicline on event-related potentials in humans
    Noam D Rudnick
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nicotine Tob Res 12:589-97. 2010
    ..Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of the partial nicotine agonist varenicline on ERPs...
  32. doi request reprint Validating γ oscillations and delayed auditory responses as translational biomarkers of autism
    Michael J Gandal
    Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, USA
    Biol Psychiatry 68:1100-6. 2010
    ..This study assessed the translational potential of auditory evoked-response endophenotypes of autism in parallel mouse and human studies of autism...
  33. doi request reprint In vitro-in vivo correlations of scalable PLGA-risperidone implants for the treatment of schizophrenia
    Laura C Amann
    Translational Neuroscience Program, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 27:1730-7. 2010
    ..To address these concerns, we previously demonstrated proof of concept for an antipsychotic implant containing risperidone and the biodegradable polymer poly(lactic-co-glycolic) acid (PLGA)...
  34. pmc Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP
    Michele P Kelly
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:577-88. 2007
    ..We conclude that expression of Galphas(*) within forebrain neurons causes PPI deficits because of a PKA-dependent decrease in cAMP and suggest that cAMP PDE inhibitors may exhibit antipsychotic-like therapeutic effects...
  35. pmc Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
    Gregory C Carlson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Proc Natl Acad Sci U S A 108:E962-70. 2011
    ..Furthermore, these data implicate reduced fast-phasic inhibition as a common underlying mechanism of schizophrenia-associated intermediate phenotypes...
  36. ncbi request reprint Corticosterone modulates auditory gating in mouse
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:897-903. 2006
    ..These data highlight the need to consider serum glucocorticoid levels when assessing human disease states associated with aberrations of information processing such as schizophrenia and depression...
  37. ncbi request reprint A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Schizophrenia Research Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 55:512-7. 2004
    ..Although gender differences in schizophrenia are evident clinically and correlate with neuroanatomic measures, their relationship to OAR has not been examined...
  38. doi request reprint Psychiatric health care provider attitudes towards implantable medication
    Mary E Dankert
    Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Psychiatry Res 177:167-71. 2010
    ..Although dozens of factors influence the future of implants, the surveyed population showed moderate to strong support for this novel treatment...
  39. pmc Ketamine exposure in adult mice leads to increased cell death in C3H, DBA2 and FVB inbred mouse strains
    Chalon R Majewski-Tiedeken
    Department of Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 92:217-27. 2008
    ..We previously demonstrated that ketamine exposure results in lasting physiological abnormalities in mice. However, the extent to which these deficits reflect neuropathologic changes is not known...
  40. pmc Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes
    John A Saunders
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Autism Res 6:69-77. 2013
    ..Autism Res 2013, 6: 69-77. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. ..
  41. doi request reprint Predator odor modulates auditory event-related potentials in mice
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuroreport 20:1260-4. 2009
    ..NR1 knockdown mice do not have deficits in this task, suggesting that sensory integration may rely on non-N-methyl-D-aspartate receptor mediated circuits...
  42. doi request reprint Role of beta2-containing nicotinic acetylcholine receptors in auditory event-related potentials
    Noam D Rudnick
    Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19312, USA
    Psychopharmacology (Berl) 202:745-51. 2009
    ..Less is known about the role of specific nicotinic acetylcholine receptor (nAChR) subtypes...
  43. doi request reprint Mouse behavioral endophenotypes for schizophrenia
    Laura C Amann
    Stanley Medical Research Institute for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Brain Res Bull 83:147-61. 2010
    ..We also, address the viability and validity of using such measures regarding their potential clinical implications, and suggest several practices that could increase the translatability of preclinical data...
  44. ncbi request reprint Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia
    Raquel E Gur
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:2029-36. 2003
    ..These results suggest that some effects of olanzapine may impact both symptoms and cognitive performance...
  45. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  46. pmc A rapid method for creating drug implants: translating laboratory-based methods into a scalable manufacturing process
    Cheng Kuo Wang
    Stanley Center for Experimental Therapeutics, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res B Appl Biomater 93:562-72. 2010
    ..Data suggest that fewer surface pores shift the mechanism from bulk to surface PLGA degradation and longer lag period. Results demonstrate that extrusion is a viable process for manufacturing antipsychotic implants...
  47. ncbi request reprint Levels-of-processing effect on word recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 54:1154-61. 2003
    ..By requiring participants to classify and encode words on either a shallow (e.g., uppercase/lowercase) or deep level (e.g., concrete/abstract), the levels-of-processing paradigm eliminates the need to generate organizational strategies...
  48. doi request reprint Electroencephalographic changes following direct current deep brain stimulation of auditory cortex: a new model for investigating neuromodulation
    Joaquin O De Rojas
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neurosurgery 72:267-75; discussion 275. 2013
    ..Therefore, there is a need for new animal models of neuromodulation...
  49. pmc Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia
    Michael J Gandal
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1504-18. 2012
    ..Finally, we propose that analogous signal-to-noise deficits in the flow of cortical information in preclinical models are useful targets for the development of new drugs that target the treatment-resistant symptoms of schizophrenia...
  50. pmc Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits
    Eddie N Billingslea
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 39:1603-13. 2014
    ..Although previous data suggest that MPEP may be beneficial for core features of autism spectrum disorders, current data suggest that such effects require intact function of NMDAR on PV interneurons. ..
  51. ncbi request reprint Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  52. doi request reprint Ketamine modulates theta and gamma oscillations
    Maciej T Lazarewicz
    Neuroengineering Laboratory, Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA
    J Cogn Neurosci 22:1452-64. 2010
    ..These findings support a role for NMDA receptors in mediating the balance between theta and gamma responses to sensory stimuli, with possible implications for dysfunction in schizophrenia...
  53. ncbi request reprint Facial emotion recognition in schizophrenia: intensity effects and error pattern
    Christian G Kohler
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1768-74. 2003
    ..The authors used color photographs of emotional and neutral expressions to investigate recognition patterns of five universal emotions in schizophrenia...
  54. ncbi request reprint Effects of strain, novelty, and NMDA blockade on auditory-evoked potentials in mice
    Steven J Siegel
    Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 28:675-82. 2003
    ..The ability to model novelty detection deficits in mice will aid in identifying genetic contributions to abnormal neuronal organization in people with schizophrenia...
  55. ncbi request reprint Development of an abbreviated schizophrenia quality of life scale using a new method
    Warren B Bilker
    Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neuropsychopharmacology 28:773-7. 2003
    ..This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments...
  56. ncbi request reprint Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol
    Avinash Budhian
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104 6272, USA
    J Microencapsul 22:773-85. 2005
    ..By varying other processing and materials parameters, the size, haloperidol incorporation and haloperidol release of the haloperidol-loaded PLGA nanoparticles were controlled...
  57. ncbi request reprint PDE inhibitors in psychiatry--future options for dementia, depression and schizophrenia?
    Tobias B Halene
    SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st Street, Philadelphia, PA 19104, United States
    Drug Discov Today 12:870-8. 2007
    ..Adverse effects are a major impediment for clinical approval. It is therefore necessary to search for more specific inhibitors at the level of different PDE sub-families and isoforms...
  58. ncbi request reprint Patient and family attitudes toward schizophrenia treatment
    Farzin Irani
    Division of Neuropsychiatry, University of Pennsylvania, Clinical Research Building, Room 145a, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 6:283-8. 2004
    ..The important contribution of family members in caring for their loved ones is also emphasized. Patient participation in biomedical research is also discussed in the context of guiding the treatment of schizophrenia...
  59. ncbi request reprint Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 992:85-95. 2003
    ..Future studies will attempt to determine the cause of these differences in sensory and sensorimotor processing between these two closely related inbred mouse strains...
  60. pmc MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder
    Wenlin Liao
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 46:88-92. 2012
    ....
  61. ncbi request reprint Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....
  62. doi request reprint Translating basic science to improve pharmacotherapy for nicotine dependence
    Jennifer M Phillips
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nicotine Tob Res 9:S583-98. 2007
    ....
  63. ncbi request reprint A unique iontophoretic patch for optimal transdermal delivery of sumatriptan
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Translational Research Laboratories, 125 S 31st St Rm 2223, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 24:1919-26. 2007
    ..Four unique prototype iontophoretic sumatriptan patch conditions were compared to a 6 mg subcutaneous injection and an oral 50 mg tablet of sumatriptan succinate...
  64. ncbi request reprint Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, Laboratory of Molecular Neuropsychopharmacolgy, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Gates Building 10th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 26:817-23. 2002
    ..Surgically-implantable formulations are a viable approach to provide long-term delivery of antipsychotic medications to patients with psychotic disorders...