Research Topics
| J M SiegelSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstemLalini Ramanathan
Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA
Neuroreport 13:1387-90. 2002..We show that prolonged sleep deprivation significantly decreased Cu/Zn-SOD activity in the hippocampus and brainstem, suggesting an alteration in the metabolism of ROS resulting in oxidative stress...- A brief history of hypocretin/orexin and narcolepsyJ M Siegel
Department of Psychiatry and Brain Research Institute, UCLA and Neurobiological Research 151A3, VA GLAHCS, North Hills, CA 91343, USA
Neuropsychopharmacology 25:S14-20. 2001..This paper reviews these events and their implications for our understanding of brain arousal and motor control systems... - Hypocretin (orexin): role in normal behavior and neuropathologyJerome M Siegel
Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, and Department of Psychiatry and Biobehavioral Sciences, Center for Sleep Research, University of California, Los Angeles, California 91343, USA
Annu Rev Psychol 55:125-48. 2004..Administration of Hcrt can reverse symptoms of narcolepsy in animals, may be effective in treating human narcolepsy, and may affect a broad range of motivated behaviors... - The neurotransmitters of sleepJerome M Siegel
Center for Sleep Research, University of California, Los Angeles, CA 91343, USA
J Clin Psychiatry 65:4-7. 2004..The transmitters discussed in this article have been the most thoroughly studied, and many aspects of the role of each of these transmitters in relation to sleep are reasonably well understood... 
Functional implications of sleep developmentJerome M Siegel
Veterans Administration Greater Los Angeles Health Care System in Sepulveda, California, USA
PLoS Biol 3:e178. 2005..Why do we sleep? The sleep patterns and mechanisms that occur throughout development may give us a clue...- The REM sleep-memory consolidation hypothesisJ M Siegel
Center for Sleep Research, Department of Veterans Affairs, Greater Los Angeles Healthcare System VA GLAHCS, North Hills, CA 91343, USA
Science 294:1058-63. 2001..Although sleep is clearly important for optimum acquisition and performance of learned tasks, a major role in memory consolidation is unproven... - Clues to the functions of mammalian sleepJerome M Siegel
Neurobiology Research 151A3, VA GLAHS Sepulveda, Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, North Hills, California 91343, USA
Nature 437:1264-71. 2005..Sleep may be an efficient time for the completion of a number of functions, but variations in sleep expression indicate that these functions may differ across species... - Narcolepsy and the hypocretin system--where motion meets emotionJerome M Siegel
Brain Research Institute, University of California, Los Angeles UCLA, and VA Greater Los Angeles Healthcare System, CA, USA
Nat Clin Pract Neurol 2:548-56. 2006..Sodium oxybate produces both reductions in cataplexy and improved waking alertness. Future treatments are likely to include Hcrt or Hcrt agonists to reverse the underlying neurochemical deficit... 
Do all animals sleep?Jerome M Siegel
Department of Psychiatry, School of Medicine, University of California, Los Angeles and Neurobiology Research 151 A3, VA GLAHS, North Hills, CA 91343, USA
Trends Neurosci 31:208-13. 2008..The enormous variation in the nature of rest and sleep states across the animal kingdom and within the mammalian class has important implications for understanding the evolution and functions of sleep...- The neurobiology of sleepJerome M Siegel
Department of Psychiatry, UCLA, North Hills, California 91343, USA
Semin Neurol 29:277-96. 2009..Damage to the pons and/or caudal midbrain can cause abnormalities in REM sleep. The persistent sleepiness of narcolepsy is a result of a loss of hypocretin function... - The distribution and morphological characteristics of serotonergic cells in the brain of monotremesP R Manger
Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
Brain Behav Evol 60:315-32. 2002..The results of our study are compared in an evolutionary context with those reported for other mammals and reptiles... - Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis studyY Y Lai
Department of Psychiatry and Biobehavioral Neuroscience, School of Medicine, University of California Los Angeles, and Veterans Affairs, Greater Los Angeles Health Care System Medical Center, North Hills, California 91343, USA
J Neurosci 21:7384-91. 2001.... - The distribution and morphological characteristics of catecholaminergic cells in the brain of monotremes as revealed by tyrosine hydroxylase immunohistochemistryP R Manger
Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
Brain Behav Evol 60:298-314. 2002..The similarity of this system across mammalian and amniote species underlines the evolutionary conservatism of the catecholaminergic system... 
Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogsM F Wu
Department Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
J Physiol 554:202-15. 2004....- State-related discharge of neurons in the brainstem of freely moving box turtles, Terrapene carolina majorM M Eiland
VAMC Sepulveda and Dept. of Psychiatry and Brain Research Institute, UCLA School of Medicine, Neurobiology Research 151A3, 16111 Plummer St, Sepulveda, CA 91343, USA
Arch Ital Biol 139:23-36. 2001..Polygraphic data showed no consistent, cyclically occurring phasic events during quiescence... - Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movementM F Wu
Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, North Hills, California 91343, USA
Am J Physiol Regul Integr Comp Physiol 283:R1079-86. 2002..The strong correlation between motor activity and Hcrt-1 release may explain some of the previously reported behavioral, physiological, and pathological phenomena ascribed to the Hcrt system... - Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behaviorJoshi John
Neurobiology Research (151A3, Veterans Administration Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
Neuron 42:619-34. 2004.... - Release of hypocretin (orexin) during waking and sleep statesLyudmila I Kiyashchenko
Department of Psychiatry and Biobehavioral Sciences and Brain Research Institute, University of California Los Angeles School of Medicine, North Hills, California 91343, USA
J Neurosci 22:5282-6. 2002..Hcrt-1 release into CSF was 67% higher during AW than during QW. Elevated levels of Hcrt during REM sleep and AW are consistent with a role for Hcrt in the central programming of motor activity... - Treatment with immunosuppressive and anti-inflammatory agents delays onset of canine genetic narcolepsy and reduces symptom severityL N Boehmer
Department of Psychiatry, University of California at Los Angeles, 90095, USA
Exp Neurol 188:292-9. 2004..Our findings show that hcrtr2 mutation is not sufficient for the full symptomatic development of canine genetic narcolepsy and suggest that the immune system may play a role in the development of this disorder... - Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleepY Y Lai
Department of Psychiatry and Biobehavioral Science, Neurobiology Research, David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, North Hills, CA 91343, USA
Neuroscience 154:431-43. 2008.... - Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsyA M Blouin
Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, CA, USA
Neurology 65:1189-92. 2005..CONCLUSIONS: This finding supports the hypothesis that narcolepsy results from the specific loss of hypocretin neurons. Loss of hypothalamic Narp may contribute to the symptoms of narcolepsy... - Monotremes and the evolution of rapid eye movement sleepJ M Siegel
Sepulveda VAMC, North Hills, CA 91343, USA
Philos Trans R Soc Lond B Biol Sci 353:1147-57. 1998.... - Cataplexy-related neurons in the amygdala of the narcoleptic dogS Gulyani
Department of Psychiatry and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 91020, USA
Neuroscience 112:355-65. 2002.... - Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate catJ Kohyama
Dept. of Psychiatry, UCLA School of Medicine, Sepulveda VAMC, North Hills, Calif 91343, USA
Sleep 21:695-9. 1998..A two-way interaction between the medulla and pons is hypothesized to play a crucial role in the control of muscle tone... - Narcolepsy: a key role for hypocretins (orexins)J M Siegel
Neurobiology Research, Veterans Administration Medical Center, North Hills, California 91343, USA
Cell 98:409-12. 1999 - Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsyThomas C Thannickal
Department of Psychiatry and Brain Research Institute, University of California, Los Angeles and Neurobiology Research, VA Greater Los Angeles Healthcare System, North Hills, Calif 91343, USA
Brain Pathol 13:340-51. 2003.... - Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate ratsBoris Y Mileykovskiy
Veterans Administration, Greater Los Angeles Health System, Sepulveda, California, USA
J Physiol 545:997-1006. 2002..These two mechanisms acting synergistically may cause generalized motor inhibition during REM sleep and cataplexy... - Fur seals display a strong drive for bilateral slow-wave sleep while on landOleg I Lyamin
Department of Psychiatry, School of Medicine, University of California Los Angeles and Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
J Neurosci 28:12614-21. 2008..These data indicate that fur seals display a homeostatic response to the loss of SWS and that alternating SWS in the two hemispheres does not adequately compensate for the absence of BSWS... - Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changesM F Wu
Department of Psychiatry, University of California, Los Angeles, CA, USA
Arch Ital Biol 149:492-8. 2011..We conclude that motor and cardiovascular changes are not sufficient to elevate CSF levels of Hcrt and we hypothesize that the emotional aspects of yard play account for the observed increase in Hcrt... - Attenuated circadian rhythms in mice lacking the prokineticin 2 geneJia Da Li
Department of Pharmacology, University of California, Irvine, Irvine, California 92697, USA
J Neurosci 26:11615-23. 2006..In addition, PK2-null mice showed accelerated acquisition of food anticipatory activity during a daytime food restriction. We conclude that PK2, acting as a SCN output factor, is important for the maintenance of robust circadian rhythms... - Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient miceWang Ping Hu
Department of Pharmacology, University of California, Irvine, CA 92697, USA
Sleep 30:247-56. 2007..In particular, mice lacking the PK2 gene (PK2-/-) have been shown to display significantly reduced rhythmicity for a variety of circadian physiological and behavioral parameters. We investigated the role of PK2 in sleep regulation... - Relationship between sleep and eye state in Cetaceans and PinnipedsO I Lyamin
Department of Psychiatry, School of Medicine, UCLA and Neurobiology Research 151A3, VAGLAHS Sepulveda, North Hills, California 91343, USA
Arch Ital Biol 142:557-68. 2004.... - Overweight and depressive symptoms among African-American womenJ M Siegel
Department of Community Health Sciences, School of Public Health, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
Prev Med 31:232-40. 2000..This study examines overweight and depressive symptoms among urban African-American women, taking into account demographic factors, health status and practices, and psychosocial constructs... - AIDS diagnosis and depression in the Multicenter AIDS Cohort Study: the ameliorating impact of pet ownershipJ M Siegel
University of California, Los Angeles, USA
AIDS Care 11:157-70. 1999..This beneficial effect of pet ownership occurred principally among persons who reported fewer confidants. These results suggest that by enhancing companionship for some HIV-infected persons, pets may buffer the stressful impact of AIDS... - Unihemispheric slow wave sleep and the state of the eyes in a white whaleO I Lyamin
Severtsov Institute of Ecology and Evolution, 33 Leninsky Prospect, Moscow, Russia
Behav Brain Res 129:125-9. 2002..Therefore, eye state alone may not accurately reflect sleep state in Cetaceans. Our data support the idea that unihemispheric sleep allows Cetaceans to monitor the environment... - Hypocretin (orexin) cell loss in Parkinson's diseaseThomas C Thannickal
Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
Brain 130:1586-95. 2007.... - Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexyThomas C Thannickal
Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research, North Hills, CA 91343, USA
Sleep 32:993-8. 2009..In this study we examined hypocretin pathology in narcolepsy without cataplexy... - Electroencephalogram asymmetry and spectral power during sleep in the northern fur sealOleg I Lyamin
UCLA and VA GLAHS, Sepulveda, CA 91343, USA
J Sleep Res 17:154-65. 2008..2-4 and 12-16 Hz. As shown in this study, the degree of EEG asymmetry and the frequency range in which it is expressed during SWS in fur seals are profoundly different from those of terrestrial mammals and birds... - Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorderYuan Yang Lai
Department of Psychiatry, School of Medicine, UCLA and Neurobiology Research 151A3 VAGLAHS Sepulveda, North Hills, CA 91343, USA
Mol Neurobiol 27:137-52. 2003..In this article, we will discuss evidence that Parkinsonism and RBD are physiologically and anatomically linked, based on our animal experiments and other studies on human patients... - Behavioral correlates of activity in identified hypocretin/orexin neuronsBoris Y Mileykovskiy
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
Neuron 46:787-98. 2005..Our findings suggest that these cells are activated during emotional and sensorimotor conditions similar to those that trigger cataplexy in narcoleptic animals... - Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonismJohn H Peever
Department of Psychiatry and Biobehavioral Neuroscience, School of Medicine, University of California, Los Angeles 90032, USA
J Neurophysiol 89:2591-600. 2003..We suggest that Hcrt regulates motor control processes and that this regulation is mediated by glutamate release in the trigeminal motor nucleus... - Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving ratsJoshi John
Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Health Care System, North Hills, CA 91343, USA
Am J Physiol Regul Integr Comp Physiol 295:R2041-9. 2008..High temporal resolution measurement of glutamate levels reveals dynamic changes in release linked to the initiation and termination of REM sleep... - Behavioral response and transmitter release during atonia elicited by medial medullary stimulationYuan Yang Lai
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, North Hills, CA 91343, USA
J Neurophysiol 104:2024-33. 2010.... - The distribution and morphological characteristics of cholinergic cells in the brain of monotremes as revealed by ChAT immunohistochemistryP R Manger
Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
Brain Behav Evol 60:275-97. 2002..This hiatus might be functionally related to the phenomenology of monotreme sleep and to the ontogeny of sleep in mammals, as juvenile placental mammals exhibit a similar combination of sleep elements to that found in adult monotremes... - Cetacean sleep: an unusual form of mammalian sleepOleg I Lyamin
Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, 16111 Plummer Street, North Hills, CA 91343, USA
Neurosci Biobehav Rev 32:1451-84. 2008..Aspects such as sentinel functions and breathing are likely to be proximate evolutionary phenomenon of this form of sleep... - Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in ratsJoshi John
Neurobiology Research (151A3, Veterans Affairs Greater Los Angeles Health Care System, North Hills, CA 91343, USA
J Physiol 548:557-62. 2003..Hcrt may act via the calcium-dependent regulation of glutamate release in certain nuclei of the central nervous system... - Why we sleepJerome M Siegel
Brain Research Institute, University of California, Los Angeles Medical Center, USA
Sci Am 289:92-7. 2003 - Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivationMonica M Eiland
University of California, Los Angeles, CA, USA
Brain Res 945:1-8. 2002..These anatomical changes suggest that the effects of sleep deprivation may be related to protein metabolism in certain brain regions... - The locus coeruleus complex of the bottlenose dolphin (Tursiops truncatus) as revealed by tyrosine hydroxylase immunohistochemistryPaul R Manger
Department of Psychiatry, University of California, Los Angeles, CA, USA
J Sleep Res 12:149-55. 2003.... - Cortical acetylcholine release is lateralized during asymmetrical slow-wave sleep in northern fur sealsJennifer L Lapierre
Department of Psychiatry, School of Medicine, University of California Los Angeles and Neurobiology Research, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
J Neurosci 27:11999-2006. 2007..These findings demonstrate that cortical ACh release is tightly linked to hemispheric EEG activation... - Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschersJoshi John
Department Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
J Physiol 560:587-92. 2004..A reduction followed by an increase in Hcrt levels coincides with symptom onset and increase in the narcoleptics. The Hcrtr2 mutation alters the normal developmental course of hypocretin levels... - Sleep viewed as a state of adaptive inactivityJerome M Siegel
Jerome M Siegel is at the Department of Psychiatry, School of Medicine, University of California, Los Angeles, California 90095, USA
Nat Rev Neurosci 10:747-53. 2009..Current evidence indicates that ecological variables are the main determinants of sleep duration and intensity across species... - Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behaviorLalini Ramanathan
Neurobiology Research 151A3, Greater Los Angeles Health Care System, North Hills, CA, USA
Behav Brain Res 207:305-9. 2010..We conclude that acute (6h) sleep loss may trigger compensatory mechanisms (like increased antioxidant responses) that prevent initial deterioration in working memory... - Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis studyTohro Kodama
Department of Psychology, Tokyo Metropolitan Institute of Neuroscience, Fuchu, Tokyo 183 8526, Japan
J Neurosci 23:1548-54. 2003..A combination of decreased monoamine and increased inhibitory amino acid release in motoneuron pools causes PIA-induced atonia and may be involved in atonia linked to rapid eye-movement sleep... - Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primatesSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
J Neurosci 27:14239-47. 2007..These findings provide strong evidence for the effectiveness of intranasal orexin-A in alleviating cognitive deficits produced by loss of sleep... - Hypocretin (orexin) and melanin concentrating hormone loss and the symptoms of Parkinson's diseaseThomas C Thannickal
Brain 131:e87. 2008 - The stuff dreams are made of: anatomical substrates of REM sleepJerome M Siegel
Nat Neurosci 9:721-2. 2006 - Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medullaBoris Y Mileykovskiy
Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia
J Neurophysiol 87:2480-9. 2002..Loss of OX function may, therefore, disturb both muscle tone facilitatory and inhibitory processes at the medullary level... - The narcoleptic borderlandJerome M Siegel
Sleep Med 4:3-4. 2003 - Unearthing the phylogenetic roots of sleepRavi Allada
Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, 2 160, Evanston, Illinois 60208, USA
Curr Biol 18:R670-R679. 2008..Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake... - Time for the sleep community to take a critical look at the purported role of sleep in memory processingRobert P Vertes
Center for Complex Systems and Brains Sciences, Florida Atlantic University, Boca Raton 33431, USA
Sleep 28:1228-9; discussion 1230-3. 2005..We briefly review the main arguments against a role for sleep in learning/memory... - The distribution and morphological characteristics of catecholaminergic cells in the diencephalon and midbrain of the bottlenose dolphin (Tursiops truncatus)Paul R Manger
School of Anatomical Sciences, Faculty of Health Science, University of the Witwatersrand, Johannesburg, Republic of South Africa
Brain Behav Evol 64:42-60. 2004..The results are discussed in relation to motor control, thermoregulation, unihemispheric sleep, and dolphin cognition...
Research Grants
- Control of Muscle Tone in nonREM SleepJerome Siegel; Fiscal Year: 2007..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
- Behavioral Role of HypocretinJerome Siegel; Fiscal Year: 2007..The proposed studies should clarify the nature of neurotransmitter control of Hcrt neurons, their involvement in narcolepsy and depression, and their normal physiological and behavioral roles in rodents and humans. ..
- Control of Muscle Tone in nonREM SleepJerome Siegel; Fiscal Year: 2009..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
- Behavioral Role of HypocretinJerome M Siegel; Fiscal Year: 2010..The proposed studies should clarify the nature of neurotransmitter control of Hcrt neurons, their involvement in narcolepsy and depression, and their normal physiological and behavioral roles in rodents and humans. ..
- Neuropathology of HypocretinJerome M Siegel; Fiscal Year: 2010....
- Sleep in CetaceansJerome Siegel; Fiscal Year: 2006..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
- LOCATION/CONTROL OF MEDULLARY NEURONS MEDIATING ATONIAJerome Siegel; Fiscal Year: 1992..They should provide important basic information on the mechanisms controlling muscle tone, and lead to a better understanding of the generation of atonia in normal REM sleep and in cataplexy...
- Hypocretin Release in Disease States and BehaviorJerome Siegel; Fiscal Year: 2004..quiet waking and REM vs. nonREM sleep. These studies will help define the role of this newly identified neurotransmitter system in relation to motor behavior, the sleep wake cycle and in human disease. ..
- Unihemispheric sleep: implications for mechanisms of sleep control and function iJerome M Siegel; Fiscal Year: 2010..It would also provide an insight into the causes of insomnia. ..