J M Siegel

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A brief history of hypocretin/orexin and narcolepsy
    J M Siegel
    Department of Psychiatry and Brain Research Institute, UCLA and Neurobiological Research 151A3, VA GLAHCS, North Hills, CA 91343, USA
    Neuropsychopharmacology 25:S14-20. 2001
  2. ncbi request reprint Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem
    Lalini Ramanathan
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA
    Neuroreport 13:1387-90. 2002
  3. pmc Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction
    Ashley M Blouin
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California 90095, USA
    Nat Commun 4:1547. 2013
  4. ncbi request reprint Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area
    L I Kiyashchenko
    Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia
    J Neurophysiol 85:2008-16. 2001
  5. ncbi request reprint Clues to the functions of mammalian sleep
    Jerome M Siegel
    Neurobiology Research 151A3, VA GLAHS Sepulveda, Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, North Hills, California 91343, USA
    Nature 437:1264-71. 2005
  6. ncbi request reprint Hypocretin (orexin): role in normal behavior and neuropathology
    Jerome M Siegel
    Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, and Department of Psychiatry and Biobehavioral Sciences, Center for Sleep Research, University of California, Los Angeles, California 91343, USA
    Annu Rev Psychol 55:125-48. 2004
  7. ncbi request reprint The neurotransmitters of sleep
    Jerome M Siegel
    Center for Sleep Research, University of California, Los Angeles, CA 91343, USA
    J Clin Psychiatry 65:4-7. 2004
  8. pmc Functional implications of sleep development
    Jerome M Siegel
    Veterans Administration Greater Los Angeles Health Care System in Sepulveda, California, USA
    PLoS Biol 3:e178. 2005
  9. ncbi request reprint The REM sleep-memory consolidation hypothesis
    J M Siegel
    Center for Sleep Research, Department of Veterans Affairs, Greater Los Angeles Healthcare System VA GLAHCS, North Hills, CA 91343, USA
    Science 294:1058-63. 2001
  10. doi request reprint Do all animals sleep?
    Jerome M Siegel
    Department of Psychiatry, School of Medicine, University of California, Los Angeles and Neurobiology Research 151 A3, VA GLAHS, North Hills, CA 91343, USA
    Trends Neurosci 31:208-13. 2008

Research Grants

  1. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2006
  2. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2007
  3. Behavioral Role of Hypocretin
    Jerome Siegel; Fiscal Year: 2007
  4. Behavioral Role of Hypocretin
    Jerome Siegel; Fiscal Year: 2009
  5. Neuropathology of Hypocretin
    Jerome Siegel; Fiscal Year: 2009
  6. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2009
  7. Behavioral Role of Hypocretin
    Jerome M Siegel; Fiscal Year: 2010
  8. Neuropathology of Hypocretin
    Jerome M Siegel; Fiscal Year: 2010
  9. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2006
  10. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2005

Collaborators

Detail Information

Publications64

  1. ncbi request reprint A brief history of hypocretin/orexin and narcolepsy
    J M Siegel
    Department of Psychiatry and Brain Research Institute, UCLA and Neurobiological Research 151A3, VA GLAHCS, North Hills, CA 91343, USA
    Neuropsychopharmacology 25:S14-20. 2001
    ..This paper reviews these events and their implications for our understanding of brain arousal and motor control systems...
  2. ncbi request reprint Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem
    Lalini Ramanathan
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA
    Neuroreport 13:1387-90. 2002
    ..We show that prolonged sleep deprivation significantly decreased Cu/Zn-SOD activity in the hippocampus and brainstem, suggesting an alteration in the metabolism of ROS resulting in oxidative stress...
  3. pmc Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction
    Ashley M Blouin
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California 90095, USA
    Nat Commun 4:1547. 2013
    ..Levels of these two peptides in humans are not simply linked to arousal, but rather to specific emotions and state transitions. Other arousal systems may be similarly emotionally specialized...
  4. ncbi request reprint Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area
    L I Kiyashchenko
    Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia
    J Neurophysiol 85:2008-16. 2001
    ..Moreover, OX-A and -B may also regulate the activity of pontine cholinoceptive and cholinergic neurons participating in muscle-tone suppression. Loss of OX function may therefore disturb both facilitatory and inhibitory motor processes...
  5. ncbi request reprint Clues to the functions of mammalian sleep
    Jerome M Siegel
    Neurobiology Research 151A3, VA GLAHS Sepulveda, Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, North Hills, California 91343, USA
    Nature 437:1264-71. 2005
    ..Sleep may be an efficient time for the completion of a number of functions, but variations in sleep expression indicate that these functions may differ across species...
  6. ncbi request reprint Hypocretin (orexin): role in normal behavior and neuropathology
    Jerome M Siegel
    Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, and Department of Psychiatry and Biobehavioral Sciences, Center for Sleep Research, University of California, Los Angeles, California 91343, USA
    Annu Rev Psychol 55:125-48. 2004
    ..Administration of Hcrt can reverse symptoms of narcolepsy in animals, may be effective in treating human narcolepsy, and may affect a broad range of motivated behaviors...
  7. ncbi request reprint The neurotransmitters of sleep
    Jerome M Siegel
    Center for Sleep Research, University of California, Los Angeles, CA 91343, USA
    J Clin Psychiatry 65:4-7. 2004
    ..The transmitters discussed in this article have been the most thoroughly studied, and many aspects of the role of each of these transmitters in relation to sleep are reasonably well understood...
  8. pmc Functional implications of sleep development
    Jerome M Siegel
    Veterans Administration Greater Los Angeles Health Care System in Sepulveda, California, USA
    PLoS Biol 3:e178. 2005
    ..Why do we sleep? The sleep patterns and mechanisms that occur throughout development may give us a clue...
  9. ncbi request reprint The REM sleep-memory consolidation hypothesis
    J M Siegel
    Center for Sleep Research, Department of Veterans Affairs, Greater Los Angeles Healthcare System VA GLAHCS, North Hills, CA 91343, USA
    Science 294:1058-63. 2001
    ..Although sleep is clearly important for optimum acquisition and performance of learned tasks, a major role in memory consolidation is unproven...
  10. doi request reprint Do all animals sleep?
    Jerome M Siegel
    Department of Psychiatry, School of Medicine, University of California, Los Angeles and Neurobiology Research 151 A3, VA GLAHS, North Hills, CA 91343, USA
    Trends Neurosci 31:208-13. 2008
    ..The enormous variation in the nature of rest and sleep states across the animal kingdom and within the mammalian class has important implications for understanding the evolution and functions of sleep...
  11. ncbi request reprint Narcolepsy and the hypocretin system--where motion meets emotion
    Jerome M Siegel
    Brain Research Institute, University of California, Los Angeles UCLA, and VA Greater Los Angeles Healthcare System, CA, USA
    Nat Clin Pract Neurol 2:548-56. 2006
    ..Sodium oxybate produces both reductions in cataplexy and improved waking alertness. Future treatments are likely to include Hcrt or Hcrt agonists to reverse the underlying neurochemical deficit...
  12. doi request reprint The neurobiology of sleep
    Jerome M Siegel
    Department of Psychiatry, UCLA, North Hills, California 91343, USA
    Semin Neurol 29:277-96. 2009
    ..Damage to the pons and/or caudal midbrain can cause abnormalities in REM sleep. The persistent sleepiness of narcolepsy is a result of a loss of hypocretin function...
  13. ncbi request reprint The distribution and morphological characteristics of serotonergic cells in the brain of monotremes
    P R Manger
    Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
    Brain Behav Evol 60:315-32. 2002
    ..The results of our study are compared in an evolutionary context with those reported for other mammals and reptiles...
  14. ncbi request reprint Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study
    Y Y Lai
    Department of Psychiatry and Biobehavioral Neuroscience, School of Medicine, University of California Los Angeles, and Veterans Affairs, Greater Los Angeles Health Care System Medical Center, North Hills, California 91343, USA
    J Neurosci 21:7384-91. 2001
    ....
  15. ncbi request reprint The distribution and morphological characteristics of catecholaminergic cells in the brain of monotremes as revealed by tyrosine hydroxylase immunohistochemistry
    P R Manger
    Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
    Brain Behav Evol 60:298-314. 2002
    ..The similarity of this system across mammalian and amniote species underlines the evolutionary conservatism of the catecholaminergic system...
  16. pmc Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs
    M F Wu
    Department Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Physiol 554:202-15. 2004
    ....
  17. ncbi request reprint State-related discharge of neurons in the brainstem of freely moving box turtles, Terrapene carolina major
    M M Eiland
    VAMC Sepulveda and Dept. of Psychiatry and Brain Research Institute, UCLA School of Medicine, Neurobiology Research 151A3, 16111 Plummer St, Sepulveda, CA 91343, USA
    Arch Ital Biol 139:23-36. 2001
    ..Polygraphic data showed no consistent, cyclically occurring phasic events during quiescence...
  18. ncbi request reprint Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement
    M F Wu
    Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, North Hills, California 91343, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1079-86. 2002
    ..The strong correlation between motor activity and Hcrt-1 release may explain some of the previously reported behavioral, physiological, and pathological phenomena ascribed to the Hcrt system...
  19. ncbi request reprint Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior
    Joshi John
    Neurobiology Research 151A3, Veterans Administration Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Neuron 42:619-34. 2004
    ....
  20. ncbi request reprint Cataplexy-related neurons in the amygdala of the narcoleptic dog
    S Gulyani
    Department of Psychiatry and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 91020, USA
    Neuroscience 112:355-65. 2002
    ....
  21. ncbi request reprint Release of hypocretin (orexin) during waking and sleep states
    Lyudmila I Kiyashchenko
    Department of Psychiatry and Biobehavioral Sciences and Brain Research Institute, University of California Los Angeles School of Medicine, North Hills, California 91343, USA
    J Neurosci 22:5282-6. 2002
    ..Hcrt-1 release into CSF was 67% higher during AW than during QW. Elevated levels of Hcrt during REM sleep and AW are consistent with a role for Hcrt in the central programming of motor activity...
  22. ncbi request reprint Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat
    J Kohyama
    Dept. of Psychiatry, UCLA School of Medicine, Sepulveda VAMC, North Hills, Calif 91343, USA
    Sleep 21:695-9. 1998
    ..A two-way interaction between the medulla and pons is hypothesized to play a crucial role in the control of muscle tone...
  23. ncbi request reprint Treatment with immunosuppressive and anti-inflammatory agents delays onset of canine genetic narcolepsy and reduces symptom severity
    L N Boehmer
    Department of Psychiatry, University of California at Los Angeles, 90095, USA
    Exp Neurol 188:292-9. 2004
    ..Our findings show that hcrtr2 mutation is not sufficient for the full symptomatic development of canine genetic narcolepsy and suggest that the immune system may play a role in the development of this disorder...
  24. ncbi request reprint Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep
    Y Y Lai
    Department of Psychiatry and Biobehavioral Science, Neurobiology Research, David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, North Hills, CA 91343, USA
    Neuroscience 154:431-43. 2008
    ....
  25. ncbi request reprint Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy
    A M Blouin
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, CA, USA
    Neurology 65:1189-92. 2005
    ..To investigate whether neuronal activity-regulated pentraxin (Narp) colocalizes with hypocretin (Hcrt or orexin) in the normal human brain and to determine if Narp staining is lost in the narcoleptic human brain...
  26. pmc Monotremes and the evolution of rapid eye movement sleep
    J M Siegel
    Sepulveda VAMC, North Hills, CA 91343, USA
    Philos Trans R Soc Lond B Biol Sci 353:1147-57. 1998
    ....
  27. ncbi request reprint Narcolepsy: a key role for hypocretins (orexins)
    J M Siegel
    Neurobiology Research, Veterans Administration Medical Center, North Hills, California 91343, USA
    Cell 98:409-12. 1999
  28. doi request reprint Fur seals display a strong drive for bilateral slow-wave sleep while on land
    Oleg I Lyamin
    Department of Psychiatry, School of Medicine, University of California Los Angeles and Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
    J Neurosci 28:12614-21. 2008
    ..These data indicate that fur seals display a homeostatic response to the loss of SWS and that alternating SWS in the two hemispheres does not adequately compensate for the absence of BSWS...
  29. ncbi request reprint Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy
    Thomas C Thannickal
    Department of Psychiatry and Brain Research Institute, University of California, Los Angeles and Neurobiology Research, VA Greater Los Angeles Healthcare System, North Hills, Calif 91343, USA
    Brain Pathol 13:340-51. 2003
    ....
  30. pmc Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate rats
    Boris Y Mileykovskiy
    Veterans Administration, Greater Los Angeles Health System, Sepulveda, California, USA
    J Physiol 545:997-1006. 2002
    ..These two mechanisms acting synergistically may cause generalized motor inhibition during REM sleep and cataplexy...
  31. pmc Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes
    M F Wu
    Department of Psychiatry, University of California, Los Angeles, CA, USA
    Arch Ital Biol 149:492-8. 2011
    ..We conclude that motor and cardiovascular changes are not sufficient to elevate CSF levels of Hcrt and we hypothesize that the emotional aspects of yard play account for the observed increase in Hcrt...
  32. pmc Attenuated circadian rhythms in mice lacking the prokineticin 2 gene
    Jia Da Li
    Department of Pharmacology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 26:11615-23. 2006
    ..In addition, PK2-null mice showed accelerated acquisition of food anticipatory activity during a daytime food restriction. We conclude that PK2, acting as a SCN output factor, is important for the maintenance of robust circadian rhythms...
  33. pmc Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice
    Wang Ping Hu
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Sleep 30:247-56. 2007
    ..In particular, mice lacking the PK2 gene (PK2-/-) have been shown to display significantly reduced rhythmicity for a variety of circadian physiological and behavioral parameters. We investigated the role of PK2 in sleep regulation...
  34. ncbi request reprint Relationship between sleep and eye state in Cetaceans and Pinnipeds
    O I Lyamin
    Department of Psychiatry, School of Medicine, UCLA and Neurobiology Research 151A3, VAGLAHS Sepulveda, North Hills, California 91343, USA
    Arch Ital Biol 142:557-68. 2004
    ....
  35. ncbi request reprint Unihemispheric slow wave sleep and the state of the eyes in a white whale
    O I Lyamin
    Severtsov Institute of Ecology and Evolution, 33 Leninsky Prospect, Moscow, Russia
    Behav Brain Res 129:125-9. 2002
    ..Therefore, eye state alone may not accurately reflect sleep state in Cetaceans. Our data support the idea that unihemispheric sleep allows Cetaceans to monitor the environment...
  36. ncbi request reprint Overweight and depressive symptoms among African-American women
    J M Siegel
    Department of Community Health Sciences, School of Public Health, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
    Prev Med 31:232-40. 2000
    ..This study examines overweight and depressive symptoms among urban African-American women, taking into account demographic factors, health status and practices, and psychosocial constructs...
  37. ncbi request reprint Behavioral correlates of activity in identified hypocretin/orexin neurons
    Boris Y Mileykovskiy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Neuron 46:787-98. 2005
    ..Our findings suggest that these cells are activated during emotional and sensorimotor conditions similar to those that trigger cataplexy in narcoleptic animals...
  38. ncbi request reprint Hypocretin (orexin) cell loss in Parkinson's disease
    Thomas C Thannickal
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Brain 130:1586-95. 2007
    ....
  39. doi request reprint Electroencephalogram asymmetry and spectral power during sleep in the northern fur seal
    Oleg I Lyamin
    UCLA and VA GLAHS, Sepulveda, CA 91343, USA
    J Sleep Res 17:154-65. 2008
    ..2-4 and 12-16 Hz. As shown in this study, the degree of EEG asymmetry and the frequency range in which it is expressed during SWS in fur seals are profoundly different from those of terrestrial mammals and birds...
  40. pmc Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy
    Thomas C Thannickal
    Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research, North Hills, CA 91343, USA
    Sleep 32:993-8. 2009
    ..In this study we examined hypocretin pathology in narcolepsy without cataplexy...
  41. pmc Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats
    Joshi John
    Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Health Care System, North Hills, CA 91343, USA
    Am J Physiol Regul Integr Comp Physiol 295:R2041-9. 2008
    ..High temporal resolution measurement of glutamate levels reveals dynamic changes in release linked to the initiation and termination of REM sleep...
  42. ncbi request reprint Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder
    Yuan Yang Lai
    Department of Psychiatry, School of Medicine, UCLA and Neurobiology Research 151A3 VAGLAHS Sepulveda, North Hills, CA 91343, USA
    Mol Neurobiol 27:137-52. 2003
    ..In this article, we will discuss evidence that Parkinsonism and RBD are physiologically and anatomically linked, based on our animal experiments and other studies on human patients...
  43. pmc Behavioral response and transmitter release during atonia elicited by medial medullary stimulation
    Yuan Yang Lai
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System Sepulveda, North Hills, CA 91343, USA
    J Neurophysiol 104:2024-33. 2010
    ....
  44. ncbi request reprint Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism
    John H Peever
    Department of Psychiatry and Biobehavioral Neuroscience, School of Medicine, University of California, Los Angeles 90032, USA
    J Neurophysiol 89:2591-600. 2003
    ..We suggest that Hcrt regulates motor control processes and that this regulation is mediated by glutamate release in the trigeminal motor nucleus...
  45. ncbi request reprint The distribution and morphological characteristics of cholinergic cells in the brain of monotremes as revealed by ChAT immunohistochemistry
    P R Manger
    Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
    Brain Behav Evol 60:275-97. 2002
    ..This hiatus might be functionally related to the phenomenology of monotreme sleep and to the ontogeny of sleep in mammals, as juvenile placental mammals exhibit a similar combination of sleep elements to that found in adult monotremes...
  46. pmc Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats
    Joshi John
    Neurobiology Research 151A3, Veterans Affairs Greater Los Angeles Health Care System, North Hills, CA 91343, USA
    J Physiol 548:557-62. 2003
    ..Hcrt may act via the calcium-dependent regulation of glutamate release in certain nuclei of the central nervous system...
  47. doi request reprint Cetacean sleep: an unusual form of mammalian sleep
    Oleg I Lyamin
    Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, 16111 Plummer Street, North Hills, CA 91343, USA
    Neurosci Biobehav Rev 32:1451-84. 2008
    ..Aspects such as sentinel functions and breathing are likely to be proximate evolutionary phenomenon of this form of sleep...
  48. ncbi request reprint Why we sleep
    Jerome M Siegel
    Brain Research Institute, University of California, Los Angeles Medical Center, USA
    Sci Am 289:92-7. 2003
  49. ncbi request reprint Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivation
    Monica M Eiland
    University of California, Los Angeles, CA, USA
    Brain Res 945:1-8. 2002
    ..These anatomical changes suggest that the effects of sleep deprivation may be related to protein metabolism in certain brain regions...
  50. ncbi request reprint The locus coeruleus complex of the bottlenose dolphin (Tursiops truncatus) as revealed by tyrosine hydroxylase immunohistochemistry
    Paul R Manger
    Department of Psychiatry, University of California, Los Angeles, CA, USA
    J Sleep Res 12:149-55. 2003
    ....
  51. ncbi request reprint Cortical acetylcholine release is lateralized during asymmetrical slow-wave sleep in northern fur seals
    Jennifer L Lapierre
    Department of Psychiatry, School of Medicine, University of California Los Angeles and Neurobiology Research, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California 91343, USA
    J Neurosci 27:11999-2006. 2007
    ..These findings demonstrate that cortical ACh release is tightly linked to hemispheric EEG activation...
  52. pmc Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers
    Joshi John
    Department Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Physiol 560:587-92. 2004
    ..A reduction followed by an increase in Hcrt levels coincides with symptom onset and increase in the narcoleptics. The Hcrtr2 mutation alters the normal developmental course of hypocretin levels...
  53. ncbi request reprint AIDS diagnosis and depression in the Multicenter AIDS Cohort Study: the ameliorating impact of pet ownership
    J M Siegel
    University of California, Los Angeles, USA
    AIDS Care 11:157-70. 1999
    ..This beneficial effect of pet ownership occurred principally among persons who reported fewer confidants. These results suggest that by enhancing companionship for some HIV-infected persons, pets may buffer the stressful impact of AIDS...
  54. doi request reprint Sleep viewed as a state of adaptive inactivity
    Jerome M Siegel
    Jerome M Siegel is at the Department of Psychiatry, School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Neurosci 10:747-53. 2009
    ..Current evidence indicates that ecological variables are the main determinants of sleep duration and intensity across species...
  55. pmc Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior
    Lalini Ramanathan
    Neurobiology Research 151A3, Greater Los Angeles Health Care System, North Hills, CA, USA
    Behav Brain Res 207:305-9. 2010
    ..We conclude that acute (6h) sleep loss may trigger compensatory mechanisms (like increased antioxidant responses) that prevent initial deterioration in working memory...
  56. ncbi request reprint Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medulla
    Boris Y Mileykovskiy
    Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg 194223, Russia
    J Neurophysiol 87:2480-9. 2002
    ..Loss of OX function may, therefore, disturb both muscle tone facilitatory and inhibitory processes at the medullary level...
  57. ncbi request reprint Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study
    Tohro Kodama
    Department of Psychology, Tokyo Metropolitan Institute of Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Neurosci 23:1548-54. 2003
    ..A combination of decreased monoamine and increased inhibitory amino acid release in motoneuron pools causes PIA-induced atonia and may be involved in atonia linked to rapid eye-movement sleep...
  58. ncbi request reprint The stuff dreams are made of: anatomical substrates of REM sleep
    Jerome M Siegel
    Nat Neurosci 9:721-2. 2006
  59. ncbi request reprint Hypocretin (orexin) and melanin concentrating hormone loss and the symptoms of Parkinson's disease
    Thomas C Thannickal
    Brain 131:e87. 2008
  60. ncbi request reprint The narcoleptic borderland
    Jerome M Siegel
    Sleep Med 4:3-4. 2003
  61. ncbi request reprint Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates
    Sam A Deadwyler
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Neurosci 27:14239-47. 2007
    ..These findings provide strong evidence for the effectiveness of intranasal orexin-A in alleviating cognitive deficits produced by loss of sleep...
  62. ncbi request reprint The distribution and morphological characteristics of catecholaminergic cells in the diencephalon and midbrain of the bottlenose dolphin (Tursiops truncatus)
    Paul R Manger
    School of Anatomical Sciences, Faculty of Health Science, University of the Witwatersrand, Johannesburg, Republic of South Africa
    Brain Behav Evol 64:42-60. 2004
    ..The results are discussed in relation to motor control, thermoregulation, unihemispheric sleep, and dolphin cognition...
  63. ncbi request reprint Time for the sleep community to take a critical look at the purported role of sleep in memory processing
    Robert P Vertes
    Center for Complex Systems and Brains Sciences, Florida Atlantic University, Boca Raton 33431, USA
    Sleep 28:1228-9; discussion 1230-3. 2005
    ..We briefly review the main arguments against a role for sleep in learning/memory...
  64. pmc Unearthing the phylogenetic roots of sleep
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, 2 160, Evanston, Illinois 60208, USA
    Curr Biol 18:R670-R679. 2008
    ..Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake...

Research Grants25

  1. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2006
    ..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
  2. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2007
    ..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
  3. Behavioral Role of Hypocretin
    Jerome Siegel; Fiscal Year: 2007
    ..The proposed studies should clarify the nature of neurotransmitter control of Hcrt neurons, their involvement in narcolepsy and depression, and their normal physiological and behavioral roles in rodents and humans. ..
  4. Behavioral Role of Hypocretin
    Jerome Siegel; Fiscal Year: 2009
    ..The proposed studies should clarify the nature of neurotransmitter control of Hcrt neurons, their involvement in narcolepsy and depression, and their normal physiological and behavioral roles in rodents and humans. ..
  5. Neuropathology of Hypocretin
    Jerome Siegel; Fiscal Year: 2009
    ....
  6. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2009
    ..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
  7. Behavioral Role of Hypocretin
    Jerome M Siegel; Fiscal Year: 2010
    ..The proposed studies should clarify the nature of neurotransmitter control of Hcrt neurons, their involvement in narcolepsy and depression, and their normal physiological and behavioral roles in rodents and humans. ..
  8. Neuropathology of Hypocretin
    Jerome M Siegel; Fiscal Year: 2010
    ....
  9. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2006
    ..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
  10. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2005
    ..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
  11. LOCATION AND CONTROL OF MEDULLARY NEURONS
    Jerome Siegel; Fiscal Year: 1990
    ..They should provide important basic information on the mechanisms controlling muscle tone, and lead to a better understanding of the generation of atonia in normal REM sleep and in cataplexy...
  12. LOCATION/CONTROL OF MEDULLARY NEURONS MEDIATING ATONIA
    Jerome Siegel; Fiscal Year: 1991
    ..They should provide important basic information on the mechanisms controlling muscle tone, and lead to a better understanding of the generation of atonia in normal REM sleep and in cataplexy...
  13. LOCATION/CONTROL OF MEDULLARY NEURONS MEDIATING ATONIA
    Jerome Siegel; Fiscal Year: 1992
    ..They should provide important basic information on the mechanisms controlling muscle tone, and lead to a better understanding of the generation of atonia in normal REM sleep and in cataplexy...
  14. Hypocretin Release in Disease States and Behavior
    Jerome Siegel; Fiscal Year: 2001
    ..quiet waking and REM vs. nonREM sleep. These studies will help define the role of this newly identified neurotransmitter system in relation to motor behavior, the sleep wake cycle and in human disease. ..
  15. Hypocretin Release in Disease States and Behavior
    Jerome Siegel; Fiscal Year: 2002
    ..quiet waking and REM vs. nonREM sleep. These studies will help define the role of this newly identified neurotransmitter system in relation to motor behavior, the sleep wake cycle and in human disease. ..
  16. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2003
    ..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
  17. Hypocretin Release in Disease States and Behavior
    Jerome Siegel; Fiscal Year: 2003
    ..quiet waking and REM vs. nonREM sleep. These studies will help define the role of this newly identified neurotransmitter system in relation to motor behavior, the sleep wake cycle and in human disease. ..
  18. Hypocretin Release in Disease States and Behavior
    Jerome Siegel; Fiscal Year: 2004
    ..quiet waking and REM vs. nonREM sleep. These studies will help define the role of this newly identified neurotransmitter system in relation to motor behavior, the sleep wake cycle and in human disease. ..
  19. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2004
    ..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
  20. Unihemispheric sleep: implications for mechanisms of sleep control and function i
    Jerome M Siegel; Fiscal Year: 2010
    ..It would also provide an insight into the causes of insomnia. ..