D Siegel

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Mol Pharmacol 52:300-5. 1997
  2. ncbi request reprint Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Clin Cancer Res 4:2065-70. 1998
  3. ncbi request reprint pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin
    D Siegel
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262
    Mol Pharmacol 44:1128-34. 1993
  4. ncbi request reprint NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms
    D Ross
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, Box C 238, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Chem Biol Interact 129:77-97. 2000
  5. ncbi request reprint Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin
    H D Beall
    School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Biochem Pharmacol 51:645-52. 1996
  6. pmc Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity
    D Ross
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver 80262, USA
    Environ Health Perspect 104:1177-82. 1996
  7. ncbi request reprint Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Pharmacol 59:263-8. 2001
  8. ncbi request reprint Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches
    S L Winski
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochemistry 40:15135-42. 2001
  9. ncbi request reprint Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Free Radic Biol Med 29:246-53. 2000
  10. ncbi request reprint Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes
    L P Schelonka
    Department of Ophthalmology, University of Colorado Health Sciences Center, Denver 80262, USA
    Invest Ophthalmol Vis Sci 41:1617-22. 2000

Detail Information

Publications11

  1. ncbi request reprint The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Mol Pharmacol 52:300-5. 1997
    ..These data demonstrate that NQO1 can reduce TQ to TQH2 and that TQH2 can function as an efficient antioxidant. This work suggests that one of the physiological functions of NQO1 may be to regenerate antioxidant forms of alpha-tocopherol...
  2. ncbi request reprint Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Clin Cancer Res 4:2065-70. 1998
    ..These data validate NSCLC as a target for NQO1-directed agents and suggest that the potential for lung toxicity be considered in the preclinical development of quinone-based antitumor drugs...
  3. ncbi request reprint pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin
    D Siegel
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262
    Mol Pharmacol 44:1128-34. 1993
    ..These data suggest that the success of attempts to exploit the elevated DT-diaphorase content of certain human tumors for improved chemotherapeutic response using mitomycin C or porfiromycin will depend on intracellular pH...
  4. ncbi request reprint NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms
    D Ross
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, Box C 238, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Chem Biol Interact 129:77-97. 2000
    ..An overview of genetic polymorphisms in NQO1 is presented and biological significance for chemoprotection, cancer susceptibility and antitumor drug action is discussed...
  5. ncbi request reprint Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin
    H D Beall
    School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Biochem Pharmacol 51:645-52. 1996
    ..Some evidence of DNA repair was also observed in the two cell lines. These results support an important role for DTD in the cytotoxicity of SN in the high DTD HT-29 colon carcinoma cell line...
  6. pmc Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity
    D Ross
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver 80262, USA
    Environ Health Perspect 104:1177-82. 1996
    ....
  7. ncbi request reprint Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Pharmacol 59:263-8. 2001
    ..These data suggest that wild-type NQO1 persists in cells whereas mutant NQO1 is rapidly degraded via ubiquitination and proteasome degradation...
  8. ncbi request reprint Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches
    S L Winski
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochemistry 40:15135-42. 2001
    ..This work demonstrates that ES936 is a potent mechanism-based inhibitor of NQO1 and may be a useful tool in defining the role of NQO1 in cellular systems and in vivo...
  9. ncbi request reprint Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues
    D Siegel
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Free Radic Biol Med 29:246-53. 2000
    ....
  10. ncbi request reprint Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes
    L P Schelonka
    Department of Ophthalmology, University of Colorado Health Sciences Center, Denver 80262, USA
    Invest Ophthalmol Vis Sci 41:1617-22. 2000
    ....
  11. ncbi request reprint Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death
    K S Zafar
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Toxicol Lett 166:261-7. 2006
    ..In summary, transfection of SK-N-MC cells with NQO1 protects against dopamine-induced toxicity...