Florian A Siebzehnrubl

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
    Florian A Siebzehnrubl
    Department of Neurosurgery, University of Florida, Gainesville, FL, USA
    EMBO Mol Med 5:1196-212. 2013
  2. doi request reprint The origins of glioma: E Pluribus Unum?
    F A Siebzehnrubl
    Department of Neuroscience, McKnight Brain Institute, University of Florida, USA
    Glia 59:1135-47. 2011
  3. doi request reprint Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells
    Florian A Siebzehnrubl
    Department of Neuropathology Franz Penzoldt Center, University of Erlangen Nuremberg, Nuremberg, Germany
    Brain Pathol 19:399-408. 2009
  4. ncbi request reprint Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
  5. ncbi request reprint Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
  6. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
  7. ncbi request reprint Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
  8. pmc Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment
    Daniel J Silver
    Department of Neurological Surgery, University of Florida, Gainesville, Florida 32611, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, Department of Neuroscience, Temple University, Philadelphia, Pennsylvania 19140, Arnold Palmer Hospital for Children, MD Anderson Cancer Center, Orlando, Florida 32806, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, D 53105 Bonn, Germany, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106
    J Neurosci 33:15603-17. 2013
  9. pmc Evidence for label-retaining tumour-initiating cells in human glioblastoma
    Loic P Deleyrolle
    McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32610, USA
    Brain 134:1331-43. 2011
  10. ncbi request reprint Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005

Collaborators

Detail Information

Publications16

  1. doi request reprint The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
    Florian A Siebzehnrubl
    Department of Neurosurgery, University of Florida, Gainesville, FL, USA
    EMBO Mol Med 5:1196-212. 2013
    ..Thus, ZEB1 is an important candidate molecule for glioblastoma recurrence, a marker of invasive tumour cells and a potential therapeutic target, along with its downstream effectors. ..
  2. doi request reprint The origins of glioma: E Pluribus Unum?
    F A Siebzehnrubl
    Department of Neuroscience, McKnight Brain Institute, University of Florida, USA
    Glia 59:1135-47. 2011
    ..Further attention is devoted to potential scenarios leading to transformation of different stem/progenitor cell types of the brain, and the probability and relevance of these scenarios for malignant tumorigenesis...
  3. doi request reprint Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells
    Florian A Siebzehnrubl
    Department of Neuropathology Franz Penzoldt Center, University of Erlangen Nuremberg, Nuremberg, Germany
    Brain Pathol 19:399-408. 2009
    ....
  4. ncbi request reprint Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
    ..Furthermore, its propensity to pass the blood-brain barrier and to increase the protein level of acetylated histone H3 in brain tissue identifies MS-275 as a promising candidate drug in the treatment of malignant gliomas...
  5. ncbi request reprint Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
    ....
  6. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
    ....
  7. ncbi request reprint Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
    ..Increased expression levels of NeuroD, Cyclin D2 and B-lymphocyte translocation gene 3 (Btg3) point to a shift towards neuronal fate determination targeted by HDAC inhibitors...
  8. pmc Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment
    Daniel J Silver
    Department of Neurological Surgery, University of Florida, Gainesville, Florida 32611, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, Department of Neuroscience, Temple University, Philadelphia, Pennsylvania 19140, Arnold Palmer Hospital for Children, MD Anderson Cancer Center, Orlando, Florida 32806, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, D 53105 Bonn, Germany, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106
    J Neurosci 33:15603-17. 2013
    ..In all, we present CSPGs as critical regulators of brain tumor histopathology and help to clarify the role of the tumor microenvironment in brain tumor invasion...
  9. pmc Evidence for label-retaining tumour-initiating cells in human glioblastoma
    Loic P Deleyrolle
    McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32610, USA
    Brain 134:1331-43. 2011
    ..Together, these findings confirm dye-retaining brain tumour cells exhibit tumour-initiation ability and are therefore viable targets for the development of therapeutics targeting this sub-population...
  10. ncbi request reprint Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
    ..This new model allows researchers to address in a systematic manner the molecular pathways of brain invasion as well as specific tumor-host interactions such as necrosis...
  11. doi request reprint Isolation and characterization of adult neural stem cells
    Florian A Siebzehnrubl
    McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 750:61-77. 2011
    ..At the end of this chapter we will also describe how to identify neural stem cells in vivo...
  12. ncbi request reprint Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen, Germany
    J Neurochem 93:992-9. 2005
    ..These observations identify chromatin-modifying enzymes as possible and promising targets for the pharmacotherapy of malignant gliomas...
  13. doi request reprint Increased precursor cell proliferation after deep brain stimulation for Parkinson's disease: a human study
    Vinata Vedam-Mai
    Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America Department of Neurology, UF Center for Movement Disorders and Restoration, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e88770. 2014
    ..Given the close proximity of the electrode trajectory to areas of the brain known as the "germinal niches," we sought to explore the possibility that DBS influences neural stem cell proliferation locally, as well as more distantly...
  14. doi request reprint Isolating and culturing of precursor cells from the adult human brain
    Florian A Siebzehnrubl
    Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 1059:79-86. 2013
    ..We describe our methodology for establishing and maintaining long-term cultures from white and grey matter, as well as a simple protocol for differentiating these cells...
  15. doi request reprint Detection of primary cilia in human glioblastoma
    Matthew R Sarkisian
    Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, 32610, USA
    J Neurooncol 117:15-24. 2014
    ....
  16. pmc Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains
    Shanshan Wang
    Department of Neurosurgery, The University of Florida, Center for Movement Disorders and Neurorestoration, College of Medicine, Gainesville, FL 32610, USA
    Brain Res 1464:61-72. 2012
    ..AHNPs engraft following ex vivo expansion and transplantation into the rodent brain, demonstrating their regenerative potential. Our data demonstrate the presence and capacity of endogenous stem/progenitor cells in the PD brain...