Florian A Siebzehnrubl

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells
    Florian A Siebzehnrubl
    Department of Neuropathology Franz Penzoldt Center, University of Erlangen Nuremberg, Nuremberg, Germany
    Brain Pathol 19:399-408. 2009
  2. ncbi The origins of glioma: E Pluribus Unum?
    F A Siebzehnrubl
    Department of Neuroscience, McKnight Brain Institute, University of Florida, USA
    Glia 59:1135-47. 2011
  3. ncbi Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
  4. ncbi Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
  5. ncbi Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
  6. ncbi The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
  7. ncbi Isolation and characterization of adult neural stem cells
    Florian A Siebzehnrubl
    McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 750:61-77. 2011
  8. ncbi Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
  9. ncbi Evidence for label-retaining tumour-initiating cells in human glioblastoma
    Loic P Deleyrolle
    McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32610, USA
    Brain 134:1331-43. 2011

Collaborators

Detail Information

Publications9

  1. ncbi Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells
    Florian A Siebzehnrubl
    Department of Neuropathology Franz Penzoldt Center, University of Erlangen Nuremberg, Nuremberg, Germany
    Brain Pathol 19:399-408. 2009
    ....
  2. ncbi The origins of glioma: E Pluribus Unum?
    F A Siebzehnrubl
    Department of Neuroscience, McKnight Brain Institute, University of Florida, USA
    Glia 59:1135-47. 2011
    ..Further attention is devoted to potential scenarios leading to transformation of different stem/progenitor cell types of the brain, and the probability and relevance of these scenarios for malignant tumorigenesis...
  3. ncbi Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
    ....
  4. ncbi Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
    ..Furthermore, its propensity to pass the blood-brain barrier and to increase the protein level of acetylated histone H3 in brain tissue identifies MS-275 as a promising candidate drug in the treatment of malignant gliomas...
  5. ncbi Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
    ..Increased expression levels of NeuroD, Cyclin D2 and B-lymphocyte translocation gene 3 (Btg3) point to a shift towards neuronal fate determination targeted by HDAC inhibitors...
  6. ncbi The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
    ....
  7. ncbi Isolation and characterization of adult neural stem cells
    Florian A Siebzehnrubl
    McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 750:61-77. 2011
    ..At the end of this chapter we will also describe how to identify neural stem cells in vivo...
  8. ncbi Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
    ..This new model allows researchers to address in a systematic manner the molecular pathways of brain invasion as well as specific tumor-host interactions such as necrosis...
  9. ncbi Evidence for label-retaining tumour-initiating cells in human glioblastoma
    Loic P Deleyrolle
    McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32610, USA
    Brain 134:1331-43. 2011
    ..Together, these findings confirm dye-retaining brain tumour cells exhibit tumour-initiation ability and are therefore viable targets for the development of therapeutics targeting this sub-population...