CAROL SIBLEY

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria
    Christopher V Plowe
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 6:121. 2007
  2. pmc The rationale and plan for creating a World Antimalarial Resistance Network (WARN)
    Carol Hopkins Sibley
    Malar J 6:118. 2007
  3. pmc World Antimalarial Resistance Network (WARN) IV: clinical pharmacology
    Karen I Barnes
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Malar J 6:122. 2007
  4. pmc Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
    Vivian N Hawkins
    Department of Genome Sciences, University of Washington, Seattle WA, USA
    Malar J 7:72. 2008
  5. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
  6. pmc World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility
    David J Bacon
    Parasitology Program, Naval Medical Research Center Detachment, Lima, Peru
    Malar J 6:120. 2007
  7. doi request reprint Monitoring antimalarial resistance: launching a cooperative effort
    Carol Hopkins Sibley
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Trends Parasitol 26:221-4. 2010
  8. pmc A database of antimalarial drug resistance
    Carol Hopkins Sibley
    Department of Genome Sciences, University of Washington, Seattle, WA 98195 7730, USA
    Malar J 5:48. 2006
  9. ncbi request reprint A network to monitor antimalarial drug resistance: a plan for moving forward
    Carol Hopkins Sibley
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Trends Parasitol 24:43-8. 2008
  10. ncbi request reprint Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine
    Michele D Hastings
    Department of Genome Sciences, School of Medicine, University of Washington, Seattle, WA 98195 7730, USA
    J Infect Dis 189:744-50. 2004

Research Grants

  1. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2006
  2. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2003
  3. DRUG RESISTANCE IN MALARIA
    CAROL SIBLEY; Fiscal Year: 2002
  4. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. pmc World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria
    Christopher V Plowe
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 6:121. 2007
    ....
  2. pmc The rationale and plan for creating a World Antimalarial Resistance Network (WARN)
    Carol Hopkins Sibley
    Malar J 6:118. 2007
    ..WARN will serve as a public resource to guide antimalarial drug treatment and prevention policies and to help confirm and characterize the new emergence of new resistance to antimalarial drugs and to contain its spread...
  3. pmc World Antimalarial Resistance Network (WARN) IV: clinical pharmacology
    Karen I Barnes
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Malar J 6:122. 2007
    ....
  4. pmc Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
    Vivian N Hawkins
    Department of Genome Sciences, University of Washington, Seattle WA, USA
    Malar J 7:72. 2008
    ..The origin and spread of mutations in Plasmodium vivax dhfr were assessed by constructing haplotypes based on sequencing dhfr and its flanking regions...
  5. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
    ..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed...
  6. pmc World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility
    David J Bacon
    Parasitology Program, Naval Medical Research Center Detachment, Lima, Peru
    Malar J 6:120. 2007
    ..Such a network would facilitate the rapid detection of strains with novel antimalarial resistance profiles and investigate suitable alternative treatments with retained efficacy...
  7. doi request reprint Monitoring antimalarial resistance: launching a cooperative effort
    Carol Hopkins Sibley
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Trends Parasitol 26:221-4. 2010
    ..The effort is planned as a collaboration with the scientific malaria community to create a global, comprehensive, and inclusive network that will provide quality-assured information on antimalarial drug resistance...
  8. pmc A database of antimalarial drug resistance
    Carol Hopkins Sibley
    Department of Genome Sciences, University of Washington, Seattle, WA 98195 7730, USA
    Malar J 5:48. 2006
    ..The database will protect the valuable investment represented by the development and deployment of novel therapies for malaria...
  9. ncbi request reprint A network to monitor antimalarial drug resistance: a plan for moving forward
    Carol Hopkins Sibley
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Trends Parasitol 24:43-8. 2008
    ....
  10. ncbi request reprint Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine
    Michele D Hastings
    Department of Genome Sciences, School of Medicine, University of Washington, Seattle, WA 98195 7730, USA
    J Infect Dis 189:744-50. 2004
    ..Still less is known about associations between specific alleles and the failure of sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo...
  11. ncbi request reprint Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites
    Sarah J Bates
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    J Infect Dis 190:1783-92. 2004
    ..Overall, these results suggest that dhfr alleles that confer high levels of resistance to antifolates are rare, even in eastern and southern Africa, where pyrimethamine has been intensively used...
  12. ncbi request reprint Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil
    Sonia Y Hunt
    Department of Genome Sciences, University of Washington, Seattle, WA 98195 7730, USA
    Mol Biochem Parasitol 139:25-32. 2005
    ..The resulting allele, 16V/51I/59R/108T is highly resistant to chlorcycloguanil, but 200-fold more sensitive to pyrimethamine than the 51I/59R/108N allele...
  13. ncbi request reprint Antifolates can have a role in the treatment of Plasmodium vivax
    Vivian N Hawkins
    Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA 98195, USA
    Trends Parasitol 23:213-22. 2007
    ..Other studies have examined the impact of dhps genotype on response to sulfadoxine. These data indicate that, under certain circumstances, SP could be a valuable tool in the fight against P. vivax...
  14. pmc Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax
    Michele D Hastings
    Department of Genome Sciences, University of Washington, Box 357730, Seattle, WA 98195 7730
    Proc Natl Acad Sci U S A 99:13137-41. 2002
    ..If that is the case, this novel class of DHFR inhibitors could provide effective and affordable treatment for chloroquine- and pyrimethamine-resistant vivax and falciparum malaria for many years to come...
  15. ncbi request reprint Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania
    Michele D Hastings
    Department of Genetics, Box 357360, University of Washington, Seattle, WA 98195 7360, USA
    Trans R Soc Trop Med Hyg 96:674-6. 2002
    ..Three isolates carried, at low levels, the leucine to isoleucine change at amino acid 164 that is associated with clinical failure of SP. Numerous other highly resistant alleles were also observed...
  16. ncbi request reprint Drug resistance in parasites: can we stay ahead of the evolutionary curve?
    Carol Hopkins Sibley
    Department of Genome Sciences, Box 357730, University of Washington, Seattle, WA 98195 7730, USA
    Trends Parasitol 19:532-7. 2003
  17. pmc Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system
    Michele D Hastings
    Department of Genome Sciences, Box 357730, University of Washington, Seattle, WA 98195 7730, USA
    Antimicrob Agents Chemother 49:733-40. 2005
    ..This study expands significantly the total number of novel dhfr alleles now identified from P. vivax and provides a foundation for understanding how antifolate resistance arises and spreads in natural P. vivax populations...
  18. ncbi request reprint Identification of the optimal third generation antifolate against P. falciparum and P. vivax
    Sonia Y Hunt
    Department of Genome Sciences, University of Washington, Box 357730, Seattle, WA 98195 7730, USA
    Mol Biochem Parasitol 144:198-205. 2005
    ..This flexibility is a key factor in their effectiveness against the highly mutant forms of DHFR...
  19. pmc Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006
    Laura K Certain
    Department of Genome Sciences, University of Washington, Seattle, Washington 98105 5065, USA
    J Infect Dis 197:1743-51. 2008
    ..We observed no triple-mutant alleles with haplotypes related to those of the Africa-derived wild-type and double-mutant alleles...
  20. ncbi request reprint Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase
    Vivian N Hawkins
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 5065, USA
    Am J Trop Med Hyg 81:348-55. 2009
    ..First, dhps alleles resistant to sulfadoxine have arisen multiple times under drug pressure. Second, there has been convergent evolution of a variety of alleles that could confer resistance to sulfa drugs...
  21. pmc Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro
    Conner I Sandefur
    Department of Genome Sciences, University of Washington, Seattle, WA 98195 7730, USA
    Mol Biochem Parasitol 154:1-5. 2007
    ..These observations suggest that the fitness of these parasites may not be compromised relative to those that carry the wild type allele, even without sustained SP drug pressure...
  22. pmc Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase
    A Lissa B Gerum
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Antimicrob Agents Chemother 46:3362-9. 2002
    ..tuberculosis DHFR. These studies suggest that compounds of this class are excellent potential leads for further development of drugs effective against M. tuberculosis...
  23. ncbi request reprint Are we losing artemisinin combination therapy already?
    Patrick E Duffy
    Malaria Antigen Discovery Program, Seattle Biomedical Research Institute and Walter Reed Army Institute of Research, Seattle, WA 98109, USA
    Lancet 366:1908-9. 2005
  24. ncbi request reprint Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand
    Kanchana Rungsihirunrat
    Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand
    Am J Trop Med Hyg 78:462-7. 2008
    ..Novel mutations that have not been identified previously at codon 512 of pvdhps (K512M, K512E, K512T) were also found...
  25. ncbi request reprint Malaria historians: analyze your old slides!
    Carol Hopkins Sibley
    Trends Parasitol 22:243-4. 2006
  26. ncbi request reprint New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity
    Andre Rosowsky
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Med Chem 47:1475-86. 2004
    ..Additional bioassay data for these compounds are also reported...
  27. ncbi request reprint The search for effective and sustainable treatments for Plasmodium falciparum malaria in Africa: a model of the selection of resistance by antifolate drugs and their combinations
    William M Watkins
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom
    Am J Trop Med Hyg 72:163-73. 2005
    ....
  28. ncbi request reprint Sensitivity to antifolates and genetic analysis of Plasmodium vivax isolates from Thailand
    Kanchana Rungsihirunrat
    Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand
    Am J Trop Med Hyg 76:1057-65. 2007
    ..Results suggest that quadruple mutant alleles confer decreased sensitivity to pyrimethamine but retain sensitivity to WR99210...
  29. ncbi request reprint Point mutations in the dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum and resistance to sulfadoxine-pyrimethamine in Sri Lanka
    Hapuarachchige C Hapuarachchi
    Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    Am J Trop Med Hyg 74:198-204. 2006
    ..In contrast, 67% (20 of 30) of the isolates carried parasites that were wild type for Pf-dhps. In Sri Lanka, detection of the triple mutant allele of Pf-dhfr will require tracking mutations at codon 51...
  30. ncbi request reprint The World Bank: false financial and statistical accounts and medical malpractice in malaria treatment
    Amir Attaran
    Institute of Population Health and Faculty of Law, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    Lancet 368:247-52. 2006

Research Grants11

  1. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2006
    ..We think that this in depth understanding of antifolate action in the parasites will ensure that WR99210 will be developed as a useful drug for the long haul against P. falciparum and P. vivax. ..
  2. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2003
    ..We think that this in depth understanding of antifolate action in the parasites will ensure that WR99210 will be developed as a useful drug for the long haul against P. falciparum and P. vivax. ..
  3. DRUG RESISTANCE IN MALARIA
    CAROL SIBLEY; Fiscal Year: 2002
    ..When completed their experiments will provide a detailed understanding of the mutations that modify function of the Pf-DHFR and Pf-DHPS enzymes or sensitivity of the enzymes to antifolate drugs. ..
  4. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2007
    ..We think that this in depth understanding of antifolate action in the parasites will ensure that WR99210 will be developed as a useful drug for the long haul against P. falciparum and P. vivax. ..