C H Sibley

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Yeast as a model system to study drugs effective against apicomplexan proteins
    C H Sibley
    Department of Genetics, University of Washington, Seattle, Washington, 98195 7360, USA
    Methods 13:190-207. 1997
  2. ncbi request reprint Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
    C H Sibley
    Department of Genetics, Box 357360, University of Washington, Seattle, WA 98195 7360, USA
    Trends Parasitol 17:582-8. 2001
  3. ncbi request reprint Mutagenesis of dihydrofolate reductase from Plasmodium falciparum: analysis in Saccharomyces cerevisiae of triple mutant alleles resistant to pyrimethamine or WR99210
    J T Ferlan
    Department of Genetics, University of Washington, P.O. Box 357360, Seattle, WA 98195-7360, USA
    Mol Biochem Parasitol 113:139-50. 2001
  4. ncbi request reprint Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210
    E G Hankins
    Department of Genetics, University of Washington, Seattle, WA 98195-7360, USA
    Mol Biochem Parasitol 117:91-102. 2001
  5. ncbi request reprint Novel approaches to tackling malarial drug resistance using yeast
    C H Sibley
    Department of Genetics, University of Washington, Seattle, USA
    IUBMB Life 52:285-9. 2001

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Yeast as a model system to study drugs effective against apicomplexan proteins
    C H Sibley
    Department of Genetics, University of Washington, Seattle, Washington, 98195 7360, USA
    Methods 13:190-207. 1997
    ..Basic protocols and methods are included. We detail some problems that might be encountered in the engineering of these yeast strains and suggest possible solutions...
  2. ncbi request reprint Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
    C H Sibley
    Department of Genetics, Box 357360, University of Washington, Seattle, WA 98195 7360, USA
    Trends Parasitol 17:582-8. 2001
    ..This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs...
  3. ncbi request reprint Mutagenesis of dihydrofolate reductase from Plasmodium falciparum: analysis in Saccharomyces cerevisiae of triple mutant alleles resistant to pyrimethamine or WR99210
    J T Ferlan
    Department of Genetics, University of Washington, P.O. Box 357360, Seattle, WA 98195-7360, USA
    Mol Biochem Parasitol 113:139-50. 2001
    ..This collateral hypersensitivity raises the possibility that opposing selection for resistance/sensitivity to PM and WR might be used to slow selection of populations of P. falciparum resistant to antifolate treatment...
  4. ncbi request reprint Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210
    E G Hankins
    Department of Genetics, University of Washington, Seattle, WA 98195-7360, USA
    Mol Biochem Parasitol 117:91-102. 2001
    ....
  5. ncbi request reprint Novel approaches to tackling malarial drug resistance using yeast
    C H Sibley
    Department of Genetics, University of Washington, Seattle, USA
    IUBMB Life 52:285-9. 2001
    ..Yeast can now be used to study antifolate drug resistance patterns that depend on the dihydrofolate reductase enzyme (DHFR) from the malaria parasite...