Etienne L Sibille

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Biological substrates underpinning diagnosis of major depression
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA 15219, USA
    Int J Neuropsychopharmacol 16:1893-909. 2013
  2. pmc Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders
    Etienne Sibille
    Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Dialogues Clin Neurosci 15:53-65. 2013
  3. pmc Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: with application to major depressive disorder
    Xingbin Wang
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Bioinformatics 13:52. 2012
  4. pmc A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism
    Li Chun Lin
    Translational Neuroscience Program, Department of Psychiatry, and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Brain 4:18. 2011
  5. pmc GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Neuropsychopharmacol 14:721-34. 2011
  6. pmc A molecular signature of depression in the amygdala
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, BST W1643, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:1011-24. 2009
  7. pmc Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analyses
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurosci Methods 167:198-206. 2008
  8. pmc Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity
    E Sibille
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:1042-56, 975. 2007
  9. ncbi request reprint Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
    Loubna Erraji-Benchekroun
    Department of Psychiatry, Columbia University, New York, New York, USA
    Biol Psychiatry 57:549-58. 2005
  10. ncbi request reprint Gene expression profiling of depression and suicide in human prefrontal cortex
    Etienne Sibille
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 29:351-61. 2004

Research Grants

  1. Transcriptome analysis in major depression
    Etienne Sibille; Fiscal Year: 2007
  2. Genomic Characterization in Depression and Suicide.
    Etienne Sibille; Fiscal Year: 2007
  3. Transcriptome analysis in major depression
    Etienne Sibille; Fiscal Year: 2009
  4. Transcriptome analysis in major depression
    Etienne L Sibille; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. doi request reprint Biological substrates underpinning diagnosis of major depression
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA 15219, USA
    Int J Neuropsychopharmacol 16:1893-909. 2013
    ..Evidence suggests that a focus on local cell circuits may provide an appropriate integration point and a critical link between underlying molecular mechanisms and neural network dysfunction in major depression. ..
  2. pmc Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders
    Etienne Sibille
    Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Dialogues Clin Neurosci 15:53-65. 2013
    ....
  3. pmc Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: with application to major depressive disorder
    Xingbin Wang
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Bioinformatics 13:52. 2012
    ..Our motivating example came from an analysis of five microarray studies in major depressive disorder (MDD), a heterogeneous psychiatric illness with mostly uncharacterized genetic mechanisms...
  4. pmc A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism
    Li Chun Lin
    Translational Neuroscience Program, Department of Psychiatry, and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Brain 4:18. 2011
    ..We hypothesized that sex differences in molecular structure may contribute to differential mood regulation and disease vulnerability...
  5. pmc GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Neuropsychopharmacol 14:721-34. 2011
    ..Results were not explained by other clinical, demographic or technical parameters. In summary, MDD was characterized by low DLPFC SST, whereas decreased PV mRNA appears to distinguish BPD from MDD...
  6. pmc A molecular signature of depression in the amygdala
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, BST W1643, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:1011-24. 2009
    ....
  7. pmc Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analyses
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurosci Methods 167:198-206. 2008
    ..As this approach can be applied post hoc, we provide tables of ratios for analysis of existing mouse and human brain datasets...
  8. pmc Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity
    E Sibille
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:1042-56, 975. 2007
    ....
  9. ncbi request reprint Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
    Loubna Erraji-Benchekroun
    Department of Psychiatry, Columbia University, New York, New York, USA
    Biol Psychiatry 57:549-58. 2005
    ..Aging leads to morphologic and functional changes in the brain and is associated with increased risk for psychiatric and neurological disorders...
  10. ncbi request reprint Gene expression profiling of depression and suicide in human prefrontal cortex
    Etienne Sibille
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 29:351-61. 2004
    ....
  11. pmc The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice
    Jennifer Joeyen-Waldorf
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Brain Res 1286:84-93. 2009
    ..This sex-by-SERT double dissociation provides a framework to investigate molecular substrates of emotionality regulation in concert with serotonin function and may contribute to the sexually dimorphic features of mood disorders...
  12. ncbi request reprint Microarray analysis of gene expression following the formalin test in the infant rat
    Gordon A Barr
    Department of Developmental Psychobiology, New York State Psychiatric Institute, New York, NY, USA
    Pain 117:6-18. 2005
    ..The increased expression of transcription factors and decreased expression of genes whose products are protective against cell death are hypothesized to underlie the long-term changes that are seen after injury in the neonate...

Research Grants5

  1. Transcriptome analysis in major depression
    Etienne Sibille; Fiscal Year: 2007
    ..The characterization of patterns of nuclei (AMY) and laminar (ACC) changes for selected genes will provide anatomical information to generate network-based hypotheses on the molecular pathology of MDD. ..
  2. Genomic Characterization in Depression and Suicide.
    Etienne Sibille; Fiscal Year: 2007
    ..The training program proposes formal courses, supervised training and frequent interactions with several research groups involved in pioneering aspects of genomic research in mood disorders. ..
  3. Transcriptome analysis in major depression
    Etienne Sibille; Fiscal Year: 2009
    ..The characterization of patterns of nuclei (AMY) and laminar (ACC) changes for selected genes will provide anatomical information to generate network-based hypotheses on the molecular pathology of MDD. ..
  4. Transcriptome analysis in major depression
    Etienne L Sibille; Fiscal Year: 2010
    ..The characterization of patterns of nuclei (AMY) and laminar (ACC) changes for selected genes will provide anatomical information to generate network-based hypotheses on the molecular pathology of MDD. ..