R D Shytle

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Nicotinic acetylcholine receptors as targets for antidepressants
    R D Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL 33613, USA
    Mol Psychiatry 7:525-35. 2002
  2. ncbi request reprint A pilot controlled trial of transdermal nicotine in the treatment of attention deficit hyperactivity disorder
    R Douglas Shytle
    Center for Infant and Child Development, Center for Aging and Brain Repair, Departments of Psychiatry, Neurosurgery, Neuroscience Program, University of South Florida, Tampa, Florida, USA
    World J Biol Psychiatry 3:150-5. 2002
  3. ncbi request reprint Mecamylamine (Inversine): an old antihypertensive with new research directions
    R D Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa 33613, USA
    J Hum Hypertens 16:453-7. 2002
  4. ncbi request reprint The Tourette's Disorder Scale (TODS): development, reliability, and validity
    R Douglas Shytle
    Center for Infant and Child Development, Department of Psychiatry and Behavioral Medicine, College of Medicine, University of South Florida, Tampa 33613, USA
    Assessment 10:273-87. 2003
  5. ncbi request reprint Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine
    R Douglas Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33613, USA
    Depress Anxiety 16:89-92. 2002
  6. ncbi request reprint Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder
    A A Silver
    University of South Florida College of Medicine, Tampa 33613, USA
    J Am Acad Child Adolesc Psychiatry 40:1103-10. 2001
  7. ncbi request reprint Mecamylamine effects on haloperidol-induced catalepsy and defecation
    P R Sanberg
    Center for Aging and Brain Repair, Department of Psychology, Pharmacology, University of South Florida, College of Medicine Tampa, Florida 33612, USA
    Int J Neurosci 109:81-90. 2001
  8. ncbi request reprint Transdermal nicotine and haloperidol in Tourette's disorder: a double-blind placebo-controlled study
    A A Silver
    Center for Infant and Child Development, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa 33613, USA
    J Clin Psychiatry 62:707-14. 2001
  9. ncbi request reprint Mecamylamine in Tourette's syndrome: a two-year retrospective case study
    A A Silver
    Department of Psychiatry, University of South Florida College of Medicine, Tampa 33613, USA
    J Child Adolesc Psychopharmacol 10:59-68. 2000
  10. ncbi request reprint Nicotine induced seizures blocked by mecamylamine and its stereoisomers
    M B Newman
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine and College of Arts and Science, Tampa 33613, USA
    Life Sci 69:2583-91. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Nicotinic acetylcholine receptors as targets for antidepressants
    R D Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL 33613, USA
    Mol Psychiatry 7:525-35. 2002
    ..If this hypothesis is supported by further preclinical and clinical research, nicotinic acetylcholine receptor antagonists may represent a novel class of therapeutic agents for treating mood disorders...
  2. ncbi request reprint A pilot controlled trial of transdermal nicotine in the treatment of attention deficit hyperactivity disorder
    R Douglas Shytle
    Center for Infant and Child Development, Center for Aging and Brain Repair, Departments of Psychiatry, Neurosurgery, Neuroscience Program, University of South Florida, Tampa, Florida, USA
    World J Biol Psychiatry 3:150-5. 2002
    ..To test the hypothesis that transdermal nicotine would be efficacious for the treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD)...
  3. ncbi request reprint Mecamylamine (Inversine): an old antihypertensive with new research directions
    R D Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa 33613, USA
    J Hum Hypertens 16:453-7. 2002
    ..With this in mind, mecamylamine should be an important research tool in the field of hypertension research, particularly in recalcitrant smokers with mild to moderate hypertension...
  4. ncbi request reprint The Tourette's Disorder Scale (TODS): development, reliability, and validity
    R Douglas Shytle
    Center for Infant and Child Development, Department of Psychiatry and Behavioral Medicine, College of Medicine, University of South Florida, Tampa 33613, USA
    Assessment 10:273-87. 2003
    ..The TODS is a simple, efficient way for clinicians and parents to rate the severity of multiple symptoms commonly found in patients with Tourette's disorder...
  5. ncbi request reprint Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine
    R Douglas Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33613, USA
    Depress Anxiety 16:89-92. 2002
  6. ncbi request reprint Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder
    A A Silver
    University of South Florida College of Medicine, Tampa 33613, USA
    J Am Acad Child Adolesc Psychiatry 40:1103-10. 2001
    ..However, further studies should be conducted to investigate its possible therapeutic effects in subjects with comorbid mood disorders and as an adjunct to neuroleptic medication...
  7. ncbi request reprint Mecamylamine effects on haloperidol-induced catalepsy and defecation
    P R Sanberg
    Center for Aging and Brain Repair, Department of Psychology, Pharmacology, University of South Florida, College of Medicine Tampa, Florida 33612, USA
    Int J Neurosci 109:81-90. 2001
    ..0 mg/kg dose. These findings suggest that a clinically relevant dose of mecamylamine (0.1 mg/kg) can affect the duration of haloperidol-induced catalepsy without having significant effects on gastrointestinal function...
  8. ncbi request reprint Transdermal nicotine and haloperidol in Tourette's disorder: a double-blind placebo-controlled study
    A A Silver
    Center for Infant and Child Development, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa 33613, USA
    J Clin Psychiatry 62:707-14. 2001
    ..r.n. basis. Further clinical research is warranted to investigate the use of novel nicotinic receptor modulating agents with improved safety profiles over nicotine...
  9. ncbi request reprint Mecamylamine in Tourette's syndrome: a two-year retrospective case study
    A A Silver
    Department of Psychiatry, University of South Florida College of Medicine, Tampa 33613, USA
    J Child Adolesc Psychopharmacol 10:59-68. 2000
    ..To test the efficacy and safety of a nicotinic, acetylcholine antagonist, mecamylamine, in the treatment of Tourette's syndrome (TS)...
  10. ncbi request reprint Nicotine induced seizures blocked by mecamylamine and its stereoisomers
    M B Newman
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine and College of Arts and Science, Tampa 33613, USA
    Life Sci 69:2583-91. 2001
    ..The results of this study may be clinically important for the future design of novel anti-seizure medications...
  11. ncbi request reprint Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat
    M B Newman
    Department of Psychology, University of South Florida College of Medicine, College of Arts and Science, Tampa 33613, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:609-20. 2001
    ..1 mg/kg). 4. These findings may have important therapeutic implications since clinical observations have shown that low doses of mecamylamine reduce tension and anxiety in patients with Tourette syndrome...
  12. ncbi request reprint Locomotor behavioral effects of prenatal and postnatal nicotine exposure in rat offspring
    M B Newman
    Department of Psychology, University of South Florida, College of Arts and Science, College of Medicine, Tampa, USA
    Behav Pharmacol 10:699-706. 1999
    ..5 mg/kg/day condition. Results are consistent with the hypothesis that rat offspring are susceptible to the neurochemical and neurobehavioral effects of prenatal/postnatal nicotine exposure...
  13. ncbi request reprint Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors
    R Douglas Shytle
    Child Development Center, Neuroimmunology Laboratory, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medciine, Tampa, Florida, USA
    J Neurochem 89:337-43. 2004
    ..Negative regulation of microglia activation may also represent additional mechanism underlying nicotine's reported neuroprotective properties...
  14. ncbi request reprint Nutraceuticals synergistically promote proliferation of human stem cells
    Paula C Bickford
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 15:118-23. 2006
    ..This demonstrates that nutrients can act to promote healing via an interaction with stem cell populations...
  15. ncbi request reprint Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds
    R Douglas Shytle
    Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Rejuvenation Res 10:173-8. 2007
    ....
  16. doi request reprint Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study
    Tony P George
    Division of Substance Abuse, Department of Psychiatry, Program for Research in Smokers with Mental Illness, Yale University School of Medicine, New Haven, CT, USA
    J Clin Psychopharmacol 28:340-4. 2008
    ..We compared the nicotinic antagonist, mecamylamine hydrochloride (MEC), with placebo as an augmentation strategy for patients with MDD who were refractory to selective serotonin reuptake inhibitor (SSRI) treatment...
  17. ncbi request reprint Nicotine's oxidative and antioxidant properties in CNS
    Mary B Newman
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Life Sci 71:2807-20. 2002
    ..This review discusses the studies that have addressed this issue, the behavioral effects of nicotine, and the possible mechanisms of action that result from nicotine administration or nicotinic receptor activation...
  18. ncbi request reprint Anxiolytic effects of mecamylamine in two animal models of anxiety
    Mary B Newman
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa 33612, USA
    Exp Clin Psychopharmacol 10:18-25. 2002
    ..If confirmed by further clinical research, nicotinic receptor antagonists like mecamylamine may represent a novel class of anxiolytics...
  19. doi request reprint Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, and Department of Neurosurgery, University of South Florida, Tampa, FL 33613, USA
    Brain Res 1214:177-87. 2008
    ..Taken together, these data further the notion of EGCG dietary supplementation as a potentially safe and effective prophylaxis for Alzheimer's disease...