CLAUDE SHUTTLEWORTH

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. ncbi request reprint NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function
    Angela M Brennan
    Department of Neurosciences, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 26:1389-406. 2006
  2. pmc The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons
    Lawrence C R Tafoya
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, USA
    BMC Neurosci 9:105. 2008
  3. pmc Hypoxia limits inhibitory effects of Zn2+ on spreading depolarizations
    Isamu Aiba
    Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico, United States of America
    PLoS ONE 8:e75739. 2013
  4. pmc Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons
    Isamu Aiba
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    J Physiol 590:5877-93. 2012
  5. pmc Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo
    Isamu Aiba
    Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    J Neurophysiol 107:1032-41. 2012
  6. pmc Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation
    C William Shuttleworth
    Dept Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Neurochem Int 56:379-86. 2010
  7. ncbi request reprint Strain-dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons
    C W Shuttleworth
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Neurosci 21:4225-36. 2001
  8. ncbi request reprint NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices
    C William Shuttleworth
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Neurosci 23:3196-208. 2003
  9. pmc Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury
    Robert M Dietz
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    J Neurochem 109:145-52. 2009
  10. pmc Emergence of a spermine-sensitive, non-inactivating conductance in mature hippocampal CA1 pyramidal neurons upon reduction of extracellular Ca2+: dependence on intracellular Mg2+ and ATP
    Christos Chinopoulos
    Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA
    Neurochem Int 50:148-58. 2007

Research Grants

  1. Secondary Calcium Responses and Excitotoxicity
    CLAUDE SHUTTLEWORTH; Fiscal Year: 2005
  2. Spreading Depolarizations and Post-Ischemic Injury
    CLAUDE W SHUTTLEWORTH; Fiscal Year: 2010
  3. Imaging Mitochondrial Function in Excitotoxicity
    CLAUDE SHUTTLEWORTH; Fiscal Year: 2007
  4. Imaging Mitochondrial Function in Excitotoxicity
    CLAUDE SHUTTLEWORTH; Fiscal Year: 2009

Collaborators

Detail Information

Publications15

  1. ncbi request reprint NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function
    Angela M Brennan
    Department of Neurosciences, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 26:1389-406. 2006
    ..These results suggest that NAD(P)H transients report mitochondrial dynamics, rather than recruitment of glycolytic metabolism, over a wide range of stimulus intensities...
  2. pmc The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons
    Lawrence C R Tafoya
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, USA
    BMC Neurosci 9:105. 2008
    ..In this study, we investigate the effects of SNAP-25 ablation on spontaneous neuronal activity and the expression of functionally distinct isoforms of this t-SNARE in GABAergic and glutamatergic neurons of the adult brain...
  3. pmc Hypoxia limits inhibitory effects of Zn2+ on spreading depolarizations
    Isamu Aiba
    Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico, United States of America
    PLoS ONE 8:e75739. 2013
    ..Such a mechanism may limit inhibitory effects of endogenous Zn(2+) accumulation in hypoxic regions close to ischemic infarcts. ..
  4. pmc Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons
    Isamu Aiba
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    J Physiol 590:5877-93. 2012
    ..These results identify a significant contribution of a late component of SD that could underlie neuronal injury in pathological circumstances...
  5. pmc Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo
    Isamu Aiba
    Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    J Neurophysiol 107:1032-41. 2012
    ..The inhibitory action of extracellular Zn(2+) on SD may counteract to some extent the neurotoxic effects of intracellular Zn(2+) accumulation in acute brain injury models...
  6. pmc Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation
    C William Shuttleworth
    Dept Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Neurochem Int 56:379-86. 2010
    ..These signals are thus appropriate for studies of mitochondrial function and dysfunction in brain slices, in addition to providing robust maps of postsynaptic neuronal activation following physiological activation...
  7. ncbi request reprint Strain-dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons
    C W Shuttleworth
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Neurosci 21:4225-36. 2001
    ....
  8. ncbi request reprint NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices
    C William Shuttleworth
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Neurosci 23:3196-208. 2003
    ....
  9. pmc Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury
    Robert M Dietz
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    J Neurochem 109:145-52. 2009
    ....
  10. pmc Emergence of a spermine-sensitive, non-inactivating conductance in mature hippocampal CA1 pyramidal neurons upon reduction of extracellular Ca2+: dependence on intracellular Mg2+ and ATP
    Christos Chinopoulos
    Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA
    Neurochem Int 50:148-58. 2007
    ..The dependence on intracellular [ATP] and [Mg(2+)] shown here, suggests a possible role for this current in disruption of ionic homeostasis during metabolic stress that accompanies excessive neuronal stimulation...
  11. ncbi request reprint GABAergic protection of hippocampal pyramidal neurons against glutamate insult: deficit in young animals compared to adults
    Aryan Azimi-Zonooz
    Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    J Neurophysiol 96:299-308. 2006
    ....
  12. ncbi request reprint Contribution of Na(+)/Ca(2+) exchange to excessive Ca(2+) loading in dendrites and somata of CA1 neurons in acute slice
    Robert M Dietz
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Hippocampus 17:1049-59. 2007
    ..However, since Na(+)/K(+) ATPase inhibition does appear to produce significant reverse-operation NCX activity, this additional Ca(2+) influx pathway may operate in ATP-deprived CA1 neurons and play a role in ischemic neurodegeneration...
  13. ncbi request reprint Microtubule disruption, not calpain-dependent loss of MAP2, contributes to enduring NMDA-induced dendritic dysfunction in acute hippocampal slices
    M M Hoskison
    Department of Neurosciences, University of New Mexico School of Medicine, MSC08 4740, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Exp Neurol 202:302-12. 2006
    ....
  14. pmc Localized loss of Ca2+ homeostasis in neuronal dendrites is a downstream consequence of metabolic compromise during extended NMDA exposures
    Thomas A Vander Jagt
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Neurosci 28:5029-39. 2008
    ..In contrast, metabolic consequences of sustained Na(+) elevations may lead to failure of ionic homeostasis in dendrites and precede Ca(2+)-dependent cellular compromise...
  15. ncbi request reprint Caffeine releasable stores of Ca2+ show depletion prior to the final steps in delayed CA1 neuronal death
    Hong Xing
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Neurophysiol 92:2960-7. 2004
    ....

Research Grants9

  1. Secondary Calcium Responses and Excitotoxicity
    CLAUDE SHUTTLEWORTH; Fiscal Year: 2005
    ..such as might occur in a very wide range of neurological disorders. ..
  2. Spreading Depolarizations and Post-Ischemic Injury
    CLAUDE W SHUTTLEWORTH; Fiscal Year: 2010
    ..This project is designed to identify new approaches to limit the onset, or consequences, of these spreading waves of activation and thereby improve functional recovery. ..
  3. Imaging Mitochondrial Function in Excitotoxicity
    CLAUDE SHUTTLEWORTH; Fiscal Year: 2007
    ..For studies of mitochondrial function in neurons destined to die following transient ischemia (Specific Aim 3), we will utilize preparations from gerbils subjected to transient forebrain ischemia. ..
  4. Imaging Mitochondrial Function in Excitotoxicity
    CLAUDE SHUTTLEWORTH; Fiscal Year: 2009
    ..For studies of mitochondrial function in neurons destined to die following transient ischemia (Specific Aim 3), we will utilize preparations from gerbils subjected to transient forebrain ischemia. ..