Vladimir Shusterman

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Dynamic tracking of ischemia in the surface electrocardiogram
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Electrocardiol 40:S179-86. 2007
  2. pmc Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Heart Circ Physiol 298:H440-50. 2010
  3. doi request reprint Slow QT interval adaptation to heart rate changes in normal ambulatory subjects
    Eathar Razak
    University of Pittsburgh, Pittsburgh, PA
    Ann Noninvasive Electrocardiol 16:148-55. 2011
  4. pmc A pilot study examining the performance of polynomial-modeled ventricular shock electrograms for rhythm discrimination in implantable devices
    Jeffrey L Williams
    Division of Cardiac Electrophysiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pacing Clin Electrophysiol 29:930-9. 2006
  5. pmc The many faces of repolarization instability: which one is prognostic?
    Vladimir Shusterman
    University of Pittsburgh, Pittsburgh, PA, USA
    J Electrocardiol 42:511-6. 2009
  6. pmc Accelerated junctional rhythm and nonalternans repolarization lability precede ventricular tachycardia in Casq2-/- mice
    Ure L Mezu
    Heart and Vascular Institute, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Cardiovasc Electrophysiol 23:1355-63. 2012
  7. doi request reprint Nocturnal peak in atrial tachyarrhythmia occurrence as a function of arrhythmia burden
    Vladimir Shusterman
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Cardiovasc Electrophysiol 23:604-11. 2012
  8. ncbi request reprint A segmental polynomial model of ventricular electrograms as a simple and efficient morphology discriminator for implantable devices
    Jeffrey L Williams
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Noninvasive Electrocardiol 11:271-80. 2006
  9. ncbi request reprint Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Room B535, Pittsburgh, PA 15213, USA
    Circulation 113:2880-7. 2006
  10. ncbi request reprint Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 282:H2076-83. 2002

Collaborators

Detail Information

Publications28

  1. pmc Dynamic tracking of ischemia in the surface electrocardiogram
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Electrocardiol 40:S179-86. 2007
    ..Holter recordings were initiated within the first 40 minutes after patients' arrival to the emergency department. Here we present preliminary results...
  2. pmc Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Heart Circ Physiol 298:H440-50. 2010
    ..006 and 0.009) but not in TNF-alpha mice. In conclusion, TWA is present in a TNF-alpha model of CHF and can be further promoted by adrenergic stimulation, along with the enhanced susceptibility for ventricular arrhythmias...
  3. doi request reprint Slow QT interval adaptation to heart rate changes in normal ambulatory subjects
    Eathar Razak
    University of Pittsburgh, Pittsburgh, PA
    Ann Noninvasive Electrocardiol 16:148-55. 2011
    ..Clinical formulas for QT correction utilize instantaneous HR. We showed previously that longer-term HR affects QT duration. We extend these findings, identifying more accurate models of QT behavior...
  4. pmc A pilot study examining the performance of polynomial-modeled ventricular shock electrograms for rhythm discrimination in implantable devices
    Jeffrey L Williams
    Division of Cardiac Electrophysiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pacing Clin Electrophysiol 29:930-9. 2006
    ..We evaluated the performance of polynomial-modeled ventricular electrograms (EGM) to discriminate between supraventricular tachycardia (SVT) and ventricular tachycardia (VT)...
  5. pmc The many faces of repolarization instability: which one is prognostic?
    Vladimir Shusterman
    University of Pittsburgh, Pittsburgh, PA, USA
    J Electrocardiol 42:511-6. 2009
    ..Therefore, the assessment of TWA needs to be dynamic and personalized to take into account the time evolution of risk and individual history...
  6. pmc Accelerated junctional rhythm and nonalternans repolarization lability precede ventricular tachycardia in Casq2-/- mice
    Ure L Mezu
    Heart and Vascular Institute, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Cardiovasc Electrophysiol 23:1355-63. 2012
    ..The CPVT phenotype is recapitulated in Casq2 -/- mice. Repolarization lability (RL)-beat-to-beat variability in the T wave morphology-has been reported in long-QT syndrome, but has not been evaluated in CPVT...
  7. doi request reprint Nocturnal peak in atrial tachyarrhythmia occurrence as a function of arrhythmia burden
    Vladimir Shusterman
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Cardiovasc Electrophysiol 23:604-11. 2012
    ..We examined circadian periodicity of atrial tachyarrhythmias (AT/AF) in a large group of patients with implantable devices, which allow continuous collection of the event data over prolonged periods of time...
  8. ncbi request reprint A segmental polynomial model of ventricular electrograms as a simple and efficient morphology discriminator for implantable devices
    Jeffrey L Williams
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Noninvasive Electrocardiol 11:271-80. 2006
    ..Such a model of ventricular EGMs is still lacking...
  9. ncbi request reprint Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Room B535, Pittsburgh, PA 15213, USA
    Circulation 113:2880-7. 2006
    ..We examined continuous dynamics of repolarization in Holter electrocardiograms with spontaneous sustained (>30 seconds) VTA...
  10. ncbi request reprint Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 282:H2076-83. 2002
    ..Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments...
  11. ncbi request reprint Calcium-dependent arrhythmias in transgenic mice with heart failure
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 284:H431-41. 2003
    ....
  12. ncbi request reprint Direct mechanical stimulation of brainstem modulates cardiac rhythm and repolarization in humans
    Vladimir Shusterman
    University of Pittsburgh, PA 15213, USA
    J Electrocardiol 35:247-56. 2002
    ..Stimulation of a localized region surrounding the caudal rootlets of the 10th nerve elicits pronounced effects on cardiac rhythm and repolarization...
  13. ncbi request reprint Detecting instabilities of cardiac rhythm
    Vladimir Shusterman
    University of Pittsburgh, PA 15213, USA
    J Electrocardiol 36:219-26. 2003
    ....
  14. ncbi request reprint Cardiac autonomic modulation by estrogen in female mice undergoing ambulatory monitoring and in vivo electrophysiologic testing
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213
    Ann Noninvasive Electrocardiol 9:142-8. 2004
    ..Estrogen is an important modulator of cardiovascular risk, but its mechanism of action is not fully understood. We investigated the effect of ovariectomy and its timing on the cardiac electrophysiology in mice...
  15. pmc Cardiac repolarization instability during psychological stress in patients with ventricular arrhythmias
    Saddam S Abisse
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Electrocardiol 44:678-83. 2011
    ....
  16. ncbi request reprint Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Scaife S572, Pittsburgh, PA 15213, USA
    Am J Physiol Heart Circ Physiol 289:H1456-67. 2005
    ..Thus abnormalities in action potential propagation and Ca(2+) handling contribute to the initiation of atrial arrhythmias in this mouse model of heart failure...
  17. pmc Regional genomic regulation of cardiac sodium-calcium exchanger by oestrogen
    Guojun Chen
    University of Pittsburgh, School of Medicine, Cardiovascular Institute, 3550 Terrace Street, Suite S 628 Scaife Hall, Pittsburgh, PA 15261, USA
    J Physiol 589:1061-80. 2011
    ..Thus, E2 upregulates NCX1 by a genomic mechanism mediated by ERs, and de novo mRNA and protein biosynthesis, in a sex- and region-dependent manner which contributes to the enhanced propensity to EADs and TdP in female hearts...
  18. ncbi request reprint From baseline to epileptiform activity: a path to synchronized rhythmicity in large-scale neural networks
    Vladimir Shusterman
    Cardiovascular Institute and Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 77:061911. 2008
    ..These findings advance the understanding of functional behavior of interconnected populations and might have implications for the analysis of diverse classes of networks...
  19. ncbi request reprint Microvolt T-wave alternans during atrial and ventricular pacing
    Alaa A Shalaby
    Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    Pacing Clin Electrophysiol 30:S178-82. 2007
    ..This can be achieved by ventricular pacing (VP). We compared MTWA during short-term VP versus atrial pacing (AP)...
  20. ncbi request reprint Tracking repolarization dynamics in real-life data
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Electrocardiol 37:180-6. 2004
    ..Analysis of time-frequency distributions embedded in repolarization dynamics facilitates detection of abrupt and transient repolarization instabilities, including changes in the level of T-wave alternans and slower periodicities...
  21. doi request reprint QT interval variability and adaptation to heart rate changes in patients with long QT syndrome
    Jan Nemec
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pacing Clin Electrophysiol 32:72-81. 2009
    ..Increased QT variability (QTV) has been reported in conditions associated with ventricular arrhythmias. Data on QTV in patients with congenital long QT syndrome (LQTS) are limited...
  22. ncbi request reprint Orthonormal-basis partitioning and time-frequency representation of cardiac rhythm dynamics
    Benhur Aysin
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    IEEE Trans Biomed Eng 52:878-89. 2005
    ..Here we show that OPTR can be applied to long multicomponent ambulatory signals to obtain the signal representation along with its time-varying spectrum...
  23. ncbi request reprint Sympathetic nervous system activity in stress and biofeedback relaxation. Monitoring SNS activity with the photoplethysmographic-wave envelope and temperature-variability signals
    Vladimir Shusterman
    Cardiac Electrophysiolgy Laboratories, University of Pittsburgh, USA
    IEEE Eng Med Biol Mag 24:52-7. 2005
  24. ncbi request reprint Implantable cardioverter-defibrillator shocks increase T-wave alternans
    Rachel Lampert
    Department of Medicine, Yale University School of Medicine New Haven, Connecticut, USA
    J Cardiovasc Electrophysiol 18:512-7. 2007
    ..However, the mechanism of shock-related proarrhythmia remains unclear. We evaluated the impact of ICD shock on repolarization instability, a factor associated with ventricular arrhythmogenesis...
  25. pmc A sodium channel pore mutation causing Brugada syndrome
    Arnold E Pfahnl
    Division of Cardiology, Atlanta Veterans Affairs Medical Center and Emory University, Atlanta, Georgia 30033, USA
    Heart Rhythm 4:46-53. 2007
    ..Both male and female carriers are symptomatic at young ages, have typical Brugada-type electrocardiogram changes, and have relatively normal corrected QT intervals...
  26. ncbi request reprint Effects of psychologic stress on repolarization and relationship to autonomic and hemodynamic factors
    Rachel Lampert
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cardiovasc Electrophysiol 16:372-7. 2005
    ..However, the physiologic pathways remain unknown. We sought to determine whether psychological stress induced in the laboratory setting alters indices of repolarization associated with arrhythmogenesis...
  27. pmc Karhunen-Loève representation distinguishes ST-T wave morphology differences in emergency department chest pain patients with non-ST-elevation myocardial infarction versus nonacute coronary syndrome
    Daniel M Schindler
    ECG Monitoring Research Laboratory, Department of Physiological Nursing, University of California, San Francisco, CA 94143 0610, USA
    J Electrocardiol 40:S145-9. 2007
    ..Electrocardiographic diagnosis of non-ST-elevation myocardial infarction (non-STEMI) is especially difficult and is delayed until cardiac biomarkers turn positive, indicating onset of myocardial necrosis...
  28. pmc A large-scale, energetic model of cardiovascular homeostasis predicts dynamics of arterial pressure in humans
    Alexander Roytvarf
    Rishon Le Zion, Israel
    IEEE Trans Biomed Eng 55:407-18. 2008
    ..The model predicted the dynamics of arterial pressure in human subjects undergoing physiological tests and provided insights into the relationships between arterial pressure and pressure wave velocity...