ERIC SHUSTA

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Blood-brain barrier genomics, proteomics, and new transporter discovery
    Eric V Shusta
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    NeuroRx 2:151-61. 2005
  2. pmc Differentiating embryonic neural progenitor cells induce blood-brain barrier properties
    Christian Weidenfeller
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 101:555-65. 2007
  3. pmc Blood-brain barrier transport of therapeutics via receptor-mediation
    Angela R Jones
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Pharm Res 24:1759-71. 2007
  4. ncbi request reprint Combinatorial approaches for the identification of brain drug delivery targets
    Charles C Stutz
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, WI 53706, USA
    Curr Pharm Des 20:1564-76. 2014
  5. pmc Modeling the blood-brain barrier using stem cell sources
    Ethan S Lippmann
    Dept, of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Dr, Madison, WI, 53706, USA
    Fluids Barriers CNS 10:2. 2013
  6. ncbi request reprint Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, WI 53706, USA
    Drug Discov Today 11:792-9. 2006
  7. pmc Identification and expression profiling of blood-brain barrier membrane proteins
    Nitin Agarwal
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 112:625-35. 2010
  8. pmc Multiplex expression cloning of blood-brain barrier membrane proteins
    Nitin Agarwal
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
    Proteomics 9:1099-108. 2009
  9. pmc A genomic comparison of in vivo and in vitro brain microvascular endothelial cells
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Cereb Blood Flow Metab 28:135-48. 2008
  10. ncbi request reprint Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 97:922-33. 2006

Collaborators

  • R J Boado
  • William Pardridge
  • Anthony R Calabria
  • Nitin Agarwal
  • Ethan S Lippmann
  • Christian Weidenfeller
  • Angela R Jones
  • Charles C Stutz
  • Benjamin J Hackel
  • XiaoBin Zhang
  • Abraham Al-Ahmad
  • Sean P Palecek
  • Clive N Svendsen
  • Helga E de Vries
  • Jennifer C Bubolz
  • Dagang Huang
  • Xin X Wang

Detail Information

Publications14

  1. pmc Blood-brain barrier genomics, proteomics, and new transporter discovery
    Eric V Shusta
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    NeuroRx 2:151-61. 2005
    ..This review will discuss the application of genomics and proteomics to blood-brain barrier research and will offer views on the prospects of such approaches...
  2. pmc Differentiating embryonic neural progenitor cells induce blood-brain barrier properties
    Christian Weidenfeller
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 101:555-65. 2007
    ..This study demonstrates that NPC-BMEC interactions are prevalent and for the first time demonstrates that NPC are capable of inducing BBB properties...
  3. pmc Blood-brain barrier transport of therapeutics via receptor-mediation
    Angela R Jones
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Pharm Res 24:1759-71. 2007
    ..Over the last decade, there have been significant developments in the arena of RMT-based brain drug transport, and this review will focus on those approaches that have been validated in an in vivo setting...
  4. ncbi request reprint Combinatorial approaches for the identification of brain drug delivery targets
    Charles C Stutz
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, WI 53706, USA
    Curr Pharm Des 20:1564-76. 2014
    ....
  5. pmc Modeling the blood-brain barrier using stem cell sources
    Ethan S Lippmann
    Dept, of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Dr, Madison, WI, 53706, USA
    Fluids Barriers CNS 10:2. 2013
    ....
  6. ncbi request reprint Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, WI 53706, USA
    Drug Discov Today 11:792-9. 2006
    ..It is expected that a better understanding of the complex mechanisms that link the BBB to neurological disease will ultimately lead to the development of innovative treatments...
  7. pmc Identification and expression profiling of blood-brain barrier membrane proteins
    Nitin Agarwal
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 112:625-35. 2010
    ..The identification of BBB membrane proteins could help better understand the molecular mechanisms responsible for BBB function and those with selective expression may have utility for BBB-targeted therapies...
  8. pmc Multiplex expression cloning of blood-brain barrier membrane proteins
    Nitin Agarwal
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
    Proteomics 9:1099-108. 2009
    ....
  9. pmc A genomic comparison of in vivo and in vitro brain microvascular endothelial cells
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Cereb Blood Flow Metab 28:135-48. 2008
    ..Genomic analysis of BMEC de-differentiation in culture has thus yielded a functionally diverse set of genes useful for comparing the in vitro and in vivo BBB...
  10. ncbi request reprint Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 97:922-33. 2006
    ..The combined use of puromycin and glucocorticoid therefore provides an in vitro system that is well suited for molecular level BBB investigations...
  11. ncbi request reprint Production of soluble and active transferrin receptor-targeting single-chain antibody using Saccharomyces cerevisiae
    Benjamin J Hackel
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Pharm Res 23:790-7. 2006
    ..This study describes the soluble production, purification, and functional testing of an anti-transferrin receptor single-chain antibody (OX26 scFv) using the yeast Saccharomyces cerevisiae...
  12. ncbi request reprint The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature
    Eric V Shusta
    Department of Chemical and Biological Engineering, University of Wisconsin, Madison, WI 53706, USA
    Neuroreport 14:1861-5. 2003
    ..The selective expression of Ro52/SS-A in brain at the microvasculature may play a role in brain vascular involvement in autoimmune diseases...
  13. ncbi request reprint Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier
    Eric V Shusta
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90024, USA
    J Neuropathol Exp Neurol 61:597-604. 2002
    ..The finding of selective expression of CD46 at the BBB is consistent with an important role played by the microvasculature in the immune surveillance of the brain...
  14. ncbi request reprint Vascular genomics of the human brain
    Eric V Shusta
    Departments of Medicine and Surgery Neurosurgery, UCLA School of Medicine, Los Angeles, California 90024, USA
    J Cereb Blood Flow Metab 22:245-52. 2002
    ....

Research Grants9

  1. Membrane Proteomics of the Blood-Brain Barrier
    ERIC SHUSTA; Fiscal Year: 2009
    ..Finally, identified BBB-specific plasma membrane protein-scFv pairs will be investigated for their potential as noninvasive drug delivery conduits. ..
  2. Proteomic Evaluation of the Blood-Brain Barrier Receptor-Mediated Transportome
    Eric V Shusta; Fiscal Year: 2010
    ..abstract_text> ..
  3. Functional Genomics of the Blood-Brain Barrier
    ERIC SHUSTA; Fiscal Year: 2004
    ..Finally, the effects of ethanol on the functional features of the in vitro model will be investigated as a preliminary validation of in vitro models for the study of the complicated interactions between HIV, ethanol, and the BBB. ..
  4. Membrane Proteomics of the Blood-Brain Barrier
    ERIC SHUSTA; Fiscal Year: 2007
    ..Finally, identified BBB-specific plasma membrane protein-scFv pairs will be investigated for their potential as noninvasive drug delivery conduits. ..
  5. Novel Antibody-Transporter Conjugates for Brain Drug Delivery
    ERIC SHUSTA; Fiscal Year: 2007
    ....