Galina V Shurin

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Regulatory dendritic cells in the tumor immunoenvironment
    Galina V Shurin
    Division of Experimental Pathology, Department of Pathology and Immunology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Cancer Immunol Immunother 61:223-30. 2012
  2. doi request reprint Low-dose chemotherapeutic agents regulate small Rho GTPase activity in dendritic cells
    Galina V Shurin
    Department of Pathology, Division of Clinical Immunopathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Immunother 31:491-9. 2008
  3. ncbi request reprint Dynamic alteration of soluble serum biomarkers in healthy aging
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA
    Cytokine 39:123-9. 2007
  4. doi request reprint Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 183:137-44. 2009
  5. pmc Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
    Ramon Kaneno
    Department of Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil
    J Transl Med 7:58. 2009
  6. doi request reprint Interferon regulatory factor 8 mediates tumor-induced inhibition of antigen processing and presentation by dendritic cells
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Immunol Immunother 58:567-74. 2009
  7. ncbi request reprint Murine prostate cancer inhibits both in vivo and in vitro generation of dendritic cells from bone marrow precursors
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Prostate 59:203-13. 2004
  8. ncbi request reprint Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells
    Zoya R Yurkovetsky
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Gene Med 8:129-37. 2006
  9. ncbi request reprint Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Immunol 178:7787-93. 2007
  10. ncbi request reprint Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells
    Valeria P Makarenkova
    Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Neuroimmunol 145:55-67. 2003

Collaborators

Detail Information

Publications30

  1. pmc Regulatory dendritic cells in the tumor immunoenvironment
    Galina V Shurin
    Division of Experimental Pathology, Department of Pathology and Immunology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Cancer Immunol Immunother 61:223-30. 2012
    ....
  2. doi request reprint Low-dose chemotherapeutic agents regulate small Rho GTPase activity in dendritic cells
    Galina V Shurin
    Department of Pathology, Division of Clinical Immunopathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Immunother 31:491-9. 2008
    ....
  3. ncbi request reprint Dynamic alteration of soluble serum biomarkers in healthy aging
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA
    Cytokine 39:123-9. 2007
    ..Serum levels of EGFR and EGF, important regulators of cell growth and differentiation, were decreased with age in healthy donors. These data suggest novel pathways, which may be involved in age-associated immunosenescence...
  4. doi request reprint Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 183:137-44. 2009
    ....
  5. pmc Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
    Ramon Kaneno
    Department of Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil
    J Transl Med 7:58. 2009
    ..e. chemomodulation, might represent a novel approach for up-regulation of functional activity of resident DCs in the tumor microenvironment or improving the efficacy of DCs prepared ex vivo for subsequent vaccinations...
  6. doi request reprint Interferon regulatory factor 8 mediates tumor-induced inhibition of antigen processing and presentation by dendritic cells
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Immunol Immunother 58:567-74. 2009
    ..Thus, the aim of this work was to analyze the role of interferon regulatory factor 8 (IRF-8) in APM protein expression and the antigen presenting capacity of DCs developed in the tumor microenvironment...
  7. ncbi request reprint Murine prostate cancer inhibits both in vivo and in vitro generation of dendritic cells from bone marrow precursors
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Prostate 59:203-13. 2004
    ..However there is little or no data on the effects of murine prostate cancer (CaP) on DC generation from bone marrow precursors...
  8. ncbi request reprint Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells
    Zoya R Yurkovetsky
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Gene Med 8:129-37. 2006
    ..Taken together, these results demonstrate that adenoviral gene transfer of CD40L, RANKL or 4-1BBL elicit a significant antitumor effect in two different tumor models, with CD40L gene transfer inducing the strongest antitumor effect...
  9. ncbi request reprint Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Immunol 178:7787-93. 2007
    ....
  10. ncbi request reprint Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells
    Valeria P Makarenkova
    Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Neuroimmunol 145:55-67. 2003
    ..This suggests a new mechanism of tumor escape and provides new targets for the immunopharmacological correction of immune effectors in cancer...
  11. ncbi request reprint Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis
    Levent Balkir
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gene Med 6:537-44. 2004
    ..The aim of this study was to identify extrinsic and intrinsic tumor-induced apoptotic pathways in DC by targeting different anti-apoptotic molecules, including FLIP, XIAP/hILP, dominant-negative procaspase-9 and HSP70...
  12. ncbi request reprint Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    J Leukoc Biol 72:1037-45. 2002
    ..In summary, these results suggest that transduction of DC with the IL-15 gene markedly stimulates DC function and protects them from tumor-induced apoptosis...
  13. ncbi request reprint Regulation of dendritic cell expansion in aged athymic nude mice by FLT3 ligand
    Galina V Shurin
    Department of Pediatrics, University of Pittsburgh Medical Center, 5725 Main Tower Childrens Hospital, 200 Lothrop Street, Pdittsburgh, PA 15213, USA
    Exp Gerontol 39:339-48. 2004
    ..In summary, abnormalities in DC generation and distribution in old athymic mice could be, in part, circumvented by the in vivo administration of FLT3L...
  14. ncbi request reprint Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice
    Yuji Satoh
    Biologic Therapeutics Program, University of Pittsburgh Cancer Institute, 5725 CHP MT, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Exp Ther Oncol 2:337-49. 2002
    ..Simultaneous local gene therapy with IL-12 will further improve clinical efficacy without placing the patient at risk for systemic toxicity...
  15. ncbi request reprint Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 174:5490-8. 2005
    ..Activation of DC with recombinant human CXCL14 was accompanied by up-regulation of NF-kappaB activity. These data suggest that CXCL14 is a potent chemoattractant and activator of DC and might be involved in DC homing in vivo...
  16. doi request reprint Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer
    Michael R Shurin
    Department of Pathology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer Res 69:2487-96. 2009
    ..Thus, labeling of tumors with phosphatidylserine is a promising strategy for cancer immunotherapy...
  17. ncbi request reprint Restoration by IL-15 of MHC class I antigen-processing machinery in human dendritic cells inhibited by tumor-derived gangliosides
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 175:3045-52. 2005
    ..These results demonstrate that IL-15 restores MHC class I APM component expression in DC down-regulated by tumor-derived gangliosides...
  18. ncbi request reprint Small rho GTPases regulate antigen presentation in dendritic cells
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 174:3394-400. 2005
    ..caCdc42 also increased endocytotic activity of DC, whereas dominant-negative Cdc42 blocked it. Thus, Rho GTPases Cdc42, RhoA, and Rac1 regulate DC functions that are critical for DC-mediated immune responses in vivo...
  19. ncbi request reprint NK cells mediate Flt3 ligand-induced protection of dendritic cell precursors in vivo from the inhibition by prostate carcinoma in the murine bone marrow metastasis model
    Irina L Tourkova
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunother 26:468-72. 2003
    ..Thus, these data demonstrate that prostate cancer inhibits DC hematopoietic precursors in vivo in the bone marrow and this effect could be abolished by a systemic administration of growth factor Flt3 ligand...
  20. ncbi request reprint Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?
    Michael R Shurin
    Department of Pathology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Metastasis Rev 25:333-56. 2006
    ..This review is limited to discussing the role of intratumoral cytokine network in the understanding immunobiology of tumor-associated dendritic cells, which seems to possess different regulatory functions at the tumor site...
  21. ncbi request reprint Inhibition of CD40 expression and CD40-mediated dendritic cell function by tumor-derived IL-10
    Michael R Shurin
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Cancer 101:61-8. 2002
    ..These findings thus demonstrate that tumor-derived factors, including IL-10, inhibit CD40 expression on DCs and DC precursors and suppress their maturation and function...
  22. ncbi request reprint Regulatory dendritic cells: new targets for cancer immunotherapy
    Michael R Shurin
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Cancer Biol Ther 11:988-92. 2011
  23. ncbi request reprint Differentiation of immunostimulatory stem-cell- and monocyte-derived dendritic cells involves maturation of intracellular compartments responsible for antigen presentation and secretion
    Svetlana N Bykovskaia
    University of Pittsburgh Medical Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 20:380-93. 2002
    ..In extended studies, cultured CD14(+) monocyte-derived DCs displayed a similar, but accelerated, temporal differentiation staging pattern...
  24. doi request reprint Targeting myeloid regulatory cells in cancer by chemotherapeutic agents
    Hiam Naiditch
    Departments of Pathology and Immunology, Experimental Pathology, University of Pittsburgh Medical Center, S735 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Immunol Res 50:276-85. 2011
    ..However, further studies are required before this new targeted therapy can find its way to patients with cancer...
  25. ncbi request reprint Gangliosides as immunomodulators
    Miroslava Potapenko
    Department of Pathology, Division of Clinical Immunopathology, University of Pittsburgh, Pittsburgh, PA, USA
    Adv Exp Med Biol 601:195-203. 2007
    ..These molecules can be considered as tumor weapons directed to attack and destroy immunosurveillance mechanisms devoted to control cancer progression...
  26. pmc Aging and the dendritic cell system: implications for cancer
    Michael R Shurin
    University of Pittsburgh Cancer Institute, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Rev Oncol Hematol 64:90-105. 2007
    ....
  27. pmc The role of TLR4 in the paclitaxel effects on neuronal growth in vitro
    Elena E Ustinova
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e56886. 2013
    ..Low doses of Pac are devoid of neuronal toxicity and thus can be safely used in a chemomodulation mode...
  28. pmc Tumor associated regulatory dendritic cells
    Yang Ma
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Semin Cancer Biol 22:298-306. 2012
    ....
  29. pmc Dendritic cells in the cancer microenvironment
    Yang Ma
    1 Departments of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Cancer 4:36-44. 2013
    ..Thus, better understanding of DC immunobiology in cancer is pivotal for designing novel or improved therapeutic approaches that will allow proper functioning of DCs in patients with cancer...
  30. pmc Dopamine receptors in human lymphocytes: radioligand binding and quantitative RT-PCR assays
    Galina P Kirillova
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Neurosci Methods 174:272-80. 2008
    ..The expression levels were comparable with those in the brain for DRD3 and DRD4, and were significantly lower for DRD2 and DRD5...