Research Topics
| James D ShullSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercrossJames D Shull
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
Mamm Genome 18:657-69. 2007....- The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesisJames D Shull
Department of Genetics, Cell Biology and Anatomy and Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
Breast Dis 28:69-86. 2007.... - Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14James D Shull
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, 68198, USA
Mamm Genome 17:751-9. 2006..4-Mb interval on RNO14 bounded by markers D14Rat50 and D14Rat12. The data from these genetic studies suggest that the ACI allele of Renag1 acts in an incompletely dominant and incompletely penetrant manner to confer URA... - Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercrossBeverly S Schaffer
Department of Genetics, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198, USA
Cancer Res 66:7793-800. 2006..These data indicate that susceptibility to E2-induced mammary cancer in the BN x ACI cross behaves as a complex trait controlled by at least five loci and multiple gene-gene interactions... 
Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female ratScott G Kurz
Department of Genetics, Cell Biology and Anatomy, 6005 Durham Research Center, 985805 Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
Endocrinology 149:3850-9. 2008..These data indicate that each of these Ept genetic determinants of estrogen action is unique in regard to the tissues in which it exerts its effects and/or the direction of its effect on estrogen responsiveness...- Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5Karen A Gould
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Mamm Genome 16:854-64. 2005..In addition to Eutr1, we obtained evidence suggestive of linkage for five additional loci on RNO2, 4, 11, 17, and X that control susceptibility to E2-induced pyometritis in the (BN x ACI)F(2) population... - Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strainsTracy E Strecker
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198, USA
Genetics 169:2189-97. 2005..These data indicate that DES-induced pituitary mass behaves as a quantitative trait and provide information that will facilitate identification of genes that determine the tumorigenic response of the pituitary gland to estrogens... - Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18Karen A Gould
Eppley Institute for Research in Cancer, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
Genetics 168:2113-25. 2004..The ACI allele of Emca2 acts in a dominant manner to increase incidence and decrease latency. Together, Emca1 and Emca2 act independently to modify susceptibility to E2-induced mammary cancer... - Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restrictionDjuana M E Harvell
Eppley Institute for Research in Cancer, and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
Endocrine 21:175-83. 2003..This study indicates that sensitivity to the inhibitory actions of dietary energy restriction on E2-induced pituitary tumorigenesis is genetically determined... - Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway ratKaren A Gould
Department of Genetics, Cell Biology and Anatomy, 985805, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
Mamm Genome 17:451-64. 2006..These observations suggest that common genetic determinants may control sensitivity to estrogen-induced thymic atrophy, maintenance of thymocyte homeostasis, and immune function... - Dietary energy restriction inhibits estrogen-induced mammary, but not pituitary, tumorigenesis in the ACI ratDjuana M E Harvell
Eppley Institute for Research in Cancer, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
Carcinogenesis 23:161-9. 2002.... - Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5Beverly S Schaffer
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA
Cancer Prev Res (Phila) 6:59-69. 2013..Cancer Prev Res; 6(1); 59-69. ©2012 AACR... - Nonrandom pattern of chromosome aberrations in 17beta-estradiol-induced rat mammary tumors: indications of distinct pathways for tumor developmentTatjana Adamovic
CMB Genetics, Goteborg University, SE 40530 Goteborg, Sweden
Genes Chromosomes Cancer 46:459-69. 2007..BN-Emca8 congenic rats, which carry the BN allele of the Emca8 QTL on RNO5 on the ACI genetic background, we were able to determine that the constitution of the germ line influences the pattern of chromosomal aberrations... - Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strainJyotsna Pandey
Department of Biological Sciences, Oakland University, Rochester, Michigan 48309, USA
Mamm Genome 16:865-72. 2005.... 
Progress and prospects in rat genetics: a community viewTimothy J Aitman
Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
Nat Genet 40:516-22. 2008..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research...- Distribution and functional impact of DNA copy number variation in the ratVictor Guryev
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
Nat Genet 40:538-45. 2008..These characteristics make the rat an excellent model for studying phenotypic effects of structural variation in relation to human complex traits and disease...
Research Grants
- Genetic Etilogy of Renal Agenesis in the ACI RatJames Shull; Fiscal Year: 2006..Upon completion of these Aims, we will better understand the genetic bases of renal agenesis in the ACI rat and will be able to assess the relevance of this animal model to renal agenesis in humans. ..