James D Shull

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis
    James D Shull
    Department of Genetics, Cell Biology and Anatomy and Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Breast Dis 28:69-86. 2007
  2. ncbi request reprint Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14
    James D Shull
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, 68198, USA
    Mamm Genome 17:751-9. 2006
  3. ncbi request reprint Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross
    James D Shull
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Mamm Genome 18:657-69. 2007
  4. ncbi request reprint Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross
    Beverly S Schaffer
    Department of Genetics, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198, USA
    Cancer Res 66:7793-800. 2006
  5. pmc Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat
    Scott G Kurz
    Department of Genetics, Cell Biology and Anatomy, 6005 Durham Research Center, 985805 Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Endocrinology 149:3850-9. 2008
  6. pmc Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains
    Tracy E Strecker
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198, USA
    Genetics 169:2189-97. 2005
  7. ncbi request reprint Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5
    Karen A Gould
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Mamm Genome 16:854-64. 2005
  8. pmc Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18
    Karen A Gould
    Eppley Institute for Research in Cancer, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Genetics 168:2113-25. 2004
  9. ncbi request reprint Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction
    Djuana M E Harvell
    Eppley Institute for Research in Cancer, and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Endocrine 21:175-83. 2003
  10. pmc Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5
    Beverly S Schaffer
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Prev Res (Phila) 6:59-69. 2013

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis
    James D Shull
    Department of Genetics, Cell Biology and Anatomy and Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Breast Dis 28:69-86. 2007
    ....
  2. ncbi request reprint Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14
    James D Shull
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, 68198, USA
    Mamm Genome 17:751-9. 2006
    ..4-Mb interval on RNO14 bounded by markers D14Rat50 and D14Rat12. The data from these genetic studies suggest that the ACI allele of Renag1 acts in an incompletely dominant and incompletely penetrant manner to confer URA...
  3. ncbi request reprint Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross
    James D Shull
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Mamm Genome 18:657-69. 2007
    ....
  4. ncbi request reprint Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross
    Beverly S Schaffer
    Department of Genetics, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198, USA
    Cancer Res 66:7793-800. 2006
    ..These data indicate that susceptibility to E2-induced mammary cancer in the BN x ACI cross behaves as a complex trait controlled by at least five loci and multiple gene-gene interactions...
  5. pmc Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat
    Scott G Kurz
    Department of Genetics, Cell Biology and Anatomy, 6005 Durham Research Center, 985805 Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Endocrinology 149:3850-9. 2008
    ..These data indicate that each of these Ept genetic determinants of estrogen action is unique in regard to the tissues in which it exerts its effects and/or the direction of its effect on estrogen responsiveness...
  6. pmc Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains
    Tracy E Strecker
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198, USA
    Genetics 169:2189-97. 2005
    ..These data indicate that DES-induced pituitary mass behaves as a quantitative trait and provide information that will facilitate identification of genes that determine the tumorigenic response of the pituitary gland to estrogens...
  7. ncbi request reprint Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5
    Karen A Gould
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Mamm Genome 16:854-64. 2005
    ..In addition to Eutr1, we obtained evidence suggestive of linkage for five additional loci on RNO2, 4, 11, 17, and X that control susceptibility to E2-induced pyometritis in the (BN x ACI)F(2) population...
  8. pmc Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18
    Karen A Gould
    Eppley Institute for Research in Cancer, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Genetics 168:2113-25. 2004
    ..The ACI allele of Emca2 acts in a dominant manner to increase incidence and decrease latency. Together, Emca1 and Emca2 act independently to modify susceptibility to E2-induced mammary cancer...
  9. ncbi request reprint Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction
    Djuana M E Harvell
    Eppley Institute for Research in Cancer, and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Endocrine 21:175-83. 2003
    ..This study indicates that sensitivity to the inhibitory actions of dietary energy restriction on E2-induced pituitary tumorigenesis is genetically determined...
  10. pmc Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5
    Beverly S Schaffer
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Prev Res (Phila) 6:59-69. 2013
    ..Cancer Prev Res; 6(1); 59-69. ©2012 AACR...
  11. ncbi request reprint Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat
    Karen A Gould
    Department of Genetics, Cell Biology and Anatomy, 985805, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Mamm Genome 17:451-64. 2006
    ..These observations suggest that common genetic determinants may control sensitivity to estrogen-induced thymic atrophy, maintenance of thymocyte homeostasis, and immune function...
  12. ncbi request reprint Dietary energy restriction inhibits estrogen-induced mammary, but not pituitary, tumorigenesis in the ACI rat
    Djuana M E Harvell
    Eppley Institute for Research in Cancer, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:161-9. 2002
    ....
  13. ncbi request reprint Nonrandom pattern of chromosome aberrations in 17beta-estradiol-induced rat mammary tumors: indications of distinct pathways for tumor development
    Tatjana Adamovic
    CMB Genetics, Goteborg University, SE 40530 Goteborg, Sweden
    Genes Chromosomes Cancer 46:459-69. 2007
    ..BN-Emca8 congenic rats, which carry the BN allele of the Emca8 QTL on RNO5 on the ACI genetic background, we were able to determine that the constitution of the germ line influences the pattern of chromosomal aberrations...
  14. ncbi request reprint Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain
    Jyotsna Pandey
    Department of Biological Sciences, Oakland University, Rochester, Michigan 48309, USA
    Mamm Genome 16:865-72. 2005
    ....
  15. doi request reprint Progress and prospects in rat genetics: a community view
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Genet 40:516-22. 2008
    ..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research...
  16. doi request reprint Distribution and functional impact of DNA copy number variation in the rat
    Victor Guryev
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Genet 40:538-45. 2008
    ..These characteristics make the rat an excellent model for studying phenotypic effects of structural variation in relation to human complex traits and disease...

Research Grants1

  1. Genetic Etilogy of Renal Agenesis in the ACI Rat
    James Shull; Fiscal Year: 2006
    ..Upon completion of these Aims, we will better understand the genetic bases of renal agenesis in the ACI rat and will be able to assess the relevance of this animal model to renal agenesis in humans. ..