G E Shull

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction
    Gary E Shull
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, OH, USA
    Biofactors 37:150-8. 2011
  2. ncbi Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants
    Gary E Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Ann N Y Acad Sci 986:453-60. 2003
  3. ncbi Gene knockout studies of Ca2+-transporting ATPases
    G E Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    Eur J Biochem 267:5284-90. 2000
  4. ncbi Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract
    G E Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267, USA
    Am J Physiol Gastrointest Liver Physiol 278:G185-90. 2000
  5. ncbi Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion
    P J Schultheis
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Clin Invest 101:1243-53. 1998
  6. ncbi Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction
    Z Spicer
    Department of Molecular Genetics, Biochemistry and Microbiology, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1369-77. 2001
  7. ncbi Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice
    C Ledoussal
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1385-96. 2001
  8. ncbi Three N-terminal variants of the AE2 Cl-/HCO3- exchanger are encoded by mRNAs transcribed from alternative promoters
    Z Wang
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524, USA
    J Biol Chem 271:7835-43. 1996
  9. ncbi Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf
    M Flagella
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 274:26946-55. 1999
  10. ncbi Rat kidney band 3 Cl-/HCO3- exchanger mRNA is transcribed from an alternative promoter
    K E Kudrycki
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Am J Physiol 264:F540-7. 1993

Detail Information

Publications110 found, 100 shown here

  1. ncbi Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction
    Gary E Shull
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, OH, USA
    Biofactors 37:150-8. 2011
    ....
  2. ncbi Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants
    Gary E Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Ann N Y Acad Sci 986:453-60. 2003
    ..The diversity of phenotypes indicates that the various Ca(2+)-transporting ATPase isoforms serve very different physiological functions...
  3. ncbi Gene knockout studies of Ca2+-transporting ATPases
    G E Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    Eur J Biochem 267:5284-90. 2000
    ..These studies are yielding important insights regarding the physiological functions of individual Ca2+-transporting ATPases in vivo...
  4. ncbi Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract
    G E Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267, USA
    Am J Physiol Gastrointest Liver Physiol 278:G185-90. 2000
    ..This approach is leading to a clearer understanding of the functions of these transporters in the living animal...
  5. ncbi Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion
    P J Schultheis
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Clin Invest 101:1243-53. 1998
    ....
  6. ncbi Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction
    Z Spicer
    Department of Molecular Genetics, Biochemistry and Microbiology, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1369-77. 2001
    ....
  7. ncbi Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice
    C Ledoussal
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1385-96. 2001
    ....
  8. ncbi Three N-terminal variants of the AE2 Cl-/HCO3- exchanger are encoded by mRNAs transcribed from alternative promoters
    Z Wang
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524, USA
    J Biol Chem 271:7835-43. 1996
    ..Thus, the use of alternative promoters leads to the production of three N-terminal variants of AE2 that exhibit tissue-specific patterns of expression...
  9. ncbi Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf
    M Flagella
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 274:26946-55. 1999
    ....
  10. ncbi Rat kidney band 3 Cl-/HCO3- exchanger mRNA is transcribed from an alternative promoter
    K E Kudrycki
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Am J Physiol 264:F540-7. 1993
    ..Thus two distinct promoters, separated by almost 5 kb of genomic sequence, are responsible for the highly tissue-specific transcription of the alternative rat erythroid and kidney band 3 mRNAs...
  11. ncbi Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger
    P J Schultheis
    Department of Molecular Genetics, Biochemistry and Microbiology, The University of Cincinnati College of Medicine, Ohio 45267 0524, USA
    Nat Genet 19:282-5. 1998
    ..These data show that NHE3 is the major absorptive Na+/H+ exchanger in kidney and intestine, and that lack of the exchanger impairs acid-base balance and Na+-fluid volume homeostasis...
  12. ncbi Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule
    P J Schultheis
    Department of Molecular Genetics, Biochemistry and Microbiology, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 273:29150-5. 1998
    ..These data indicate that the loss of NCC activity in the mouse causes only subtle perturbations of sodium and fluid volume homeostasis, but renal handling of Mg2+ and Ca2+ are altered, as observed in Gitelman's syndrome...
  13. ncbi Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2
    C Ledoussal
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Physiol Renal Physiol 281:F718-27. 2001
    ....
  14. ncbi Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene
    M Periasamy
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 274:2556-62. 1999
    ....
  15. ncbi cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump
    S E Burk
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524
    J Biol Chem 264:18561-8. 1989
    ..These data show that the enzyme is a Ca2+-transporting ATPase and that its mRNA is expressed in a broad variety of both muscle and non-muscle tissues...
  16. ncbi Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4
    T P Keeton
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 268:2740-8. 1993
    ..The alternative mRNAs for each of the four genes are expressed in a tissue-specific manner and encode enzyme variants with different combinations of calmodulin-binding domains and C termini...
  17. ncbi Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle
    J Kao
    Department of Molecular and Cellular Physiology, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol 277:L264-70. 1999
    ....
  18. ncbi Primary structure of the rat kidney band 3 anion exchange protein deduced from a cDNA
    K E Kudrycki
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 264:8185-92. 1989
    ..Northern blot hybridization studies indicate that two additional Band 3 mRNAs, which differ in size from the major 4.5-kilobase pair transcript in kidney, are expressed at low levels in kidney and brain...
  19. ncbi HCO-3 reabsorption in renal collecting duct of NHE-3-deficient mouse: a compensatory response
    S Nakamura
    Department of Internal Medicine, Biochemistry and Microbiology, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267, USA
    Am J Physiol 276:F914-21. 1999
    ..In CCD, H+-ATPase, and in the OMCD, both H+-ATPase and gastric H+-K+-ATPase contribute to the enhanced compensatory HCO-3 reabsorption in NHE-3-deficient animals...
  20. ncbi Molecular cloning of a third isoform of the calmodulin-sensitive plasma membrane Ca2+-transporting ATPase that is expressed predominantly in brain and skeletal muscle
    J Greeb
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 264:18569-76. 1989
    ..However, PMCA2 and PMCA3 mRNAs exhibit a high degree of tissue specificity. PMCA2 mRNAs are expressed predominantly in brain and heart, whereas PMCA3 mRNAs are expressed predominantly in brain and skeletal muscle...
  21. ncbi cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger
    K E Kudrycki
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 265:462-71. 1990
    ..Band 3 mRNAs were observed in many tissues but high levels of expression occurred only in spleen and kidney. Five Band 3 transcripts, ranging in size from 3.6 to 4.9 kilobases, were detected, including three that are expressed in heart...
  22. ncbi Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain
    N R Baird
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 274:4377-82. 1999
    ..Northern blot analysis demonstrated that the mRNA encoding NHE5 is expressed in multiple regions of the brain, including hippocampus, consistent with the possibility that it regulates intracellular pH in hippocampal and other neurons...
  23. ncbi Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia
    Z Spicer
    Departments of Molecular Genetics, Biochemistry, and Microbiology and Environmental Health, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 275:21555-65. 2000
    ....
  24. ncbi Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice
    P Meneton
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Invest 101:536-42. 1998
    ..In addition, cHKA-/- mice lost twice as much body weight as cHKA+/+ mice. These results demonstrate that, during K+ deprivation, cHKA plays a critical role in the maintenance of K+ homeostasis in vivo...
  25. ncbi Cloning, renal distribution, and regulation of the rat Na+-HCO3- cotransporter
    C E Burnham
    Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol 274:F1119-26. 1998
    ..In the kidney, NBC-1 is expressed mainly in the proximal tubule, with traces found in medullary thick ascending limb and papilla. HCO3- loading decreased NBC-1 mRNA levels, which were unchanged either by metabolic acidosis or by CDA...
  26. ncbi Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2
    P J Kozel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 273:18693-6. 1998
    ..These data demonstrate that PMCA2 is required for both balance and hearing and suggest that it may be a major source of the calcium used in the formation and maintenance of otoconia...
  27. ncbi Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric
    Lara R Gawenis
    Department of Molecular Genetics, Biochemistry and Microbiology, Unniversity of Cincinnati College of Medicine, Ohio 45267, USA
    J Biol Chem 279:30531-9. 2004
    ..These results demonstrate that AE2 is essential for gastric acid secretion and for normal development of secretory canalicular and tubulovesicular membranes in mouse parietal cells...
  28. ncbi Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger
    Z Wang
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 268:11925-8. 1993
    ..This suggests that NHE-2 plays an important role in gastrointestinal physiology and functions in many other organ systems as well...
  29. ncbi Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36
    Y R Su
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, Ohio 45267 0524
    Genomics 22:605-9. 1994
    ..Multipoint linkage analysis placed the AE3 gene between D2S128 and D2S126 on a genetic map of chromosome 2, corroborating the chromosomal localization of AE3 obtained by physical mapping methods...
  30. ncbi Micropuncture analysis of single-nephron function in NHE3-deficient mice
    J N Lorenz
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Am J Physiol 277:F447-53. 1999
    ..In animals with NHE3 deficiency, normalization of fluid delivery to the distal tubule is achieved through alterations in filtration rate and/or downstream transport processes...
  31. ncbi Analysis of the 5' end of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and identification of extensive trinucleotide repeat sequences in the 5' untranslated region
    S E Burk
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    Biochim Biophys Acta 1240:119-24. 1995
    ..Analysis of genomic sequences 5' to the transcription initiation site revealed potential binding sites for transcription factors that are active in muscle and brain...
  32. ncbi Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function
    Y Ji
    Division of Cardiology, Department of Internal Medicine, The Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0542, USA
    J Biol Chem 275:38073-80. 2000
    ..However, the resulting deficit is partially compensated by alterations in phospholamban/SERCA2 interactions and by up-regulation of the Na(+)-Ca(2+) exchanger...
  33. ncbi Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger
    Lara R Gawenis
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 280:12781-9. 2005
    ....
  34. ncbi Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach
    Jie Xu
    Research Services, Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    Proc Natl Acad Sci U S A 105:17955-60. 2008
    ..We propose that Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells...
  35. ncbi Primary structure of rat plasma membrane Ca(2+)-ATPase isoform 4 and analysis of alternative splicing patterns at splice site A
    T P Keeton
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524
    Biochem J 306:779-85. 1995
    ....
  36. ncbi cDNA cloning of the beta-subunit of the rat gastric H,K-ATPase
    G E Shull
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 265:12123-6. 1990
    ..Northern blot analyses of poly(A)+ RNAs from 13 tissues demonstrate that the H,K-ATPase beta-subunit mRNA is expressed at high level in stomach and is not expressed in any of the other tissues...
  37. ncbi Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3
    L H Liu
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 272:30538-45. 1997
    ..These results indicate that SERCA3 plays a critical role in endothelial cell Ca2+ signaling events involved in nitric oxide-mediated relaxation of vascular smooth muscle...
  38. ncbi Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect
    Alison L Woo
    Department of Molecular Genetics, Biochemistry, and Microbiology, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Am J Physiol Renal Physiol 284:F1190-8. 2003
    ....
  39. ncbi NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice
    Yanfang Guan
    Dept of Molecular and Cellular Physiology, Univ of Cincinnati College of Medicine, 231 Albert Sabin Way, Medical Sciences Bldg, Cincinnati, OH 45267 0576, USA
    Am J Physiol Gastrointest Liver Physiol 291:G689-99. 2006
    ..We conclude that constitutive absence of NHE2 results in a compensatory increase in a Na(+)-dependent, EIPA-sensitive acid extruder distinct from NHE1, NHE3, or SITS-sensitive transporters...
  40. ncbi Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump
    L H Liu
    Departments of Molecular Genetics, Biochemistry and Microbiology and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 276:26737-40. 2001
    ..These findings provide the first direct demonstration that a perturbation of Ca(2+) homeostasis or signaling can serve as a primary initiating event in cancer...
  41. ncbi Cloning and functional expression of a human kidney Na+:HCO3- cotransporter
    C E Burnham
    Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    J Biol Chem 272:19111-4. 1997
    ..6-kilobase mRNA is highly expressed in kidney and pancreas, with detectable levels in brain. Functional studies in transiently transfected HEK-293 cells demonstrate that the cloned transporter mediates Na+:HCO3- cotransport...
  42. ncbi Rat gastric H,K-ATPase beta-subunit gene: intron/exon organization, identification of multiple transcription initiation sites, and analysis of the 5'-flanking region
    P R Newman
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Genomics 11:252-62. 1991
    ..These include a sequence that may form a triple helix and an adjacent sequence with the potential to form Z-DNA...
  43. ncbi Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Renal Physiol 282:F133-43. 2002
    ..These data indicate the presence of a previously unrecognized K(+)-dependent SCH-28080 and ouabain-insensitive proton secretory mechanism in the cortical collecting tubule that may play an important role in acid-base homeostasis...
  44. ncbi The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice
    R J Paul
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, OH 45267-0576, USA
    Novartis Found Symp 246:228-38; discussion 238-43, 272-6. 2002
    ..The use of these gene-altered models has provided evidence clearly implicating a major role for the SR in modulating smooth muscle Ca2+ and contractility, with the caveat that this modulation is tissue specific...
  45. ncbi Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes
    P R Newman
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524
    DNA Cell Biol 9:749-62. 1990
    ..Other conserved sequences, including possible response elements for Ca2+ and cAMP, which are known intracellular mediators of acid secretion, are located up to 2 kb 5' to the transcription initiation site...
  46. ncbi Regulation of gene expression by hypoxia: a molecular approach
    D Beitner-Johnson
    Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, OH 45267 0576, USA
    Respir Physiol 110:87-97. 1997
    ....
  47. ncbi Volume density, distribution, and ultrastructure of secretory and basolateral membranes and mitochondria predict parietal cell secretory (dys)function
    Marian L Miller
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Biomed Biotechnol 2010:394198. 2010
    ..Alterations in acid secretion, then, cause significant changes not only in the Vd of secretory membranes but also in mitochondria and basolateral membranes...
  48. ncbi Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3
    Hassane Amlal
    Departments of Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
    J Physiol 553:511-22. 2003
    ..These defects occur despite increased circulating levels of vasopressin. We propose that an ADH-independent mechanism is responsible for the downregulation of AQP2 and the resulting polyuria in NHE3 null mice...
  49. ncbi Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase
    John N Lorenz
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    J Am Soc Nephrol 17:2457-63. 2006
    ..These data indicate that TGF requires activity of the alpha1 Na,K-ATPase, presumably in the MD. Furthermore, the data show that neither NHE2 nor colonic H,K-ATPase is essential for initiation of TGF responses...
  50. ncbi Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4
    Gbolahan W Okunade
    Department of Molecular Genetics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 279:33742-50. 2004
    ....
  51. ncbi Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine
    William T Noonan
    Department of Genome Science, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Regul Integr Comp Physiol 288:R685-91. 2005
    ....
  52. ncbi Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes
    Gbolahan W Okunade
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 282:26517-27. 2007
    ..These data show that loss of the Golgi Ca(2+) pump causes Golgi stress, expansion of the Golgi, increased apoptosis, and embryonic lethality and demonstrates that SPCA1 haploinsufficiency causes a genetic predisposition to cancer...
  53. ncbi The unique ultrastructure of secretory membranes in gastric parietal cells depends upon the presence of H+, K+ -ATPase
    Marian L Miller
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, 3223 Eden Avenue, Cincinnati, OH 45267 0056, USA
    Cell Tissue Res 309:369-80. 2002
    ....
  54. ncbi Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel
    William G Sinkins
    Department of Physiology, Rammelkamp Center for Education and Research, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Am J Physiol Cell Physiol 297:C1533-43. 2009
    ..e., Ca(2+)-ATPase) in isolated membranes, or in purified PMCA preparations, was inhibited by MTX. Together, these results suggest that MTX binds to and converts the PMCA pump into a Ca(2+)-permeable nonselective cation channel...
  55. ncbi Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases
    Vikram Prasad
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 283:31303-14. 2008
    ..These data show that AE3 and NKCC1 affect Ca2+ handling, PLN regulation, and expression and localization of major cardiac phosphatases and that their combined loss impairs cardiac function...
  56. ncbi Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter
    Lara R Gawenis
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 282:9042-52. 2007
    ....
  57. ncbi Reduced NHE3-mediated Na+ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice
    Emily M Bradford
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, ML0524, Cincinnati, OH 45267 0524, USA
    Am J Physiol Gastrointest Liver Physiol 296:G886-98. 2009
    ....
  58. ncbi Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice
    Li Liu
    Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Cell Physiol 292:C423-31. 2007
    ....
  59. ncbi Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice
    Peter J Kozel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, OH 45267, USA
    Hear Res 164:231-9. 2002
    ..0007) permanent threshold shifts at 16 and 32 kHz that were 15 or 25 dB greater than those observed in Pmca2+/+ littermates. Pmca2 may be the first gene with a known mutated protein product that confers increased susceptibility to NIHL...
  60. ncbi Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter
    Jamie W Meyer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Physiol Heart Circ Physiol 283:H1846-55. 2002
    ..In phasic portal vein smooth muscle from Nkcc1(-/-) mice, however, a sharp reduction in mechanical force was noted. These results indicate that NKCC1 can be important for the maintenance of normal blood pressure and vascular tone...
  61. ncbi The predicted translation product of a cardiac AE3 mRNA contains an N terminus distinct from that of the brain AE3 Cl-/HCO3- exchanger. Cloning of a cardiac AE3 cDNA, organization of the AE3 gene, and identification of an alternative transcription initiat
    S C Linn
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 267:7927-35. 1992
    ..Therefore, alternative promoter and exon usage are involved in generation of the two AE3 mRNAs...
  62. ncbi Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome
    John N Lorenz
    Department of Molecular Genetics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 277:37871-80. 2002
    ..These data show that the loss of ROMK in the mouse causes perturbations of electrolyte, acid-base, and fluid-volume homeostasis, reduced absorption of NaCl in the TALH, and impaired tubuloglomerular feedback...
  63. ncbi Phenotypes of SERCA and PMCA knockout mice
    Vikram Prasad
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Biochem Biophys Res Commun 322:1192-203. 2004
    ..These unique phenotypes provide new information about the cellular functions of these pumps, the requirement of their activities for higher order physiological processes, and the pathophysiological consequences of pump dysfunction...
  64. ncbi SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+
    Jie Xu
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Am J Physiol Cell Physiol 289:C493-505. 2005
    ..Disease states that are associated with increased ammonia (NH3)/NH4+ generation (e.g., Helicobacter pylori) may impair gastric HCO3- secretion and therefore predispose patients to peptic ulcer by inhibiting SLC26A9...
  65. ncbi Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice
    Li Liu
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, OH 45267 0576, USA
    Am J Physiol Cell Physiol 290:C1239-47. 2006
    ..e., Ca(2+) homeostasis, of bladder smooth muscle...
  66. ncbi In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea
    Alison L Woo
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267 0524, USA
    J Biol Chem 277:49036-46. 2002
    ....
  67. ncbi Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury
    Yigang Wang
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Circ Res 93:776-82. 2003
    ....
  68. ncbi Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents
    Xu Wu
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Clin Invest 119:976-85. 2009
    ..Thus, Pmca4b likely reduces the local Ca2+ signals involved in reactive cardiomyocyte hypertrophy via calcineurin regulation...
  69. ncbi Structure of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and characterization of alternative splicing and transcription products. Skeletal muscle-specific splicing results in a plasma membrane Ca(2+)-ATPase with a novel calmodulin-binding domain
    S E Burk
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 267:19683-90. 1992
    ..Exon 8 is inserted immediately before the sequence encoding a putative phospholipid binding domain and thus may alter regulatory interactions of the enzyme with acidic phospholipids...
  70. ncbi Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells
    Snezana Petrovic
    Department of Medicine, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1207-16. 2002
    ....
  71. ncbi Identification of an apical Cl-/HCO3- exchanger in gastric surface mucous and duodenal villus cells
    Jie Xu
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1225-34. 2003
    ..These data show that AE4 is an apical Cl-/HCO3- exchanger in gastric mucous cells and duodenal villus cells. On the basis of its function and location, we propose that AE4 may play an important role in mucosal protection...
  72. ncbi Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice
    Vikram Prasad
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, ML 524, Cincinnati, OH 45267 0524, USA
    Ann N Y Acad Sci 1099:276-86. 2007
    ..These phenotypes indicate that PMCA1 serves essential housekeeping functions, whereas PMCA4 and particularly PMCA2 serve more specialized physiological functions...
  73. ncbi Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pump
    A M Gunteski-Hamblin
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Biochemistry 31:7600-8. 1992
    ..Similarity comparisons show that the two enzymes are more closely related to the known Ca2+ pumps than to other P-type ATPases.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. ncbi Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus
    M S Crowson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    J Biol Chem 267:13740-8. 1992
    ..Furthermore, expression of its mRNA in kidney raises the possibility that the enzyme also corresponds to the H+,K(+)-ATPase that seems to play a role in K+ absorption and H+ secretion in the distal nephron...
  75. ncbi CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor
    Emily M Bradford
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1531-42. 2010
    ..These data reveal a requirement for CLIC5 in the maintenance of normal systemic energy metabolism...
  76. ncbi Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury
    Michael P Kurnellas
    Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    FASEB J 19:298-300. 2005
    ..Our findings suggest that a reduction in PMCA2 level or activity leading to delays in calcium clearance may cause neuronal damage and loss in the spinal cord...
  77. ncbi Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates that nongastric H-K-ATPase functions as proton pump in vivo
    Nikolay B Pestov
    Dept of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, Med Univ of Ohio, 3035 Arlington Ave, Toledo, OH 43614, USA
    Am J Physiol Cell Physiol 291:C366-74. 2006
    ....
  78. ncbi Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia
    Douglas B Kintner
    Dept of Neurological Surgery, University of Wisconsin School of Medicine, Madison, WI 53792, USA
    Am J Physiol Cell Physiol 292:C1113-22. 2007
    ..Our study suggests that NKCC1 acting in concert with NCX causes a perturbation of Ca(m)(2+) homeostasis and mitochondrial dysfunction and cell death following in vitro ischemia...
  79. ncbi PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum
    Janet E Simpson
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1079-88. 2007
    ..We conclude that 1) PAT-1 is the major contributor to basal Cl(-)/HCO(3)(-) and SO(4)(2-)/HCO(3)(-) exchange across the apical membrane and 2) PAT-1 plays a role in pH(i) regulation in the upper villous epithelium of the murine duodenum...
  80. ncbi Hypotension in NKCC1 null mice: role of the kidneys
    Susan M Wall
    Renal Division, Emory Univ School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 290:F409-16. 2006
    ..Increased Na+ transporter expression, increased plasma renin, and reduced plasma ANP, as observed in NKCC1 null mice, should increase vascular volume and blood pressure, thus minimizing hypotension...
  81. ncbi Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release
    Gui Su
    Department of Neurosurgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Am J Physiol Cell Physiol 282:C1147-60. 2002
    ..Our study suggests that stimulation of NKCC1 is required for high-[K(+)](o)-induced swelling, which contributes to glutamate release from astrocytes under high [K(+)](o)...
  82. ncbi ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. A role in ischemic neuronal death
    Jing Luo
    Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Biol Chem 282:28274-84. 2007
    ..Taken together, these results suggest that activation of ERK1/2-p90(RSK) pathways following in vitro ischemia phosphorylates NHE1 and increases its activity, which subsequently contributes to neuronal damage...
  83. ncbi A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage
    Jing Luo
    Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Cereb Blood Flow Metab 28:737-46. 2008
    ..NCX1+/-/NKCC1+/- mice had a significantly reduced infarct volume at 24 and 72 h reperfusion. In conclusion, these data suggest that NKCC1 in conjunction with NCX1 plays a role in reperfusion-induced brain injury after ischemia...
  84. ncbi Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms
    I Jeanette Lynch
    North Florida South Georgia Veterans Health System, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 294:F621-7. 2008
    ..These studies are the first nonpharmacological demonstration that both HKalpha(1) and HKalpha(2) contribute to H secretion in both A-type and B-type ICs in animals fed a normal diet...
  85. ncbi Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2
    Fiona Hanner
    Department of Physiology, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Renal Physiol 294:F937-44. 2008
    ....
  86. ncbi Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1
    Rodney C Diaz
    Department of Otolaryngology Head and Neck Surgery, University of California Davis School of Medicine, 1515 Newton Court, Davis, CA 95618, USA
    J Assoc Res Otolaryngol 8:422-34. 2007
    ..These observations provide insight into the detailed mechanisms of EP generation, and results of combination-knockout experiments may have important implications in the future treatment of drug-induced and age-related hearing losses...
  87. ncbi Decreased neuronal death in Na+/H+ exchanger isoform 1-null mice after in vitro and in vivo ischemia
    Jing Luo
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Neurosci 25:11256-68. 2005
    ..05). These results imply that NHE1 activity disrupts Na+ and Ca2+ homeostasis and contributes to ischemic neuronal damage...
  88. ncbi Aberrant retinal projections in congenitally deaf mice: how are phenotypic characteristics specified in development and evolution?
    Deborah L Hunt
    Center for Neuroscience, University of California at Davis, Davis, California 95616, USA
    Anat Rec A Discov Mol Cell Evol Biol 287:1051-66. 2005
    ....
  89. ncbi Transepithelial HCO3- absorption is defective in renal thick ascending limbs from Na+/H+ exchanger NHE1 null mutant mice
    David W Good
    Department of Medicine, University of Texas Medical Branch, 301 Univ Boulevard, Galveston, TX 77555, USA
    Am J Physiol Renal Physiol 287:F1244-9. 2004
    ..Paradoxically, a reduction in NHE1-mediated H(+) extrusion across the basolateral membrane leads to a decrease in apical Na(+)/H(+) exchange activity that reduces HCO(3)(-) absorption...
  90. ncbi Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel
    Lara R Gawenis
    Dalton Cardiovascular Research Center, Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1140-9. 2004
    ....
  91. ncbi An alternate pathway of cAMP-stimulated Cl secretion across the NKCC1-null murine duodenum
    Nancy M Walker
    Dalton Cardiovascular Research Center and the Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Gastroenterology 123:531-41. 2002
    ..In this study, we evaluate the role of NKCC1 in determining the relative rates of transepithelial Cl(-) and HCO(3)(-) secretion during cAMP stimulation of the duodenum...
  92. ncbi Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Biol Chem 277:37881-7. 2002
    ..Despite loss of ROMK expression, the normokalemic null mice exhibited significantly increased kaliuresis, indicating alternative mechanisms for K(+) absorption/secretion in the nephron...
  93. ncbi NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo
    Michael Gekle
    Physiologisches Institut, Universitat Wurzburg, Germany
    Am J Physiol Renal Physiol 287:F469-73. 2004
    ..Thus a reduction in NHE3 activity or abundance causes tubular proteinuria. These data show that NHE3 supports proximal tubular RME of filtered proteins in vivo...
  94. ncbi Increased tolerance to oxygen and glucose deprivation in astrocytes from Na(+)/H(+) exchanger isoform 1 null mice
    Douglas B Kintner
    Department of Neurosurgery, University of Wisconsin Medical School, Madison, WI 53792, USA
    Am J Physiol Cell Physiol 287:C12-21. 2004
    ..These results suggest that NHE1 is the major pH(i) regulatory mechanism in cortical astrocytes and that ablation of NHE1 in astrocytes attenuates ischemia-induced disruption of ionic regulation and swelling...
  95. ncbi Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice
    Lane L Clarke
    Dalton Cardiovascular Research Center and Departmentof Biomedical Sciences, University of Missouri, Columbia, 65211, USA
    Am J Physiol Gastrointest Liver Physiol 286:G1050-8. 2004
    ..Based on these findings, we conclude that antimicrobial peptide activity in CF mouse intestine is compromised by inadequate dissolution of Paneth cell granules within the crypt lumens...
  96. ncbi SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells
    Abdelilah Arredouani
    Unité d Endocrinologie et Métabolisme, University of Louvain Faculty of Medicine, Brussels, Belgium
    Diabetes 51:3245-53. 2002
    ..However, a lack of SERCA3 is insufficient in itself to alter glucose homeostasis or impair insulin secretion in mice...
  97. ncbi Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk
    Timothy A Reinhardt
    Periparturient Diseases of Cattle Research Unit, United States Department of Agriculture Agriculture Research Service, National Animal Disease Center, Ames, Iowa 50010, USA
    J Biol Chem 279:42369-73. 2004
    ..This major secretory function represents a novel biological role for the plasma membrane Ca2+-ATPases, which are generally regarded as premier regulators of intracellular Ca2+...
  98. ncbi Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome
    Johannes Loffing
    Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, CH 1005 Lausanne
    J Am Soc Nephrol 15:2276-88. 2004
    ..Thus, loss of NCC leads to major structural remodeling of the renal distal tubule that goes along with marked changes in glomerular and tubular function, which may explain some of the clinical features of Gitelman's syndrome...
  99. ncbi Na-K-Cl cotransporter-mediated intracellular Na+ accumulation affects Ca2+ signaling in astrocytes in an in vitro ischemic model
    Brett Lenart
    Department of Neurosurgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Neurosci 24:9585-97. 2004
    ..These findings imply that stimulation of NKCC1 activity leads to Na+ accumulation after OGD/REOX and that subsequent reverse-mode operation of NCX contributes to increased Ca2+ accumulation by intracellular Ca2+ stores...
  100. ncbi Stimulation of astrocyte Na+/H+ exchange activity in response to in vitro ischemia depends in part on activation of ERK1/2
    Douglas B Kintner
    Department of Neurosurgery, University of Wisconsin Medical School, H4 332 Clinical Sciences Center, 600 Highland Ave, Madison, Wisconsin 53792, USA
    Am J Physiol Cell Physiol 289:C934-45. 2005
    ..Together, our data suggest that ERK1/2 is involved in activation of NHE1 in astrocytes after in vitro ischemia. NHE1-mediated Na+ accumulation subsequently alters Ca2+ homeostasis via Na+/Ca2+ exchange...
  101. ncbi Intestinal NaCl transport in NHE2 and NHE3 knockout mice
    Lara R Gawenis
    Dalton Cardiovascular Research Center and Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Am J Physiol Gastrointest Liver Physiol 282:G776-84. 2002
    ....