ALAN SHULDINER

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Genetics of obesity: more complicated than initially thought
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Lipids 38:97-101. 2003
  2. pmc Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Environ Health 11:6. 2012
  3. pmc Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference
    Patrick F McArdle
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, RM, 492, Baltimore, MD 21201, USA
    BMC Cardiovasc Disord 12:16. 2012
  4. doi request reprint CYP2C19 and clopidogrel response: more than validation in the real world
    A R Shuldiner
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 91:170-1. 2012
  5. pmc Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study
    Charles C Hsu
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    BMC Med Genet 12:16. 2011
  6. pmc Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study
    Audrey Y Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 10:108. 2009
  7. pmc Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Genet 8:66. 2007
  8. pmc Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 114:1414-7. 2004
  9. pmc Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
    JAMA 302:849-57. 2009
  10. pmc Obesity genes and gene-environment-behavior interactions: recommendations for a way forward
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:S79-81. 2008

Research Grants

  1. GENETICS OF OSTEOPOROSIS IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2004
  2. Longevity Genes in Founder Populations
    ALAN SHULDINER; Fiscal Year: 2005
  3. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2007
  4. Genome-wide Search for CVD Gene-Environment Interactions
    ALAN SHULDINER; Fiscal Year: 2007
  5. Clinical Research Career Development (RMI)
    ALAN SHULDINER; Fiscal Year: 2007
  6. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2007
  7. GENETIC AND CLINICAL MANIFESTATIONS OF DIABETES
    ALAN SHULDINER; Fiscal Year: 2004
  8. MALDI-TOF MS for High Throughput SNP Analysis
    ALAN SHULDINER; Fiscal Year: 2002
  9. PHARMACOGENETICS OF PRO12ALA PPAR GAMMA 2 IN DIABETES
    ALAN SHULDINER; Fiscal Year: 2002
  10. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2003

Detail Information

Publications93

  1. ncbi request reprint Genetics of obesity: more complicated than initially thought
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Lipids 38:97-101. 2003
    ..Further research will translate these new insights on the pathophysiological basis of obesity into new medications and diagnostic tests...
  2. pmc Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Environ Health 11:6. 2012
    ..Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid function...
  3. pmc Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference
    Patrick F McArdle
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, RM, 492, Baltimore, MD 21201, USA
    BMC Cardiovasc Disord 12:16. 2012
    ..In this report, we demonstrate its use in assessing direct causal relations between serum bilirubin levels and CVD risk factors, including obesity, cholesterol, measures of vascular function and blood pressure...
  4. doi request reprint CYP2C19 and clopidogrel response: more than validation in the real world
    A R Shuldiner
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 91:170-1. 2012
    ..Whether studies from real-world EHR-biobanks will supplant randomized clinical trials to provide a sufficient evidence base to change practice is less certain...
  5. pmc Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study
    Charles C Hsu
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    BMC Med Genet 12:16. 2011
    ..Our aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP...
  6. pmc Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study
    Audrey Y Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 10:108. 2009
    ..However, few data are available in non-European ethnic groups or in a population-based cohort...
  7. pmc Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Genet 8:66. 2007
    ..Each individual in the study has a non zero probability of consanguinity. Systolic and diastolic blood pressures are shown to have appreciable dominance variance components...
  8. pmc Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 114:1414-7. 2004
    ..These findings provide insights into how aging modifies genetic susceptibility to alterations in oxidative phosphorylation and T2DM...
  9. pmc Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
    JAMA 302:849-57. 2009
    ..However, nonresponsiveness is widely recognized and is related to recurrent ischemic events...
  10. pmc Obesity genes and gene-environment-behavior interactions: recommendations for a way forward
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:S79-81. 2008
    ....
  11. ncbi request reprint Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study
    W H Linda Kao
    Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, 615 N Wolfe Street, Room W6513, Baltimore, MD 21205, USA
    Diabetes 52:1568-72. 2003
    ..We conclude that among nonobese African Americans, the Pro/Ala genotype is associated with markers of greater insulin sensitivity...
  12. ncbi request reprint Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetesand Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 54:2245-50. 2005
    ..001; OR 1.64-1.71). To our knowledge, these data provide the first evidence for association between variation in the adiponectin receptors and type 2 diabetes...
  13. pmc Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish
    Patrick F McArdle
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arthritis Rheum 58:2874-81. 2008
    ..This study was undertaken to investigate associations between uric acid levels and single-nucleotide polymorphisms (SNPs)...
  14. pmc Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women
    Caroline G P Roberts
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Hered 64:107-13. 2007
    ....
  15. ncbi request reprint Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysis
    Nanette I Steinle
    University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Clin Nutr 75:1098-106. 2002
    ..Eating behavior and thus dietary intake affect the development of obesity-related diseases such as diabetes, hypertension, and hyperlipidemia...
  16. ncbi request reprint Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3292-9. 2004
    ..These findings, coupled with similar findings in Utah Caucasians, suggest that sequence variation in CASQ1 may influence risk of type 2 diabetes...
  17. ncbi request reprint Exploring the genetics of longevity in the Old Order Amish
    John Sorkin
    Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Mech Ageing Dev 126:347-50. 2005
    ..In this article, we describe our strategy for identifying variants in genes that influence longevity in the Amish and present the results of our studies to date...
  18. ncbi request reprint Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3337-41. 2004
    ..022; dominant model, P = 0.010). The results of this study provide evidence that variants in both the P1 and P2 promoters of HNF4A increase risk for typical type 2 diabetes...
  19. ncbi request reprint Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish
    Mona M Sabra
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, United States
    Mol Genet Metab 85:133-9. 2005
    ..VAMP4 is expressed in liver and skeletal muscle and participates in intracellular trafficking of secreted and membrane-associated proteins...
  20. ncbi request reprint A genome-wide scan of serum lipid levels in the Old Order Amish
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Atherosclerosis 173:89-96. 2004
    ....
  21. ncbi request reprint SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study
    Michael J Garant
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Diabetes 51:231-7. 2002
    ..We conclude from this large prospective study that the G allele of SNP43 of CAPN10 or another allele or gene that is in linkage disequilibrium with it increases susceptibility to type 2 diabetes in African-Americans...
  22. ncbi request reprint Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor
    Daniela Mentuccia
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Diabetes 51:880-3. 2002
    ..This variant strongly associates with insulin resistance and, in subjects with the Trp64Arg ADRB3 variant, an increased BMI, suggesting an interaction between these two common gene variants...
  23. pmc Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program
    Kathleen A Jablonski
    The Biostatistics Center, George Washington University, Rockville, Maryland, USA
    Diabetes 59:2672-81. 2010
    ....
  24. pmc Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification
    Haiqing Shen
    Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 30:2648-54. 2010
    ..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
  25. pmc A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro
    Nicole Hoppman
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Bone 47:272-80. 2010
    ..Collectively, these findings suggest that sequence variation in FGFBP1 may contribute to variation in BMD, possibly influencing osteoporosis risk...
  26. pmc The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Epidemiol 168:1016-23. 2008
    ..Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference...
  27. pmc From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene
    Ying Wang
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:226-31. 2009
    ..Thus, variants in STK39 may influence BP by increasing STK39 expression and consequently altering renal Na(+) excretion, thus unifying rare and common BP-regulating alleles in the same physiological pathway...
  28. ncbi request reprint The genetics of obesity
    Coleen M Damcott
    Division of Endocrinolog, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, MD 21201, USA
    Endocrinol Metab Clin North Am 32:761-86. 2003
    ..Positional cloning of these genes will undoubtedly unveil new insights into the molecular and pathophysiologic mechanisms of energy homeostasis and obesity...
  29. ncbi request reprint Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 56:3053-62. 2007
    ..We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish...
  30. pmc Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study)
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 104:606-12. 2009
    ....
  31. pmc Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Hum Hered 65:91-104. 2008
    ..Using Y chromosome short tandem repeat (YSTR) genotypes, (1) evaluate the accuracy and completeness of the Lancaster County Old Order Amish (OOA) genealogical records and (2) estimate YSTR mutation rates...
  32. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    ..The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown...
  33. pmc Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hum Hered 64:214-9. 2007
    ..The purpose of the current study was to replicate this association in the Old Order Amish...
  34. pmc The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study
    Braxton D Mitchell
    Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Heart J 155:823-8. 2008
    ..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
  35. ncbi request reprint Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 55:2654-9. 2006
    ..04 and P = 0.007, respectively). These data provide replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity...
  36. ncbi request reprint Quantitative trait loci for BMD identified by autosome-wide linkage scan to chromosomes 7q and 21q in men from the Amish Family Osteoporosis Study
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 21:1433-42. 2006
    ..Using autosome-wide linkage analysis in 964 Amish, strong evidence was found for the presence of genes affecting hip and spine BMD in men on chromosomes 7q31 and 21q22 (LOD = 4.15 and 3.36, respectively)...
  37. ncbi request reprint Reduced incidence of hip fracture in the Old Order Amish
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 19:308-13. 2004
    ..The incidence of hip fracture was estimated in a community of Old Order Amish and compared with available data from non-Amish whites. Hip fracture rates were 40% lower in the Amish, and the Amish also experienced higher BMD...
  38. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006
    ..However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood...
  39. ncbi request reprint Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish
    Nanette I Steinle
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 90:6672-7. 2005
    ..Its gene, GHRL, is located on chromosome 3 in a region where we have shown linkage to eating behavior, percentage body fat, and total and low-density lipoprotein cholesterol levels in subjects of the Amish Family Diabetes Study...
  40. pmc Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 89:2916-22. 2004
    ....
  41. pmc Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 660 West Redwood Street, Rm 494, Baltimore, MD 21201, USA
    Hum Genet 126:567-74. 2009
    ..03). Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk...
  42. pmc Genetic effects on postprandial variations of inflammatory markers in healthy individuals
    Yu Ching Cheng
    Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 18:1417-22. 2010
    ..Genetic factors appear to play a significant role influencing basal inflammatory levels but to have minimal influence on post-fat intake inflammatory changes...
  43. pmc Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels
    Yu Ching Cheng
    Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:329-37. 2009
    ..Matrix metalloproteinase (MMP)-1 may play a role in cardiovascular disease susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens...
  44. ncbi request reprint Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Rm 478, Baltimore, MD 21201, USA
    Diabetes 54:268-74. 2005
    ..51 LOD units (to 0.71). These findings, combined with a two-point LOD score of 2.35 for SNP +2019, provide evidence that variation in APM1 is responsible for linkage of adiponectin levels to 3q27 in the Old Order Amish...
  45. pmc Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabe
    Soren Snitker
    Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore School of Medicine, 660 W Redwood St, Howard Hall Rm 598 B, Baltimore, MD 21201 1596, USA
    Diabetes Care 27:1365-8. 2004
    ....
  46. ncbi request reprint The relationship between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Room N3W130, 22 South Greene Street, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 90:4536-41. 2005
    ..We reported previously that Old Order Amish (OOA) women have fewer hip fractures and higher bone mineral density (BMD) than non-Amish Caucasian women...
  47. ncbi request reprint Variation in the lamin A/C gene: associations with metabolic syndrome
    Nanette I Steinle
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Arterioscler Thromb Vasc Biol 24:1708-13. 2004
    ..To determine whether polymorphisms in LMNA influence susceptibility to metabolic syndrome and its constituent components...
  48. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect...
  49. ncbi request reprint Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 56:1363-8. 2007
    ..These results, coupled with similar findings in Pima Indians, suggest that sequence variation in ARHGEF11 may influence risk of type 2 diabetes...
  50. doi request reprint Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Baltimore, MD, USA
    Am Heart J 165:176-82. 2013
    ..Spaced administration of a clopidogrel and a single-tablet formulation of aspirin and immediate-release omeprazole (PA32540) was considered as an alternative that might reduce this potential pharmacodynamic interaction...
  51. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
  52. ncbi request reprint Genetics of insulin resistance
    Maria M Mercado
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 494, Baltimore, MD 21201, USA
    Curr Diab Rep 2:83-95. 2002
    ....
  53. pmc Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish
    Erin D Michos
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Calcif Tissue Int 84:195-202. 2009
    ..Either there is no causal relationship between 25(OH)D and CVD risk, or if there is, it may be mediated through mechanisms other than subclinical vascular disease severity...
  54. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  55. ncbi request reprint The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity
    Francesco S Celi
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, 660 West Redwood Street, Room 494, Baltimore, MD 21201, USA
    Curr Diab Rep 2:179-85. 2002
    ..These findings indicate a central role of PPAR gamma in fat cell biology and in the pathophysiology of obesity, diabetes, and insulin resistance...
  56. pmc Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
    ..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction...
  57. ncbi request reprint Does having children extend life span? A genealogical study of parity and longevity in the Amish
    Patrick F McArdle
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 61:190-5. 2006
    ..We evaluated this issue by using genealogical data from an Old Order Amish community in Lancaster, Pennsylvania, a population characterized by large nuclear families, homogeneous lifestyle, and extensive genealogical records...
  58. ncbi request reprint Determinants of coronary artery and aortic calcification in the Old Order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:717-24. 2007
    ..Our goal was to characterize risk factors for CAC and AC and to estimate the genetic contribution to their variation...
  59. pmc COL4A1 is associated with arterial stiffness by genome-wide association scan
    Kirill V Tarasov
    Laboratory of Cardiovascular Science, Laboratory of Genetics, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:151-8. 2009
    ..Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV...
  60. ncbi request reprint Genetics of diabetes
    Richard B Horenstein
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, 660 West Redwood Street, Room 494, Baltimore, MD 21201, USA
    Rev Endocr Metab Disord 5:25-36. 2004
  61. ncbi request reprint Comparative studies of resistin expression and phylogenomics in human and mouse
    Rong Ze Yang
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 310:927-35. 2003
    ..The high expression of resistin in human leukemia cells suggests a hitherto unidentified biological function of resistin in leukocytes...
  62. ncbi request reprint Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver
    Sanjay B Jadhao
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Hepatology 39:1297-302. 2004
    ....
  63. pmc The association of podocin R229Q polymorphism with increased albuminuria or reduced estimated GFR in a large population-based sample of US adults
    Anna Kottgen
    Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 52:868-75. 2008
    ....
  64. doi request reprint Genotyping: one piece of the puzzle to personalize antiplatelet therapy
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, Sinai Hospital of Baltimore, Baltimore, Maryland 21215, USA
    J Am Coll Cardiol 56:112-6. 2010
    ..Prospective clinical trials to test new algorithms for optimal personalized antiplatelet therapy are needed to provide the evidence base required for the routine adoption of genotyping into clinical practice...
  65. ncbi request reprint A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3
    Elsie M Allen
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:1292-6. 2003
    ..01) to autoimmune thyroiditis and/or AITD-hypothyroidism was also detected in five other regions. We conclude that a gene on chromosome 5q11.2-q14.3 is likely to contribute to susceptibility to AITD in the Amish...
  66. ncbi request reprint Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
    ..In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity...
  67. pmc Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells
    Li Liu
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Protein Expr Purif 60:225-31. 2008
    ....
  68. ncbi request reprint BMI in the Old Order Amish
    Soren Snitker
    Med Sci Sports Exerc 36:1447; author reply 1448. 2004
  69. ncbi request reprint A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 52:1864-71. 2003
    ....
  70. ncbi request reprint Association between body fat response to exercise training and multilocus ADR genotypes
    Dana A Phares
    Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
    Obes Res 12:807-15. 2004
    ..To examine the contribution of adrenergic receptor (ADR) gene polymorphisms and their gene-gene interactions to the variability of exercise training-induced body fat response...
  71. ncbi request reprint No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal women
    Eric S Rawson
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Metabolism 51:801-5. 2002
    ..These results suggest that the presence of the Trp64Arg variant in the beta(3)-adrenoceptor should not be a hindrance to weight reduction...
  72. pmc Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits
    Winston S Chu
    Division of Endocrinology 111J 1 LR, Department of Medicine, University of Arkansas for Medical Sciences, John L McClellan Memorial Veterans Hospital, 4700 W 7th Street, Little Rock, AR 72205, USA
    Diabetes 56:856-62. 2007
    ..ATF6 does not appear to play a major role in type 2 diabetes, but further work is required to identify the cause of the allelic expression imbalance...
  73. ncbi request reprint Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effects
    Edward P Weiss
    Department of Kinesiology, University of Maryland, College Park 20742 2611, USA
    Physiol Genomics 10:145-57. 2002
    ..These results highlight the importance of including behavioral and environmental factors in the design of studies seeking to assess the impact of genes on physiological and clinical outcome phenotypes...
  74. ncbi request reprint Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24
    Wen Chi Hsueh
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Diabetes 52:550-7. 2003
    ..07, P = 0.000085 for HbA(1c) and LOD = 1.50 for glucose 0). In conclusion, our findings provide evidence that type 2 diabetes susceptibility genes reside on chromosomes 1, 14, and 18...
  75. ncbi request reprint Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians
    Lijun Ma
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85004, USA
    Diabetes 56:1454-9. 2007
    ..01). These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance...
  76. ncbi request reprint Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
  77. ncbi request reprint Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in women
    Edward P Weiss
    Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
    Metabolism 54:97-102. 2005
    ..However, these men are particularly responsive with respect to the magnitude of endurance training-induced improvement in insulin action...
  78. pmc Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects
    Katharine R Owen
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, U K
    Diabetes 56:879-83. 2007
    ..However, in a meta-analysis including other available data, there is evidence that rs4641 has a modest effect on diabetes susceptibility (1.10 [1.04-1.16], P = 0.001)...
  79. ncbi request reprint A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study
    Wen Chi Hsueh
    Department of Medicine, School of Medicine, University of California, San Francisco, California, USA
    Diabetes 56:2643-8. 2007
    ..The goal of our study was to identify chromosomal regions that are likely to harbor genetic determinants of these traits...
  80. ncbi request reprint FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women
    Edward P Weiss
    Department of Kinesiology, University of Maryland, College Park, MD, USA
    Am J Clin Nutr 85:102-8. 2007
    ..However, most of those studies have not accounted for the interactive and potentially confounding effects of habitual physical activity and diet...
  81. doi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  82. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development...
  83. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  84. pmc Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study
    Marie Hélène Roy-Gagnon
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    J Hypertens 26:729-36. 2008
    ..Additionally, to our knowledge, no study has examined the genetics of BP recovery from the CPT, including whether shared genetic factors influence both reactivity and recovery...
  85. ncbi request reprint Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes
    Swapan Kumar Das
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Diabetes 55:2631-9. 2006
    ..Our data suggest that sequences in or upstream of DUSP12 may contribute to type 2 diabetes susceptibility, but the lack of replication suggests a small effect size...
  86. ncbi request reprint Adiponectin levels and genotype: a potential regulator of life span in humans
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 63:447-53. 2008
    ....
  87. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  88. ncbi request reprint Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Diabetes 55:2541-8. 2006
    ..These data exclude USF1 as a major contributor to type 2 diabetes susceptibility and the basis for the chromosome 1q linkage. They reveal only limited evidence for replication of USF1 effects on continuous metabolic traits...
  89. pmc TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    Jose C Florez
    Diabetes Prevention Program Outcomes Study Coordinating Center, George Washington University, Rockville, MD 20852, USA
    N Engl J Med 355:241-50. 2006
    ....
  90. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  91. ncbi request reprint The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish
    Daniela Mentuccia
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    Thyroid 15:1223-7. 2005
    ..These findings could be secondary to a different genetic background or to environmental factors specific for this population...
  92. ncbi request reprint Genetic and environmental influences on bone mineral density in pre- and post-menopausal women
    Lillian B Brown
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Osteoporos Int 16:1849-56. 2005
    ..Overall, these analyses suggest that many, but not all, of the genetic factors influencing variation in BMD are common to both pre- and post-menopausal women...
  93. pmc Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles
    Lawrence F Bielak
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Atherosclerosis 196:888-95. 2008
    ....

Research Grants35

  1. GENETICS OF OSTEOPOROSIS IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2004
    ..This proposal brings together three strong research groups with complementary interests: Alan Shuldiner, M.D. and Elizabeth Streeten, M.D. at the University of Maryland, Braxton Mitchell, Ph.D...
  2. Longevity Genes in Founder Populations
    ALAN SHULDINER; Fiscal Year: 2005
    ..These advances will impact substantially on the health and quality of life of older Americans. ..
  3. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2007
    ..Discovery of T2DM susceptibility genes will provide critical insights into molecular mechanisms that will impact substantially on the care and quality of life of millions of Americans with T2DM. ..
  4. Genome-wide Search for CVD Gene-Environment Interactions
    ALAN SHULDINER; Fiscal Year: 2007
    ....
  5. Clinical Research Career Development (RMI)
    ALAN SHULDINER; Fiscal Year: 2007
    ..The University of Maryland Multidisciplinary ClinicalResearch Career Development Program will be theprimary mechanism for attracting high qualityjunior faculty andtraining these Scholars in clinicalresearch at UMB. ..
  6. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2007
    ..Discovery of T2DM susceptibility genes will provide critical insights into molecular mechanisms that will impact substantially on the care and quality of life of millions of Americans with T2DM. ..
  7. GENETIC AND CLINICAL MANIFESTATIONS OF DIABETES
    ALAN SHULDINER; Fiscal Year: 2004
    ..abstract_text> ..
  8. MALDI-TOF MS for High Throughput SNP Analysis
    ALAN SHULDINER; Fiscal Year: 2002
    ..These investigators, whose research would be greatly advanced through access to this technology include: (I) Alan Shuldiner (Genetics of diabetes, osteoporosis, and longevity in the Amish; diabetes pharmacogenomics), (2) Frederick ..
  9. PHARMACOGENETICS OF PRO12ALA PPAR GAMMA 2 IN DIABETES
    ALAN SHULDINER; Fiscal Year: 2002
    ....
  10. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2003
    ..This proposal brings together two strong research groups with complementary interests: Alan Shuldiner, M.D. at the University of Maryland, and Braxton Mitchell, Ph.D...
  11. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2009
    ..In addition, as part of the American Recovery and Reinvestment Act, this Competitive Revision will provide job opportunities and security and stimulate the economy. ..