Arti Shukla

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation
    Joyce K Thompson
    Department of Pathology, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    Part Fibre Toxicol 11:24. 2014
  2. pmc Curcumin: a double hit on malignant mesothelioma
    Jill M Miller
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, HSRF 216, Burlington, VT 05405 0068
    Cancer Prev Res (Phila) 7:330-40. 2014
  3. pmc ERK2 is essential for the growth of human epithelioid malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:1075-86. 2011
  4. pmc Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 41:114-23. 2009
  5. pmc Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Am J Pathol 175:2197-206. 2009
  6. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
  7. pmc Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Clin Cancer Res 19:2071-83. 2013
  8. ncbi request reprint Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2
    Christy A Barlow
    Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1361-9. 2007
  9. pmc Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    BMC Cancer 13:400. 2013
  10. pmc Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
    Part Fibre Toxicol 10:39. 2013

Collaborators

Detail Information

Publications35

  1. pmc Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation
    Joyce K Thompson
    Department of Pathology, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    Part Fibre Toxicol 11:24. 2014
    ..It has also been demonstrated that asbestos can induce inflammation, perhaps due to activation of inflammasomes...
  2. pmc Curcumin: a double hit on malignant mesothelioma
    Jill M Miller
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, HSRF 216, Burlington, VT 05405 0068
    Cancer Prev Res (Phila) 7:330-40. 2014
    ..g., NF-κB, toll-like receptors (TLR), and IL-1β. Our data indicate that curcumin has a double effect on malignant mesothelioma cells through induction of pyroptosis while subsequently protecting against inflammation...
  3. pmc ERK2 is essential for the growth of human epithelioid malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:1075-86. 2011
    ..After injection of sarcomatoid human MM (PPMMill) cells into SCID mice, both shERK1 and shERK2 lines showed significant decreased tumor growth, suggesting heterogeneous effects of ERKs in individual MMs...
  4. pmc Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 41:114-23. 2009
    ..Results reveal that ATF3 modulates production of inflammatory cytokines (IL-1 beta, IL-13, G-CSF) and growth factors (VEGF and PDGF-BB) in human mesothelial cells...
  5. pmc Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Am J Pathol 175:2197-206. 2009
    ..Since activated CREB1 also is increased endogenously in human MM and modifies migration and resistance to Dox-induced apoptosis, inhibition of CREB1 may be a new strategy for MM therapy...
  6. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
    ..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
  7. pmc Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Clin Cancer Res 19:2071-83. 2013
    ..Malignant mesothelioma is a devastating disease with a need for new treatment strategies. In the present study, we showed the importance of extracellular signal-regulated kinase 5 (ERK5) in malignant mesothelioma tumor growth and treatment...
  8. ncbi request reprint Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2
    Christy A Barlow
    Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1361-9. 2007
    ....
  9. pmc Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    BMC Cancer 13:400. 2013
    ..The systemic toxicities of these treatments emphasize the need for more effective, localized treatment regimens...
  10. pmc Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
    Part Fibre Toxicol 10:39. 2013
    ..Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear...
  11. pmc Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Ann N Y Acad Sci 1203:7-14. 2010
    ..Results suggest that inflammation and cytokine production precede and may be critical to the development of MMs...
  12. ncbi request reprint Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo
    Astrid Haegens
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    J Immunol 178:1800-8. 2007
    ..05) in Tg(+) vs Tg(-) mice. Our findings demonstrate that airway epithelial NF-kappaB activity plays a role in orchestrating the inflammatory response as well as cell proliferation in response to asbestos...
  13. pmc Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Part Fibre Toxicol 7:26. 2010
    ....
  14. pmc Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells
    Timothy N Perkins
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Part Fibre Toxicol 9:6. 2012
    ..Finally, primary human bronchial epithelial cells (NHBE) were used to comparatively assess silica particle-induced alterations in gene expression...
  15. pmc Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1)
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    J Toxicol Environ Health A 73:423-36. 2010
    ....
  16. pmc A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Histochem Cytochem 60:658-74. 2012
    ....
  17. pmc An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA
    Am J Respir Cell Mol Biol 45:906-14. 2011
    ..They also indicate that ERK2 plays a role in modulating asbestos toxicity by regulating genes critical to cell injury and survival that are differentially expressed in human mesotheliomas...
  18. ncbi request reprint Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-alpha
    Muyao Li
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 197:418-25. 2003
    ..This may contribute to the increased risk for vascular disease associated with aging and diabetes mellitus (DM)...
  19. pmc A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos
    Sylke A Buder-Hoffmann
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Pathol 174:449-59. 2009
    ..PKCdelta-dependent PKD phosphorylation by asbestos is causally linked to a cellular pathway that involves the phosphorylation of both ERK1/2 and JNK1/2, which play opposing roles in the apoptotic response induced by asbestos...
  20. pmc Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice
    Arti Shukla
    Department of Pathology, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Am J Pathol 170:140-51. 2007
    ..These results also implicate targeted interruption of PKC-delta as a potential therapeutic option in asbestos-induced lung diseases...
  21. pmc Oxidant-mediated cAMP response element binding protein activation: calcium regulation and role in apoptosis of lung epithelial cells
    Christy A Barlow
    Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 34:7-14. 2006
    ..These data support a novel communication between Ca2+-ERK1/2 and CREB elicited by H2O2, and further provide evidence that CREB is an important regulator of apoptosis in oxidant-mediated responses of lung epithelial cells...
  22. pmc Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:233-44. 2011
    ..These results suggest APMS are efficacious for the localized delivery of lower effective DOX concentrations in MM and represent a novel means of treating intracavitary tumors...
  23. pmc Assessing nanotoxicity in cells in vitro
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:219-31. 2010
    ..Conversely, intrathoracic or intrapleural injection of nanomaterials into rodents can be misleading because they bypass normal clearance mechanisms, and non-pathogenic fibers and particles can test positively in these assays...
  24. ncbi request reprint The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity
    Arti Shukla
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Cancer Res 64:7780-6. 2004
    ..Our work shows that the glutathione-controlled redox status of the epithelial cell plays a pivotal role in asbestos-induced epidermal growth factor receptor and proto-oncogene activation as well as AP-1 activity...
  25. pmc New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Am J Pathol 182:1065-77. 2013
    ....
  26. ncbi request reprint Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1018-25. 2003
    ..Studies collectively indicate that mitochondria are initial targets of asbestos-induced DNA damage and apoptosis via an oxidant-related mechanism...
  27. ncbi request reprint Role of mitogen-activated protein kinases (MAPK) in cell injury and proliferation by environmental particulates
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington 05404, USA
    Mol Cell Biochem 234:111-8. 2002
    ....
  28. ncbi request reprint Cell signaling and transcription factor activation by asbestos in lung injury and disease
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beumont Avenue, Burlington 05405, USA
    Int J Biochem Cell Biol 35:1198-209. 2003
    ..The elucidation and relevance of critical signaling cascades to lung injury or repair following asbestos exposure could aid in developing strategies to prevent or treat asbestos-associated lung and pleural diseases...
  29. ncbi request reprint Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung
    Arti Shukla
    Department of Pharmacology, University of Vermont College of Medicine, 89 Beaumont Ave Burlington, Vermont 05405, USA
    FASEB J 20:997-9. 2006
    ..These data reveal a potentially important link between asbestos signaling and integrity of the extracellular matrix (ECM) that likely contributes to asbestos-induced lung remodeling and diseases...
  30. ncbi request reprint Asbestos-induced apoptosis is protein kinase C delta-dependent
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 29:198-205. 2003
    ..However, H2O2-induced apoptosis was not inhibited by cell lines stably expressing either dnPKC delta or dnPKC alpha, suggesting that activation of PKC delta has a distinct role in the development of asbestos-induced apoptosis...
  31. ncbi request reprint Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1117-29. 2003
    ..There is strong evidence supporting the premise that oxidants contribute to asbestos-induced lung injury; thus, strategies for reducing oxidant stress to pulmonary cells may attenuate the deleterious effects of asbestos...
  32. ncbi request reprint Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles"
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 43:504-5. 2007
  33. pmc Malignant mesothelioma: development to therapy
    Joyce K Thompson
    Pathology Department, University of Vermont, College of Medicine, Burlington, Vermont
    J Cell Biochem 115:1-7. 2014
    ..This article focuses on developmental mechanisms as well as current therapies available for MM...
  34. pmc Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells
    Kheng Newick
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, United States of America
    PLoS ONE 7:e39404. 2012
    ....
  35. ncbi request reprint Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells
    Cynthia R Timblin
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Toxicol Appl Pharmacol 179:98-104. 2002
    ....