K Shuai

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Regulation of cytokine signaling pathways by PIAS proteins
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Cell Res 16:196-202. 2006
  2. ncbi request reprint The STAT family of proteins in cytokine signaling
    K Shuai
    Department of Medicine, University of California, Los Angeles 90095, USA
    Prog Biophys Mol Biol 71:405-22. 1999
  3. ncbi request reprint Regulation of gene-activation pathways by PIAS proteins in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 5:593-605. 2005
  4. ncbi request reprint Regulation of JAK-STAT signalling in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 3:900-11. 2003
  5. ncbi request reprint Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells
    M Gross
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California, CA 90095, USA
    Oncogene 20:3880-7. 2001
  6. pmc Inhibition of Stat1-mediated gene activation by PIAS1
    B Liu
    Division of Hematology Oncology, Department of Medicine, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 95:10626-31. 1998
  7. ncbi request reprint Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription
    K A Mowen
    Division of Biology and UCSD Cancer Center, University of California, San Diego, Bonner Hall 3138, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 104:731-41. 2001
  8. pmc A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
    B Liu
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:3203-7. 2001
  9. pmc Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction
    J Liao
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 97:5267-72. 2000
  10. ncbi request reprint Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation
    B Liu
    Division of Hematology Oncology, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 276:36624-31. 2001

Collaborators

  • Bin Liu
  • M Gross
  • Guoping Fan
  • M David
  • P Jay
  • J Kim
  • J Tan
  • Y Fu
  • T H Rea
  • Kenneth M Murphy
  • Hao Wu
  • D D Chang
  • Yin Shen
  • Michael Teitell
  • Joseph A Loo
  • Wei Zhu
  • Fei He
  • Robert Modlin
  • Anne O'Garra
  • JAMES DARNELL
  • Serge Y Fuchs
  • Fang Liu
  • Oxana A Malakhova
  • Samuel Tahk
  • Johanna ten Hoeve
  • Meelad M Dawlaty
  • Aryaman Shalizi
  • Shrikrishna Dadke
  • Minghao Zhong
  • Dong Er Zhang
  • Keun Il Kim
  • J Liao
  • Jianyin Long
  • Taruna Arora
  • K A Mowen
  • Esther Kao
  • Claudio Sustmann
  • Jan M van Deursen
  • Karthik B Jeganathan
  • Liviu Malureanu
  • Rudolf Grosschedl
  • Shu Chin Yip
  • Sophie Cotteret
  • Yue Yang
  • Parizad M Bilimoria
  • Azad Bonni
  • Alexey Ivanov
  • Tony Ng
  • Vasili Chernishof
  • Benjamin G Neel
  • Judith Stegmuller
  • Jonathan Chernoff
  • Frank Rauscher
  • Fawaz Haj
  • Brice Gaudilliere
  • Kelly A Wong
  • Zahara M Jaffer
  • Weiguo Zou
  • K G Suresh Kumar
  • Jiann Kae Luo
  • Olaf Schaefer
  • Xiaomin Chen
  • Kenji Takeuchi
  • Xiang Mao
  • Melissa A Henriksen
  • Zhiyong Ren
  • C D Chung
  • Theresa L Murphy
  • Youzhong Yuan
  • Kenneth J Ritchie
  • Hongchin He
  • Isao Matsuura
  • Ming Yan
  • Luke F Peterson
  • Michael P Malakhov
  • Dongming He
  • Guannan Wang
  • Michel Tremblay
  • Maria de Jesus Ibarra-Sanchez
  • J Tang
  • H R Herschman
  • B T Schurter
  • P Berta
  • X Rao

Detail Information

Publications32

  1. ncbi request reprint Regulation of cytokine signaling pathways by PIAS proteins
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Cell Res 16:196-202. 2006
    ..This article is to review the role of PIAS proteins in the regulation of STAT and NF-kB signaling pathways...
  2. ncbi request reprint The STAT family of proteins in cytokine signaling
    K Shuai
    Department of Medicine, University of California, Los Angeles 90095, USA
    Prog Biophys Mol Biol 71:405-22. 1999
    ..The JAK/STAT field remains to be challenging and exciting...
  3. ncbi request reprint Regulation of gene-activation pathways by PIAS proteins in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 5:593-605. 2005
    ..In this article, we review the current understanding of the molecular basis, specificity and physiological roles of PIAS proteins in the regulation of gene-activation pathways in the immune system...
  4. ncbi request reprint Regulation of JAK-STAT signalling in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 3:900-11. 2003
  5. ncbi request reprint Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells
    M Gross
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California, CA 90095, USA
    Oncogene 20:3880-7. 2001
    ..Our results identify PIASy as a transcriptional corepressor of AR and suggest that different PIAS proteins have distinct effects on AR signaling in prostate cancer cells...
  6. pmc Inhibition of Stat1-mediated gene activation by PIAS1
    B Liu
    Division of Hematology Oncology, Department of Medicine, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 95:10626-31. 1998
    ..These results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway...
  7. ncbi request reprint Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription
    K A Mowen
    Division of Biology and UCSD Cancer Center, University of California, San Diego, Bonner Hall 3138, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 104:731-41. 2001
    ....
  8. pmc A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
    B Liu
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:3203-7. 2001
    ..Our studies identify PIASy as a transcriptional corepressor of Stat1 and suggest that different PIAS proteins may repress STAT-mediated gene activation through distinct mechanisms...
  9. pmc Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction
    J Liao
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 97:5267-72. 2000
    ..Thus, the cytokine-induced PIAS1-Stat1 interaction is mediated through the specific recognition of the dimeric form of Stat1 by PIAS1...
  10. ncbi request reprint Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation
    B Liu
    Division of Hematology Oncology, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 276:36624-31. 2001
    ..Our results identify a novel function of PIAS1 in the induction of JNK-dependent apoptosis, independent of the previously known inhibitory activity of PIAS1 in STAT-mediated gene activation...
  11. ncbi request reprint DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling
    Guoping Fan
    Department of Human Genetics, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095, USA
    Development 132:3345-56. 2005
    ..Thus, demethylation of these two groups of genes and subsequent elevation of STAT activity are key mechanisms that control the timing and magnitude of astroglial differentiation...
  12. pmc Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation
    Samuel Tahk
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:11643-8. 2007
    ..Our results demonstrate that PIASy cooperates with PIAS1 to regulate the specificity and magnitude of NF-kappaB/STAT1-mediated gene activation...
  13. pmc Regulation of the sumoylation system in gene expression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Curr Opin Cell Biol 20:288-93. 2008
    ..Finally, the sumoylation system can also be regulated through crosstalk with other post-translational modifications, including phosphorylation, ubiquitination, and acetylation...
  14. pmc The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, 11 934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 330:521-5. 2010
    ..Our studies have identified an epigenetic mechanism that negatively regulates the differentiation of natural T(reg) cells...
  15. doi request reprint Summon SUMO to wrestle with inflammation
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 35:731-2. 2009
    ..2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes...
  16. ncbi request reprint PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Immunol 5:891-8. 2004
    ..Our data indicate that PIAS1 is a physiologically important negative regulator of STAT1 and suggest that PIAS1 is critical for the IFN-gamma- or IFN-beta-mediated innate immune responses...
  17. ncbi request reprint Specific inhibition of Stat3 signal transduction by PIAS3
    C D Chung
    Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
    Science 278:1803-5. 1997
    ..Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3...
  18. ncbi request reprint A role for IL-12 receptor expression and signal transduction in host defense in leprosy
    J Kim
    Division of Dermatology, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 167:779-86. 2001
    ..Interestingly, IL-12Rbeta2 in lepromatous patients could be up-regulated by stimulation with M. tuberculosis. These data suggest that Th response to M. leprae determines IL-12Rbeta2 expression and function in host defense in leprosy...
  19. pmc Negative regulation of NF-kappaB signaling by PIAS1
    Bin Liu
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    Mol Cell Biol 25:1113-23. 2005
    ..Consistently, Pias1 null mice showed elevated proinflammatory cytokines. Our results identify PIAS1 as a novel negative regulator of NF-kappaB...
  20. pmc Identification of a nuclear Stat1 protein tyrosine phosphatase
    Johanna ten Hoeve
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Biol 22:5662-8. 2002
    ..The dephosphorylation of Stat3, but not Stat5 or Stat6, is also affected in TC-PTP-null cells. Our results identify TC45 as a PTP responsible for the dephosphorylation of Stat1 in the nucleus...
  21. ncbi request reprint PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4
    Taruna Arora
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    J Biol Chem 278:21327-30. 2003
    ..Finally the inhibitory activity of PIASx on Stat4-mediated gene activation is abolished by the histone deacetylase inhibitor trichostatin A. Our results suggest that PIASx may function as a co-repressor of Stat4...
  22. pmc Targeting the PIAS1 SUMO ligase pathway to control inflammation
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Pharmacol Sci 29:505-9. 2008
    ..These findings support a hypothesis that therapies targeting the PIAS1 SUMO ligase pathway might be developed for the treatment of inflammatory disorders such as rheumatoid arthritis and atherosclerosis...
  23. ncbi request reprint Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell 129:903-14. 2007
    ..Our results identify a signaling pathway in which proinflammatory stimuli activate the IKKalpha-mediated sumoylation-dependent phosphorylation of PIAS1 for the immediate repression of inflammatory gene activation...
  24. ncbi request reprint Serine phosphorylation: arming Stat1 against infection
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Immunity 19:771-2. 2003
    ..suggest that serine phosphorylation of Stat1, an important signal transducer and activator of transcription in interferon (IFN) signaling, is required for Stat1 to fight against a highly pathogenic infection...
  25. ncbi request reprint PIASy-mediated repression of the androgen receptor is independent of sumoylation
    Mitchell Gross
    Division of Hematology Oncology, Department of Medicine, University of California, 11 934 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    Oncogene 23:3059-66. 2004
    ..Our results suggest that PIASy may repress AR by recruiting histone deacetylases, independent of its SUMO ligase activity...
  26. ncbi request reprint Regulation of protein tyrosine phosphatase 1B by sumoylation
    Shrikrishna Dadke
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nat Cell Biol 9:80-5. 2007
    ..These results suggest that sumoylation, which has been implicated primarily in processes in the nucleus and nuclear pore, also modulates a key enzyme-substrate signalling complex that regulates metabolism and cell proliferation...
  27. pmc UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
    Oxana A Malakhova
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 25:2358-67. 2006
    ..These data implicate Ubp43 as a novel in vivo inhibitor of signal transduction pathways that are specifically triggered by type I IFN...
  28. pmc Protein ISGylation modulates the JAK-STAT signaling pathway
    Oxana A Malakhova
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Genes Dev 17:455-60. 2003
    ..These findings identify UBP43 as a novel negative regulator of IFN signaling and suggest the involvement of protein ISGylation in the regulation of the JAK-STAT pathway...
  29. ncbi request reprint PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:10037-46. 2007
    ....
  30. pmc Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha
    Meelad M Dawlaty
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cell 133:103-15. 2008
    ..Furthermore, mice with low amounts of RanBP2 are highly sensitive to tumor formation. Together, these data identify RanBP2 as a chromosomal instability gene that regulates Topo IIalpha by sumoylation and suppresses tumorigenesis...
  31. pmc Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT
    Jianyin Long
    Center for Advanced Biotechnology and Medicine, Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 100:9791-6. 2003
    ..Taken together, our studies indicate that PIASy can inhibit TGF-beta/Smad transcriptional responses through interactions with Smad proteins and HDAC...
  32. pmc Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle
    Minghao Zhong
    Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:3966-71. 2005
    ..We conclude that a parallel STAT1 phosphodimer not bound to DNA most likely undergoes a conformational rearrangement (parallel to antiparallel) to present the phosphotyrosine efficiently for dephosphorylation...

Research Grants20

  1. Regulation of Cytokine Signaling by PIAS Protein
    Ke Shuai; Fiscal Year: 2004
    ..These studies will provide important information on the understanding of the cytokine-triggered gene activation pathways and will enhance our ability to design rational therapeutic strategies employing cytokines. ..
  2. Signaling to PIAS1 to Regulate Immune Responses
    Ke Shuai; Fiscal Year: 2010
    ..This proposal is to study a newly identified signaling pathway that functions to balance immune responses. These studies will enhance our ability to design novel therapeutic strategies for the treatment of immune diseases. ..
  3. The Role of PIAS1 in Immune Regulation
    Ke Shuai; Fiscal Year: 2006
    ..The significance of the PIASl-mediated NF-kappaB regulation and the involvement of PIASl-regulated Stat1-dependent gene activation in antiviral response will be examined. ..
  4. The Role of PIAS1 in Immune Regulation
    Ke Shuai; Fiscal Year: 2007
    ..The significance of the PIASl-mediated NF-kappaB regulation and the involvement of PIASl-regulated Stat1-dependent gene activation in antiviral response will be examined. ..
  5. The Role of PIAS1 in Immune Regulation
    Ke Shuai; Fiscal Year: 2009
    ..The significance of the PIASl-mediated NF-kappaB regulation and the involvement of PIASl-regulated Stat1-dependent gene activation in antiviral response will be examined. ..
  6. Signaling to PIAS1 to Regulate Immune Responses
    Ke Shuai; Fiscal Year: 2009
    ..This proposal is to study a newly identified signaling pathway that functions to balance immune responses. These studies will enhance our ability to design novel therapeutic strategies for the treatment of immune diseases. ..
  7. Signaling to PIAS1 to Regulate Immune Responses
    Ke Shuai; Fiscal Year: 2010
    ..This proposal is to study a newly identified signaling pathway that functions to balance immune responses. These studies will enhance our ability to design novel therapeutic strategies for the treatment of immune diseases. ..
  8. Regulation of STAT Activity by Tyrosine Phosphatases
    Ke Shuai; Fiscal Year: 2005
    ..We will test the hypothesis that TC45 has intrinsic substrate specificity toward STATs by biochemical assays and domain-swapping analysis. The dephosphorylation of other STATs will be examined. ..
  9. The Role of PIAS1 in Immune Regulation
    Ke Shuai; Fiscal Year: 2005
    ..The significance of the PIASl-mediated NF-kappaB regulation and the involvement of PIASl-regulated Stat1-dependent gene activation in antiviral response will be examined. ..
  10. INHIBITION OF CYTOKINE SIGNALING BY PIS PROTEINS
    Ke Shuai; Fiscal Year: 1999
    ....
  11. INHIBITION OF CYTOKINE SIGNALING BY PIS PROTEINS
    Ke Shuai; Fiscal Year: 2000
    ....
  12. INHIBITION OF CYTOKINE SIGNALING BY PIS PROTEINS
    Ke Shuai; Fiscal Year: 2001
    ....
  13. INHIBITION OF CYTOKINE SIGNALING BY PIS PROTEINS
    Ke Shuai; Fiscal Year: 2002
    ....
  14. Regulation of STAT Activity by Tyrosine Phosphatases
    Ke Shuai; Fiscal Year: 2002
    ..We will test the hypothesis that TC45 has intrinsic substrate specificity toward STATs by biochemical assays and domain-swapping analysis. The dephosphorylation of other STATs will be examined. ..
  15. Regulation of STAT Activity by Tyrosine Phosphatases
    Ke Shuai; Fiscal Year: 2003
    ..We will test the hypothesis that TC45 has intrinsic substrate specificity toward STATs by biochemical assays and domain-swapping analysis. The dephosphorylation of other STATs will be examined. ..
  16. Regulation of STAT Activity by Tyrosine Phosphatases
    Ke Shuai; Fiscal Year: 2004
    ..We will test the hypothesis that TC45 has intrinsic substrate specificity toward STATs by biochemical assays and domain-swapping analysis. The dephosphorylation of other STATs will be examined. ..
  17. The Role of PIAS1 in Immune Regulation
    Ke Shuai; Fiscal Year: 2010
    ..The significance of the PIASl-mediated NF-kappaB regulation and the involvement of PIASl-regulated Stat1-dependent gene activation in antiviral response will be examined. ..