Boris I Shraiman

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Epistasis in a model of molecular signal transduction
    Alain Pumir
    Laboratoire de Physique, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS Comput Biol 7:e1001134. 2011
  2. pmc Mechanical stress inference for two dimensional cell arrays
    Kevin K Chiou
    Department of Physics, University of California, Santa Barbara, California, USA
    PLoS Comput Biol 8:e1002512. 2012
  3. pmc Order and stochastic dynamics in Drosophila planar cell polarity
    Yoram Burak
    Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    PLoS Comput Biol 5:e1000628. 2009
  4. pmc Mechanical feedback as a possible regulator of tissue growth
    Boris I Shraiman
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:3318-23. 2005
  5. pmc On the mechanism of wing size determination in fly development
    Lars Hufnagel
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 104:3835-40. 2007
  6. pmc A dynamical model of ommatidial crystal formation
    David K Lubensky
    Department of Physics, University of Michigan, Ann Arbor, MI 48109 1040, USA
    Proc Natl Acad Sci U S A 108:11145-50. 2011
  7. pmc Collective and single cell behavior in epithelial contact inhibition
    Alberto Puliafito
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 109:739-44. 2012
  8. pmc Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling
    Madhav Mani
    Kavli Institute for Theoretical Physics and Department of Physics, University of California, Santa Barbara, CA 93101
    Proc Natl Acad Sci U S A 110:20420-5. 2013
  9. ncbi request reprint On the role of glypicans in the process of morphogen gradient formation
    Lars Hufnagel
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California, Santa Barbara, CA 93106, USA
    Dev Biol 300:512-22. 2006
  10. pmc Emergent gene order in a model of modular polyketide synthases
    Benjamin Callahan
    Department of Physics, University of California, Santa Barbara, CA 93106 9530, USA
    Proc Natl Acad Sci U S A 106:19410-5. 2009

Research Grants

  1. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2002
  2. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2003
  3. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2004
  4. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2005
  5. KITP Interdisciplinary Biology Initiative
    Boris Shraiman; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. pmc Epistasis in a model of molecular signal transduction
    Alain Pumir
    Laboratoire de Physique, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS Comput Biol 7:e1001134. 2011
    ..Our model study defines a theoretical framework for interpretation of experimental data and provides statistical predictions for the structure of genetic interaction expected for moderately complex biological circuits...
  2. pmc Mechanical stress inference for two dimensional cell arrays
    Kevin K Chiou
    Department of Physics, University of California, Santa Barbara, California, USA
    PLoS Comput Biol 8:e1002512. 2012
    ..The proposed method opens a way for quantitative and detailed experimental tests of models of cell and tissue mechanics...
  3. pmc Order and stochastic dynamics in Drosophila planar cell polarity
    Yoram Burak
    Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    PLoS Comput Biol 5:e1000628. 2009
    ..Finally we define and discuss some of the experimental predictions of the model...
  4. pmc Mechanical feedback as a possible regulator of tissue growth
    Boris I Shraiman
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:3318-23. 2005
    ..The proposed mechanism of growth control is not specific to imaginal disc growth and could be of general relevance. Several experimental tests of the proposed mechanism are suggested...
  5. pmc On the mechanism of wing size determination in fly development
    Lars Hufnagel
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 104:3835-40. 2007
    ..This analysis provides an alternative hypothesis for the size determination process. Novel experimental approaches will be needed to test this model...
  6. pmc A dynamical model of ommatidial crystal formation
    David K Lubensky
    Department of Physics, University of Michigan, Ann Arbor, MI 48109 1040, USA
    Proc Natl Acad Sci U S A 108:11145-50. 2011
    ....
  7. pmc Collective and single cell behavior in epithelial contact inhibition
    Alberto Puliafito
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 109:739-44. 2012
    ....
  8. pmc Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling
    Madhav Mani
    Kavli Institute for Theoretical Physics and Department of Physics, University of California, Santa Barbara, CA 93101
    Proc Natl Acad Sci U S A 110:20420-5. 2013
    ..Our construction of a simplified signal transduction map allows a generalization of the positional value model and emphasizes the important role intercellular interactions play in growth and patterning of tissues. ..
  9. ncbi request reprint On the role of glypicans in the process of morphogen gradient formation
    Lars Hufnagel
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California, Santa Barbara, CA 93106, USA
    Dev Biol 300:512-22. 2006
    ..In particular, our model suggests that Dlp acts by allowing Wg to diffuse on cell surface while protecting it from loss and degradation, and that Dlp rather than acting as Wg co-receptor competes with receptors for morphogen binding...
  10. pmc Emergent gene order in a model of modular polyketide synthases
    Benjamin Callahan
    Department of Physics, University of California, Santa Barbara, CA 93106 9530, USA
    Proc Natl Acad Sci U S A 106:19410-5. 2009
    ..In addition to computer simulation of a simplified model of PKS evolution, we provide a mathematical framework describing the secondary selection mechanism, which generalizes beyond the context of the present model...
  11. pmc Dynamic mutation-selection balance as an evolutionary attractor
    Sidhartha Goyal
    Kavli Institute for Theoretical Physics, Department of Physics, University of California, Santa Barbara, CA 93106, USA
    Genetics 191:1309-19. 2012
    ..This may explain the maintenance of mitochondria and other asexual genomes...

Research Grants6

  1. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2002
    ..Progress in the analysis and understanding of complex signal transduction pathways would have an impact on the development of pharmacological interventions for numerous clinical syndromes linked to pathologies in enzymatic signaling. ..
  2. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2003
    ..Progress in the analysis and understanding of complex signal transduction pathways would have an impact on the development of pharmacological interventions for numerous clinical syndromes linked to pathologies in enzymatic signaling. ..
  3. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2004
    ..Progress in the analysis and understanding of complex signal transduction pathways would have an impact on the development of pharmacological interventions for numerous clinical syndromes linked to pathologies in enzymatic signaling. ..
  4. Adaptive Regulation in Signal Transduction
    Boris Shraiman; Fiscal Year: 2005
    ..Progress in the analysis and understanding of complex signal transduction pathways would have an impact on the development of pharmacological interventions for numerous clinical syndromes linked to pathologies in enzymatic signaling. ..
  5. KITP Interdisciplinary Biology Initiative
    Boris Shraiman; Fiscal Year: 2007
    ..All programs are made publicly available via KITP website. In addition, we propose to sponsor educational outreach activities, including a workshop for high school science teachers. ..