Joseph B Shrager

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema
    Dong Kwan Kim
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Respir Res 4:1. 2003
  2. pmc Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse
    Sanford Levine
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 183:483-90. 2011
  3. ncbi Parasternal intercostal muscle remodeling in severe chronic obstructive pulmonary disease
    Sanford Levine
    Department of Surgery, Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 101:1297-302. 2006
  4. ncbi Cytokine response is lower after lung volume reduction through bilateral thoracoscopy versus sternotomy
    Michael E Friscia
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 83:252-6. 2007
  5. ncbi Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm
    Taitan Nguyen
    Respiratory Muscle Research Laboratory, Section of General Thoracic Surgery 4 Silverstein Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 98:2004-10. 2005
  6. ncbi Lung cancer in transplant recipients: a single-institution experience
    Zahoor Ahmed
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Surg 139:902-6. 2004
  7. ncbi Two commonly used neoadjuvant chemoradiotherapy regimens for locally advanced stage III non-small cell lung carcinoma: long-term results and associations with pathologic response
    Mitchell Machtay
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 127:108-13. 2004
  8. ncbi Comparison of stages I-II thymoma treated by complete resection with or without adjuvant radiation
    Sunil Singhal
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Pennsylvania, Philadelphia, USA
    Ann Thorac Surg 76:1635-41; discussion 1641-2. 2003
  9. doi Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans
    Sanford Levine
    Department of Surgery, University of Pennsylvania, USA
    N Engl J Med 358:1327-35. 2008
  10. ncbi Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regenerative therapy
    Alexander S Krupnick
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Appl Physiol 94:411-9. 2003

Collaborators

Detail Information

Publications37

  1. pmc Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema
    Dong Kwan Kim
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Respir Res 4:1. 2003
    ....
  2. pmc Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse
    Sanford Levine
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 183:483-90. 2011
    ..Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy...
  3. ncbi Parasternal intercostal muscle remodeling in severe chronic obstructive pulmonary disease
    Sanford Levine
    Department of Surgery, Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 101:1297-302. 2006
    ..The physiological significance of this difference in remodeling between these two inspiratory rib cage muscles remains to be elucidated...
  4. ncbi Cytokine response is lower after lung volume reduction through bilateral thoracoscopy versus sternotomy
    Michael E Friscia
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 83:252-6. 2007
    ..We measured these levels after lung volume reduction surgery through BVATS and sternotomy...
  5. ncbi Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm
    Taitan Nguyen
    Respiratory Muscle Research Laboratory, Section of General Thoracic Surgery 4 Silverstein Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 98:2004-10. 2005
    ..Am J Respir Crit Care Med 168: 706-713, 2003) suggests that diaphragm remodeling elicited by severe COPD should decrease ATP utilization by the diaphragm...
  6. ncbi Lung cancer in transplant recipients: a single-institution experience
    Zahoor Ahmed
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Surg 139:902-6. 2004
    ..That aggressive surgical treatment of lung cancer (LC) is justified by stage-based outcome in immunosuppressed solid organ transplant recipients...
  7. ncbi Two commonly used neoadjuvant chemoradiotherapy regimens for locally advanced stage III non-small cell lung carcinoma: long-term results and associations with pathologic response
    Mitchell Machtay
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 127:108-13. 2004
    ....
  8. ncbi Comparison of stages I-II thymoma treated by complete resection with or without adjuvant radiation
    Sunil Singhal
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Pennsylvania, Philadelphia, USA
    Ann Thorac Surg 76:1635-41; discussion 1641-2. 2003
    ..Studies addressing this issue generally report few patients and lump all patients beyond stage I together in the analysis...
  9. doi Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans
    Sanford Levine
    Department of Surgery, University of Pennsylvania, USA
    N Engl J Med 358:1327-35. 2008
    ..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm...
  10. ncbi Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regenerative therapy
    Alexander S Krupnick
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Appl Physiol 94:411-9. 2003
    ....
  11. doi Thoracoscopic total parietal pleurectomy for primary spontaneous pneumothorax
    Derek P Nathan
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 85:1825-7. 2008
    ..We describe here the technique of thoracoscopic total parietal pleurectomy and the early outcomes afterward...
  12. ncbi Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implications
    Sanford Levine
    Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Respir Crit Care Med 168:706-13. 2003
    ..Moreover, our single-fiber results suggest that COPD-associated diaphragm remodeling decreases diaphragmatic force generation by adaptations within each fiber type as well as by fiber type transformations...
  13. ncbi Comparative study of subxiphoid versus video-thoracoscopic pericardial "window"
    Patrick K H O'Brien
    Section of General Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 80:2013-9. 2005
    ..We hypothesized that the true window into the pleural space created by the latter might improve the duration of freedom from recurrent effusion...
  14. ncbi Myosin gene mutation correlates with anatomical changes in the human lineage
    Hansell H Stedman
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 428:415-8. 2004
    ..This represents the first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record...
  15. ncbi Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease
    Mary Elizabeth Kreider
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 83:1140-4. 2007
    ..To shed light on the risk-benefit ratio for this recommendation, we examined the morbidity and mortality associated with video-assisted thoracoscopic surgical (VATS) lung biopsy in a group of outpatients...
  16. doi Improved survival after pulmonary metastasectomy for soft tissue sarcoma
    Jarrod D Predina
    Division of Thoracic Surgery, Joan Karnell Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Thorac Oncol 6:913-9. 2011
    ..With improved patient selection criteria and advanced chemotherapy agents, we hypothesized that survival after metastasectomy for STS has improved in recent years...
  17. ncbi Catamenial pneumothorax: optimal hormonal and surgical management
    M Blair Marshall
    Section of General Thoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Eur J Cardiothorac Surg 27:662-6. 2005
    ..To provide further information addressing the etiology, optimal hormonal management and surgical management in catamenial pneumothorax (CP)...
  18. doi Should asymptomatic enlarged thymus glands be resected?
    Smit Singla
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 140:977-83. 2010
    ..Patients frequently have an "enlarged thymus" incidentally identified on imaging. We sought to determine whether thymectomy is appropriate in patients with diffusely enlarged thymus glands...
  19. ncbi Sarcomeres are added in series to emphysematous rat diaphragm after lung volume reduction surgery
    Joseph B Shrager
    Department of Surgery, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Chest 121:210-5. 2002
    ..We used a model of elastase-induced emphysema in rats to test the hypothesis that sarcomere addition occurs following LVRS...
  20. doi Management of alveolar air leaks after pulmonary resection
    Sunil Singhal
    Division of Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 89:1327-35. 2010
    ..We used available literature and expert consensus to formulate suggestions regarding the preferred approaches to both routine and prolonged alveolar air leaks. This review summarizes our findings...
  21. ncbi Transcervical thymectomy for myasthenia gravis achieves results comparable to thymectomy by sternotomy
    Joseph B Shrager
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Thorac Surg 74:320-6; discussion 326-7. 2002
    ..Furthermore, preoperative prognostic factors have not been clearly defined...
  22. ncbi Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study
    Kiarash Emami
    Dept of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    J Appl Physiol 104:773-86. 2008
    ....
  23. doi Extended transcervical thymectomy in the treatment of myasthenia gravis
    Sanjay G Khicha
    Division of Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, PA 19104, USA
    Ann N Y Acad Sci 1132:336-43. 2008
    ....
  24. ncbi Outcomes after 151 extended transcervical thymectomies for myasthenia gravis
    Joseph B Shrager
    Department of Surgery, Division of Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 82:1863-9. 2006
    ..The ideal operative technique for thymectomy in myasthenia gravis (MG) remains controversial. We present the largest series of extended transcervical thymectomy to provide outcomes data to compare with transsternal procedures...
  25. ncbi Anterior surgical approaches to the thoracic outlet
    M Blair Marshall
    Division of Thoracic Surgery, Department of Surgery, Georgetown University Medical Center, Washington, DC, USA
    J Thorac Cardiovasc Surg 131:1255-60. 2006
    ..We have used this approach for pathologic disease at the thoracic outlet and modified it. Our experience is described in this article...
  26. ncbi Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family
    Philippe R Desjardins
    Department of Surgery, School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Biol Evol 19:375-93. 2002
    ..One of the novel human genes is found to have introns at positions shared only with the molluscan catchin/MyHC gene, providing evidence for the structure of a pre-Cambrian ancestral gene...
  27. ncbi Which patients with stage III non-small cell lung cancer should undergo surgical resection?
    Vivek Patel
    University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Oncologist 10:335-44. 2005
    ..By necessity, given the paucity of strong data, a good deal of opinion is offered. The choice to proceed with aggressive, combined modality treatment is presented in light of extent of local disease as well as patient performance status...
  28. ncbi Suction vs water seal after pulmonary resection: a randomized prospective study
    M Blair Marshall
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 121:831-5. 2002
    ..To evaluate whether suction or water seal is superior in the management of chest tubes after pulmonary resection...
  29. ncbi Benign expectoration of a surgical clip through a pneumonectomy stump
    Zahoor Ahmed
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 124:1025-6. 2002
  30. ncbi Pain and physical function are similar following axillary, muscle-sparing vs posterolateral thoracotomy
    E Andrew Ochroch
    Department of Anesthesiology, University of Pennsylvania Health System, 3400 Spruce St, 680 Dulles, Philadelphia, PA 19104, USA
    Chest 128:2664-70. 2005
    ....
  31. doi Early outcomes after bilateral thoracoscopy versus median sternotomy for lung volume reduction
    Matthew M Puc
    From the Division of Thoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA USA Division of Thoracic Surgery, Department of Surgery, St Luke s Health Network, Bethlehem, PA USA and Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA USA
    Innovations (Phila) 5:97-102. 2010
    ..Our hypothesis was that a VATS approach would provide equivalent or less morbidity than MS despite being applied to a group of patients subjectively selected to be higher risk than those undergoing MS...
  32. ncbi Invited commentary
    Joseph B Shrager
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Thorac Surg 81:334. 2006
  33. ncbi Mediastinal talcoma masquerading as thymoma
    Zahoor Ahmed
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 75:568-9. 2003
    ..Awareness of such a possibility following talc pleurodesis may allow surgeons to avoid unnecessary mediastinal exploration, and its occurrence suggests that talc administration simultaneous with mechanical pleurodesis should be avoided...
  34. ncbi Tracheal trauma
    Joseph B Shrager
    Section of General Thoracic Surgery, 4 Silverstein Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia PA 19104, USA
    Chest Surg Clin N Am 13:291-304. 2003
    ..Grillo...
  35. doi Spontaneous chylopericardium: delineation of the underlying anatomic pathology by CT lymphangiography
    Maxim Itkin
    Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 87:1595-7. 2009
    ..We theorized that the development of the pathologic lymphatic ducts in close proximity to the pericardium resulted in the development of the slowly accumulating chylopericardium...
  36. ncbi Osteogenic sarcoma presenting with lung metastasis
    Arthur P Staddon
    The Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, Pennsylvania 19106, USA
    Oncologist 7:144-53. 2002
    ..Multimodality treatment options using chemotherapy, orthopedic surgery and thoracic surgery are presented. Physical medicine and rehabilitation evaluation and treatment are included. Current research options are discussed...
  37. ncbi Current presentation and optimal surgical management of sternoclavicular joint infections
    Howard K Song
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Ann Thorac Surg 73:427-31. 2002
    ..Infection of the stemoclavicular joint is unusual, and treatment of this entity has not been standardized. We sought to characterize the current presentation and optimal management of this disease...