Research Topics
Genomes and Genes | Joseph B ShragerSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysemaDong Kwan Kim
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Respir Res 4:1. 2003....- Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuseSanford Levine
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Respir Crit Care Med 183:483-90. 2011..Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy... 
Parasternal intercostal muscle remodeling in severe chronic obstructive pulmonary diseaseSanford Levine
Department of Surgery, Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
J Appl Physiol 101:1297-302. 2006..The physiological significance of this difference in remodeling between these two inspiratory rib cage muscles remains to be elucidated...- Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragmTaitan Nguyen
Respiratory Muscle Research Laboratory, Section of General Thoracic Surgery 4 Silverstein Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
J Appl Physiol 98:2004-10. 2005..Am J Respir Crit Care Med 168: 706-713, 2003) suggests that diaphragm remodeling elicited by severe COPD should decrease ATP utilization by the diaphragm... - Cytokine response is lower after lung volume reduction through bilateral thoracoscopy versus sternotomyMichael E Friscia
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 83:252-6. 2007..We measured these levels after lung volume reduction surgery through BVATS and sternotomy... - Two commonly used neoadjuvant chemoradiotherapy regimens for locally advanced stage III non-small cell lung carcinoma: long-term results and associations with pathologic responseMitchell Machtay
Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 127:108-13. 2004.... - Comparison of stages I-II thymoma treated by complete resection with or without adjuvant radiationSunil Singhal
Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Pennsylvania, Philadelphia, USA
Ann Thorac Surg 76:1635-41; discussion 1641-2. 2003..32) between the radiated and unradiated groups. CONCLUSIONS: These data support the contention that margin-negative surgical resection alone is sufficient treatment for both stages I and II thymoma... - Lung cancer in transplant recipients: a single-institution experienceZahoor Ahmed
Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Arch Surg 139:902-6. 2004.... - Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regenerative therapyAlexander S Krupnick
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Appl Physiol 94:411-9. 2003.... 
Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humansSanford Levine
Department of Surgery, University of Pennsylvania, USA
N Engl J Med 358:1327-35. 2008..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm...- Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung diseaseMary Elizabeth Kreider
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 83:1140-4. 2007..To shed light on the risk-benefit ratio for this recommendation, we examined the morbidity and mortality associated with video-assisted thoracoscopic surgical (VATS) lung biopsy in a group of outpatients... - Comparative study of subxiphoid versus video-thoracoscopic pericardial "window"John C Kucharczuk
Section of General Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 80:2013-9. 2005..41; p = 0.014). CONCLUSIONS: Operative time and minor procedural morbidity are higher with thoracoscopic pericardial window, but long-term control of effusion seemed to be better than after subxiphoid surgical drainage... - Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implicationsSanford Levine
Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
Am J Respir Crit Care Med 168:706-13. 2003..Moreover, our single-fiber results suggest that COPD-associated diaphragm remodeling decreases diaphragmatic force generation by adaptations within each fiber type as well as by fiber type transformations... - Thoracoscopic total parietal pleurectomy for primary spontaneous pneumothoraxDerek P Nathan
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 85:1825-7. 2008..We describe here the technique of thoracoscopic total parietal pleurectomy and the early outcomes afterward... - Myosin gene mutation correlates with anatomical changes in the human lineageHansell H Stedman
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 428:415-8. 2004..This represents the first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record... - Sarcomeres are added in series to emphysematous rat diaphragm after lung volume reduction surgeryJoseph B Shrager
Department of Surgery, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Chest 121:210-5. 2002..We used a model of elastase-induced emphysema in rats to test the hypothesis that sarcomere addition occurs following LVRS... - Should asymptomatic enlarged thymus glands be resected?Smit Singla
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 140:977-83. 2010..Patients frequently have an "enlarged thymus" incidentally identified on imaging. We sought to determine whether thymectomy is appropriate in patients with diffusely enlarged thymus glands... - Improved survival after pulmonary metastasectomy for soft tissue sarcomaJarrod D Predina
Division of Thoracic Surgery, Joan Karnell Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Thorac Oncol 6:913-9. 2011..With improved patient selection criteria and advanced chemotherapy agents, we hypothesized that survival after metastasectomy for STS has improved in recent years... - Catamenial pneumothorax: optimal hormonal and surgical managementM Blair Marshall
Section of General Thoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Eur J Cardiothorac Surg 27:662-6. 2005..To provide further information addressing the etiology, optimal hormonal management and surgical management in catamenial pneumothorax (CP)... - Management of alveolar air leaks after pulmonary resectionSunil Singhal
Division of Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 89:1327-35. 2010..We used available literature and expert consensus to formulate suggestions regarding the preferred approaches to both routine and prolonged alveolar air leaks. This review summarizes our findings... - Transcervical thymectomy for myasthenia gravis achieves results comparable to thymectomy by sternotomyJoseph B Shrager
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, USA
Ann Thorac Surg 74:320-6; discussion 326-7. 2002..Furthermore, preoperative prognostic factors have not been clearly defined... - Extended transcervical thymectomy in the treatment of myasthenia gravisSanjay G Khicha
Division of Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, PA 19104, USA
Ann N Y Acad Sci 1132:336-43. 2008.... - Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene familyPhilippe R Desjardins
Department of Surgery, School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
Mol Biol Evol 19:375-93. 2002..One of the novel human genes is found to have introns at positions shared only with the molluscan catchin/MyHC gene, providing evidence for the structure of a pre-Cambrian ancestral gene... - Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI studyKiarash Emami
Dept of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
J Appl Physiol 104:773-86. 2008.... - Outcomes after 151 extended transcervical thymectomies for myasthenia gravisJoseph B Shrager
Department of Surgery, Division of Thoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Thorac Surg 82:1863-9. 2006..The ideal operative technique for thymectomy in myasthenia gravis (MG) remains controversial. We present the largest series of extended transcervical thymectomy to provide outcomes data to compare with transsternal procedures... - Which patients with stage III non-small cell lung cancer should undergo surgical resection?Vivek Patel
University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Oncologist 10:335-44. 2005..By necessity, given the paucity of strong data, a good deal of opinion is offered. The choice to proceed with aggressive, combined modality treatment is presented in light of extent of local disease as well as patient performance status... - Anterior surgical approaches to the thoracic outletM Blair Marshall
Division of Thoracic Surgery, Department of Surgery, Georgetown University Medical Center, Washington, DC, USA
J Thorac Cardiovasc Surg 131:1255-60. 2006..We have used this approach for pathologic disease at the thoracic outlet and modified it. Our experience is described in this article... - Suction vs water seal after pulmonary resection: a randomized prospective studyM Blair Marshall
Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Chest 121:831-5. 2002..Adoption of this practice may result in lower morbidity and lower hospital costs... - Pain and physical function are similar following axillary, muscle-sparing vs posterolateral thoracotomyE Andrew Ochroch
Department of Anesthesiology, University of Pennsylvania Health System, 3400 Spruce St, 680 Dulles, Philadelphia, PA 19104, USA
Chest 128:2664-70. 2005.... - Benign expectoration of a surgical clip through a pneumonectomy stumpZahoor Ahmed
Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 124:1025-6. 2002 - Invited commentaryJoseph B Shrager
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Thorac Surg 81:334. 2006 - Spontaneous chylopericardium: delineation of the underlying anatomic pathology by CT lymphangiographyMaxim Itkin
Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 87:1595-7. 2009..We theorized that the development of the pathologic lymphatic ducts in close proximity to the pericardium resulted in the development of the slowly accumulating chylopericardium... - Osteogenic sarcoma presenting with lung metastasisArthur P Staddon
The Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, Pennsylvania 19106, USA
Oncologist 7:144-53. 2002..Multimodality treatment options using chemotherapy, orthopedic surgery and thoracic surgery are presented. Physical medicine and rehabilitation evaluation and treatment are included. Current research options are discussed... - Mediastinal talcoma masquerading as thymomaZahoor Ahmed
Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 75:568-9. 2003..Awareness of such a possibility following talc pleurodesis may allow surgeons to avoid unnecessary mediastinal exploration, and its occurrence suggests that talc administration simultaneous with mechanical pleurodesis should be avoided... - Current presentation and optimal surgical management of sternoclavicular joint infectionsHoward K Song
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Ann Thorac Surg 73:427-31. 2002..This approach has minimal impact on upper extremity function... - Tracheal traumaJoseph B Shrager
Section of General Thoracic Surgery, 4 Silverstein Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia PA 19104, USA
Chest Surg Clin N Am 13:291-304. 2003..Grillo...