Straub J, Sholler G, Nishi R. Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro. BMC Dev Biol. 2007;7:10 pubmed
..This suggests that the availability of BDNF in vivo fails to reach a threshold necessary to induce proliferation. We suggest that excess TrkB stimulation of sympathoblasts in vivo may lead to the genesis of neuroblastoma. ..
Saulnier Sholler G, Kalkunte S, Greenlaw C, McCarten K, Forman E. Antitumor activity of nifurtimox observed in a patient with neuroblastoma. J Pediatr Hematol Oncol. 2006;28:693-5 pubmed
..Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing. ..
Saulnier Sholler G, Bergendahl G, Brard L, Singh A, Heath B, Bingham P, et al. A phase 1 study of nifurtimox in patients with relapsed/refractory neuroblastoma. J Pediatr Hematol Oncol. 2011;33:25-30 pubmed publisher
..A Phase 2 study to determine the antitumor efficacy of nifurtimox is currently underway. ..