Dolores M Shoback

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Clinical practice. Hypoparathyroidism
    Dolores Shoback
    University of California, San Francisco, Department of Veterans Affairs Medical Center, San Francisco 94121, USA
    N Engl J Med 359:391-403. 2008
  2. ncbi request reprint Update in osteoporosis and metabolic bone disorders
    Dolores Shoback
    Endocrine Research Unit, San Francisco Department of Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Clin Endocrinol Metab 92:747-53. 2007
  3. pmc Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial
    Anne L Schafer
    Department of Medicine, University of California, San Francisco, 4150 Clement Street, 111N, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 97:3522-9. 2012
  4. ncbi request reprint Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes
    Zhiqiang Cheng
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Endocrinology 148:4984-92. 2007
  5. pmc Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover
    Melita M Dvorak-Ewell
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Bone Miner Res 26:2935-47. 2011
  6. pmc Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function
    Qing Dong
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0434, USA
    J Clin Endocrinol Metab 95:E245-52. 2010
  7. pmc The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development
    Wenhan Chang
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
    Sci Signal 1:ra1. 2008
  8. ncbi request reprint Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons
    Wenhan Chang
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, California 94121, USA
    J Biol Chem 282:25030-40. 2007
  9. ncbi request reprint Extracellular Ca2+-sensing receptors--an overview
    Wenhan Chang
    Endocrine Research Unit, Department of Medicine, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    Cell Calcium 35:183-96. 2004
  10. pmc Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study)
    Anne L Schafer
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 96:E1982-9. 2011

Research Grants

Collaborators

Detail Information

Publications17

  1. doi request reprint Clinical practice. Hypoparathyroidism
    Dolores Shoback
    University of California, San Francisco, Department of Veterans Affairs Medical Center, San Francisco 94121, USA
    N Engl J Med 359:391-403. 2008
  2. ncbi request reprint Update in osteoporosis and metabolic bone disorders
    Dolores Shoback
    Endocrine Research Unit, San Francisco Department of Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Clin Endocrinol Metab 92:747-53. 2007
    ....
  3. pmc Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial
    Anne L Schafer
    Department of Medicine, University of California, San Francisco, 4150 Clement Street, 111N, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 97:3522-9. 2012
    ..PTH therapy improves bone mineral density (BMD) and decreases fractures in postmenopausal osteoporosis, but cost and the burden of daily injections limit its use...
  4. ncbi request reprint Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes
    Zhiqiang Cheng
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Endocrinology 148:4984-92. 2007
    ..These results support the idea that physical interactions between CaRs and GABA-B-R1s modulate the growth and differentiation of GPCs, potentially by altering the function of CaRs...
  5. pmc Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover
    Melita M Dvorak-Ewell
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Bone Miner Res 26:2935-47. 2011
    ....
  6. pmc Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function
    Qing Dong
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0434, USA
    J Clin Endocrinol Metab 95:E245-52. 2010
    ..Most mutations are clustered in the N-terminal and Cys-rich regions of the extracellular domain (ECD) and seven-transmembrane domain. Disease-causing mutations are uncommon in the C terminus of ECD...
  7. pmc The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development
    Wenhan Chang
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
    Sci Signal 1:ra1. 2008
    ..Mice in which chondrocyte-specific deletion of Casr was induced between E16 and E18 were viable but showed delayed growth plate development. Our data show a critical role for the CaSR in early embryogenesis and skeletal development...
  8. ncbi request reprint Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons
    Wenhan Chang
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, California 94121, USA
    J Biol Chem 282:25030-40. 2007
    ....
  9. ncbi request reprint Extracellular Ca2+-sensing receptors--an overview
    Wenhan Chang
    Endocrine Research Unit, Department of Medicine, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    Cell Calcium 35:183-96. 2004
    ..Studies of CaR-knockout mice confirm the importance of CaRs in the parathyroid gland and kidney. The functions of CaRs in tissues other than kidney and parathyroid gland, however, remain to be elucidated...
  10. pmc Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study)
    Anne L Schafer
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 96:E1982-9. 2011
    ..The undercarboxylated form of the osteoblast-secreted protein osteocalcin has favorable effects on fat and glucose metabolism in mice. In human subjects, cross-sectional studies suggest a relevant association...
  11. ncbi request reprint Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes
    Luis Rodriguez
    Endocrine Research Unit, Department of Medicine, Department of Veterans Affairs Medical Center, University of California, San Francisco, 94121, USA
    Endocrinology 146:5294-303. 2005
    ..Taken together, our data support the idea that expression of (Exon5(-))CaRs may compensate for the loss of full-length CaRs and be responsible for sensing changes in [Ca(2+)](e) in GPCs in CaR(-/-) mice...
  12. ncbi request reprint Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells
    Wenhan Chang
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Endocrinology 143:1467-74. 2002
    ..These data support a role for CaRs in mediating high [Ca(2+)](o)-induced differentiation of C5.18 cells...
  13. ncbi request reprint Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone
    Melita M Dvorak
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, University of California, San Francisco, California 94121, USA
    Endocrinology 148:3156-63. 2007
    ....
  14. ncbi request reprint Fanconi's syndrome in HIV+ adults: report of three cases and literature review
    Karen E Earle
    Endocrinology Division, Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Bone Miner Res 19:714-21. 2004
    ..This was temporally related to their HIV treatment. Physicians caring for patients with HIV should recognize the association of this rare syndrome with antiretroviral medications and monitor their patients carefully...
  15. ncbi request reprint Calcimimetics in the treatment of primary hyperparathyroidism
    Diana M Antoniucci
    Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco 94121, USA
    J Bone Miner Res 17:N141-5. 2002
  16. doi request reprint Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review
    Vivian Y Pao
    Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Miner Res 24:1135-9. 2009
    ....
  17. ncbi request reprint The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism
    Dolores M Shoback
    Department of Medicine, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 88:5644-9. 2003
    ....

Research Grants5

  1. DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORS
    Dolores Shoback; Fiscal Year: 2002
    ..Our studies should provide insights into mechanisms underlying CaR responsiveness in secretion and growth. ..
  2. Diabetes Endocrinology and Metabolism Training Grant
    Michael German; Fiscal Year: 2007
    ....
  3. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores Shoback; Fiscal Year: 2009
    ....
  4. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2010
    ....