Michael Shlipak

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals
    Linda F Fried
    Renal Section, VA Pittsburgh Healthcare System, Pennsylvania 15240, USA
    J Am Coll Cardiol 41:1364-72. 2003
  2. pmc Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis
    Ruth Dubin
    Department of Medicine, Division Nephrology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    BMC Nephrol 12:3. 2011
  3. doi request reprint Biomarkers for incident CKD: a new framework for interpreting the literature
    Michael G Shlipak
    San Francisco Veterans Administration Medical Center, 4150 Clement Street, 111A1, San Francisco, CA 94121, USA
    Nat Rev Nephrol 9:478-83. 2013
  4. pmc Update on cystatin C: incorporation into clinical practice
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Kidney Dis 62:595-603. 2013
  5. pmc Urinary markers of kidney injury and kidney function decline in HIV-infected women
    Michael G Shlipak
    Department of Medicine, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 61:565-73. 2012
  6. pmc Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study
    Michael G Shlipak
    Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif, USA
    Am J Med 121:50-7. 2008
  7. pmc Clinical and subclinical cardiovascular disease and kidney function decline in the elderly
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Atherosclerosis 204:298-303. 2009
  8. pmc Rate of kidney function decline in older adults: a comparison using creatinine and cystatin C
    Michael G Shlipak
    General Internal Medicine Section, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Nephrol 30:171-8. 2009
  9. pmc Rapid decline of kidney function increases cardiovascular risk in the elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco VA Medical Center and Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 20:2625-30. 2009
  10. ncbi request reprint Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease
    Michael G Shlipak
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 145:237-46. 2006

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals
    Linda F Fried
    Renal Section, VA Pittsburgh Healthcare System, Pennsylvania 15240, USA
    J Am Coll Cardiol 41:1364-72. 2003
    ..This study was designed to evaluate the relationship between elevated creatinine levels and cardiovascular events...
  2. pmc Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis
    Ruth Dubin
    Department of Medicine, Division Nephrology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    BMC Nephrol 12:3. 2011
    ..73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that reduced kidney function would be characterized by abnormalities of hemostasis...
  3. doi request reprint Biomarkers for incident CKD: a new framework for interpreting the literature
    Michael G Shlipak
    San Francisco Veterans Administration Medical Center, 4150 Clement Street, 111A1, San Francisco, CA 94121, USA
    Nat Rev Nephrol 9:478-83. 2013
    ..This Review offers a conceptual framework for interpreting the results of studies evaluating biomarkers of declining kidney function and incident CKD. ..
  4. pmc Update on cystatin C: incorporation into clinical practice
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Kidney Dis 62:595-603. 2013
    ..We conclude by addressing frequently asked questions related to implementing cystatin C use in a clinical setting. ..
  5. pmc Urinary markers of kidney injury and kidney function decline in HIV-infected women
    Michael G Shlipak
    Department of Medicine, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 61:565-73. 2012
    ..We hypothesized that urine markers of kidney injury would be associated with declining kidney function among HIV-infected women...
  6. pmc Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study
    Michael G Shlipak
    Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif, USA
    Am J Med 121:50-7. 2008
    ..The study purpose was to evaluate the ability of 6 biomarkers to improve the prediction of cardiovascular events among persons with established coronary artery disease...
  7. pmc Clinical and subclinical cardiovascular disease and kidney function decline in the elderly
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Atherosclerosis 204:298-303. 2009
    ..As a proxy for the renovascular system, we evaluated the association of clinical and subclinical cardiovascular disease (CVD) with kidney function decline...
  8. pmc Rate of kidney function decline in older adults: a comparison using creatinine and cystatin C
    Michael G Shlipak
    General Internal Medicine Section, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Nephrol 30:171-8. 2009
    ..The aim of this study was to determine the decline in the estimated glomerular filtration rate (eGFR) in elderly persons and to compare estimates based on creatinine and cystatin C...
  9. pmc Rapid decline of kidney function increases cardiovascular risk in the elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco VA Medical Center and Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 20:2625-30. 2009
    ..97 to 1.45). The association of rapid decline with each outcome did not differ by the presence or absence of CKD. In conclusion, declining kidney function associates with higher risk for HF, MI, and PAD among patients with or without CKD...
  10. ncbi request reprint Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease
    Michael G Shlipak
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 145:237-46. 2006
    ..73 m2)...
  11. pmc Symptoms characteristic of heart failure among CKD patients without diagnosed heart failure
    Michael G Shlipak
    University of California, San Francisco, General Internal Medicine, San Francisco VA Medical Center, 4150 Clement St, 111A1, San Francisco, CA 94109, USA
    J Card Fail 17:17-23. 2011
    ..Epidemiological studies typically diagnose heart failure (HF) at the time of hospitalization, and have not evaluated the prevalence of HF symptoms in CKD patients without a prior HF diagnosis...
  12. doi request reprint Comparison of cardiovascular prognosis by 3 serum cystatin C methods in the Heart and Soul Study
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA, USA
    Clin Chem 57:737-45. 2011
    ..Other companies, including Gentian and Roche, have developed cystatin C assays that can be used with most routine clinical chemistry analyzers...
  13. pmc Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease
    Michael G Shlipak
    San Francisco VA Medical Center, CA, USA
    BMC Nephrol 12:2. 2011
    ..This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk...
  14. pmc Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects
    Rebecca Scherzer
    University of California, San Francisco, CA 94121, USA
    Am J Clin Nutr 88:1088-96. 2008
    ....
  15. pmc Kidney function decline in the elderly: impact of lipoprotein-associated phospholipase A(2)
    Carmen A Peralta
    San Francisco VA Medical Center, Calif, USA
    Am J Nephrol 34:512-8. 2011
    ..Whether lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) levels are associated with kidney function decline has not been well studied...
  16. pmc Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    BMC Nephrol 9:9. 2008
    ..Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort...
  17. pmc Serum creatinine and functional limitation in elderly persons
    Michelle C Odden
    Department of Epidemiology, School of Public Health, University of California, Berkeley, USA
    J Gerontol A Biol Sci Med Sci 64:370-6. 2009
    ..We hypothesized that higher serum creatinine would be associated with self-reported functional limitation in community-dwelling elderly...
  18. pmc Trajectories of kidney function decline in young black and white adults with preserved GFR: results from the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Carmen A Peralta
    University of California San Francisco, San Francisco, CA, USA
    Am J Kidney Dis 62:261-6. 2013
    ..Strong racial discrepancies in end-stage renal disease exist. Whether there are race differences in kidney function loss in younger healthy persons is not well established...
  19. pmc Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
    Rebecca Scherzer
    Northern California Institute for Research and Education, San Francisco, CA, USA
    Am J Clin Nutr 87:1809-17. 2008
    ..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects...
  20. ncbi request reprint African ancestry, socioeconomic status, and kidney function in elderly African Americans: a genetic admixture analysis
    Carmen A Peralta
    Department of Medicine, University of California at San Francisco, San Francisco, California 94124, USA
    J Am Soc Nephrol 17:3491-6. 2006
    ..Rather, kidney dysfunction in elderly African Americans seems more attributable to differences in environmental and social factors...
  21. pmc Reduced kidney function and preclinical atherosclerosis in HIV-infected individuals: the study of fat redistribution and metabolic change in HIV infection (FRAM)
    Vasantha Jotwani
    University of California, San Francisco, Calif, USA
    Am J Nephrol 33:453-60. 2011
    ..We investigated whether reduced estimated glomerular filtration rate (eGFR) and albuminuria are associated with subclinical vascular disease, as assessed by carotid intima-medial thickness (cIMT)...
  22. pmc Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophy
    Carl Grunfeld
    Office of the Principal Investigator, The FRAM Study, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    AIDS 24:1717-26. 2010
    ..controls. Therefore, we determined change in regional adipose tissue from baseline examination to 5 years later among participants in the study of Fat Redistribution and Metabolic Change in HIV Infection...
  23. pmc Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 55:316-22. 2010
    ..To determine the association of inflammatory markers, fibrinogen, and C-reactive protein (CRP), with 5-year mortality risk...
  24. pmc Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study
    David Singh
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Nephrol Dial Transplant 22:1087-92. 2007
    ..In this study, we compared the relative strengths of association of cystatin C and estimated glomerular filtration rate (eGFR) with inflammatory biomarkers...
  25. doi request reprint Chronic kidney disease, plasma lipoproteins, and coronary artery calcium incidence: the Multi-Ethnic Study of Atherosclerosis
    Julio A Lamprea-Montealegre
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 33:652-8. 2013
    ..To determine the association of chronic kidney disease and coronary artery calcium (CAC) incidence, and the distribution of lipoproteins across categories of kidney function and their association with CAC risk...
  26. pmc Association of low level viremia with inflammation and mortality in HIV-infected adults
    Abigail Eastburn
    University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e26320. 2011
    ..Whether HIV viremia, particularly at low levels is associated with inflammation, increased coagulation, and all-cause mortality is unclear...
  27. pmc Association of HIV infection, demographic and cardiovascular risk factors with all-cause mortality in the recent HAART era
    Leslie Cockerham
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 53:102-6. 2010
    ..To determine the relationship of HIV infection, demographic, and cardiovascular disease (CVD) risk factors with mortality in the recent highly active antiretroviral therapy era...
  28. pmc Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health Study
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 25:119-24. 2010
    ..The objective of this study was to determine whether elevated markers of inflammation are independently associated with longitudinal kidney function decline...
  29. ncbi request reprint Impact of renal insufficiency on mortality in advanced lower extremity peripheral arterial disease
    ANN M O'HARE
    Division of Nephrology, Box 111J, Nephrology, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 16:514-9. 2005
    ..Death rates were particularly high among those with a GFR <30 ml/min per 1.73 m(2). This finding may be partly explained by their more frequent presentation with ischemic ulceration or gangrene rather than rest pain...
  30. pmc Association of HIV infection and HIV/HCV coinfection with C-reactive protein levels: the fat redistribution and metabolic change in HIV infection (FRAM) study
    Jason Reingold
    University of California, San Francisco, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 48:142-8. 2008
    ..We evaluated C-reactive protein (CRP) in HIV-infected and HIV/HCV-coinfected individuals in the era of effective antiretroviral (ARV) therapy...
  31. pmc Cystatin C concentration as a predictor of systolic and diastolic heart failure
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Card Fail 14:19-26. 2008
    ..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study...
  32. pmc C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study
    Mary S Beattie
    Department of Medicine, University of California, San Francisco, USA
    Circulation 107:245-50. 2003
    ..Elevated levels of C-reactive protein (CRP) are associated with an increased risk of coronary events, but whether inflammation is associated with inducible ischemia in patients with stable coronary disease is unknown...
  33. ncbi request reprint Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  34. pmc Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of Atherosclerosis
    Ruth Dubin
    Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 26:1903-8. 2011
    ..Pentraxin-3 (PTX3), an inflammatory marker thought to be related to vascular inflammation, is elevated in advanced chronic kidney disease (CKD). Whether PTX3 is associated with mild to moderate kidney dysfunction is unknown...
  35. pmc Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals
    Kevin E Yarasheski
    Department of Medicine, Washington University, St Louis, Missouri, USA
    J Gerontol A Biol Sci Med Sci 66:332-40. 2011
    ..We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls...
  36. pmc Regional adipose tissue and lipid and lipoprotein levels in HIV-infected women
    Judith Currier
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    J Acquir Immune Defic Syndr 48:35-43. 2008
    ..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described...
  37. pmc Racial and ethnic differences in kidney function decline among persons without chronic kidney disease
    Carmen A Peralta
    Department of Medicine, University of California San Francisco, San Francisco, California 94121, USA
    J Am Soc Nephrol 22:1327-34. 2011
    ..Traditional risk factors do not explain these differences fully, highlighting the need to explore these disparities...
  38. pmc Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected persons
    ANDY CHOI
    University of California, San Francisco, CA, USA
    Am J Kidney Dis 56:872-82. 2010
    ..However, the clinical importance of increased cystatin C level and albuminuria in the HIV-infected population has not been studied...
  39. pmc Cystatin C and carotid intima-media thickness in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Anh L Bui
    Department of Medicine, University of California, San Francisco, CA, USA
    Am J Kidney Dis 53:389-98. 2009
    ..We therefore explored whether serum cystatin C level is associated with carotid intima-media thickness (IMT) in ambulatory adults without clinical heart disease...
  40. pmc Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 25:993-7. 2010
    ..The threshold of CKD or albuminuria at which FGF-23 begins to change is unknown...
  41. ncbi request reprint Risk factors and secondary prevention in women with heart disease: the Heart and Estrogen/progestin Replacement Study
    Eric Vittinghoff
    University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, 74 New Montgomery, Suite 600, San Francisco, California 94105, USA
    Ann Intern Med 138:81-9. 2003
    ..Risk factors for coronary heart disease events have most commonly been evaluated in healthy men...
  42. pmc Filtration markers may have prognostic value independent of glomerular filtration rate
    Navdeep Tangri
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    J Am Soc Nephrol 23:351-9. 2012
    ..trace protein and cystatin C seem to provide more consistent prognostic information than creatinine...
  43. pmc Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study
    Michelle C Odden
    Department of Medicine, San FranciscoVeterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Arch Intern Med 167:2213-9. 2007
    ..Cystatin C measurement may be more sensitive than creatinine for detecting impaired kidney function in persons with HIV...
  44. ncbi request reprint Association of chronic kidney disease with clinical outcomes after coronary revascularization: the Arterial Revascularization Therapies Study (ARTS)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, Calif, USA
    Am Heart J 149:512-9. 2005
    ..In the Arterial Revascularization Therapies Study (ARTS), we compared long-term clinical outcomes after CABG or PCI with multivessel stenting in patients with CKD...
  45. ncbi request reprint Relationship between hepatitis C and chronic kidney disease: results from the Third National Health and Nutrition Examination Survey
    Judith I Tsui
    General Internal Medicine, Section 111A1, VA Medical Center, 4150 Clement Street, San Francisco, CA 94124, USA
    J Am Soc Nephrol 17:1168-74. 2006
    ....
  46. ncbi request reprint Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, and General Internal Medicine Section, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Faancisco, CA 94121, USA
    Arch Intern Med 165:2666-70. 2005
    ..The association of cystatin C, a novel marker of renal function, with risk for developing complications related to peripheral arterial disease (PAD) has not been examined...
  47. ncbi request reprint Differences in medical care and disease outcomes among black and white women with heart disease
    Ashish K Jha
    Division of General Medicine, San Francisco VA Medical Center, San Francisco, USA
    Circulation 108:1089-94. 2003
    ..We sought to evaluate differences in medical care and clinical outcomes among black and white women with established coronary artery disease...
  48. pmc Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul study
    Judith I Tsui
    Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine Boston Medical Center, Boston, MA 02118, USA
    J Card Fail 15:451-6. 2009
    ..How hepatitis C virus (HCV) affects coronary heart disease (CHD) risk factors and outcomes is largely unknown...
  49. ncbi request reprint Association of antihypertensive therapy and diastolic hypotension in chronic kidney disease
    Carmen A Peralta
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, CA 94121, USA
    Hypertension 50:474-80. 2007
    ..Given recent evidence suggesting adverse effects of diastolic hypotension, these results suggest potential risks in patients with CKD from aggressive attempts to control systolic blood pressure...
  50. pmc Association of anemia with diastolic dysfunction among patients with coronary artery disease in the Heart and Soul Study
    Deepu Nair
    Department of Department of Medicine, University of California, San Francisco, California, USA
    Am J Cardiol 95:332-6. 2005
    ..6, 95% CI 0.6 to 4.6) were not significantly associated with LVH. We found anemia to be strongly associated with diastolic dysfunction but not with LVH in this community-based sample of outpatients who had established coronary disease...
  51. pmc HIV viremia and changes in kidney function
    Chris T Longenecker
    University of California, San Francisco, California 94121, USA
    AIDS 23:1089-96. 2009
    ..To evaluate the effect of HIV infection on longitudinal changes in kidney function and to identify independent predictors of kidney function changes in HIV-infected individuals...
  52. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  53. ncbi request reprint Observational research databases in renal disease
    Michael Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, and Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    J Am Soc Nephrol 16:3477-84. 2005
    ..This review summarizes the types of research analyses that can be conducted using existing databases, the types of research databases available, and a general approach for addressing a proposed research question using existing data...
  54. pmc Blood pressure components and end-stage renal disease in persons with chronic kidney disease: the Kidney Early Evaluation Program (KEEP)
    Carmen A Peralta
    Department of Medicine, San Francisco VA Medical Center, San Francisco, California, USA
    Arch Intern Med 172:41-7. 2012
    ..Treatment of hypertension is difficult in chronic kidney disease (CKD), and blood pressure goals remain controversial. The association between each blood pressure component and end-stage renal disease (ESRD) risk is less well known...
  55. ncbi request reprint Clinician awareness of adherence to hypertension guidelines
    Michael A Steinman
    Division of Geriatrics, San Francisco VA Medical Center and the University of California, San Francisco 94121, USA
    Am J Med 117:747-54. 2004
    ..We compared clinicians' beliefs about their adherence to hypertension guidelines with data on their actual performance...
  56. ncbi request reprint Chronic renal insufficiency and cardiovascular events in the elderly: findings from the Cardiovascular Health Study
    Michael G Shlipak
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Am J Geriatr Cardiol 13:81-90. 2004
    ..The identification of CRI in the elderly and the use of cardiovascular prevention therapies represent a major opportunity to reduce their burden of cardiovascular morbidity...
  57. pmc Cystatin C as a marker of cognitive function in elders: findings from the health ABC study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
    Ann Neurol 63:798-802. 2008
    ..92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15)...
  58. ncbi request reprint The presence of frailty in elderly persons with chronic renal insufficiency
    Michael G Shlipak
    Epidemiology and Biostatistics, University of California, San Francisco, General Internal Medicine Section, Medical Service, San Francisco Veterans Affairs Medical Center San Francisco, CA 94121, USA
    Am J Kidney Dis 43:861-7. 2004
    ..We hypothesized that chronic renal insufficiency (CRI) would be associated with a greater prevalence of frailty and disability in the elderly...
  59. pmc The differential association of kidney dysfunction with small and large arterial elasticity: the multiethnic study of atherosclerosis
    Carmen A Peralta
    General Internal Medicine Section 111A1, Veterans Affairs Medical Center, San Francisco, CA 94124, USA
    Am J Epidemiol 169:740-8. 2009
    ..26, 0.48, 0.45). Early kidney dysfunction is significantly associated with decreased arterial elasticity in smaller arteries and, to a lesser degree, in larger arteries...
  60. ncbi request reprint Predictors of heart failure among women with coronary disease
    Kirsten Bibbins-Domingo
    Division of General Internal Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143 1364, USA
    Circulation 110:1424-30. 2004
    ..We determined the risk factors for developing heart failure among postmenopausal women with established coronary disease...
  61. pmc HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy
    Andy I Choi
    Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    AIDS 23:2143-9. 2009
    ..To identify risk factors associated with kidney function decline in a contemporary cohort of treated and untreated HIV-infected patients...
  62. ncbi request reprint The relative safety of ephedra compared with other herbal products
    Stephen Bent
    Osher Center for Integrative Medicine at the University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, 111 A1, 4150 Clement Street, San Francisco, California 94121, USA
    Ann Intern Med 138:468-71. 2003
    ..Ephedra is widely used in dietary supplements that are marketed to promote weight loss or increase energy; however, the safety of this product has been questioned because of numerous case reports of adverse events...
  63. ncbi request reprint The incidence of end-stage renal disease is increasing faster than the prevalence of chronic renal insufficiency
    Chi yuan Hsu
    University of California, San Francisco, San Francisco, California 94143 0532, USA
    Ann Intern Med 141:95-101. 2004
    ..The steady increase in end-stage renal disease (ESRD) incidence is a worldwide public health crisis...
  64. ncbi request reprint Pharmacotherapy for heart failure in patients with renal insufficiency
    Michael G Shlipak
    Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 138:917-24. 2003
    ..Future clinical trials in heart failure should include a representative number of patients with renal insufficiency to improve the evidence base and outcomes in this vulnerable population...
  65. pmc Long-term clinical consequences of acute kidney injury in the HIV-infected
    Andy I Choi
    Department of Medicine, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Kidney Int 78:478-85. 2010
    ..Additionally, AKI affected almost one of six patients with HIV who survived at least 90 days following discharge...
  66. pmc Race differences in prevalence of chronic kidney disease among young adults using creatinine-based glomerular filtration rate-estimating equations
    Carmen A Peralta
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 25:3934-9. 2010
    ..Current creatinine-based glomerular filtration rate (GFR)-estimating equations may misclassify young, healthy blacks...
  67. ncbi request reprint Fracture and the risk of coronary events in women with heart disease
    Paul D Varosy
    Department of Medicine, University of California, San Francisco 94143 0124, USA
    Am J Med 115:196-202. 2003
    ..Osteoporosis is associated with aortic calcification and cardiovascular mortality. However, whether skeletal fractures predict the risk of coronary events is unknown...
  68. pmc Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 58:338-45. 2010
    ....
  69. pmc Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons
    Andy I Choi
    Department of Medicine, San Francisco Veterans Affairs Medical Center, and University of California, San Francisco, USA
    Circulation 121:651-8. 2010
    ..We examined the association between longitudinal measures of kidney function and albuminuria with risk of atherosclerotic CVD and heart failure in a contemporary cohort of HIV-infected individuals...
  70. pmc The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Carmen A Peralta
    Department of Medicine, University of California San Francisco, USA
    Am J Nephrol 31:202-8. 2010
    ..05 (4.81-17.02) for black men with >80% African ancestry. Genetic factors common to African ancestry may be associated with increased risk of early kidney dysfunction in a young, healthy population, particularly among black men...
  71. ncbi request reprint Association of total and central obesity with mortality in postmenopausal women with coronary heart disease
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 64115, USA
    Am J Epidemiol 158:1161-70. 2003
    ....
  72. ncbi request reprint Creatinine levels and cardiovascular events in women with heart disease: do small changes matter?
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Am J Kidney Dis 43:37-44. 2004
    ....
  73. ncbi request reprint Lipid changes on hormone therapy and coronary heart disease events in the Heart and Estrogen/progestin Replacement Study (HERS)
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA
    Am Heart J 146:870-5. 2003
    ..To explore possible mechanisms, we examined the association between lipid changes and CHD outcomes among women assigned to hormone therapy...
  74. pmc Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California at San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:173-9. 2007
    ..Cystatin C is a novel and sensitive endogenous marker of kidney function. Whether cystatin C concentrations are associated with adverse events among ambulatory persons with CHD is unknown...
  75. pmc Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul Study
    Carmen A Peralta
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco, California 94124, USA
    Am J Hypertens 19:939-46. 2006
    ..Whether kidney function in the normal range is associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure is unclear...
  76. ncbi request reprint Association of hepatitis C seropositivity with increased risk for developing end-stage renal disease
    Judith I Tsui
    Department of Medicine, University of California, San Francisco, and San Francisco General Hospital, CA 94124, USA
    Arch Intern Med 167:1271-6. 2007
    ..We undertook this study to determine whether having a positive HCV test result was associated with an increased risk for developing treated end-stage renal disease (ESRD)...
  77. pmc Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Card Fail 12:601-7. 2006
    ..We evaluate whether cystatin C is associated with left ventricular hypertrophy, diastolic dysfunction, and systolic dysfunction among 818 outpatients with coronary artery disease who were free of clinical heart failure...
  78. ncbi request reprint Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition Study
    Kirsten Bibbins-Domingo
    Division of General Internal Medicine, San Francisco General Hospital, CA 94143 1364, USA
    Arch Intern Med 166:1396-402. 2006
    ..Our objective was to determine whether the association of chronic kidney disease with incident heart failure differs between blacks and whites...
  79. ncbi request reprint Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Am J Kidney Dis 50:412-20. 2007
    ..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain...
  80. ncbi request reprint Effect of hormone therapy on mortality rates among women with heart failure and coronary artery disease
    Kirsten Bibbins-Domingo
    Division of General Internal Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Cardiol 95:289-91. 2005
    ..Over the 4.1-year follow-up, estrogen plus progestin use had no effect on all-cause mortality (hazard ratio 1.0, 95% confidence interval 0.7 to 1.4, p = 0.8) in women with heart failure and coronary disease...
  81. ncbi request reprint Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
    ..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community...
  82. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
    ..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease...
  83. ncbi request reprint Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
    Circulation 113:388-93. 2006
    ..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population...
  84. ncbi request reprint Cystatin-C and inflammatory markers in the ambulatory elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, Calif 94121, USA
    Am J Med 118:1416. 2005
    ..We compared cystatin-C, a novel marker of renal function, with creatinine and estimated glomerular filtration rate (eGFR) as predictors of C-reactive protein and fibrinogen levels...
  85. pmc Risk factors for chronic kidney disease among American Indians and Alaska Natives--findings from the Kidney Early Evaluation Program
    Stacey E Jolly
    General Internal Medicine Division, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Nephrol 29:440-6. 2009
    ..Less is known about chronic kidney disease (CKD) among AIAN and whether risk factors differ for low estimated glomerular filtration rate (eGFR) versus albuminuria with a normal eGFR...
  86. ncbi request reprint Cardiovascular disease risk status in elderly persons with renal insufficiency
    Michael G Shlipak
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    Kidney Int 62:997-1004. 2002
    ..We determined the prevalence of elevated cardiovascular disease risk status among elderly persons with renal insufficiency...
  87. pmc Measured GFR does not outperform estimated GFR in predicting CKD-related complications
    Chi yuan Hsu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Am Soc Nephrol 22:1931-7. 2011
    ..These results raise questions regarding the conventional view that iGFR is the "gold standard" measure of kidney function...
  88. pmc Fat distribution in men with HIV infection
    Peter Bacchetti
    University of California, San Francisco Veterans Affairs Medical Center, Metabolism Section, 94121, USA
    J Acquir Immune Defic Syndr 40:121-31. 2005
    ..Which changes are specific to HIV were determined by comparison with control subjects and the associations among different adipose tissue depots were determined...
  89. ncbi request reprint Race and renal impairment in heart failure: mortality in blacks versus whites
    Grace L Smith
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06520, USA
    Circulation 111:1270-7. 2005
    ..We sought to determine in HF patients the 1-year mortality risks associated with elevated creatinine and impaired estimated glomerular filtration rate (eGFR) and to quantify racial differences in mortality...
  90. pmc Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Atherosclerosis 197:407-14. 2008
    ....
  91. ncbi request reprint Cystatin C concentration as a risk factor for heart failure in older adults
    Mark J Sarnak
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 142:497-505. 2005
    ..Previous studies that evaluated the association of kidney function with incident heart failure may be limited by the insensitivity of serum creatinine concentration for detecting abnormal kidney function...
  92. ncbi request reprint Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Gerontol A Biol Sci Med Sci 61:743-8. 2006
    ....
  93. ncbi request reprint Racial and sex differences in refusal of coronary angiography
    Paul A Heidenreich
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
    Am J Med 113:200-7. 2002
    ..To determine the effect of patient refusal on racial and sex differences in the use of coronary angiography and in outcomes among elderly patients with acute myocardial infarction...
  94. ncbi request reprint A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study
    Neil A Zakai
    Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, USA
    Arch Intern Med 165:2214-20. 2005
    ..Anemia is viewed as a negative prognostic factor in the elderly population; its independent impact on survival is unclear...
  95. ncbi request reprint Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, 2000 Broadway St, 3rd Floor, Oakland, California 94612 2304, USA
    Circulation 113:2713-23. 2006
    ..It is unclear, however, whether this relation is explained by underlying kidney disease, treatment differences, or associated comorbidity...
  96. ncbi request reprint Kidney function as a predictor of noncardiovascular mortality
    Linda F Fried
    VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    J Am Soc Nephrol 16:3728-35. 2005
    ..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease...
  97. doi request reprint Prevalence and associations of anemia of CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Samy I McFarlane
    Division of Endocrinology, SUNY Downstate and Kings County Hospital Centers, Brooklyn, NY 11203, USA
    Am J Kidney Dis 51:S46-55. 2008
    ..We compared anemia prevalence and characteristics in the National Kidney Foundation Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004 populations...
  98. ncbi request reprint Renal impairment and outcomes in heart failure: systematic review and meta-analysis
    Grace L Smith
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Am Coll Cardiol 47:1987-96. 2006
    ..We estimated the prevalence of renal impairment in heart failure (HF) patients and the magnitude of associated mortality risk using a systematic review of published studies...
  99. ncbi request reprint Relationship between homocysteine and mortality in chronic kidney disease
    Vandana Menon
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Circulation 113:1572-7. 2006
    ..The relationship between total homocysteine (tHcy) and outcomes has not been investigated in patients with chronic kidney disease stages 3 to 4...
  100. pmc Association of mild to moderate kidney dysfunction and coronary calcification
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    J Am Soc Nephrol 19:579-85. 2008
    ..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality...
  101. pmc Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Ann Intern Med 148:501-8. 2008
    ..Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated...

Research Grants8

  1. Elucidating the Kidney's Role in Cardiovascular Risk
    Michael Shlipak; Fiscal Year: 2003
    ....
  2. Elucidating the Kidney's Role in Cardiovascular Risk
    Michael Shlipak; Fiscal Year: 2004
    ....
  3. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2004
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  4. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2005
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  5. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2006
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  6. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2007
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  7. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2008
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  8. The Aging Kidney in HIV-Infection: biomarkers for early detection of injury
    Michael G Shlipak; Fiscal Year: 2010
    ....