Research Topics
Species | Michael ShlipakSummaryAffiliation: University of California Country: USA Publications
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Publications
Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individualsLinda F Fried
Renal Section, VA Pittsburgh Healthcare System, Pennsylvania 15240, USA
J Am Coll Cardiol 41:1364-72. 2003..This study was designed to evaluate the relationship between elevated creatinine levels and cardiovascular events...
Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosisRuth Dubin
Department of Medicine, Division Nephrology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
BMC Nephrol 12:3. 2011..73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that reduced kidney function would be characterized by abnormalities of hemostasis...- Urinary markers of kidney injury and kidney function decline in HIV-infected womenMichael G Shlipak
Department of Medicine, San Francisco VA Medical Center, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 61:565-73. 2012..We hypothesized that urine markers of kidney injury would be associated with declining kidney function among HIV-infected women... - Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney diseaseMichael G Shlipak
San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
Ann Intern Med 145:237-46. 2006..73 m2)... - Rate of kidney function decline in older adults: a comparison using creatinine and cystatin CMichael G Shlipak
General Internal Medicine Section, San Francisco VA Medical Center, San Francisco, CA 94121, USA
Am J Nephrol 30:171-8. 2009..The aim of this study was to determine the decline in the estimated glomerular filtration rate (eGFR) in elderly persons and to compare estimates based on creatinine and cystatin C... - Rapid decline of kidney function increases cardiovascular risk in the elderlyMichael G Shlipak
General Internal Medicine Section, San Francisco VA Medical Center and Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Am Soc Nephrol 20:2625-30. 2009..97 to 1.45). The association of rapid decline with each outcome did not differ by the presence or absence of CKD. In conclusion, declining kidney function associates with higher risk for HF, MI, and PAD among patients with or without CKD... - Clinical and subclinical cardiovascular disease and kidney function decline in the elderlyMichael G Shlipak
San Francisco VA Medical Center, San Francisco, CA 94121, USA
Atherosclerosis 204:298-303. 2009..As a proxy for the renovascular system, we evaluated the association of clinical and subclinical cardiovascular disease (CVD) with kidney function decline... - Symptoms characteristic of heart failure among CKD patients without diagnosed heart failureMichael G Shlipak
University of California, San Francisco, General Internal Medicine, San Francisco VA Medical Center, 4150 Clement St, 111A1, San Francisco, CA 94109, USA
J Card Fail 17:17-23. 2011..Epidemiological studies typically diagnose heart failure (HF) at the time of hospitalization, and have not evaluated the prevalence of HF symptoms in CKD patients without a prior HF diagnosis... - Uromodulin concentrations are not associated with incident CKD among persons with coronary artery diseaseMichael G Shlipak
San Francisco VA Medical Center, CA, USA
BMC Nephrol 12:2. 2011..This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk... 
Comparison of cardiovascular prognosis by 3 serum cystatin C methods in the Heart and Soul StudyMichael G Shlipak
San Francisco VA Medical Center, San Francisco, CA, USA
Clin Chem 57:737-45. 2011..Other companies, including Gentian and Roche, have developed cystatin C assays that can be used with most routine clinical chemistry analyzers...- Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul StudyMichael G Shlipak
Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif, USA
Am J Med 121:50-7. 2008..The study purpose was to evaluate the ability of 6 biomarkers to improve the prediction of cardiovascular events among persons with established coronary artery disease... - Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjectsRebecca Scherzer
University of California, San Francisco, CA 94121, USA
Am J Clin Nutr 88:1088-96. 2008.... - Kidney function decline in the elderly: impact of lipoprotein-associated phospholipase A(2)Carmen A Peralta
San Francisco VA Medical Center, Calif, USA
Am J Nephrol 34:512-8. 2011..Whether lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) levels are associated with kidney function decline has not been well studied... - Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)Christopher Keller
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
BMC Nephrol 9:9. 2008..Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort... - Serum creatinine and functional limitation in elderly personsMichelle C Odden
Department of Epidemiology, School of Public Health, University of California, Berkeley, USA
J Gerontol A Biol Sci Med Sci 64:370-6. 2009..We hypothesized that higher serum creatinine would be associated with self-reported functional limitation in community-dwelling elderly... - African ancestry, socioeconomic status, and kidney function in elderly African Americans: a genetic admixture analysisCarmen A Peralta
Department of Medicine, University of California at San Francisco, San Francisco, California 94124, USA
J Am Soc Nephrol 17:3491-6. 2006..Rather, kidney dysfunction in elderly African Americans seems more attributable to differences in environmental and social factors... - Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophyCarl Grunfeld
Office of the Principal Investigator, The FRAM Study, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
AIDS 24:1717-26. 2010..controls. Therefore, we determined change in regional adipose tissue from baseline examination to 5 years later among participants in the study of Fat Redistribution and Metabolic Change in HIV Infection... - Reduced kidney function and preclinical atherosclerosis in HIV-infected individuals: the study of fat redistribution and metabolic change in HIV infection (FRAM)Vasantha Jotwani
University of California, San Francisco, Calif, USA
Am J Nephrol 33:453-60. 2011..We investigated whether reduced estimated glomerular filtration rate (eGFR) and albuminuria are associated with subclinical vascular disease, as assessed by carotid intima-medial thickness (cIMT)... - Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjectsRebecca Scherzer
Northern California Institute for Research and Education, San Francisco, CA, USA
Am J Clin Nutr 87:1809-17. 2008..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects... - Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohortPhyllis C Tien
Department of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 55:316-22. 2010..To determine the association of inflammatory markers, fibrinogen, and C-reactive protein (CRP), with 5-year mortality risk... - Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul StudyDavid Singh
Department of Medicine, University of California, San Francisco, CA 94121, USA
Nephrol Dial Transplant 22:1087-92. 2007..In this study, we compared the relative strengths of association of cystatin C and estimated glomerular filtration rate (eGFR) with inflammatory biomarkers... - Chronic kidney disease, plasma lipoproteins, and coronary artery calcium incidence: the Multi-Ethnic Study of AtherosclerosisJulio A Lamprea-Montealegre
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Arterioscler Thromb Vasc Biol 33:652-8. 2013..To determine the association of chronic kidney disease and coronary artery calcium (CAC) incidence, and the distribution of lipoproteins across categories of kidney function and their association with CAC risk... - Association of low level viremia with inflammation and mortality in HIV-infected adultsAbigail Eastburn
University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e26320. 2011..Whether HIV viremia, particularly at low levels is associated with inflammation, increased coagulation, and all-cause mortality is unclear... - Association of HIV infection, demographic and cardiovascular risk factors with all-cause mortality in the recent HAART eraLeslie Cockerham
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 53:102-6. 2010..To determine the relationship of HIV infection, demographic, and cardiovascular disease (CVD) risk factors with mortality in the recent highly active antiretroviral therapy era... - Impact of renal insufficiency on mortality in advanced lower extremity peripheral arterial diseaseANN M O'HARE
Division of Nephrology, Box 111J, Nephrology, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Am Soc Nephrol 16:514-9. 2005..Death rates were particularly high among those with a GFR <30 ml/min per 1.73 m(2). This finding may be partly explained by their more frequent presentation with ischemic ulceration or gangrene rather than rest pain... - Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health StudyChristopher Keller
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Nephrol Dial Transplant 25:119-24. 2010..The objective of this study was to determine whether elevated markers of inflammation are independently associated with longitudinal kidney function decline... - Cystatin C concentration as a predictor of systolic and diastolic heart failureAndrew Moran
Department of Medicine, University of California at San Francisco, San Francisco, California, USA
J Card Fail 14:19-26. 2008..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study... - Cystatin C and mortality risk in the elderly: the health, aging, and body composition studyMichael G Shlipak
University of San Francisco, General Internal Medicine Section, VA Medical Center (111A1, 4150 Clement Street, San Francisco, CA 94121, USA
J Am Soc Nephrol 17:254-61. 2006..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine... - C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul StudyMary S Beattie
Department of Medicine, University of California, San Francisco, USA
Circulation 107:245-50. 2003..CONCLUSION: Elevated CRP levels are associated with inducible ischemia in patients with stable coronary disease, particularly among those not treated with beta-blockers or statins... - Regional adipose tissue and lipid and lipoprotein levels in HIV-infected womenJudith Currier
Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
J Acquir Immune Defic Syndr 48:35-43. 2008..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described... - Age-related skeletal muscle decline is similar in HIV-infected and uninfected individualsKevin E Yarasheski
Department of Medicine, Washington University, St Louis, Missouri, USA
J Gerontol A Biol Sci Med Sci 66:332-40. 2011..We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls... - Association of HIV infection and HIV/HCV coinfection with C-reactive protein levels: the fat redistribution and metabolic change in HIV infection (FRAM) studyJason Reingold
University of California, San Francisco, San Francisco, CA, USA
J Acquir Immune Defic Syndr 48:142-8. 2008..We evaluated C-reactive protein (CRP) in HIV-infected and HIV/HCV-coinfected individuals in the era of effective antiretroviral (ARV) therapy... - Racial and ethnic differences in kidney function decline among persons without chronic kidney diseaseCarmen A Peralta
Department of Medicine, University of California San Francisco, San Francisco, California 94121, USA
J Am Soc Nephrol 22:1327-34. 2011..Traditional risk factors do not explain these differences fully, highlighting the need to explore these disparities... - Cystatin C and carotid intima-media thickness in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA)Anh L Bui
Department of Medicine, University of California, San Francisco, CA, USA
Am J Kidney Dis 53:389-98. 2009..We therefore explored whether serum cystatin C level is associated with carotid intima-media thickness (IMT) in ambulatory adults without clinical heart disease... - Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected personsANDY CHOI
University of California, San Francisco, CA, USA
Am J Kidney Dis 56:872-82. 2010..However, the clinical importance of increased cystatin C level and albuminuria in the HIV-infected population has not been studied... - Risk factors and secondary prevention in women with heart disease: the Heart and Estrogen/progestin Replacement StudyEric Vittinghoff
University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, 74 New Montgomery, Suite 600, San Francisco, California 94105, USA
Ann Intern Med 138:81-9. 2003..Established drugs for secondary prevention, including aspirin, beta-blockers, and lipid-lowering agents, are underused in these women, especially those at highest risk... - Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, CA, USA
Nephrol Dial Transplant 25:993-7. 2010..The threshold of CKD or albuminuria at which FGF-23 begins to change is unknown... - Filtration markers may have prognostic value independent of glomerular filtration rateNavdeep Tangri
Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
J Am Soc Nephrol 23:351-9. 2012..trace protein and cystatin C seem to provide more consistent prognostic information than creatinine... - Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of AtherosclerosisRuth Dubin
Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, CA, USA
Nephrol Dial Transplant 26:1903-8. 2011..Pentraxin-3 (PTX3), an inflammatory marker thought to be related to vascular inflammation, is elevated in advanced chronic kidney disease (CKD). Whether PTX3 is associated with mild to moderate kidney dysfunction is unknown... - Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM studyMichelle C Odden
Department of Medicine, San FranciscoVeterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
Arch Intern Med 167:2213-9. 2007..Cystatin C measurement may be more sensitive than creatinine for detecting impaired kidney function in persons with HIV... - Relationship between hepatitis C and chronic kidney disease: results from the Third National Health and Nutrition Examination SurveyJudith I Tsui
General Internal Medicine, Section 111A1, VA Medical Center, 4150 Clement Street, San Francisco, CA 94124, USA
J Am Soc Nephrol 17:1168-74. 2006.... - Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health StudyANN M O'HARE
Nephrology Division, Department of Medicine, and General Internal Medicine Section, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Faancisco, CA 94121, USA
Arch Intern Med 165:2666-70. 2005..The association of cystatin C, a novel marker of renal function, with risk for developing complications related to peripheral arterial disease (PAD) has not been examined... - Association of chronic kidney disease with clinical outcomes after coronary revascularization: the Arterial Revascularization Therapies Study (ARTS)Joachim H Ix
Department of Medicine, University of California, San Francisco, Calif, USA
Am Heart J 149:512-9. 2005..When compared with ARTS participants with normal renal function, those with CKD had substantially elevated risk of adverse clinical outcomes after coronary revascularization... - Differences in medical care and disease outcomes among black and white women with heart diseaseAshish K Jha
Division of General Medicine, San Francisco VA Medical Center, San Francisco, USA
Circulation 108:1089-94. 2003..We sought to evaluate differences in medical care and clinical outcomes among black and white women with established coronary artery disease... - Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul studyJudith I Tsui
Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine Boston Medical Center, Boston, MA 02118, USA
J Card Fail 15:451-6. 2009..How hepatitis C virus (HCV) affects coronary heart disease (CHD) risk factors and outcomes is largely unknown... - HIV viremia and changes in kidney functionChris T Longenecker
University of California, San Francisco, California 94121, USA
AIDS 23:1089-96. 2009..To evaluate the effect of HIV infection on longitudinal changes in kidney function and to identify independent predictors of kidney function changes in HIV-infected individuals... - Fetuin-A and incident diabetes mellitus in older personsJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
JAMA 300:182-8. 2008..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown... - Association of antihypertensive therapy and diastolic hypotension in chronic kidney diseaseCarmen A Peralta
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, CA 94121, USA
Hypertension 50:474-80. 2007..Given recent evidence suggesting adverse effects of diastolic hypotension, these results suggest potential risks in patients with CKD from aggressive attempts to control systolic blood pressure... - Association of anemia with diastolic dysfunction among patients with coronary artery disease in the Heart and Soul StudyDeepu Nair
Department of Department of Medicine, University of California, San Francisco, California, USA
Am J Cardiol 95:332-6. 2005..6, 95% CI 0.6 to 4.6) were not significantly associated with LVH. We found anemia to be strongly associated with diastolic dysfunction but not with LVH in this community-based sample of outpatients who had established coronary disease... - Observational research databases in renal diseaseMichael Shlipak
General Internal Medicine Section, Veterans Affairs Medical Center, and Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California, USA
J Am Soc Nephrol 16:3477-84. 2005..This review summarizes the types of research analyses that can be conducted using existing databases, the types of research databases available, and a general approach for addressing a proposed research question using existing data... - Blood pressure components and end-stage renal disease in persons with chronic kidney disease: the Kidney Early Evaluation Program (KEEP)Carmen A Peralta
Department of Medicine, San Francisco VA Medical Center, San Francisco, California, USA
Arch Intern Med 172:41-7. 2012..Treatment of hypertension is difficult in chronic kidney disease (CKD), and blood pressure goals remain controversial. The association between each blood pressure component and end-stage renal disease (ESRD) risk is less well known... - HIV-infected persons continue to lose kidney function despite successful antiretroviral therapyAndy I Choi
Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
AIDS 23:2143-9. 2009..To identify risk factors associated with kidney function decline in a contemporary cohort of treated and untreated HIV-infected patients... - Race differences in prevalence of chronic kidney disease among young adults using creatinine-based glomerular filtration rate-estimating equationsCarmen A Peralta
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Nephrol Dial Transplant 25:3934-9. 2010..Current creatinine-based glomerular filtration rate (GFR)-estimating equations may misclassify young, healthy blacks... - Cystatin C and the risk of death and cardiovascular events among elderly personsMichael G Shlipak
General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
N Engl J Med 352:2049-60. 2005..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community... - The differential association of kidney dysfunction with small and large arterial elasticity: the multiethnic study of atherosclerosisCarmen A Peralta
General Internal Medicine Section 111A1, Veterans Affairs Medical Center, San Francisco, CA 94124, USA
Am J Epidemiol 169:740-8. 2009..26, 0.48, 0.45). Early kidney dysfunction is significantly associated with decreased arterial elasticity in smaller arteries and, to a lesser degree, in larger arteries... - Risk factors for chronic kidney disease among American Indians and Alaska Natives--findings from the Kidney Early Evaluation ProgramStacey E Jolly
General Internal Medicine Division, University of California San Francisco, San Francisco, CA 94143, USA
Am J Nephrol 29:440-6. 2009..Less is known about chronic kidney disease (CKD) among AIAN and whether risk factors differ for low estimated glomerular filtration rate (eGFR) versus albuminuria with a normal eGFR... - Cardiovascular disease risk status in elderly persons with renal insufficiencyMichael G Shlipak
General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
Kidney Int 62:997-1004. 2002..We determined the prevalence of elevated cardiovascular disease risk status among elderly persons with renal insufficiency... - The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) StudyCarmen A Peralta
Department of Medicine, University of California San Francisco, USA
Am J Nephrol 31:202-8. 2010..05 (4.81-17.02) for black men with >80% African ancestry. Genetic factors common to African ancestry may be associated with increased risk of early kidney dysfunction in a young, healthy population, particularly among black men... - Effect of hormone therapy on mortality rates among women with heart failure and coronary artery diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
Am J Cardiol 95:289-91. 2005..Over the 4.1-year follow-up, estrogen plus progestin use had no effect on all-cause mortality (hazard ratio 1.0, 95% confidence interval 0.7 to 1.4, p = 0.8) in women with heart failure and coronary disease... - Association between kidney function and albuminuria with cardiovascular events in HIV-infected personsAndy I Choi
Department of Medicine, San Francisco Veterans Affairs Medical Center, and University of California, San Francisco, USA
Circulation 121:651-8. 2010..We examined the association between longitudinal measures of kidney function and albuminuria with risk of atherosclerotic CVD and heart failure in a contemporary cohort of HIV-infected individuals... - The relative safety of ephedra compared with other herbal productsStephen Bent
Osher Center for Integrative Medicine at the University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, 111 A1, 4150 Clement Street, San Francisco, California 94121, USA
Ann Intern Med 138:468-71. 2003..Ephedra is widely used in dietary supplements that are marketed to promote weight loss or increase energy; however, the safety of this product has been questioned because of numerous case reports of adverse events... - Pharmacotherapy for heart failure in patients with renal insufficiencyMichael G Shlipak
Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
Ann Intern Med 138:917-24. 2003..Future clinical trials in heart failure should include a representative number of patients with renal insufficiency to improve the evidence base and outcomes in this vulnerable population... - Fracture and the risk of coronary events in women with heart diseasePaul D Varosy
Department of Medicine, University of California, San Francisco 94143 0124, USA
Am J Med 115:196-202. 2003..Osteoporosis is associated with aortic calcification and cardiovascular mortality. However, whether skeletal fractures predict the risk of coronary events is unknown... - Association of total and central obesity with mortality in postmenopausal women with coronary heart diseaseAlka M Kanaya
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 64115, USA
Am J Epidemiol 158:1161-70. 2003.... - Creatinine levels and cardiovascular events in women with heart disease: do small changes matter?Michael G Shlipak
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Am J Kidney Dis 43:37-44. 2004.... - Chronic renal insufficiency and cardiovascular events in the elderly: findings from the Cardiovascular Health StudyMichael G Shlipak
General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Am J Geriatr Cardiol 13:81-90. 2004..The identification of CRI in the elderly and the use of cardiovascular prevention therapies represent a major opportunity to reduce their burden of cardiovascular morbidity... - The presence of frailty in elderly persons with chronic renal insufficiencyMichael G Shlipak
Epidemiology and Biostatistics, University of California, San Francisco, General Internal Medicine Section, Medical Service, San Francisco Veterans Affairs Medical Center San Francisco, CA 94121, USA
Am J Kidney Dis 43:861-7. 2004..We hypothesized that chronic renal insufficiency (CRI) would be associated with a greater prevalence of frailty and disability in the elderly... - The incidence of end-stage renal disease is increasing faster than the prevalence of chronic renal insufficiencyChi yuan Hsu
University of California, San Francisco, San Francisco, California 94143 0532, USA
Ann Intern Med 141:95-101. 2004..The steady increase in end-stage renal disease (ESRD) incidence is a worldwide public health crisis... - Predictors of heart failure among women with coronary diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143 1364, USA
Circulation 110:1424-30. 2004..We determined the risk factors for developing heart failure among postmenopausal women with established coronary disease... - Long-term clinical consequences of acute kidney injury in the HIV-infectedAndy I Choi
Department of Medicine, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Kidney Int 78:478-85. 2010..Additionally, AKI affected almost one of six patients with HIV who survived at least 90 days following discharge... - Clinician awareness of adherence to hypertension guidelinesMichael A Steinman
Division of Geriatrics, San Francisco VA Medical Center and the University of California, San Francisco 94121, USA
Am J Med 117:747-54. 2004..We compared clinicians' beliefs about their adherence to hypertension guidelines with data on their actual performance... - Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive studyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
J Am Geriatr Soc 58:338-45. 2010.... - Cystatin C as a marker of cognitive function in elders: findings from the health ABC studyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
Ann Neurol 63:798-802. 2008..92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15)... - Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health StudyANN M O'HARE
Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
Circulation 113:388-93. 2006..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population... - Association of hepatitis C seropositivity with increased risk for developing end-stage renal diseaseJudith I Tsui
Department of Medicine, University of California, San Francisco, and San Francisco General Hospital, CA 94124, USA
Arch Intern Med 167:1271-6. 2007..We undertook this study to determine whether having a positive HCV test result was associated with an increased risk for developing treated end-stage renal disease (ESRD)... - Lipid changes on hormone therapy and coronary heart disease events in the Heart and Estrogen/progestin Replacement Study (HERS)Michael G Shlipak
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA
Am Heart J 146:870-5. 2003..To explore possible mechanisms, we examined the association between lipid changes and CHD outcomes among women assigned to hormone therapy... - Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
Circulation 113:1760-7. 2006..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease... - Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143-0532, USA
J Card Fail 12:601-7. 2006..83; 95% CI 0.75 to 4.46; P = .15). CONCLUSION: Higher cystatin C concentrations are strongly associated with left ventricular hypertrophy and diastolic dysfunction in outpatients with coronary artery disease and without heart failure... - Cystatin-C and inflammatory markers in the ambulatory elderlyMichael G Shlipak
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, Calif 94121, USA
Am J Med 118:1416. 2005..We compared cystatin-C, a novel marker of renal function, with creatinine and estimated glomerular filtration rate (eGFR) as predictors of C-reactive protein and fibrinogen levels... - Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul StudyCarmen A Peralta
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco, California 94124, USA
Am J Hypertens 19:939-46. 2006..Whether kidney function in the normal range is associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure is unclear... - Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition StudyKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, CA 94143 1364, USA
Arch Intern Med 166:1396-402. 2006..Our objective was to determine whether the association of chronic kidney disease with incident heart failure differs between blacks and whites... - Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)Joachim H Ix
Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
Am J Kidney Dis 50:412-20. 2007..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain... - Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California at San Francisco, San Francisco, CA 94143 0532, USA
Circulation 115:173-9. 2007..Cystatin C is a novel and sensitive endogenous marker of kidney function. Whether cystatin C concentrations are associated with adverse events among ambulatory persons with CHD is unknown... - Measured GFR does not outperform estimated GFR in predicting CKD-related complicationsChi yuan Hsu
Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
J Am Soc Nephrol 22:1931-7. 2011..These results raise questions regarding the conventional view that iGFR is the "gold standard" measure of kidney function... - Fat distribution in men with HIV infectionPeter Bacchetti
University of California, San Francisco Veterans Affairs Medical Center, Metabolism Section, 94121, USA
J Acquir Immune Defic Syndr 40:121-31. 2005..CONCLUSION: Both peripheral and central subcutaneous lipoatrophy was found in HIV infection. Lipoatrophy in HIV-positive men is not associated with reciprocally increased VAT... - Cystatin C as a risk factor for outcomes in chronic kidney diseaseVandana Menon
Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Ann Intern Med 147:19-27. 2007.... - The clinical challenge of cardiorenal syndromeMichael G Shlipak
Circulation 110:1514-7. 2004 - Association between anaemia and N-terminal pro-B-type natriuretic peptide (NT-proBNP): findings from the Heart and Soul StudyArati S Desai
Department of Medicine, Johns Hopkins University, United States
Eur J Heart Fail 9:886-91. 2007..Anaemia is associated with elevated levels of natriuretic peptides. Whether the association of anaemia with natriuretic peptides is independent of other cardiovascular risk factors is unclear... - Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched studyAli Ahmed
University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Cardiol 99:393-8. 2007..Patients with diastolic HF should be evaluated for CKD, and the role of inhibitors of the renin-angiotensin system in these patients needs to be investigated... - Renal function and risk of hip and vertebral fractures in older womenKristine E Ensrud
Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
Arch Intern Med 167:133-9. 2007..An increased rate of hip fractures has been reported in patients with end-stage renal disease, but the effect of less severe renal dysfunction on fracture risk is uncertain... - Microalbuminuria in HIV infectionLynda Anne Szczech
Duke University Medical Center, Department of Medicine, Division of Nephrology, Durham, North Carolina, USA
AIDS 21:1003-9. 2007..Microalbuminuria is associated with increased risk of cardiovascular disease and mortality. The objective of the study was to evaluate if HIV infection was an independent risk factor for microalbuminuria... - Renal impairment and outcomes in heart failure: systematic review and meta-analysisGrace L Smith
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Am Coll Cardiol 47:1987-96. 2006..CONCLUSIONS: Renal impairment is common among HF patients and confers excess mortality. Renal function should be considered in risk stratification and evaluation of therapeutic strategies for HF patients... - Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) StudyAlan S Go
Division of Research, Kaiser Permanente of Northern California, 2000 Broadway St, 3rd Floor, Oakland, California 94612 2304, USA
Circulation 113:2713-23. 2006..It is unclear, however, whether this relation is explained by underlying kidney disease, treatment differences, or associated comorbidity... - Cystatin C: research priorities targeted to clinical decision makingMichael G Shlipak
Am J Kidney Dis 51:358-61. 2008 - Racial and sex differences in refusal of coronary angiographyPaul A Heidenreich
Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Am J Med 113:200-7. 2002..To determine the effect of patient refusal on racial and sex differences in the use of coronary angiography and in outcomes among elderly patients with acute myocardial infarction... - Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA)Ian H De Boer
Division of Nephrology, University of Washington, Seattle, WA 98195, USA
Atherosclerosis 197:407-14. 2008.... - Kidney function, electrocardiographic findings, and cardiovascular events among older adultsBryan Kestenbaum
Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
Clin J Am Soc Nephrol 2:501-8. 2007..Associations seemed stronger for participants with CKD; however, no significant interactions were detected. Resting electrocardiographic abnormalities are common in CKD and independently predict future clinical CV events in this setting... - Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosisBryan Kestenbaum
University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
Ann Intern Med 148:501-8. 2008..Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated... - Trends in mineral metabolism: Kidney Early Evaluation Program (KEEP) and the National Health and Nutrition Examination Survey (NHANES) 1999-2004Joseph A Vassalotti
National Kidney Foundation, Mount Sinai School of Medicine, One Gustave L Levy Pl, Nephrology Box 1243, New York, NY 10029 6574, USA
Am J Kidney Dis 51:S56-68. 2008..No study specifically examined mineral metabolism trends in a generalizable sample of patients at increased CKD risk... - Cystatin-C, renal function, and incidence of hip fracture in postmenopausal womenAndrea Z LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Am Geriatr Soc 56:1434-41. 2008..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass... - Kidney function as a predictor of noncardiovascular mortalityLinda F Fried
VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
J Am Soc Nephrol 16:3728-35. 2005..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease...
Research Grants
- Elucidating the Kidney's Role in Cardiovascular RiskMichael Shlipak; Fiscal Year: 2004....
- Heart Failure Incidence and Progression in Renal DiseaseMichael Shlipak; Fiscal Year: 2007..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
- The Aging Kidney in HIV-Infection: biomarkers for early detection of injuryMichael G Shlipak; Fiscal Year: 2010....