PAULA SHIREMAN

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones
    Matthew J McHale
    Department of Surgery, University of Texas Health Science Center, San Antonio, USA
    Am J Physiol Regul Integr Comp Physiol 302:R331-9. 2012
  2. pmc Reproducibility of quantitative RT-PCR array in miRNA expression profiling and comparison with microarray analysis
    Yongxin Chen
    Department of Surgery, University of Texas Health Science Center, San Antonio, TX 78229, USA
    BMC Genomics 10:407. 2009
  3. pmc The chemokine system in arteriogenesis and hind limb ischemia
    Paula K Shireman
    South Texas Veterans Health Care System, Department of Surgery, Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA
    J Vasc Surg 45:A48-56. 2007
  4. ncbi request reprint MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration
    Paula K Shireman
    Department of Surgery, University of Texas Health Science Center, MC 7741, San Antonio, TX 78229 3900, USA
    J Leukoc Biol 81:775-85. 2007
  5. ncbi request reprint MCP-1 parallels inflammatory and regenerative responses in ischemic muscle
    Paula K Shireman
    South Texas Veterans Health Care System, San Antonio, TX 78229 3900, USA
    J Surg Res 134:145-57. 2006
  6. ncbi request reprint Differential necrosis despite similar perfusion in mouse strains after ischemia
    Paula K Shireman
    The South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Surg Res 129:242-50. 2005
  7. ncbi request reprint Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury
    Veronica Contreras-Shannon
    Univ of Texas Health Science Center, 7703 Floyd Curl Dr, MC 7741, San Antonio, TX 78229 3900, USA
    Am J Physiol Cell Physiol 292:C953-67. 2007
  8. pmc Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment
    Carlo O Martinez
    Department of Surgery, The University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    Am J Physiol Regul Integr Comp Physiol 299:R832-42. 2010
  9. ncbi request reprint Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration
    Oscar Ochoa
    Department of Surgery, University of Texas Health Science Center, San Antonio, TX, USA
    Am J Physiol Regul Integr Comp Physiol 293:R651-61. 2007
  10. ncbi request reprint Duplex screening for asymptomatic carotid artery disease in Hispanic diabetic patients undergoing lower extremity revascularization: is it a worthwhile endeavor?
    W Tracey Jones
    Division of Vascular Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Tex Med 99:50-3. 2003

Research Grants

  1. Chemokines and Immune Cells in Hind Limb Ischemia
    PAULA SHIREMAN; Fiscal Year: 2009
  2. Chemokines and Immune Cells in Hind Limb Ischemia
    PAULA SHIREMAN; Fiscal Year: 2006
  3. The Chemokine System in Collateral Artery Formation
    PAULA SHIREMAN; Fiscal Year: 2006
  4. Chemokines and Immune Cells in Hind Limb Ischemia
    Paula K Shireman; Fiscal Year: 2010

Collaborators

  • Linda M McManus
  • B Toursarkissian
  • Dongxu Sun
  • Ryan T Hagino
  • Wei Zheng
  • William A Kuziel
  • Jonathan A L Gelfond
  • Yongxin Chen
  • Joel E Michalek
  • Oscar Ochoa
  • Carlo O Martinez
  • Suresh I Prajapati
  • Matthew J McHale
  • Charles Keller
  • Veronica Contreras-Shannon
  • Sara M Reyes-Reyna
  • Anson P Pierce
  • Javier La Fontaine
  • Sukkyoo Lee
  • W Tracey Jones
  • Laurel Porter
  • Zaheer U Sarwar
  • Anna S Salinas
  • Damon P Cardenas
  • Brian P Rubin
  • Jinu Abraham
  • Jason T Wells
  • Amanda T McCleish
  • Ali N Bahadur
  • James D Lechleiter
  • Isabel Q Wu
  • Gary B Chisholm
  • Francis M Torres
  • Eric De Waal
  • Lindsay L Waite
  • Asish R Chaudhuri
  • H Stella Shin
  • Marque A Allen
  • Christian E Davis
  • Holly Van Remmen
  • Marie E Csete
  • Aphrodite Vasilaki
  • Lawrence B Harkless
  • Marcus Dayala
  • John Schoolfield

Detail Information

Publications24

  1. pmc Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones
    Matthew J McHale
    Department of Surgery, University of Texas Health Science Center, San Antonio, USA
    Am J Physiol Regul Integr Comp Physiol 302:R331-9. 2012
    ..Recovery following muscle injury was different between males and females, and sex-specific hormones contributed to these differences, suggesting that sex-specific treatments could be beneficial after injury...
  2. pmc Reproducibility of quantitative RT-PCR array in miRNA expression profiling and comparison with microarray analysis
    Yongxin Chen
    Department of Surgery, University of Texas Health Science Center, San Antonio, TX 78229, USA
    BMC Genomics 10:407. 2009
    ..Our study critically evaluated the performance of a novel miRNA expression profiling approach, quantitative RT-PCR array (qPCR-array), compared to miRNA detection with oligonucleotide microchip (microarray)...
  3. pmc The chemokine system in arteriogenesis and hind limb ischemia
    Paula K Shireman
    South Texas Veterans Health Care System, Department of Surgery, Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA
    J Vasc Surg 45:A48-56. 2007
    ..Special emphasis will be placed on the roles of monocytes/macrophages and CCL2/monocyte chemotactic protein-1 (MCP-1) in these processes...
  4. ncbi request reprint MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration
    Paula K Shireman
    Department of Surgery, University of Texas Health Science Center, MC 7741, San Antonio, TX 78229 3900, USA
    J Leukoc Biol 81:775-85. 2007
    ..Impaired muscle regeneration in MCP-1-/- mice suggests an important role for macrophages and MCP-1 in tissue reparative processes...
  5. ncbi request reprint MCP-1 parallels inflammatory and regenerative responses in ischemic muscle
    Paula K Shireman
    South Texas Veterans Health Care System, San Antonio, TX 78229 3900, USA
    J Surg Res 134:145-57. 2006
    ..However, the magnitude and temporal sequence of MCP-1 expression in relation to tissue injury and regeneration following ischemic injury remains unknown...
  6. ncbi request reprint Differential necrosis despite similar perfusion in mouse strains after ischemia
    Paula K Shireman
    The South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Surg Res 129:242-50. 2005
    ..We have comprehensively characterized the mouse hind limb ischemia model and determined how different genetic backgrounds of mice affect recovery...
  7. ncbi request reprint Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury
    Veronica Contreras-Shannon
    Univ of Texas Health Science Center, 7703 Floyd Curl Dr, MC 7741, San Antonio, TX 78229 3900, USA
    Am J Physiol Cell Physiol 292:C953-67. 2007
    ....
  8. pmc Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment
    Carlo O Martinez
    Department of Surgery, The University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    Am J Physiol Regul Integr Comp Physiol 299:R832-42. 2010
    ..muscle regeneration. Finally, other chemokines, in addition to MCP-1 and MCP-5, may activate CCR2-dependent regenerative processes resulting in an intermediate phenotype in MCP-1-/- mice...
  9. ncbi request reprint Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration
    Oscar Ochoa
    Department of Surgery, University of Texas Health Science Center, San Antonio, TX, USA
    Am J Physiol Regul Integr Comp Physiol 293:R651-61. 2007
    ..Thus CCR2-dependent events in injured skeletal muscle, including impaired macrophage recruitment, contribute to restoration of tissue VEGF levels and the dynamic processes of capillary formation and muscle regeneration...
  10. ncbi request reprint Duplex screening for asymptomatic carotid artery disease in Hispanic diabetic patients undergoing lower extremity revascularization: is it a worthwhile endeavor?
    W Tracey Jones
    Division of Vascular Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Tex Med 99:50-3. 2003
    ..However, screening in older patients is recommended to identify persons with moderate stenosis (peak systolic velocity greater than 175 cm/sec) whose disease is more likely to progress...
  11. ncbi request reprint Does lower limb revascularization result in an improvement in sensory perception thresholds?
    Boulos Toursarkissian
    Section of Vascular Surgery, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Ann Vasc Surg 16:309-13. 2002
    ..It may, however, prevent further degradation. The degree of preoperative neuropathy does not affect outcome in terms of limb salvage...
  12. ncbi request reprint Does the efficacy of dorsalis pedis artery bypasses vary among diabetic patients of different ethnic backgrounds?
    Boulos Toursarkissian
    Section of Vascular Surgery, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Vasc Endovascular Surg 36:207-12. 2002
    ..The usefulness of duplex-derived flow velocities in the dorsalis pedis to predict long-term graft patency warrants further investigation...
  13. ncbi request reprint Early duplex-derived hemodynamic parameters after lower extremity bypass in diabetics: implications for mid-term outcomes
    Boulos Toursarkissian
    Division of Vascular Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Ann Vasc Surg 16:601-7. 2002
    ..04; DG 43% vs. 8% limb loss, p <0.04). We conclude that intensive graft duplex surveillance does not identify grafts likely to develop stenoses. However, a number of features allow the prediction of ultimate graft failure or limb loss...
  14. ncbi request reprint Angiographic scoring of vascular occlusive disease in the diabetic foot: relevance to bypass graft patency and limb salvage
    Boulos Toursarkissian
    Section of Vascular Surgery, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Vasc Surg 35:494-500. 2002
    ..We graded the severity of occlusive disease in foot vessels of patients with diabetes and correlated the scoring obtained with graft patency and limb salvage...
  15. ncbi request reprint Healing of transmetatarsal amputation in the diabetic patient: is angiography predictive?
    Boulos Toursarkissian
    Division of Vascular Surgery, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Ann Vasc Surg 19:769-73. 2005
    ..TMA healing can be expected in a majority of diabetic patients after adequate revascularization but cannot be predicted by angiographic findings. Efforts should be made to achieve primary wound closure...
  16. ncbi request reprint Outcomes following distal bypass graft occlusion in diabetics
    Boulos Toursarkissian
    Division of Vascular Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Ann Vasc Surg 17:670-5. 2003
    ..Limb loss following primary distal bypass failure in diabetics is high. Repeat interventions have limited success. The findings justify aggressive programs of graft maintenance, and vigorous attempts at early closure of foot wounds...
  17. pmc Bone marrow-derived cell regulation of skeletal muscle regeneration
    Dongxu Sun
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas, USA
    FASEB J 23:382-95. 2009
    ..Future studies in regenerative medicine must include consideration of the role of BM-derived cells, possibly macrophages, in CCR2-dependent events that regulate effective skeletal muscle regeneration...
  18. ncbi request reprint Oxidation and structural perturbation of redox-sensitive enzymes in injured skeletal muscle
    Anson P Pierce
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 43:1584-93. 2007
    ....
  19. ncbi request reprint Current concepts in diabetic microvascular dysfunction
    Javier La Fontaine
    Department of Orthopedics, Podiatry Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Am Podiatr Med Assoc 96:245-52. 2006
    ..These late-term complications are primarily disorders of the vascular system. This article reviews the process of microvascular dysfunction and how it may relate to the pathogenesis of diabetic foot problems...
  20. ncbi request reprint Major lower-extremity amputation: contemporary experience in a single Veterans Affairs institution
    Boulos Toursarkissian
    Section of Vascular Surgery, Audie Murphy Veterans Hospital, San Antonio, Texas, USA
    Am Surg 68:606-10. 2002
    ..One-year mortality is high. Low rehabilitation rates especially in dialysis patients mandate further efforts in this regard. Vigilant follow-up of the contralateral limb is essential...
  21. ncbi request reprint Chemokines and diabetic wound healing
    Oscar Ochoa
    Department of Surgery, University of Texas Health Science Center, San Antonio TX 78229 3900, USA
    Vascular 15:350-5. 2007
    ..The potential roles of chemokines and inflammatory or immune cells in nonhealing diabetic wounds, including impairments in growth factor expression, angiogenesis, extracellular matrix formation, and reepithelialization, are examined...
  22. pmc Near-infrared imaging of injured tissue in living subjects using IR-820
    Suresh I Prajapati
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX, USA
    Mol Imaging 8:45-54. 2009
    ..IR-820 can also be employed to map regional lymph nodes. This novel contrast agent is anticipated to be a useful and an inexpensive tool for screening a wide variety of preclinical models of human diseases...
  23. pmc Crimson carrier, a long-acting contrast agent for in vivo near-infrared imaging of injured and diseased muscle
    Suresh I Prajapati
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Muscle Nerve 42:245-51. 2010
    ..The unique long-acting pharmacokinetics and urinary excretion route characteristics make crimson carrier a contrast agent of choice for the visualization of tumors and injured muscle or other tissues in live animal studies...
  24. ncbi request reprint Glutathione-peroxidase-1 null muscle progenitor cells are globally defective
    Sukkyoo Lee
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30333, USA
    Free Radic Biol Med 41:1174-84. 2006
    ....

Research Grants11

  1. Chemokines and Immune Cells in Hind Limb Ischemia
    PAULA SHIREMAN; Fiscal Year: 2009
    ..A better understanding of how new blood vessels help muscle recover from injury could lead to new therapies, including tissue engineering strategies, to help patients recover from these devastating injuries. ..
  2. Chemokines and Immune Cells in Hind Limb Ischemia
    PAULA SHIREMAN; Fiscal Year: 2006
    ..abstract_text> ..
  3. The Chemokine System in Collateral Artery Formation
    PAULA SHIREMAN; Fiscal Year: 2006
    ..These investigations, under the guidance of my mentors and coupled with the courses and seminars in this proposal will substantially broaden my scientific experience to allow me to become an independent scientist. ..
  4. Chemokines and Immune Cells in Hind Limb Ischemia
    Paula K Shireman; Fiscal Year: 2010
    ..A better understanding of how new blood vessels help muscle recover from injury could lead to new therapies, including tissue engineering strategies, to help patients recover from these devastating injuries. ..