Research Topics
| Bruce T ShiramizuSummaryAffiliation: University of Hawaii Country: USA Publications
Research Grants
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Detail Information
Publications
HIV proviral DNA associated with decreased neuropsychological functionBruce Shiramizu
University of Hawaii, John A Burns School of Medicine, Hawaii AIDS Clinical Research Program, 3675 Kilauea Avenue, Young Building, 5th Floor, Honolulu, HI 96816, USA
J Neuropsychiatry Clin Neurosci 19:157-63. 2007..However, HIV DNA did not predict future changes in neuropsychological deficits. The data suggest that HIV DNA and neuropsychological deficits may co-vary over time...- Presence of high-risk human papillomavirus genotype and human immunodeficiency virus DNA in anal high-grade and low-grade squamous intraepithelial lesionsBruce Shiramizu
University of Hawaii, Hawaii Center of AIDS, Honolulu, HI 96813, USA
AIDS Res Hum Retroviruses 29:178-81. 2013..30, p=0.28), which did not change when adjusted for nadir CD4 cell count and HIV RNA levels. The findings warrant further investigation of HIV DNA and its relationship with HPV in LGSIL/HGSIL pathogenesis... - Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapyB Shiramizu
Hawaii Center for AIDS, University of Hawaii Manoa, Honolulu, HI, USA
J Neurovirol 18:69-73. 2012..5 years. These findings suggest that antiviral strategies may need to target intra-monocyte HIV DNA... - Minimal disease assessment in the treatment of children and adolescents with intermediate-risk (Stage III/IV) B-cell non-Hodgkin lymphoma: a children's oncology group reportBruce Shiramizu
University of Hawaii John A Burns School of Medicine, 3675 Kilauea Ave, Honolulu, HI 96816, USA
Br J Haematol 153:758-63. 2011..This feasibility study supports future investigations to assess the validity and significance of MD screening in a larger cohort of patients with intermediate-risk mature B-NHL... - Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disordersBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
J Neuropsychiatry Clin Neurosci 21:68-74. 2009..These findings demonstrate for the first time that the severity of HIV-1-associated neurocognitive disorders is proportional to the amount of circulating HIV DNA... 
HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, ThailandBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
Int J Med Sci 4:13-8. 2007..These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD...
Feasibility assessment of cerebrospinal fluid from HIV-1-infected children for HIV proviral DNA and monocyte chemoattractant protein 1 allelesBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI
J Investig Med 54:468-72. 2006..This study demonstrates, for the first time, that CSF HIV DNA and MCP1 SNP can be measured and could be potential tools in future clinical studies to understand the pathogenesis of pediatric HAE...- Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: a Children's Cancer Group Lymphoma Biology StudyB Shiramizu
University of Hawaii, Honolulu, USA
J Pediatr Hematol Oncol 23:282-5. 2001..Because primary infection occurs in children, a prospective study was undertaken to detect HHV6 in those with pediatric Hodgkin disease (HD)... - Assessing immunoglobulin heavy chain rearrangements in pediatric CD20-positive and CD20-negative classic Hodgkin's diseaseBruce Shiramizu
University of Hawaii, Honolulu, Hawaii, USA
Clin Lymphoma 5:184-9. 2004..Unique PSPs could be used to assess MRD in advanced-stage HD specimens. Future studies should focus on improved detection and analysis of more cases to identify appropriate specimens in assessing clinical implications of MRD detection... - Circulating proviral HIV DNA and HIV-associated dementiaBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
AIDS 19:45-52. 2005..To determine if HAD is associated with the level of HIV-1 infection within circulating leukocytes, we quantified HIV-1 DNA copy number in peripheral blood mononuclear cells (PBMC), and in PBMC subsets... - Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemiaBruce Shiramizu
Retrovirology Research Laboratory, Pacific Biomedical Research Center, Honolulu, Hawaii 92818, USA
Pediatr Hematol Oncol 19:543-51. 2002..However, the data support TTV transmission through blood products and suggest that the CNS is not a sanctuary site for TTV... - Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancyBruce Shiramizu
University of Hawaii, Honolulu, Hawii, USA
J Acquir Immune Defic Syndr 32:370-4. 2003..Further studies are needed to better understand the morbidity to infants and mothers treated with NRTI to prevent vertical transmission of HIV... - Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reactionBruce Shiramizu
University of Hawaii John A Burns School of Medicine, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
Front Biosci 9:255-61. 2004..From selected cases with relatively high HIV-1 DNA copies/cell, inverse PCR successfully identified viral integration. This type of assay could facilitate further studies when relatively high viral copies/cell are needed for screening... - Epigenetic changes in the DAP-kinase CpG island in pediatric lymphomaBruce Shiramizu
Departments of Pediatrics and Medicine, John A Burns School of Medicine, Pacific Biomedical Research Center, University of Hawaii, Honolulu, USA
Med Pediatr Oncol 41:527-31. 2003..The purpose of this study was to elucidate epigenetic changes in the DAP-kinase promoter region of pediatric cases to determine associations with aberrant hypermethylation... - Correlation of single photon emission computed tomography parameters as a noninvasive alternative to liver biopsies in assessing liver involvement in the setting of HIV and hepatitis C virus coinfection: a multicenter trial of the Adult AIDS Clinical TriaBruce Shiramizu
University of Hawaii, Honolulu, Hawaii 96816, USA
J Acquir Immune Defic Syndr 33:329-35. 2003..A larger study is needed to demonstrate whether SPECT parameters alone or with other markers can provide information on fibrosis with the clinical significance obtained through liver biopsy... - Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohortVictor G Valcour
Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
J Acquir Immune Defic Syndr 43:405-10. 2006..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk... 
Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok ThailandSilvia Ratto-Kim
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
J Neuroimmunol 195:100-7. 2008..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts...- HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complicationsVictor G Valcour
Hawaii Center for AIDS, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
J Leukoc Biol 87:621-6. 2010..Herein, we summarize our current understanding of monocyte HIV DNA and central nervous system dysfunction in humans. We present a model to understand these relationships and suggest possible treatment approaches to be tested... - Diabetes, insulin resistance, and dementia among HIV-1-infected patientsVictor G Valcour
University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
J Acquir Immune Defic Syndr 38:31-6. 2005..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection... - Pathogenesis of HIV-associated non-Hodgkin lymphomaDeirdre Killebrew
Retrovirology Research Laboratory, Leahi Hospital, Young Bldg, 5th Fl, 3675 Kilauea Ave, Honolulu, HI 96816, USA
Curr HIV Res 2:215-21. 2004..The focus of this review will be on the role viral pathogenesis plays in oncogenic transformation... - Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV CohortVictor Valcour
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
J Neurovirol 12:387-91. 2006..395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001)... - Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individualsMariana Gerschenson
Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
Antivir Ther 10:M83-9. 2005..Thigh fat mtDNA levels were 45-55% lower than abdomen and neck. These studies help demonstrate that mtDNA levels can vary in different subcutaneous adipose depots suggesting possible metabolic differences... - Short-term effects of extended-release niacin on endothelial function in HIV-infected patients on stable antiretroviral therapyDominic C Chow
Hawaii Center for AIDS, University of Hawaii John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
AIDS 24:1019-23. 2010..To assess the short-term effects of extended-release niacin (ERN) on endothelial function in HIV-infected patients with low high-density lipoprotein-cholesterol (HDL-c) levels... - HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?Cecilia M Shikuma
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
Clin Infect Dis 40:1846-8. 2005..9 vs. 0.9 copies/10(6) PBMCs; P = .006)... - TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integrationQigui Yu
Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
J Med Virol 66:276-84. 2002..Our data indicate that PBMC and PBMC subsets are not the major sites of TTV replication... - Incident neuropathy in HIV-infected patients on HAARTBeau K Nakamoto
Hawaii Center for AIDS, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
AIDS Res Hum Retroviruses 26:759-65. 2010..However, current or prior history of d-drug treatment is not a significant risk factor for incident DSP in subjects who had previously tolerated d-drug treatment without developing a toxic DSP... - Chemotoxicity recovery of mitochondria in non-Hodgkin lymphoma resulting in minimal residual diseaseIan Kusao
Department of Physiology, University of Hawaii, Honolulu, Hawaii 96816, USA
Pediatr Blood Cancer 51:193-7. 2008..This study hypothesized that the mitochondria play an important role in a cell's recovery from toxicity via a compensatory increase in mtDNA... - Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cellsNingjie Hu
Hawaii AIDS Clinical Research Program, University of Hawaii at Manoa, Leahi Hospital, Honolulu, HI 96816, USA
Vaccine 27:2994-3006. 2009....
Research Grants
- HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive FunctionBruce T Shiramizu; Fiscal Year: 2010..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
- Activated Immune Parameters Associated with HIV & AgingBruce Shiramizu; Fiscal Year: 2004....
- HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive FunctionBruce Shiramizu; Fiscal Year: 2007..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
- Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin LymphomaBruce Shiramizu; Fiscal Year: 2007..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. ..
- HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive FunctionBruce Shiramizu; Fiscal Year: 2009..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..