Bruce T Shiramizu

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. pmc HIV proviral DNA associated with decreased neuropsychological function
    Bruce Shiramizu
    University of Hawaii, John A Burns School of Medicine, Hawaii AIDS Clinical Research Program, 3675 Kilauea Avenue, Young Building, 5th Floor, Honolulu, HI 96816, USA
    J Neuropsychiatry Clin Neurosci 19:157-63. 2007
  2. pmc Screening for residual disease in pediatric burkitt lymphoma using consensus primer pools
    Melissa Agsalda
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
    Adv Hematol 2009:412163. 2009
  3. pmc Mitochondrial DNA in residual leukemia cells in cerebrospinal fluid in children with acute lymphoblastic leukemia
    Kathryn Egan
    Department of Child and Adolescent Psychiatry, Tripler Army Medical Center, Hawaii, USA
    J Clin Med Res 2:225-9. 2010
  4. pmc Presence of high-risk human papillomavirus genotype and human immunodeficiency virus DNA in anal high-grade and low-grade squamous intraepithelial lesions
    Bruce Shiramizu
    University of Hawaii, Hawaii Center of AIDS, Honolulu, HI 96813, USA
    AIDS Res Hum Retroviruses 29:178-81. 2013
  5. pmc Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapy
    B Shiramizu
    Hawaii Center for AIDS, University of Hawaii Manoa, Honolulu, HI, USA
    J Neurovirol 18:69-73. 2012
  6. pmc HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
    Int J Med Sci 4:13-8. 2007
  7. pmc Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disorders
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
    J Neuropsychiatry Clin Neurosci 21:68-74. 2009
  8. ncbi request reprint Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: a Children's Cancer Group Lymphoma Biology Study
    B Shiramizu
    University of Hawaii, Honolulu, USA
    J Pediatr Hematol Oncol 23:282-5. 2001
  9. pmc Minimal disease assessment in the treatment of children and adolescents with intermediate-risk (Stage III/IV) B-cell non-Hodgkin lymphoma: a children's oncology group report
    Bruce Shiramizu
    University of Hawaii John A Burns School of Medicine, 3675 Kilauea Ave, Honolulu, HI 96816, USA
    Br J Haematol 153:758-63. 2011
  10. ncbi request reprint Feasibility assessment of cerebrospinal fluid from HIV-1-infected children for HIV proviral DNA and monocyte chemoattractant protein 1 alleles
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI
    J Investig Med 54:468-72. 2006

Collaborators

Detail Information

Publications32

  1. pmc HIV proviral DNA associated with decreased neuropsychological function
    Bruce Shiramizu
    University of Hawaii, John A Burns School of Medicine, Hawaii AIDS Clinical Research Program, 3675 Kilauea Avenue, Young Building, 5th Floor, Honolulu, HI 96816, USA
    J Neuropsychiatry Clin Neurosci 19:157-63. 2007
    ..However, HIV DNA did not predict future changes in neuropsychological deficits. The data suggest that HIV DNA and neuropsychological deficits may co-vary over time...
  2. pmc Screening for residual disease in pediatric burkitt lymphoma using consensus primer pools
    Melissa Agsalda
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
    Adv Hematol 2009:412163. 2009
    ....
  3. pmc Mitochondrial DNA in residual leukemia cells in cerebrospinal fluid in children with acute lymphoblastic leukemia
    Kathryn Egan
    Department of Child and Adolescent Psychiatry, Tripler Army Medical Center, Hawaii, USA
    J Clin Med Res 2:225-9. 2010
    ..KEYWORDS: Minimal residual disease; Acute lymphoblastic leukemia; Central nervous system; Cerebrospinal fluid; Mitochondria...
  4. pmc Presence of high-risk human papillomavirus genotype and human immunodeficiency virus DNA in anal high-grade and low-grade squamous intraepithelial lesions
    Bruce Shiramizu
    University of Hawaii, Hawaii Center of AIDS, Honolulu, HI 96813, USA
    AIDS Res Hum Retroviruses 29:178-81. 2013
    ..30, p=0.28), which did not change when adjusted for nadir CD4 cell count and HIV RNA levels. The findings warrant further investigation of HIV DNA and its relationship with HPV in LGSIL/HGSIL pathogenesis...
  5. pmc Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapy
    B Shiramizu
    Hawaii Center for AIDS, University of Hawaii Manoa, Honolulu, HI, USA
    J Neurovirol 18:69-73. 2012
    ..5 years. These findings suggest that antiviral strategies may need to target intra-monocyte HIV DNA...
  6. pmc HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
    Int J Med Sci 4:13-8. 2007
    ..These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD...
  7. pmc Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disorders
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
    J Neuropsychiatry Clin Neurosci 21:68-74. 2009
    ..These findings demonstrate for the first time that the severity of HIV-1-associated neurocognitive disorders is proportional to the amount of circulating HIV DNA...
  8. ncbi request reprint Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: a Children's Cancer Group Lymphoma Biology Study
    B Shiramizu
    University of Hawaii, Honolulu, USA
    J Pediatr Hematol Oncol 23:282-5. 2001
    ..Because primary infection occurs in children, a prospective study was undertaken to detect HHV6 in those with pediatric Hodgkin disease (HD)...
  9. pmc Minimal disease assessment in the treatment of children and adolescents with intermediate-risk (Stage III/IV) B-cell non-Hodgkin lymphoma: a children's oncology group report
    Bruce Shiramizu
    University of Hawaii John A Burns School of Medicine, 3675 Kilauea Ave, Honolulu, HI 96816, USA
    Br J Haematol 153:758-63. 2011
    ..This feasibility study supports future investigations to assess the validity and significance of MD screening in a larger cohort of patients with intermediate-risk mature B-NHL...
  10. ncbi request reprint Feasibility assessment of cerebrospinal fluid from HIV-1-infected children for HIV proviral DNA and monocyte chemoattractant protein 1 alleles
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI
    J Investig Med 54:468-72. 2006
    ..This study demonstrates, for the first time, that CSF HIV DNA and MCP1 SNP can be measured and could be potential tools in future clinical studies to understand the pathogenesis of pediatric HAE...
  11. ncbi request reprint Assessing immunoglobulin heavy chain rearrangements in pediatric CD20-positive and CD20-negative classic Hodgkin's disease
    Bruce Shiramizu
    University of Hawaii, Honolulu, Hawaii, USA
    Clin Lymphoma 5:184-9. 2004
    ..Unique PSPs could be used to assess MRD in advanced-stage HD specimens. Future studies should focus on improved detection and analysis of more cases to identify appropriate specimens in assessing clinical implications of MRD detection...
  12. ncbi request reprint Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reaction
    Bruce Shiramizu
    University of Hawaii John A Burns School of Medicine, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    Front Biosci 9:255-61. 2004
    ..From selected cases with relatively high HIV-1 DNA copies/cell, inverse PCR successfully identified viral integration. This type of assay could facilitate further studies when relatively high viral copies/cell are needed for screening...
  13. ncbi request reprint Correlation of single photon emission computed tomography parameters as a noninvasive alternative to liver biopsies in assessing liver involvement in the setting of HIV and hepatitis C virus coinfection: a multicenter trial of the Adult AIDS Clinical Tria
    Bruce Shiramizu
    University of Hawaii, Honolulu, Hawaii 96816, USA
    J Acquir Immune Defic Syndr 33:329-35. 2003
    ..A larger study is needed to demonstrate whether SPECT parameters alone or with other markers can provide information on fibrosis with the clinical significance obtained through liver biopsy...
  14. pmc Circulating proviral HIV DNA and HIV-associated dementia
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
    AIDS 19:45-52. 2005
    ..To determine if HAD is associated with the level of HIV-1 infection within circulating leukocytes, we quantified HIV-1 DNA copy number in peripheral blood mononuclear cells (PBMC), and in PBMC subsets...
  15. ncbi request reprint Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy
    Bruce Shiramizu
    University of Hawaii, Honolulu, Hawii, USA
    J Acquir Immune Defic Syndr 32:370-4. 2003
    ..Further studies are needed to better understand the morbidity to infants and mothers treated with NRTI to prevent vertical transmission of HIV...
  16. ncbi request reprint Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia
    Bruce Shiramizu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, Honolulu, Hawaii 92818, USA
    Pediatr Hematol Oncol 19:543-51. 2002
    ..However, the data support TTV transmission through blood products and suggest that the CNS is not a sanctuary site for TTV...
  17. ncbi request reprint Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma
    Bruce Shiramizu
    Departments of Pediatrics and Medicine, John A Burns School of Medicine, Pacific Biomedical Research Center, University of Hawaii, Honolulu, USA
    Med Pediatr Oncol 41:527-31. 2003
    ..The purpose of this study was to elucidate epigenetic changes in the DAP-kinase promoter region of pediatric cases to determine associations with aberrant hypermethylation...
  18. ncbi request reprint Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohort
    Victor G Valcour
    Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Acquir Immune Defic Syndr 43:405-10. 2006
    ..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk...
  19. pmc Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand
    Silvia Ratto-Kim
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
    J Neuroimmunol 195:100-7. 2008
    ..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts...
  20. pmc HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications
    Victor G Valcour
    Hawaii Center for AIDS, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    J Leukoc Biol 87:621-6. 2010
    ..Herein, we summarize our current understanding of monocyte HIV DNA and central nervous system dysfunction in humans. We present a model to understand these relationships and suggest possible treatment approaches to be tested...
  21. pmc Diabetes, insulin resistance, and dementia among HIV-1-infected patients
    Victor G Valcour
    University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
    J Acquir Immune Defic Syndr 38:31-6. 2005
    ..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection...
  22. ncbi request reprint The role of HIV and monocytes/macrophages in adipose tissue biology
    Cecilia M Shikuma
    Departments of Medicine, Cell and Molecular Biology, Tropical Medicine, Medical Microbiology, and Pharmacology, University of Hawaii, Honolulu, HI
    J Acquir Immune Defic Syndr 65:151-9. 2014
    ..To assess the role of HIV and monocytes/macrophages in adipose tissue dysregulation...
  23. pmc Short-term effects of extended-release niacin on endothelial function in HIV-infected patients on stable antiretroviral therapy
    Dominic C Chow
    Hawaii Center for AIDS, University of Hawaii John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    AIDS 24:1019-23. 2010
    ..To assess the short-term effects of extended-release niacin (ERN) on endothelial function in HIV-infected patients with low high-density lipoprotein-cholesterol (HDL-c) levels...
  24. ncbi request reprint HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 40:1846-8. 2005
    ..9 vs. 0.9 copies/10(6) PBMCs; P = .006)...
  25. ncbi request reprint Pathogenesis of HIV-associated non-Hodgkin lymphoma
    Deirdre Killebrew
    Retrovirology Research Laboratory, Leahi Hospital, Young Bldg, 5th Fl, 3675 Kilauea Ave, Honolulu, HI 96816, USA
    Curr HIV Res 2:215-21. 2004
    ..The focus of this review will be on the role viral pathogenesis plays in oncogenic transformation...
  26. ncbi request reprint Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort
    Victor Valcour
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
    J Neurovirol 12:387-91. 2006
    ..395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001)...
  27. ncbi request reprint Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individuals
    Mariana Gerschenson
    Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Antivir Ther 10:M83-9. 2005
    ..Thigh fat mtDNA levels were 45-55% lower than abdomen and neck. These studies help demonstrate that mtDNA levels can vary in different subcutaneous adipose depots suggesting possible metabolic differences...
  28. ncbi request reprint TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration
    Qigui Yu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    J Med Virol 66:276-84. 2002
    ..Our data indicate that PBMC and PBMC subsets are not the major sites of TTV replication...
  29. pmc Chemotoxicity recovery of mitochondria in non-Hodgkin lymphoma resulting in minimal residual disease
    Ian Kusao
    Department of Physiology, University of Hawaii, Honolulu, Hawaii 96816, USA
    Pediatr Blood Cancer 51:193-7. 2008
    ..This study hypothesized that the mitochondria play an important role in a cell's recovery from toxicity via a compensatory increase in mtDNA...
  30. pmc Incident neuropathy in HIV-infected patients on HAART
    Beau K Nakamoto
    Hawaii Center for AIDS, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    AIDS Res Hum Retroviruses 26:759-65. 2010
    ..However, current or prior history of d-drug treatment is not a significant risk factor for incident DSP in subjects who had previously tolerated d-drug treatment without developing a toxic DSP...
  31. ncbi request reprint Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder
    Beau K Nakamoto
    Hawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA
    J Neurovirol 19:601-5. 2013
    ..This finding was not present in an HIV-seronegative control. While ferumoxytol may have potential as an imaging biomarker for monocyte/macrophage accumulation in patients with HAND, future study is needed...
  32. pmc Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells
    Ningjie Hu
    Hawaii AIDS Clinical Research Program, University of Hawaii at Manoa, Leahi Hospital, Honolulu, HI 96816, USA
    Vaccine 27:2994-3006. 2009
    ....

Research Grants9

  1. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce T Shiramizu; Fiscal Year: 2010
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
  2. Activated Immune Parameters Associated with HIV & Aging
    Bruce Shiramizu; Fiscal Year: 2004
    ....
  3. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce Shiramizu; Fiscal Year: 2006
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
  4. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce Shiramizu; Fiscal Year: 2007
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
  5. Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma
    Bruce Shiramizu; Fiscal Year: 2007
    ..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. ..
  6. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce Shiramizu; Fiscal Year: 2007
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
  7. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce Shiramizu; Fiscal Year: 2009
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..