Kenneth S Shindler

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis
    Zoe Fonseca-Kelly
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania Scheie Eye Institute Philadelphia, PA, USA
    Front Neurol 3:84. 2012
  2. pmc Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis
    Thomas A Quinn
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute Philadelphia, PA, USA
    Front Neurol 2:50. 2011
  3. pmc Different mechanisms of inflammation induced in virus and autoimmune-mediated models of multiple sclerosis in C57BL6 mice
    Abhinoy Kishore
    Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia West Bengal 741252, India
    Biomed Res Int 2013:589048. 2013
  4. pmc SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
    Reas S Khan
    Scheie Eye Institute and F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania Philadelphia, PA, USA
    Front Cell Neurosci 6:63. 2012
  5. pmc Oral resveratrol reduces neuronal damage in a model of multiple sclerosis
    Kenneth S Shindler
    FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neuroophthalmol 30:328-39. 2010
  6. ncbi request reprint Long-term follow-up and prognosis of orbital apex syndrome resulting from nasopharyngeal rhabdomyosarcoma
    Kenneth S Shindler
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Ophthalmol 140:236-41. 2005
  7. pmc Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis
    Kenneth S Shindler
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104 6100, United States
    Exp Eye Res 87:208-13. 2008
  8. ncbi request reprint Intermittent headaches as the presenting sign of subacute angle-closure glaucoma
    Kenneth S Shindler
    Scheie Eye Institute, Philadelphia, PA 19104, USA
    Neurology 65:757-8. 2005
  9. ncbi request reprint Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis
    Kenneth S Shindler
    Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, 51 N 39th Street, Philadelphia, PA 19104, USA
    Mult Scler 12:526-32. 2006
  10. pmc SIRT1 activation confers neuroprotection in experimental optic neuritis
    Kenneth S Shindler
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 48:3602-9. 2007

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis
    Zoe Fonseca-Kelly
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania Scheie Eye Institute Philadelphia, PA, USA
    Front Neurol 3:84. 2012
    ..Importantly, neuroprotective effects can occur without immunosuppression, suggesting a potential additive benefit of resveratrol in combination with anti-inflammatory therapies for MS...
  2. pmc Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis
    Thomas A Quinn
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute Philadelphia, PA, USA
    Front Neurol 2:50. 2011
    ..Results suggest that different clinical disease courses of optic nerve inflammation may trigger distinct mechanisms of neuronal damage, or RGCs in different rodent strains may have variable resistance to neuronal degeneration...
  3. pmc Different mechanisms of inflammation induced in virus and autoimmune-mediated models of multiple sclerosis in C57BL6 mice
    Abhinoy Kishore
    Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia West Bengal 741252, India
    Biomed Res Int 2013:589048. 2013
    ..The presence of dual mechanisms of demyelination may be responsible for the failure of immunosuppression to promote long-term remission in many MS patients. ..
  4. pmc SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
    Reas S Khan
    Scheie Eye Institute and F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania Philadelphia, PA, USA
    Front Cell Neurosci 6:63. 2012
    ..Results suggest SIRT1 activators can mediate neuroprotective effects during optic neuritis by these mechanisms, and they have the potential to preserve neurons in other neurodegenerative diseases that involve oxidative stress...
  5. pmc Oral resveratrol reduces neuronal damage in a model of multiple sclerosis
    Kenneth S Shindler
    FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neuroophthalmol 30:328-39. 2010
    ..Neuronal loss in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), correlates with permanent neurological dysfunction. Current MS therapies have limited the ability to prevent neuronal damage...
  6. ncbi request reprint Long-term follow-up and prognosis of orbital apex syndrome resulting from nasopharyngeal rhabdomyosarcoma
    Kenneth S Shindler
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Ophthalmol 140:236-41. 2005
    ..The prognosis for recovery of vision and ocular motility in patients with an orbital apex syndrome due to nasopharyngeal rhabdomyosarcoma is examined...
  7. pmc Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis
    Kenneth S Shindler
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104 6100, United States
    Exp Eye Res 87:208-13. 2008
    ..RGCs die by an apoptotic mechanism triggered by axonal injury. Potential neuroprotective therapies to prevent permanent RGC loss from optic neuritis will likely need to be initiated prior to axonal injury to preserve neuronal function...
  8. ncbi request reprint Intermittent headaches as the presenting sign of subacute angle-closure glaucoma
    Kenneth S Shindler
    Scheie Eye Institute, Philadelphia, PA 19104, USA
    Neurology 65:757-8. 2005
    ..Patients with subacute angle closure misdiagnosed with migraine are older and have shorter-duration headaches than patients with typical migraine...
  9. ncbi request reprint Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis
    Kenneth S Shindler
    Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, 51 N 39th Street, Philadelphia, PA 19104, USA
    Mult Scler 12:526-32. 2006
    ..8% by day 18. No RGC loss occurred in eyes without optic neuritis. The fact that inflammation precedes RGC loss suggests that neuronal loss during optic neuritis occurs secondary to the inflammatory process...
  10. pmc SIRT1 activation confers neuroprotection in experimental optic neuritis
    Kenneth S Shindler
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 48:3602-9. 2007
    ..The authors examined potential neuroprotective effects in optic neuritis by SRT647 and SRT501, two structurally and mechanistically distinct activators of SIRT1, an enzyme involved in cellular stress resistance and survival...
  11. pmc Bowman-Birk inhibitor suppresses autoimmune inflammation and neuronal loss in a mouse model of multiple sclerosis
    Tarik Touil
    Department of Neurology, Thomas Jefferson University, Jefferson Hospital for Neuroscience, 900 Walnut Street, Suite 300, Philadelphia, PA 19107, USA
    J Neurol Sci 271:191-202. 2008
    ..BBI reduces inflammation and attenuates neuronal loss, making it an excellent candidate for oral therapy in MS. BBI likely ameliorates EAE by inhibiting multiple pathways involved in disease pathogenesis...
  12. doi request reprint AAV2 gene therapy readministration in three adults with congenital blindness
    Jean Bennett
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 309 Stellar Chance Labs, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Sci Transl Med 4:120ra15. 2012
    ....
  13. pmc Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis
    Jayasri Das Sarma
    Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neuroinflammation 6:14. 2009
    ..IL-17A signals through its receptor, IL-17RA, which is expressed in many peripheral tissues; however, expression of IL-17RA in the central nervous system (CNS) and its role in CNS inflammation are not well understood...
  14. pmc Mechanisms of primary axonal damage in a viral model of multiple sclerosis
    Jayasri Das Sarma
    Department of Neurology and Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neurosci 29:10272-80. 2009
    ..These results have important implications for the design of neuroprotective strategies for CNS demyelinating disease, and our model identifies the spike protein as a therapeutic target to prevent axonal transport of neurotropic viruses...
  15. pmc Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus
    Kenneth S Shindler
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA
    J Neuropathol Exp Neurol 70:470-80. 2011
    ....
  16. pmc The human visual cortex responds to gene therapy-mediated recovery of retinal function
    Manzar Ashtari
    Diffusion Tensor Image Analyses and Brain Morphometry Center, Department of Radiology, Children s Hospital of Philadelphia CHOP, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:2160-8. 2011
    ..In addition, these data suggest that gene therapy resulted in not only sustained and improved visual ability, but also enhanced contrast sensitivity...
  17. pmc Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis
    Mahasweta Dutt
    FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Stellar Chance Laboratories, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 51:1439-45. 2010
    ..Here the authors examined whether corticosteroids administered early in the disease course can prevent RGC loss in experimental optic neuritis...
  18. pmc In vivo detection of experimental optic neuritis by pupillometry
    Kenneth S Shindler
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Stellar Chance Laboratories, 3rd Floor, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Exp Eye Res 100:1-6. 2012
    ..Furthermore, results demonstrate that decreased visual function occurs early in optic neuritis, before optic nerve inflammation reaches its peak level...
  19. ncbi request reprint Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice
    Yangtai Guan
    Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, USA
    J Neuroimmunol 178:40-8. 2006
    ..The fact that inflammation precedes RGC loss suggests that neuronal loss during optic neuritis occurs secondary to the inflammatory process in isolated optic neuritis...
  20. ncbi request reprint Automated combined kinetic and static perimetry: an alternative to standard perimetry in patients with neuro-ophthalmic disease and glaucoma
    Stacy L Pineles
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Arch Ophthalmol 124:363-9. 2006
    ..To create a fully automated, combined perimetry program consisting of a static examination and a kinetic examination, and to compare the results of this test with standard static and kinetic visual fields (VFs)...
  21. pmc Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus
    Kenneth S Shindler
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 82:8882-6. 2008
    ..In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies...
  22. pmc The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma
    Xiaodong Cheng
    Department of Neurology, Jefferson Hospital for Neuroscience, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, USA
    J Neuroimmunol 185:75-86. 2007
    ..These data suggest that one mechanism of IL-12 suppression of EAE is mediated by PD-1/PD-L signaling downstream of IFN-gamma induction in CD11b+ APCs. The regulation of PD-1/PD-L1 may have potential therapeutic effects for EAE and MS...
  23. pmc Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity
    Yong Chen
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:3582-7. 2013
    ..Deletion of Dexras1 in mice attenuates NO-mediated cell death in dissociated primary cortical neurons and retinal ganglion cells in vivo. Thus, Dexras1 appears to mediate NMDA-elicited neurotoxicity via NO and iron influx...
  24. doi request reprint The diagnostic and economic yield of neuroimaging in neuro-ophthalmology
    Sonia Mehta
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Neuroophthalmol 32:139-44. 2012
    ..We assessed the diagnostic and economic yield of CT and MRI across all patients evaluated in a neuro-ophthalmology practice...
  25. doi request reprint Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
    Albert M Maguire
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lancet 374:1597-605. 2009
    ..We therefore did a phase 1 trial to assess the effect of gene therapy on retinal and visual function in children and adults with Leber's congenital amaurosis...
  26. pmc Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity
    Gregory F Wu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA
    J Autoimmun 36:56-64. 2011
    ..These results indicate that DCs are capable of perpetuating CNS-targeted autoimmunity when antigens are readily available, but other APCs are required to efficiently initiate pathogenic cognate CD4 T cell responses...
  27. pmc Safety and efficacy of gene transfer for Leber's congenital amaurosis
    Albert M Maguire
    Scheie Eye Institute, University of Pennsylvania, USA
    N Engl J Med 358:2240-8. 2008
    ..Although the follow-up was very short and normal vision was not achieved, this study provides the basis for further gene therapy studies in patients with LCA...

Research Grants3

  1. Prevention of Neuronal Damage in Optic Neuritis
    KENNETH SHINDLER; Fiscal Year: 2007
    ..This proposal will serve as an ideal platform for the principal investigator to begin a career aimed at understanding mechanisms of optic nerve damage and its correlation to clinical findings. ..
  2. Mechanism of SIRT1 activator mediated neuroprotection of retinal ganglion cells
    Kenneth S Shindler; Fiscal Year: 2010
    ....