Research Topics
Species | Alan W ShindelSummaryAffiliation: University of California Country: USA Publications
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Publications
Sexuality education in North American medical schools: current status and future directionsAlan W Shindel
Department of Urology, University of California, Davis, Sacramento, CA 95816, USA
J Sex Med 10:3-17; quiz 18. 2013..Despite this expectation there are no universal standards or expectations regarding the sexuality education of medical students...
Sexual function and depressive symptoms among female North American medical studentsAlan W Shindel
University of California Davis Department of Urology, Sacramento, CA 95816, USA
J Sex Med 8:391-9. 2011..Depression and sexual dysfunction are often comorbid...- Pentoxifylline attenuates transforming growth factor-beta1-stimulated elastogenesis in human tunica albuginea-derived fibroblasts part 2: Interference in a TGF-beta1/Smad-dependent mechanism and downregulation of AAT1Guiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, United States
J Sex Med 7:1787-97. 2010..Pentoxifylline (PTX) antagonizes the effects of TGF-beta1 and has been utilized in our clinic for the management of PD although the mechanisms of action are not entirely clear... - The impact of sexual orientation on sexuality and sexual practices in North American medical studentsBenjamin N Breyer
University of California, Department of Urology, San Francisco, CA 94143, USA
J Sex Med 7:2391-400. 2010..There has been limited investigation of the sexuality and sexual dysfunction in non-heterosexual subjects by the sexual medicine community. Additional research in these populations is needed... - The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat modelYun Ching Huang
Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA, USA
J Sex Med 7:1391-400. 2010..Adipose tissue-derived stem cells (ADSC) have been shown to differentiate into endothelial cells and secrete vasculotrophic and neurotrophic factors... - Treatment of stress urinary incontinence with adipose tissue-derived stem cellsGuiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California, USA
Cytotherapy 12:88-95. 2010..Effective treatment for stress urinary incontinence (SUI) is lacking. This study investigated whether transplantation of adipose tissue-derived stem cells (ADSC) can treat SUI in a rat model... - Sexual dysfunction, HIV, and AIDS in men who have sex with menAlan W Shindel
Department of Urology, University of California, Davis, Sacramento, USA
AIDS Patient Care STDS 25:341-9. 2011..05). Use of phosphodiesterase 5 (PDE5) inhibitor drugs was much more common in HIV-infected men. HIV infection is a risk factor for poorer sexual function primarily due to higher risk of erectile dysfunction in men with AIDS... - Pentoxifylline treatment and penile calcifications in men with Peyronie's diseaseJames F Smith
Department of Urology, University of California, San Francisco, CA, USA
Asian J Androl 13:322-5. 2011..0% versus 78.3%, P=0.002). Treatment with PTX appeared to stabilize or reduce calcium content in PD plaques. A randomized controlled trial is warranted to further explore this effect... - Labeling and tracking of mesenchymal stromal cells with EdUGuiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
Cytotherapy 11:864-73. 2009..In the present study we tested a new thymidine analog, 5-ethynyl-2-deoxyuridine (EdU), for labeling and tracking of mesenchymal stromal cells (MSC), specifically adipose tissue-derived stem cells (ADSC)... - Who is the 40-year-old virgin and where did he/she come from? Data from the National Survey of Family GrowthMichael L Eisenberg
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
J Sex Med 6:2154-61. 2009..Individuals who have not engaged in sexual activity may theoretically have diminished overall quality of life, as recent evidence suggests that sexual activity may be related to overall health status in adults... - Effect of sexually transmitted infections, lifetime sexual partner count, and recreational drug use on lower urinary tract symptoms in men who have sex with menBenjamin N Breyer
Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA
Urology 79:188-93. 2012..LUTS in men are a source of considerable morbidity, distress, and medical expense... - Erectile dysfunction and premature ejaculation in men who have sex with menAlan W Shindel
Department of Urology, University of California, Davis, Sacramento, CA 95817, USA
J Sex Med 9:576-84. 2012..Quantitative research into sexual function and dysfunction in men who have sex with men (MSM) has been sparse due in large part to a lack of validated, quantitative instruments for the assessment of sexuality in this population... - The impact of infertility on family size in the USA: data from the National Survey of Family GrowthBenjamin N Breyer
Department of Urology, University of California, 400 Parnassus St, Ste A 633, Campus Box 0738, San Francisco, CA 94143, USA
Hum Reprod 25:2360-5. 2010..The aim of the current study is to determine if a diagnosis of infertility is associated with family size in the USA... - Medical student sexuality: how sexual experience and sexuality training impact U.S. and Canadian medical students' comfort in dealing with patients' sexuality in clinical practiceAlan W Shindel
Department of Urology, University of California, San Francisco, CA, USA
Acad Med 85:1321-30. 2010..To determine factors associated with students' comfort in addressing patients' sexuality in the clinical context... - Modulation of smooth muscle tonus in the lower urinary tract: interplay of myosin light-chain kinase (MLCK) and MLC phosphatase (MLCP)Guiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, University of California School of Medicine, San Francisco, CA 94143 0738, USA
BJU Int 108:E66-70. 2011..To assess and compare the expression and activity of myosin light-chain kinase (MLCK) and MLC phosphatase (MLCP) in rat bladder and urethra... - Predictors of sexual bother in a population of male North American medical studentsJames F Smith
Department of Urology, University of California San Francisco, San Francisco, CA, USA
J Sex Med 8:3363-9. 2011..The prevalence and associations of sexual bother in male medical students has not been extensively studied... - HIV status is an independent risk factor for reporting lower urinary tract symptomsBenjamin N Breyer
Department of Urology, University of California San Francisco, San Francisco, California 94143, USA
J Urol 185:1710-5. 2011..We determined whether HIV/AIDS status is an independent risk factor for self-reported bothersome lower urinary tract symptoms in a large contemporary cohort... - Pentoxifylline attenuates transforming growth factor-β1-stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts part 1: impact on extracellular matrixAlan W Shindel
University of California Knuppe Molecular Urology Laboratory, Department of Urology, San Francisco, CA 94143, USA
J Sex Med 7:2077-85. 2010..Pentoxifylline (PTX) antagonizes the effects of TGF-β1 and has been utilized in our clinic for the management of PD... - An Internet survey of demographic and health factors associated with risk of sexual dysfunction in women who have sex with womenAlan W Shindel
Department of Urology, University of California at Davis, Sacramento, CA 95816, USA
J Sex Med 9:1261-71. 2012..There has been scant attention to predictors of sexual dysfunction in women who have sex with women (WSW)... - Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cellsMaurice M Garcia
Department of Urology, University of California School of Medicine Knuppe Molecular Urology Laboratory, San Francisco, CA 94143 0738, USA
J Sex Med 7:89-98. 2010..Erectile dysfunction (ED) is a major complication of type 2 diabetes, and many diabetic men with ED are refractory to common ED therapies... - Contraceptive usage patterns in North American medical studentsTami S Rowen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
Contraception 83:459-65. 2011..Students also represent a large sample of reproductive-age individuals. In this study, we examined contraceptive usage patterns in North American medical students... - The effect of long-term hormonal treatment on voiding patterns during filling cystometry and on urethral histology in a postpartum, ovariectomized female ratBenjamin N Breyer
Department of Urology, Knuppe Molecular Urology Laboratory, University of California, San Francisco, CA, USA
BJU Int 106:1775-81. 2010.... - Sexual function and depressive symptoms among male North American medical studentsJames F Smith
Department of Urology, University of California, San Francisco, San Francisco, CA, USA
J Sex Med 7:3909-17. 2010..The role of sexuality as an association of medical student well-being has not been extensively studied... - Adipose derived stem cells ameliorate hyperlipidemia associated detrusor overactivity in a rat modelYun Ching Huang
Knuppe Molecular Urology Laboratory, Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
J Urol 183:1232-40. 2010..Adipose tissue derived stem cells can differentiate into muscle and neuron-like cells in vitro. We investigate the usefulness of adipose tissue derived stem cells for overactive bladder in obese hyperlipidemic rats... - Are sonographic characteristics associated with progression to surgery in men with Peyronie's disease?Benjamin N Breyer
Department of Urology, University of California San Francisco, California 94143 1695, USA
J Urol 183:1484-8. 2010..We determined the relationship between ultrasound characteristics and progression to surgical intervention in men with Peyronie's disease... - The use of complementary and alternative fertility treatment in couples seeking fertility care: data from a prospective cohort in the United StatesJames F Smith
Department of Urology, University of California, San Francisco, California 94143 1695, USA
Fertil Steril 93:2169-74. 2010..To determine the prevalence of complementary and alternative medicine (CAM) use among couples seeking fertility care and to identify the predictors of CAM use in this population... - Subcutaneous penile insertion of domino fragments by incarcerated males in southwest United States prisons: a report of three casesSteven J Hudak
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
J Sex Med 9:632-4. 2012..Self-insertion of penile foreign bodies is performed worldwide, largely due to a perception that it will enhance sexual performance and virility. There are relatively few cases reported in the United States... - Tunica-sparing ossified Peyronie's plaque excisionMichael L Eisenberg
Department of Urology, University of California, San Francisco, CA, USA
BJU Int 107:622-5. 2011..As tunical excision can result in impotence and decrease penile sensation, we describe a novel method of tunical preserving excision of such lesions... - Recreational urethral sounding is associated with high risk sexual behaviour and sexually transmitted infectionsBenjamin N Breyer
Department of Urology, University of California San Francisco, San Francisco, CA, USA
BJU Int 110:720-5. 2012..Realistic strategies for risk reduction should be discussed with men who engage in recreational sounding... - Use of barrier protection for sexual activity among women who have sex with womenTami S Rowen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA
Int J Gynaecol Obstet 120:42-5. 2013..To assess the frequency and associations of barrier protection use during sexual activity in a population of women who have sex with women (WSW)... - Neurotrophic effects of brain-derived neurotrophic factor and vascular endothelial growth factor in major pelvic ganglia of young and aged ratsGuiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
BJU Int 105:114-20. 2010..To investigate the neurotrophic effect of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in cultured major pelvic ganglia (MPG) derived from young and aged rats... - Sexual, marital, and social impact of a man's perceived infertility diagnosisJames F Smith
Department of Urology, University of California, San Francisco, CA 94143, USA
J Sex Med 6:2505-15. 2009..Male factor infertility is a relatively common problem. This diagnosis may increase sexual, marital, and relationship strain in male partners of infertile couples... - Transglanular repair of impending penile prosthetic cylinder extrusionAlan W Shindel
University of California, San Francisco, Department of Urology, San Francisco, CA, USA
J Sex Med 7:2884-90. 2010..In some cases, impending extrusion can be identified and managed before frank erosion occurs... - Emerging gene and stem cell therapies for the treatment of erectile dysfunctionAhmed Harraz
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
Nat Rev Urol 7:143-52. 2010..The long-term safety of both gene and stem cell therapy must be thoroughly investigated before large-scale human studies can be considered... - The future is today: emerging drugs for the treatment of erectile dysfunctionMaarten Albersen
Basic Research Fellow Male Sexual Dysfunction, University of California at San Francisco, Department of Urology, Knuppe Molecular Urology Laboratory, Campus Box 0738, San Francisco, CA 94143 0738, USA
Expert Opin Emerg Drugs 15:467-80. 2010..PDE type 5 inhibitors (PDE5I) now account for the largest segment of the ED market. While these drugs are highly efficacious for many men, a relatively large subset of ED patients who do not respond to PDE5I is increasingly recognized... - Evaluation and management of priapism: 2009 updateYun Ching Huang
Department of Urology, University of California, San Francisco, CA 94143, USA
Nat Rev Urol 6:262-71. 2009..Nonischemic priapism occurs more rarely than ischemic priapism, and is most often the result of trauma. This subtype of priapism, which is generally not painful, is usually initially managed with conservative treatment... - Urologic aspects of HIV infectionAlan W Shindel
Department of Urology, University of California at San Francisco, 400 Parnassus Avenue, Suite A 660, San Francisco, CA 94143 0738, USA
Med Clin North Am 95:129-51. 2011..Management algorithms are outlined and indications for referral to a urologist are emphasized... - Molecular mechanisms related to parturition-induced stress urinary incontinenceGuiting Lin
Department of Urology, School of Medicine, University of California, San Francisco, CA 94143, USA
Eur Urol 55:1213-22. 2009..The molecular mechanisms underlying stress urinary incontinence (SUI) at the tissue level are poorly understood...