Research Topics
Species | Alan W ShindelSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The impact of infertility on family size in the USA: data from the National Survey of Family GrowthBenjamin N Breyer
Department of Urology, University of California, 400 Parnassus St, Ste A 633, Campus Box 0738, San Francisco, CA 94143, USA
Hum Reprod 25:2360-5. 2010..The aim of the current study is to determine if a diagnosis of infertility is associated with family size in the USA...
Premature ejaculation in infertile couples: prevalence and correlatesAlan W Shindel
Washington University in Saint Louis Surgery, Division of Urology, St Louis, MO, USA
J Sex Med 5:485-91. 2008..The incidence of premature ejaculation (PE) and other sexual problems in infertile couples is unknown...- 2009 update on phosphodiesterase type 5 inhibitor therapy part 1: Recent studies on routine dosing for penile rehabilitation, lower urinary tract symptoms, and other indications (CME)Alan W Shindel
Department of Urology, University of California San Francisco, 400 Parnassus St, San Francisco, CA 94143 0738, USA
J Sex Med 6:1794-808; quiz 1793, 1809-10. 2009..Highly selective inhibitors of phosphodiesterase type 5 (PDE5I) have been commercially available for over a decade. Our knowledge of these drugs continues to expand... - 2009 update on phosphodiesterase type 5 inhibitor therapy part 2: updates on optimal utilization for sexual concerns and rare toxicities in this classAlan W Shindel
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
J Sex Med 6:2352-64; quiz 2365-6. 2009..Highly selective inhibitors of phosphodiesterase type 5 (PDE5I) have been commercially available for over a decade. Our knowledge of these drugs continues to expand... 
Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivoAlan W Shindel
University of California Knuppe Molecular Urology Laboratory Department of Urology, School of Medicine, San Francisco, CA, USA
J Sex Med 7:1518-28. 2010..Epimedium species (aka horny goat weed) have been utilized for the treatment of erectile dysfunction in Traditional Chinese Medicine for many years. Icariin (ICA) is the active moiety of Epimedium species...- Pentoxifylline attenuates transforming growth factor-β1-stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts part 1: impact on extracellular matrixAlan W Shindel
University of California Knuppe Molecular Urology Laboratory, Department of Urology, San Francisco, CA 94143, USA
J Sex Med 7:2077-85. 2010..Pentoxifylline (PTX) antagonizes the effects of TGF-β1 and has been utilized in our clinic for the management of PD... - The sexual lives of medical students: a single institution surveyAlan W Shindel
Washington University in Saint Louis Department of Surgery, Division of Urology, St Louis, MO, USA
J Sex Med 5:796-803. 2008..Little is known about the personal sexual lives of medical students... - Urologist practice patterns in the management of Peyronie's disease: a nationwide surveyAlan W Shindel
Washington University in Saint Louis Department of Surgery, Division of Urology, St Louis, MO, USA
J Sex Med 5:954-64. 2008..Peyronie's disease (PD) is a poorly understood clinical entity. Aim. We endeavored to determine how contemporary urologists in the United States manage PD... - Medical student sexuality: how sexual experience and sexuality training impact U.S. and Canadian medical students' comfort in dealing with patients' sexuality in clinical practiceAlan W Shindel
Department of Urology, University of California, San Francisco, CA, USA
Acad Med 85:1321-30. 2010..To determine factors associated with students' comfort in addressing patients' sexuality in the clinical context... - Pentoxifylline attenuates transforming growth factor-beta1-stimulated elastogenesis in human tunica albuginea-derived fibroblasts part 2: Interference in a TGF-beta1/Smad-dependent mechanism and downregulation of AAT1Guiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, United States
J Sex Med 7:1787-97. 2010..Pentoxifylline (PTX) antagonizes the effects of TGF-beta1 and has been utilized in our clinic for the management of PD although the mechanisms of action are not entirely clear... - The impact of sexual orientation on sexuality and sexual practices in North American medical studentsBenjamin N Breyer
University of California, Department of Urology, San Francisco, CA 94143, USA
J Sex Med 7:2391-400. 2010..There has been limited investigation of the sexuality and sexual dysfunction in non-heterosexual subjects by the sexual medicine community. Additional research in these populations is needed... - The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat modelYun Ching Huang
Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA, USA
J Sex Med 7:1391-400. 2010..Adipose tissue-derived stem cells (ADSC) have been shown to differentiate into endothelial cells and secrete vasculotrophic and neurotrophic factors... - Predictors of sexual bother in a population of male North American medical studentsJames F Smith
Department of Urology, University of California San Francisco, San Francisco, CA, USA
J Sex Med 8:3363-9. 2011..The prevalence and associations of sexual bother in male medical students has not been extensively studied... - Pentoxifylline treatment and penile calcifications in men with Peyronie's diseaseJames F Smith
Department of Urology, University of California, San Francisco, CA, USA
Asian J Androl 13:322-5. 2011..0% versus 78.3%, P=0.002). Treatment with PTX appeared to stabilize or reduce calcium content in PD plaques. A randomized controlled trial is warranted to further explore this effect... - Treatment of stress urinary incontinence with adipose tissue-derived stem cellsGuiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California, USA
Cytotherapy 12:88-95. 2010..Effective treatment for stress urinary incontinence (SUI) is lacking. This study investigated whether transplantation of adipose tissue-derived stem cells (ADSC) can treat SUI in a rat model... - Penile sonographic and clinical characteristics in men with Peyronie's diseaseJames F Smith
University of California Department of Urology, 1600 Divisadero, Box 1695, San Francisco, CA 94143, USA
J Sex Med 6:2858-67. 2009..Ultrasonography of the penis is readily available to the urologist and gives good anatomic detail of soft tissue structures. It has not been widely utilized in the assessment of Peyronie's disease (PD)... - Socioeconomic, anthropomorphic, and demographic predictors of adult sexual activity in the United States: data from the national survey of family growthMichael L Eisenberg
University of California The Department of Urology, San Francisco, CA, USA
J Sex Med 7:50-8. 2010.... - The sexual lives of residents and fellows in graduate medical education programs: a single institution surveyGenoa G Ferguson
Washington University in Saint Louis, Department of Surgery, Division of Urology, St Louis, MO, USA
J Sex Med 5:2756-65. 2008..The prevalence of sexual problems among resident physicians has not been investigated... - Sexual dysfunction, HIV, and AIDS in men who have sex with menAlan W Shindel
Department of Urology, University of California, Davis, Sacramento, USA
AIDS Patient Care STDS 25:341-9. 2011..05). Use of phosphodiesterase 5 (PDE5) inhibitor drugs was much more common in HIV-infected men. HIV infection is a risk factor for poorer sexual function primarily due to higher risk of erectile dysfunction in men with AIDS... - Effect of sexually transmitted infections, lifetime sexual partner count, and recreational drug use on lower urinary tract symptoms in men who have sex with menBenjamin N Breyer
Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA
Urology 79:188-93. 2012..LUTS in men are a source of considerable morbidity, distress, and medical expense... - Labeling and tracking of mesenchymal stromal cells with EdUGuiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
Cytotherapy 11:864-73. 2009..In the present study we tested a new thymidine analog, 5-ethynyl-2-deoxyuridine (EdU), for labeling and tracking of mesenchymal stromal cells (MSC), specifically adipose tissue-derived stem cells (ADSC)... - The use of complementary and alternative fertility treatment in couples seeking fertility care: data from a prospective cohort in the United StatesJames F Smith
Department of Urology, University of California, San Francisco, California 94143 1695, USA
Fertil Steril 93:2169-74. 2010..To determine the prevalence of complementary and alternative medicine (CAM) use among couples seeking fertility care and to identify the predictors of CAM use in this population... - Modulation of smooth muscle tonus in the lower urinary tract: interplay of myosin light-chain kinase (MLCK) and MLC phosphatase (MLCP)Guiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, University of California School of Medicine, San Francisco, CA 94143 0738, USA
BJU Int 108:E66-70. 2011..To assess and compare the expression and activity of myosin light-chain kinase (MLCK) and MLC phosphatase (MLCP) in rat bladder and urethra... - Sexual function and quality of life in the male partner of infertile couples: prevalence and correlates of dysfunctionAlan W Shindel
Department of Surgery, Division of Urology, Washington University in Saint Louis, Saint Louis, Missouri, USA
J Urol 179:1056-9. 2008..We prospectively collected data on mental and physical health related quality of life as well as sexual and relationship function in couples presenting for the treatment of infertility... - Erectile dysfunction and premature ejaculation in men who have sex with menAlan W Shindel
Department of Urology, University of California, Davis, Sacramento, CA 95817, USA
J Sex Med 9:576-84. 2012..Quantitative research into sexual function and dysfunction in men who have sex with men (MSM) has been sparse due in large part to a lack of validated, quantitative instruments for the assessment of sexuality in this population... - Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cellsMaurice M Garcia
Department of Urology, University of California School of Medicine Knuppe Molecular Urology Laboratory, San Francisco, CA 94143 0738, USA
J Sex Med 7:89-98. 2010..Erectile dysfunction (ED) is a major complication of type 2 diabetes, and many diabetic men with ED are refractory to common ED therapies... - Sexual function and depressive symptoms among male North American medical studentsJames F Smith
Department of Urology, University of California, San Francisco, San Francisco, CA, USA
J Sex Med 7:3909-17. 2010..The role of sexuality as an association of medical student well-being has not been extensively studied... - HIV status is an independent risk factor for reporting lower urinary tract symptomsBenjamin N Breyer
Department of Urology, University of California San Francisco, San Francisco, California 94143, USA
J Urol 185:1710-5. 2011..We determined whether HIV/AIDS status is an independent risk factor for self-reported bothersome lower urinary tract symptoms in a large contemporary cohort... - Contraceptive usage patterns in North American medical studentsTami S Rowen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
Contraception 83:459-65. 2011..Students also represent a large sample of reproductive-age individuals. In this study, we examined contraceptive usage patterns in North American medical students... - Neurotrophic effects of brain-derived neurotrophic factor and vascular endothelial growth factor in major pelvic ganglia of young and aged ratsGuiting Lin
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
BJU Int 105:114-20. 2010..To investigate the neurotrophic effect of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in cultured major pelvic ganglia (MPG) derived from young and aged rats... - Who is the 40-year-old virgin and where did he/she come from? Data from the National Survey of Family GrowthMichael L Eisenberg
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
J Sex Med 6:2154-61. 2009..Individuals who have not engaged in sexual activity may theoretically have diminished overall quality of life, as recent evidence suggests that sexual activity may be related to overall health status in adults... - An Internet survey of demographic and health factors associated with risk of sexual dysfunction in women who have sex with womenAlan W Shindel
Department of Urology, University of California at Davis, Sacramento, CA 95816, USA
J Sex Med 9:1261-71. 2012..There has been scant attention to predictors of sexual dysfunction in women who have sex with women (WSW)... - The effect of long-term hormonal treatment on voiding patterns during filling cystometry and on urethral histology in a postpartum, ovariectomized female ratBenjamin N Breyer
Department of Urology, Knuppe Molecular Urology Laboratory, University of California, San Francisco, CA, USA
BJU Int 106:1775-81. 2010.... - Are sonographic characteristics associated with progression to surgery in men with Peyronie's disease?Benjamin N Breyer
Department of Urology, University of California San Francisco, California 94143 1695, USA
J Urol 183:1484-8. 2010..We determined the relationship between ultrasound characteristics and progression to surgical intervention in men with Peyronie's disease... - Adipose derived stem cells ameliorate hyperlipidemia associated detrusor overactivity in a rat modelYun Ching Huang
Knuppe Molecular Urology Laboratory, Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
J Urol 183:1232-40. 2010..Adipose tissue derived stem cells can differentiate into muscle and neuron-like cells in vitro. We investigate the usefulness of adipose tissue derived stem cells for overactive bladder in obese hyperlipidemic rats... - Sexual, marital, and social impact of a man's perceived infertility diagnosisJames F Smith
Department of Urology, University of California, San Francisco, CA 94143, USA
J Sex Med 6:2505-15. 2009..Male factor infertility is a relatively common problem. This diagnosis may increase sexual, marital, and relationship strain in male partners of infertile couples... - Subcutaneous penile insertion of domino fragments by incarcerated males in southwest United States prisons: a report of three casesSteven J Hudak
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
J Sex Med 9:632-4. 2012..Self-insertion of penile foreign bodies is performed worldwide, largely due to a perception that it will enhance sexual performance and virility. There are relatively few cases reported in the United States... - Molecular mechanisms related to parturition-induced stress urinary incontinenceGuiting Lin
Department of Urology, School of Medicine, University of California, San Francisco, CA 94143, USA
Eur Urol 55:1213-22. 2009..The molecular mechanisms underlying stress urinary incontinence (SUI) at the tissue level are poorly understood... - Use of barrier protection for sexual activity among women who have sex with womenTami S Rowen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA
Int J Gynaecol Obstet 120:42-5. 2013..To assess the frequency and associations of barrier protection use during sexual activity in a population of women who have sex with women (WSW)... - Recreational urethral sounding is associated with high risk sexual behaviour and sexually transmitted infectionsBenjamin N Breyer
Department of Urology, University of California San Francisco, San Francisco, CA, USA
BJU Int 110:720-5. 2012..Realistic strategies for risk reduction should be discussed with men who engage in recreational sounding... - Androgen blockade for the treatment of high-flow priapismKuwong B Mwamukonda
Urology Department, University of California San Francisco, California 94143, USA
J Sex Med 7:2532-7. 2010..In cases that do not resolve spontaneously, standard management is by selective embolization, resulting in resolution rates as high as 78%; however, erectile dysfunction (ED) is a frequent complication, occurring in up to 39% of cases... - Tunica-sparing ossified Peyronie's plaque excisionMichael L Eisenberg
Department of Urology, University of California, San Francisco, CA, USA
BJU Int 107:622-5. 2011..As tunical excision can result in impotence and decrease penile sensation, we describe a novel method of tunical preserving excision of such lesions... - Transglanular repair of impending penile prosthetic cylinder extrusionAlan W Shindel
University of California, San Francisco, Department of Urology, San Francisco, CA, USA
J Sex Med 7:2884-90. 2010..In some cases, impending extrusion can be identified and managed before frank erosion occurs... - Evaluation and management of priapism: 2009 updateYun Ching Huang
Department of Urology, University of California, San Francisco, CA 94143, USA
Nat Rev Urol 6:262-71. 2009..Nonischemic priapism occurs more rarely than ischemic priapism, and is most often the result of trauma. This subtype of priapism, which is generally not painful, is usually initially managed with conservative treatment... - Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's diseaseEugene W Lee
Department of Surgery, Division of Urology, Washington University School of Medicine, St Louis, Missouri, USA
Int Braz J Urol 34:191-6; discussion 197. 2008..Report the results using porcine small intestinal submucosa (SIS) as a graft material in the surgical management of Peyronie's disease (PD)... - Emerging gene and stem cell therapies for the treatment of erectile dysfunctionAhmed Harraz
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
Nat Rev Urol 7:143-52. 2010..The long-term safety of both gene and stem cell therapy must be thoroughly investigated before large-scale human studies can be considered... - The future is today: emerging drugs for the treatment of erectile dysfunctionMaarten Albersen
Basic Research Fellow Male Sexual Dysfunction, University of California at San Francisco, Department of Urology, Knuppe Molecular Urology Laboratory, Campus Box 0738, San Francisco, CA 94143 0738, USA
Expert Opin Emerg Drugs 15:467-80. 2010..PDE type 5 inhibitors (PDE5I) now account for the largest segment of the ED market. While these drugs are highly efficacious for many men, a relatively large subset of ED patients who do not respond to PDE5I is increasingly recognized... - A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacySamuel L Washington
School of Medicine, University of California at San Francisco, San Francisco, California, USA
Drug Des Devel Ther 4:159-71. 2010..In this study, we review the current state of the art with respect to this new management strategy for ED, highlighting published reports of the efficacy and tolerability of the daily dose tadalafil regimen... - Ureteric embolization with stainless-steel coils for managing refractory lower urinary tract fistula: a 12-year experienceAlan W Shindel
Department of Surgery, Division of Urology, Washington University, St Louis, MO, USA
BJU Int 99:364-8. 2007.... - Unintentional transurethral Foley catheterization of the right renal pelvisAlan W Shindel
Barnes Jewish Hospital, Washington University School of Medicine, St Louis, MO, USA
Urol Nurs 28:48-9. 2008..Pertinent medical history/presentation, clinical interactions, and clinical implications are discussed... - Urologic aspects of HIV infectionAlan W Shindel
Department of Urology, University of California at San Francisco, 400 Parnassus Avenue, Suite A 660, San Francisco, CA 94143 0738, USA
Med Clin North Am 95:129-51. 2011..Management algorithms are outlined and indications for referral to a urologist are emphasized... - Does the number and size of veins ligated at left-sided microsurgical subinguinal varicocelectomy affect semen analysis outcomes?Alan W Shindel
Division of Urology, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Urology 69:1176-80. 2007..To determine whether the preoperative and intraoperative findings at unilateral microsurgical subinguinal varicocelectomy are predictive of semen analysis changes postoperatively... - Mohs micrographic surgery for penile cancer: management and long-term followupAlan W Shindel
Division of Urology, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Urol 178:1980-5. 2007..The efficacy of this procedure for squamous cell carcinoma of the penis was reviewed... - Transobturator approach to suburethral sling placement in the treatment of stress urinary incontinence in womenAlan W Shindel
Barnes-Jewish Hospital, Division of Urology, Department of Surgery, 1 Barnes-Jewish Hospital Place, Campus Box 8242, Saint Louis, MO 63110, USA
Expert Rev Med Devices 2:613-22. 2005.... - Urethral slings placed by the transobturator approach: evolution in the technique and review of the literatureAlan W Shindel
Department of Surgery, Division of Urology, Washington University Medical Center, Campus Box 8242, One Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
Curr Urol Rep 6:385-92. 2005..In this article, we describe the theory behind urethral slings for SUI, the anatomy of the obturator canal, and early data on the safety and efficacy of transobturator urethral slings in the treatment of SUI...