Jai Moo Shin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Functional consequences of the oligomeric form of the membrane-bound gastric H,K-ATPase
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA jaishin ucla edu
    Biochemistry 44:16321-32. 2005
  2. pmc Novel approaches to inhibition of gastric acid secretion
    George Sachs
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 12:437-47. 2010
  3. doi request reprint Gastric H+,K+-ATPase
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Compr Physiol 1:2141-53. 2011
  4. pmc Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438)
    Jai Moo Shin
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, 11301 Wilshire Blvd, Bldg 113, CA 90073, USA
    J Pharmacol Exp Ther 339:412-20. 2011
  5. pmc 1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs
    Jai Moo Shin
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Molecules 14:5247-80. 2009
  6. ncbi request reprint Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Am Chem Soc 126:7800-11. 2004
  7. ncbi request reprint Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo
    Jai Moo Shin
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Biochem Pharmacol 71:837-49. 2006
  8. pmc The gastric H,K ATPase as a drug target: past, present, and future
    George Sachs
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
    J Clin Gastroenterol 41:S226-42. 2007
  9. pmc The gastric HK-ATPase: structure, function, and inhibition
    Jai Moo Shin
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Pflugers Arch 457:609-22. 2009
  10. ncbi request reprint Gastric H,K-ATPase as a drug target
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Dig Dis Sci 51:823-33. 2006

Detail Information

Publications18

  1. ncbi request reprint Functional consequences of the oligomeric form of the membrane-bound gastric H,K-ATPase
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA jaishin ucla edu
    Biochemistry 44:16321-32. 2005
    ..It appears that the catalytic subunits of the oligomer during turnover in intact gastric vesicles are restricted to a reciprocal E(1):E(2) configuration...
  2. pmc Novel approaches to inhibition of gastric acid secretion
    George Sachs
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 12:437-47. 2010
    ..pylori eradication...
  3. doi request reprint Gastric H+,K+-ATPase
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Compr Physiol 1:2141-53. 2011
    ....
  4. pmc Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438)
    Jai Moo Shin
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, 11301 Wilshire Blvd, Bldg 113, CA 90073, USA
    J Pharmacol Exp Ther 339:412-20. 2011
    ..Hence, this K(+)-competitive inhibitor of the gastric H,K-ATPase should provide longer-lasting inhibition of gastric acid secretion compared with previous drugs of this class...
  5. pmc 1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs
    Jai Moo Shin
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Molecules 14:5247-80. 2009
    ..New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition...
  6. ncbi request reprint Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Am Chem Soc 126:7800-11. 2004
    ..The PPI accumulates in the secretory canaliculus of the parietal cell due to pyridine protonation then binds to the pump and is activated by the second protonation on the surface of the protein to allow disulfide formation...
  7. ncbi request reprint Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo
    Jai Moo Shin
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Biochem Pharmacol 71:837-49. 2006
    ....
  8. pmc The gastric H,K ATPase as a drug target: past, present, and future
    George Sachs
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
    J Clin Gastroenterol 41:S226-42. 2007
    ..The review concludes with a discussion of the mechanism of action and binding regions of a possible new class of drug for acid control, the K competitive acid pump antagonists...
  9. pmc The gastric HK-ATPase: structure, function, and inhibition
    Jai Moo Shin
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Pflugers Arch 457:609-22. 2009
    ..This enzyme is inhibited by the unique proton pump inhibitor class of drug, allowing therapy of acid-related diseases...
  10. ncbi request reprint Gastric H,K-ATPase as a drug target
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Dig Dis Sci 51:823-33. 2006
  11. ncbi request reprint The basis of differentiation of PPIs
    George Sachs
    Membrane Biology Laboratory, University of California at Los Angeles, California, USA
    Drugs Today (Barc) 40:9-14. 2004
    ..This has also been demonstrated in an analysis comparing pantoprazole to both omeprazoles, with pantoprazole showing superior relief of nighttime heartburn in patients with GERD...
  12. pmc Pharmacology of proton pump inhibitors
    Jai Moo Shin
    Membrane Biology, David Geffen School of Medicine, University of California at Los Angeles, Room 324, Building 113, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 10:528-34. 2008
    ..PPIs with longer half-life promise to improve acid suppression. All PPIs give excellent healing of peptic ulcers and produce good results in reflux esophagitis. PPIs combined with antibiotics eradicate Helicobacter pylori...
  13. ncbi request reprint Restoration of acid secretion following treatment with proton pump inhibitors
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Gastroenterology 123:1588-97. 2002
    ..Their different durations of action may reflect different rates of pump reactivation due to differing accessibility of the disulfides to glutathione...
  14. ncbi request reprint Differences in binding properties of two proton pump inhibitors on the gastric H+,K+-ATPase in vivo
    Jai Moo Shin
    Department of Physiology and Medicine, University of California, Los Angeles, CA 90073, USA
    Biochem Pharmacol 68:2117-27. 2004
    ..This is consistent with the luminal exposure of cysteine 813 and 892 and the intra-membranal location of cysteine 822 in the 3D structure of the H(+),K(+)-ATPase...
  15. ncbi request reprint Current trends in the treatment of upper gastrointestinal disease
    George Sachs
    Geffen School of Medicine at UCLA and GWLA Health Center, Los Angeles, USA
    Best Pract Res Clin Gastroenterol 16:835-49. 2002
    ..Research continues in an attempt to find improved means of acid control and better methods for the eradication of H. pylori based on unique proteins expressed by the organism to resist gastric acidity...
  16. pmc Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling
    Cindy Zer
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Physiol Genomics 31:343-51. 2007
    ..Approximately one-third of the TNF-alpha-induced genes in FLS are regulated by the p38 MAPK signal pathway, showing that p38 MAPK is a possible target for suppressing proinflammatory gene expressions in rheumatoid arthritis...
  17. ncbi request reprint Topography of the membrane domain of the liver Na+-dependent bile acid transporter
    Olga Mareninova
    Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Biochemistry 44:13702-12. 2005
    ..This new method provided evidence for seven membrane segments giving a new model of the membrane domain of this protein and probably the homologous ileal transporter, with H7/H8 as the transport region...
  18. pmc Simple diagnostic tests to detect toxic alcohol intoxications
    Jai Moo Shin
    Medical and Research Services VHAGLA Healthcare System, UCLA Membrane Biology Laboratory, Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, Los Angeles, CA, USA
    Transl Res 152:194-201. 2008
    ..The relatively high sensitivity and specificity of the tests as a whole will facilitate the rapid diagnosis of each of these alcohol intoxications...