Donghun Shin

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Wnt/β-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate
    Juhoon So
    Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Biol Open 2:30-6. 2013
  2. doi request reprint Cellular and molecular basis of liver development
    Donghun Shin
    Department of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Compr Physiol 3:799-815. 2013
  3. pmc Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
    Mech Dev 128:525-35. 2012
  4. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
  5. pmc Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogensis in the zebrafish, Danio rerio
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e62470. 2013
  6. pmc Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish
    Tae Young Choi
    Department of Developmental Biology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Gastroenterology 146:776-88. 2014
  7. ncbi request reprint Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
  8. pmc Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
    Ryan M Anderson
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    Dev Biol 334:213-23. 2009
  9. pmc Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin Signaling
    Evan R Delgado
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Am J Pathol 184:2111-22. 2014
  10. pmc Sox9b is a key regulator of pancreaticobiliary ductal system development
    Marion Delous
    Department of Biochemistry, Program in Developmental and Stem Cell Biology, Liver Center and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 8:e1002754. 2012

Collaborators

Detail Information

Publications10

  1. pmc Wnt/β-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate
    Juhoon So
    Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Biol Open 2:30-6. 2013
    ....
  2. doi request reprint Cellular and molecular basis of liver development
    Donghun Shin
    Department of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Compr Physiol 3:799-815. 2013
    ....
  3. pmc Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
    Mech Dev 128:525-35. 2012
    ..Altogether, these studies reveal that there is more than one way to form a liver, and provide molecular insights into the phenomenon of tissue plasticity...
  4. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
  5. pmc Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogensis in the zebrafish, Danio rerio
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e62470. 2013
    ..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
  6. pmc Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish
    Tae Young Choi
    Department of Developmental Biology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Gastroenterology 146:776-88. 2014
    ..To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of hepatocyte ablation can be controlled...
  7. ncbi request reprint Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  8. pmc Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
    Ryan M Anderson
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    Dev Biol 334:213-23. 2009
    ..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate...
  9. pmc Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin Signaling
    Evan R Delgado
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Am J Pathol 184:2111-22. 2014
    ..Thus, using a rapid and cost-effective computational methodology, we have identified a novel and specific small-molecule inhibitor of Wnt signaling that may have implications for HCC treatment. ..
  10. pmc Sox9b is a key regulator of pancreaticobiliary ductal system development
    Marion Delous
    Department of Biochemistry, Program in Developmental and Stem Cell Biology, Liver Center and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 8:e1002754. 2012
    ..Together, these data reveal key roles for SOX9 in the morphogenesis of the pancreaticobiliary ductal system, and they cast human Sox9 as a candidate gene for pancreaticobiliary duct malformation-related pathologies...