Genomes and Genes
Affiliation: University of Pittsburgh
- Wnt/β-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fateJuhoon So
Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Biol Open 2:30-6. 2013....
- Cellular and molecular basis of liver developmentDonghun Shin
Department of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Compr Physiol 3:799-815. 2013....
- Intrinsic and extrinsic modifiers of the regulative capacity of the developing liverDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
Mech Dev 128:525-35. 2012..Altogether, these studies reveal that there is more than one way to form a liver, and provide molecular insights into the phenomenon of tissue plasticity...
- Restriction of hepatic competence by Fgf signalingDonghun Shin
Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
Development 138:1339-48. 2011..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
- Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogensis in the zebrafish, Danio rerioCarsten Stuckenholz
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 8:e62470. 2013..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
- Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafishTae Young Choi
Department of Developmental Biology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Gastroenterology 146:776-88. 2014..To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of hepatocyte ablation can be controlled...
- Bmp and Fgf signaling are essential for liver specification in zebrafishDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
Development 134:2041-50. 2007....
- Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regenerationRyan M Anderson
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
Dev Biol 334:213-23. 2009..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate...
- Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin SignalingEvan R Delgado
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Am J Pathol 184:2111-22. 2014..Thus, using a rapid and cost-effective computational methodology, we have identified a novel and specific small-molecule inhibitor of Wnt signaling that may have implications for HCC treatment. ..
- Sox9b is a key regulator of pancreaticobiliary ductal system developmentMarion Delous
Department of Biochemistry, Program in Developmental and Stem Cell Biology, Liver Center and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 8:e1002754. 2012..Together, these data reveal key roles for SOX9 in the morphogenesis of the pancreaticobiliary ductal system, and they cast human Sox9 as a candidate gene for pancreaticobiliary duct malformation-related pathologies...