Masahito Shimojo

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurochem 96:1130-8. 2006
  2. pmc REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
    Mol Cell Biol 23:9025-31. 2003
  3. ncbi Characterization of the nuclear targeting signal of REST/NRSF
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Biomedical Biological Sciences Research Building, 741 Limestone Street, Lexington, KY 40536 0509, USA
    Neurosci Lett 398:161-6. 2006
  4. pmc Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Biol Chem 283:34880-6. 2008
  5. ncbi Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF)
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, Lexington, KY 40536 0298, USA
    Life Sci 74:2213-25. 2004
  6. ncbi Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor
    Louis B Hersh
    Department of Cellular and Molecular Biochemistry, University of Kentucky, 800 Rose St, Lexington, KY 40536 0298, USA
    Life Sci 72:2021-8. 2003
  7. doi RE1-silencing transcription factor (REST) and REST-interacting LIM domain protein (RILP) affect P19CL6 differentiation
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone St, BBSRB, Lexington, KY 40536 0509, USA
    Genes Cells 16:90-100. 2011

Research Grants

Collaborators

Detail Information

Publications7

  1. ncbi Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurochem 96:1130-8. 2006
    ..These results show that RILP is required for REST/NRSF nuclear targeting and function...
  2. pmc REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
    Mol Cell Biol 23:9025-31. 2003
    ..We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors...
  3. ncbi Characterization of the nuclear targeting signal of REST/NRSF
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Biomedical Biological Sciences Research Building, 741 Limestone Street, Lexington, KY 40536 0509, USA
    Neurosci Lett 398:161-6. 2006
    ..A point mutation in the zinc finger structure that disrupts its conformation remains nuclear. These data suggest that REST/NRSF contains a NLS around ZFD-5, while the putative NLS at residues 512-522 is non-functional...
  4. pmc Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Biol Chem 283:34880-6. 2008
    ..Thus, this study suggests that REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and that HAP1 controls REST/NRSF cellular localization in neurons...
  5. ncbi Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF)
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, Lexington, KY 40536 0298, USA
    Life Sci 74:2213-25. 2004
    ..Protein kinase A regulation of the cholinergic gene locus in PC 12 cells can thus be attributed, at least in part, to increased synthesis of REST4, which in turn derepresses the repressor activity of REST/NRSF...
  6. ncbi Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor
    Louis B Hersh
    Department of Cellular and Molecular Biochemistry, University of Kentucky, 800 Rose St, Lexington, KY 40536 0298, USA
    Life Sci 72:2021-8. 2003
    ..Thus in PC12 cells protein kinase A promotes the production of REST4, which in turn de-represses of the cholinergic gene locus by inactivating the transcription repressor NRSF/REST...
  7. doi RE1-silencing transcription factor (REST) and REST-interacting LIM domain protein (RILP) affect P19CL6 differentiation
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone St, BBSRB, Lexington, KY 40536 0509, USA
    Genes Cells 16:90-100. 2011
    ..These results suggest that RILP expression and function control REST action more so than does REST expression and is an important regulatory role in cardiomyocyte differentiation...

Research Grants1

  1. Study of novel REST/NRSF-Interacting LIM domain Protein
    Masahito Shimojo; Fiscal Year: 2005
    ..Dr. Shimojo will have access to shared-use equipment, laboratory space, and faculty and staff, which will enhance the likelihood that the proposed objectives will be successfully accomplished. ..