Naoko Shima

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi Phenotype-based identification of mouse chromosome instability mutants
    Naoko Shima
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 163:1031-40. 2003
  2. ncbi Forward genetic screens for meiotic and mitotic recombination-defective mutants in mice
    Laura Reinholdt
    The Jackson Laboratory, Bar Harbor, ME, USA
    Methods Mol Biol 262:87-107. 2004
  3. ncbi The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm
    Naoko Shima
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, 9th Fl Vet Research Tower, Ithaca, NY 14853, USA
    Mol Cell Biol 24:10381-9. 2004
  4. ncbi The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation
    Hong Zan
    Center for Immunology, School of Medicine and School of Biological Sciences, University of California, Irvine, CA, USA
    EMBO J 24:3757-69. 2005
  5. ncbi A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
    Naoko Shima
    Department of Genetics, Cell Biology and Development, College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nat Genet 39:93-8. 2007
  6. ncbi Genetic screen for chromosome instability in mice: Mcm4 and breast cancer
    Naoko Shima
    Department of Genetics, Cell Biology and Development, Medical School and College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell Cycle 6:1135-40. 2007
  7. ncbi A reduction of licensed origins reveals strain-specific replication dynamics in mice
    Tsuyoshi Kawabata
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mamm Genome 22:506-17. 2011
  8. ncbi Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression
    Tsuyoshi Kawabata
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell 41:543-53. 2011
  9. ncbi Functional screen of human MCM2-7 variant alleles for disease-causing potential
    Nathan A Steere
    Department of Genetics, Cell Biology and Development, College of Biological Sciences, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States
    Mutat Res 666:74-8. 2009

Research Grants

  1. Backup origins: their role in replication fork recovery and tumor suppression
    Naoko Shima; Fiscal Year: 2010

Collaborators

  • J Schimenti
  • Robert J Munroe
  • Tsuyoshi Kawabata
  • Satoru Yamaguchi
  • Tavanna Buske
  • Spencer W Luebben
  • Ilze Matise
  • Nathan A Steere
  • Hong Zan
  • Laura Reinholdt
  • Marsha Wallace
  • Ivar Ilves
  • Michael R Botchan
  • Ivan Liachko
  • Catherine A Andrews
  • Tomoka Nakamura
  • Ahmed Al-Qahtani
  • Albert J Evinger Iii
  • Paolo Casali
  • Yuan Zhong
  • Zhenming Xu
  • Terry Ashley

Detail Information

Publications9

  1. ncbi Phenotype-based identification of mouse chromosome instability mutants
    Naoko Shima
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 163:1031-40. 2003
    ....
  2. ncbi Forward genetic screens for meiotic and mitotic recombination-defective mutants in mice
    Laura Reinholdt
    The Jackson Laboratory, Bar Harbor, ME, USA
    Methods Mol Biol 262:87-107. 2004
    ..Both strategies have proved effective in identifying desired classes of mutations...
  3. ncbi The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm
    Naoko Shima
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, 9th Fl Vet Research Tower, Ithaca, NY 14853, USA
    Mol Cell Biol 24:10381-9. 2004
    ..These data suggest a unique role of Polq in maintaining genomic integrity, which is probably distinctive from the major homologous recombination pathway regulated by ATM...
  4. ncbi The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation
    Hong Zan
    Center for Immunology, School of Medicine and School of Biological Sciences, University of California, Irvine, CA, USA
    EMBO J 24:3757-69. 2005
    ....
  5. ncbi A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
    Naoko Shima
    Department of Genetics, Cell Biology and Development, College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nat Genet 39:93-8. 2007
    ..These findings suggest that hypomorphic alleles of the genes encoding the subunits of the MCM2-7 complex may increase breast cancer risk...
  6. ncbi Genetic screen for chromosome instability in mice: Mcm4 and breast cancer
    Naoko Shima
    Department of Genetics, Cell Biology and Development, Medical School and College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell Cycle 6:1135-40. 2007
    ..These findings demonstrate, for the first time, the causative role of an Mcm mutation in cancer development. Furthermore, this raises the possibility that hypomorphic mutations in MCM2-7 genes may increase breast cancer risk in humans...
  7. ncbi A reduction of licensed origins reveals strain-specific replication dynamics in mice
    Tsuyoshi Kawabata
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mamm Genome 22:506-17. 2011
    ..Moreover, p53 is required for the development of mice that suffer from intrinsic replication stress...
  8. ncbi Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression
    Tsuyoshi Kawabata
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell 41:543-53. 2011
    ..These findings suggest that dormant origins constitute a major pathway for stalled fork recovery, contributing to faithful chromosome segregation and tumor suppression...
  9. ncbi Functional screen of human MCM2-7 variant alleles for disease-causing potential
    Nathan A Steere
    Department of Genetics, Cell Biology and Development, College of Biological Sciences, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States
    Mutat Res 666:74-8. 2009
    ..This screen identified a MCM5 variant allele with pathogenic potential. This allele deserves further investigations on its effect on cancer development in human populations...

Research Grants1

  1. Backup origins: their role in replication fork recovery and tumor suppression
    Naoko Shima; Fiscal Year: 2010
    ..The goal of this proposal is to provide information for the development of new cancer therapies. ..