Cecilia M Shikuma

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. pmc Determinants of epidermal nerve fibre density in antiretroviral-naïve HIV-infected individuals
    Cm Shikuma
    University of Hawaii, Honolulu, HI 96816, USA
    HIV Med 13:602-8. 2012
  2. pmc Vitamin D levels and markers of arterial dysfunction in HIV
    Cecilia M Shikuma
    University of Hawaii, Honolulu, Hawaii 96816, USA
    AIDS Res Hum Retroviruses 28:793-7. 2012
  3. pmc Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV
    Cecilia M Shikuma
    Hawaii Center for AIDS, Department of Medicine, University of Hawaii, Honolulu, HI, USA
    Antivir Ther 17:1233-42. 2012
  4. pmc Change in high-sensitivity c-reactive protein levels following initiation of efavirenz-based antiretroviral regimens in HIV-infected individuals
    Cecilia M Shikuma
    University of Hawaii, Honolulu, Hawaii, USA
    AIDS Res Hum Retroviruses 27:461-8. 2011
  5. ncbi request reprint HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 40:1846-8. 2005
  6. ncbi request reprint Changes in weight and lean body mass during highly active antiretroviral therapy
    C M Shikuma
    Dept of Medicine, Hawaii AIDS Clinical Research Program, University of Hawaii, Manoa, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 39:1223-30. 2004
  7. ncbi request reprint Insulin resistance in the HIV-infected population: the potential role of mitochondrial dysfunction
    C M Shikuma
    Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu 96816, USA
    Curr Drug Targets Infect Disord 5:255-62. 2005
  8. pmc Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    AIDS Res Hum Retroviruses 24:1255-62. 2008
  9. ncbi request reprint Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii at Manoa, Manoa Leihi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Acquir Immune Defic Syndr 44:540-50. 2007
  10. ncbi request reprint Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy
    C M Shikuma
    Pacific Biomedical Research Center, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    AIDS 15:1801-9. 2001

Detail Information

Publications48

  1. pmc Determinants of epidermal nerve fibre density in antiretroviral-naïve HIV-infected individuals
    Cm Shikuma
    University of Hawaii, Honolulu, HI 96816, USA
    HIV Med 13:602-8. 2012
    ....
  2. pmc Vitamin D levels and markers of arterial dysfunction in HIV
    Cecilia M Shikuma
    University of Hawaii, Honolulu, Hawaii 96816, USA
    AIDS Res Hum Retroviruses 28:793-7. 2012
    ..36). Lower vitamin D levels are associated with evidence of subclinical arterial dysfunction in HIV-infected individuals. The significance of these findings warrants further investigation...
  3. pmc Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV
    Cecilia M Shikuma
    Hawaii Center for AIDS, Department of Medicine, University of Hawaii, Honolulu, HI, USA
    Antivir Ther 17:1233-42. 2012
    ..We hypothesized that the continued existence of neurocognitive impairment (NCI) despite potent antiretroviral (ARV) therapy is mediated by the inability of such therapy to control this monocyte/macrophage reservoir...
  4. pmc Change in high-sensitivity c-reactive protein levels following initiation of efavirenz-based antiretroviral regimens in HIV-infected individuals
    Cecilia M Shikuma
    University of Hawaii, Honolulu, Hawaii, USA
    AIDS Res Hum Retroviruses 27:461-8. 2011
    ..hsCRP levels increased significantly only in women. Randomization to abacavir had no effect on changes in hsCRP levels. Changes in hsCRP levels did not correlate with changes in fasting metabolic parameters...
  5. ncbi request reprint HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 40:1846-8. 2005
    ..9 vs. 0.9 copies/10(6) PBMCs; P = .006)...
  6. ncbi request reprint Changes in weight and lean body mass during highly active antiretroviral therapy
    C M Shikuma
    Dept of Medicine, Hawaii AIDS Clinical Research Program, University of Hawaii, Manoa, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 39:1223-30. 2004
    ..Few studies have prospectively evaluated the impact of highly active antiretroviral therapy (HAART) on body weight and lean body mass (LBM) or explored the impact of baseline immunologic or virological changes on these parameters...
  7. ncbi request reprint Insulin resistance in the HIV-infected population: the potential role of mitochondrial dysfunction
    C M Shikuma
    Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu 96816, USA
    Curr Drug Targets Infect Disord 5:255-62. 2005
    ..Based on current knowledge, mitochondrial dysfunction can be hypothesized to play a key role in each of these components...
  8. pmc Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    AIDS Res Hum Retroviruses 24:1255-62. 2008
    ..We conclude that CI and CIV levels in PBMCs correlate to their respective levels in fat and may have utility as surrogate markers of mitochondrial dysfunction in lipoatrophy...
  9. ncbi request reprint Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii at Manoa, Manoa Leihi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Acquir Immune Defic Syndr 44:540-50. 2007
    ..To assess metabolic changes after initiation of protease inhibitor (PI)-sparing regimens in antiretroviral-naive patients...
  10. ncbi request reprint Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy
    C M Shikuma
    Pacific Biomedical Research Center, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    AIDS 15:1801-9. 2001
    ....
  11. ncbi request reprint Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohort
    Victor G Valcour
    Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Acquir Immune Defic Syndr 43:405-10. 2006
    ..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk...
  12. pmc Diabetes, insulin resistance, and dementia among HIV-1-infected patients
    Victor G Valcour
    University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
    J Acquir Immune Defic Syndr 38:31-6. 2005
    ..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection...
  13. pmc The role of HIV and monocytes/macrophages in adipose tissue biology
    Cecilia M Shikuma
    Departments of Medicine, Cell and Molecular Biology, Tropical Medicine, Medical Microbiology, and Pharmacology, University of Hawaii, Honolulu, HI
    J Acquir Immune Defic Syndr 65:151-9. 2014
    ..To assess the role of HIV and monocytes/macrophages in adipose tissue dysregulation...
  14. pmc Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder
    Beau K Nakamoto
    Hawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA
    J Neurovirol 19:601-5. 2013
    ..This finding was not present in an HIV-seronegative control. While ferumoxytol may have potential as an imaging biomarker for monocyte/macrophage accumulation in patients with HAND, future study is needed...
  15. pmc Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals
    Beau K Nakamoto
    University of Hawaii, Honolulu, HI, USA
    J Neurovirol 18:303-12. 2012
    ..Deep gray matter structures and the hippocampus may be vulnerable in subjects with comorbid abnormal glucose metabolism, but our results should be confirmed in further studies...
  16. ncbi request reprint Aerobic Fitness Levels and Validation of a Non Exercise VO2max Prediction Equation for HIV-Infected Patients on HAART
    Katherine Sullivan
    Department of Kinesiology and Rehabilitation Science, College of Education, University of Hawaii Manoa, Honolulu, Hawaii
    HIV Clin Trials 15:69-77. 2014
    ..Based on the level of error associated with utilizing APMHR and N-EX VO2max equations with HIV+ individuals, neither should be used in this population for exercise prescription. ..
  17. pmc HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications
    Victor G Valcour
    Hawaii Center for AIDS, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    J Leukoc Biol 87:621-6. 2010
    ..Herein, we summarize our current understanding of monocyte HIV DNA and central nervous system dysfunction in humans. We present a model to understand these relationships and suggest possible treatment approaches to be tested...
  18. ncbi request reprint Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individuals
    Mariana Gerschenson
    Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Antivir Ther 10:M83-9. 2005
    ..Thigh fat mtDNA levels were 45-55% lower than abdomen and neck. These studies help demonstrate that mtDNA levels can vary in different subcutaneous adipose depots suggesting possible metabolic differences...
  19. pmc IL-1Β enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease
    Emilie Jalbert
    Hawaii Center for HIV AIDS, Honolulu, Hawaii, United States of America Department of Tropical Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
    PLoS ONE 8:e75500. 2013
    ....
  20. pmc Predictors of 25-hydroxyvitamin D levels in HIV-infected patients in Hawai'i
    Louie Mar A Gangcuangco
    University of Hawai i, Honolulu, HI, USA
    Hawaii J Med Public Health 72:197-201. 2013
    ..Seasonal variation in 25(OH)D was observed but the significance of winter visit was not preserved in the final multivariate model. Ethnicity and BMI were better predictors of 25(OH)D levels than season in the tropics...
  21. pmc Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-α levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors
    Cecilia M Shikuma
    1 University of Hawaii, Honolulu, Hawaii
    AIDS Res Hum Retroviruses 30:142-6. 2014
    ....
  22. pmc Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms
    Victor G Valcour
    University of Hawaii, NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, Hawaii 96816, USA
    AIDS 18:S79-86. 2004
    ....
  23. pmc Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand
    Silvia Ratto-Kim
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
    J Neuroimmunol 195:100-7. 2008
    ..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts...
  24. pmc Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV
    Cecilia M Shikuma
    Hawaii Center for AIDS, University of Hawaii, Honolulu, Hawaii, United States of America
    PLoS ONE 9:e90330. 2014
    ..Rates of insulin resistance are increased in HIV-infected patients on stable antiretroviral therapy (ART). Such increase may partially be due to HIV-induced immune dysregulation involving monocytes (MO) and its subsets...
  25. pmc Incident neuropathy in HIV-infected patients on HAART
    Beau K Nakamoto
    Hawaii Center for AIDS, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    AIDS Res Hum Retroviruses 26:759-65. 2010
    ..However, current or prior history of d-drug treatment is not a significant risk factor for incident DSP in subjects who had previously tolerated d-drug treatment without developing a toxic DSP...
  26. ncbi request reprint Symptomatic distal sensory polyneuropathy in HIV after age 50
    M R Watters
    Office of Neurology and Aging Research, Hawaii AIDS Clinical Trials Unit, University of Hawaii, Honolulu 96816, USA
    Neurology 62:1378-83. 2004
    ..To determine if aging changes the frequency, severity, or manifestations of symptomatic distal sensory polyneuropathy (SxDSPN) in patients with HIV-1...
  27. pmc Albuminuria as a marker of cardiovascular risk in HIV-infected individuals receiving stable antiretroviral therapy
    Chawat Tongma
    John A Burns School of Medicine, University of Hawai i, Honolulu, HI
    Hawaii J Med Public Health 72:34-8. 2013
    ..We utilized a cross-sectional baseline data from the Hawai'i Aging with HIV-Cardiovascular Study cohort...
  28. pmc Poorer neuropsychological performance increases risk for social services among HIV-infected individuals
    Tracie M Umaki
    Hawai i Center for AIDS, John A Burns School of Medicine, University of Hawai i at Manoa, Honolulu, HI all authors
    Hawaii J Med Public Health 72:422-6. 2013
    ..Poorer NP performance among HIV-infected individuals is associated with increased risk for social services. Interventions to address causes of cognitive dysfunction in this population may decrease demand for social services. ..
  29. pmc Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy
    Jason D Barbour
    Hawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA Department of Tropical Medicine, John A Burns School of Medicine, Honolulu, HI, USA Electronic address
    Atherosclerosis 232:52-8. 2014
    ..These factors are distinct components of a shared atherogenic process; 1) vascular endothelial molecular expression and 2) vascular monocytes that enter into the vascular endothelium and promote atherosclerotic plaque...
  30. doi request reprint Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170)
    Robert J McLinden
    University of Hawai i at Manoa, Honolulu, Hawaii, USA
    AIDS 26:1-9. 2012
    ..We investigated the impact of neutralizing antibodies (NAbs) on CD4 T-cell count and viral load in a cohort of HAART recipients who underwent extended structured treatment interruption...
  31. ncbi request reprint Validation of the human activity profile in HIV-positive individuals on HAART
    Ronald K Hetzler
    Department of Kinesiology and Rehabilitation Science, College of Education, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA
    HIV Clin Trials 10:254-60. 2009
    ..The HAP is a 94-item questionnaire for estimating functional capacity based on estimated metabolic equivalents for activities of daily living...
  32. ncbi request reprint Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection
    V G Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Neurology 68:525-7. 2007
    ..Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE...
  33. ncbi request reprint High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission
    V R Nerurkar
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii, Honolulu, USA
    J Med Virol 56:123-7. 1998
    ....
  34. pmc HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study
    V G Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
    Neurology 72:992-8. 2009
    ..This study aimed to determine if immunologic and virologic factors influence cognition after first-time HAART in Thai individuals with HIV-associated dementia (HAD) and Thai individuals without HAD (non-HAD)...
  35. ncbi request reprint Sterol regulatory element-binding proteins and reactive oxygen species: potential role in highly-active antiretroviral therapy (HAART)-associated lipodystrophy
    P V Nerurkar
    Retrovirology Research Laboratory, Leahi Hospital, Honolulu, Hawaii 96816, USA
    Clin Biochem 34:519-29. 2001
    ....
  36. ncbi request reprint Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders
    Y Lu
    Retrovirology Research Laboratory, Hawaii AIDS Research Consortium, and Native Hawaiian Health Research Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii 96816, USA
    Int J Infect Dis 3:186-91. 1999
    ....
  37. ncbi request reprint Lamivudine-associated macrocytosis in HIV-infected patients
    Thana Khawcharoenporn
    Department of Medicine, University of Hawaii, Honolulu, Hawaii, HI 96813, USA
    Int J STD AIDS 18:39-40. 2007
    ..We found that lamivudine was strongly associated with macrocytosis (OR = 24.6 [2.9-3223.0], P = 0.001). This association may be due to lamivudine's effect on erythrocyte synthesis...
  38. ncbi request reprint TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration
    Qigui Yu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    J Med Virol 66:276-84. 2002
    ..Our data indicate that PBMC and PBMC subsets are not the major sites of TTV replication...
  39. ncbi request reprint Assessing the needs for HIV medical care in Hawai'i
    Lisa R Marten
    Hawai i AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawai i at Manoa, Honolulu, HI 96816, USA
    Hawaii Med J 68:74-8. 2009
    ..Supporting more than one provider option and linking with ancillary services may help keep HIV patients in care...
  40. pmc Comparative effectiveness of initial antiretroviral therapy regimens: ACTG 5095 and 5142 clinical trials relative to ART-CC cohort study
    Michael J Mugavero
    Division of Infectious Disease, Department of Medicine, University of Alabama, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 58:253-60. 2011
    ....
  41. ncbi request reprint Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry
    Emilie Jalbert
    Hawaii Center for HIV AIDS, University of Hawaii Manoa, Honolulu, Hawaii 96813, USA
    Cytometry A 83:280-6. 2013
    ..Concurrent assessment of multiple receptors will provide insight and greater understanding of the complex interactions involved in cellular migration...
  42. ncbi request reprint Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial
    Roy M Gulick
    Cornell HIV Clinical Trials Unit, Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
    JAMA 296:769-81. 2006
    ..Three-drug antiretroviral regimens are standard of care for initial treatment of human immunodeficiency virus 1 (HIV-1) infection, but a 4-drug regimen could improve antiretroviral activity and be more effective than a 3-drug regimen...
  43. ncbi request reprint Design issues in initial HIV-treatment trials: focus on ACTG A5095
    Heather J Ribaudo
    Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Boston, USA
    Antivir Ther 11:751-60. 2006
    ..We also hope to inform the field regarding issues in choosing composite versus virological endpoints as well as other key considerations in trial design and monitoring...
  44. ncbi request reprint Metabolic complications of HIV therapy
    Dominic C Chow
    IAPAC Mon 12:302-17. 2006
  45. ncbi request reprint Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression
    Roy M Gulick
    Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    AIDS 21:813-23. 2007
    ..To compare a quadruple-nucleoside with an efavirenz-containing regimen for treatment of HIV-1 infection...
  46. ncbi request reprint Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    Roy M Gulick
    Weill Medical College of Cornell University, New York, USA
    N Engl J Med 350:1850-61. 2004
    ....
  47. ncbi request reprint A study of the immunology, virology, and safety of prednisone in HIV-1-infected subjects with CD4 cell counts of 200 to 700 mm(-3)
    Robert S Wallis
    The University Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, USA
    J Acquir Immune Defic Syndr 32:281-6. 2003
    ..The potential role of corticosteroids as tools to examine this question will be limited by concerns regarding their toxicity; however, further studies of other agents to limit cellular activation in AIDS are warranted...
  48. ncbi request reprint Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:1049-57. 2007
    ..Whole body and abdominal obesity are associated with increased risk of diabetes mellitus and heart disease. The effects of testosterone therapy on whole body and visceral fat mass in HIV-infected men with abdominal obesity are unknown...

Research Grants18

  1. Role of macrophages in HIV Lipoatrophy
    Cecilia Shikuma; Fiscal Year: 2007
    ..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
  2. HAWAII ACTU - ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM
    Cecilia Shikuma; Fiscal Year: 2004
    ..abstract_text> ..
  3. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia M Shikuma; Fiscal Year: 2010
    ..We will also study the role of mitochondria (a source of energy for the cell) and HIV in the development of neuropathy. ..
  4. Role of macrophages in HIV Lipoatrophy
    Cecilia M Shikuma; Fiscal Year: 2010
    ..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
  5. Role of Oxidative Stress and Inflammation in HIV Cardiovascular Risk
    Cecilia M Shikuma; Fiscal Year: 2010
    ..End of Abstract) ..
  6. Role of Oxidative Stress and Inflammation in HIV Cardiovascular Risk
    Cecilia Shikuma; Fiscal Year: 2009
    ..End of Abstract) ..
  7. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia Shikuma; Fiscal Year: 2009
    ..We will also study the role of mitochondria (a source of energy for the cell) and HIV in the development of neuropathy. ..
  8. Role of macrophages in HIV Lipoatrophy
    Cecilia Shikuma; Fiscal Year: 2009
    ..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
  9. HAWAII ACTU - ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM
    Cecilia Shikuma; Fiscal Year: 2007
    ..abstract_text> ..
  10. Role of macrophages in HIV Lipoatrophy
    Cecilia Shikuma; Fiscal Year: 2006
    ..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
  11. Mitochondrial Function and HIV Lipoatrophy
    Cecilia Shikuma; Fiscal Year: 2005
    ..Obtained ATP levels will be correlated with level of adipocyte apoptosis as well as with adipocyte mtDNA copies/cell by real-time PCR and SC adipose tissue expression of select oxidative phosphorylation (OXPHOS) genes. ..
  12. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia M Shikuma; Fiscal Year: 2010
    ..We will also study the role of mitochondria (a source of energy for the cell) and HIV in the development of neuropathy. ..