Yuzuru Shiio

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor
    Yanlai Lai
    Greehey Children s Cancer Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 6:e16975. 2011
  2. ncbi request reprint Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4
    Yuzuru Shiio
    Institute for Systems Biology, Seattle, Washington 98103 8904, USA
    J Biol Chem 281:2750-6. 2006
  3. pmc The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1
    Yanlai Lai
    Greehey Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Arch Biochem Biophys 518:103-10. 2012
  4. ncbi request reprint Quantitative proteomic analysis of chromatin-associated factors
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Soc Mass Spectrom 14:696-703. 2003
  5. pmc Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mol Cell Biol 26:1386-97. 2006
  6. pmc Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence
    David J Elzi
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 109:12052-7. 2012
  7. pmc Quantitative proteomic identification of the BRCA1 ubiquitination substrates
    Meihua Song
    Department of Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Proteome Res 10:5191-8. 2011
  8. pmc Wnt antagonist SFRP1 functions as a secreted mediator of senescence
    David J Elzi
    Greehey Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, USA
    Mol Cell Biol 32:4388-99. 2012
  9. pmc Proteomic dissection of the von Hippel-Lindau (VHL) interactome
    Yanlai Lai
    The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Proteome Res 10:5175-82. 2011
  10. ncbi request reprint Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
    Yuzuru Shiio
    Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Nat Protoc 1:139-45. 2006

Research Grants

Collaborators

Detail Information

Publications14

  1. pmc Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor
    Yanlai Lai
    Greehey Children s Cancer Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 6:e16975. 2011
    ..However, several lines of evidence suggest that there are unidentified substrates or targets for VHL that play important roles in tumor suppression...
  2. ncbi request reprint Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4
    Yuzuru Shiio
    Institute for Systems Biology, Seattle, Washington 98103 8904, USA
    J Biol Chem 281:2750-6. 2006
    ..These results suggest that up-regulation of mtCLIC, together with a reduction in Bcl-2 and Bcl-xL, sensitizes Myc-expressing cells to the proapoptotic action of Bax...
  3. pmc The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1
    Yanlai Lai
    Greehey Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Arch Biochem Biophys 518:103-10. 2012
    ..We also demonstrate that HP1 increases the chromatin association of VHL. These results suggest a role for the VHL-HP1 interaction in VHL chromatin targeting...
  4. ncbi request reprint Quantitative proteomic analysis of chromatin-associated factors
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Soc Mass Spectrom 14:696-703. 2003
    ..The method will be widely applicable to various biological systems and reveal changes in chromatin-associated regulatory factors that underlie biological phenomena...
  5. pmc Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mol Cell Biol 26:1386-97. 2006
    ..These results suggest that SAP25 is a novel core component of the mSin3 corepressor complex whose subcellular location is regulated by PML...
  6. pmc Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence
    David J Elzi
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 109:12052-7. 2012
    ..We demonstrate that IGFBP3 is a critical downstream target of PAI-1-induced senescence. These results suggest a role for an extracellular cascade of secreted proteins in the regulation of cellular senescence...
  7. pmc Quantitative proteomic identification of the BRCA1 ubiquitination substrates
    Meihua Song
    Department of Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Proteome Res 10:5191-8. 2011
    ..The quantitative proteomics approach we devised for the identification of BRCA1 substrates will facilitate the identification of ubiquitin ligase-substrate pairs...
  8. pmc Wnt antagonist SFRP1 functions as a secreted mediator of senescence
    David J Elzi
    Greehey Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, USA
    Mol Cell Biol 32:4388-99. 2012
    ....
  9. pmc Proteomic dissection of the von Hippel-Lindau (VHL) interactome
    Yanlai Lai
    The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Proteome Res 10:5175-82. 2011
    ..Our analysis of the VHL19 interactome also uncovered that VHL19 displays an affinity to collagens and their biosynthesis enzymes...
  10. ncbi request reprint Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
    Yuzuru Shiio
    Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Nat Protoc 1:139-45. 2006
    ....
  11. pmc Histone sumoylation is associated with transcriptional repression
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    Proc Natl Acad Sci U S A 100:13225-30. 2003
    ..We present evidence suggesting that histone sumoylation mediates gene silencing through recruitment of histone deacetylase and heterochromatin protein 1...
  12. pmc Quantitative proteomic analysis of Myc oncoprotein function
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    EMBO J 21:5088-96. 2002
    ..These effects are dependent on the highly conserved Myc Box II region. Our results reveal a novel cytoskeletal function for Myc and indicate the feasibility of quantitative whole-proteome analysis in mammalian cells...
  13. pmc Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry
    Frank Desiere
    Nestle Research Center, 1000 Lausanne 26, Switzerland
    Genome Biol 6:R9. 2005
    ..This resource could serve as an expandable repository for MS-derived proteome information...
  14. ncbi request reprint Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:1112-22. 2005
    ..The data suggest that in particular tumor types, such as those associated with CML, c-Myc contributes to tumorigenesis by inhibiting Ras antiproliferative activity...

Research Grants6

  1. Quantitative Proteomic Analysis of the Secretory Pattern of Senescent Cells
    Yuzuru Shiio; Fiscal Year: 2007
    ....
  2. Analysis of the VHL-HIF hydroxylase pathway
    Yuzuru Shiio; Fiscal Year: 2007
    ..These studies should provide a better understanding of the biological functions of VHL and advance the nascent field of proteomics-based biology. ..
  3. Analysis of the VHL-HIF hydroxylase pathway
    Yuzuru Shiio; Fiscal Year: 2009
    ..These studies should provide a better understanding of the biological functions of VHL and advance the nascent field of proteomics-based biology. ..
  4. Analysis of the VHL-HIF hydroxylase pathway
    Yuzuru Shiio; Fiscal Year: 2010
    ..These studies should provide a better understanding of the biological functions of VHL and advance the nascent field of proteomics-based biology. ..