Yuzuru Shiio

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4
    Yuzuru Shiio
    Institute for Systems Biology, Seattle, Washington 98103 8904, USA
    J Biol Chem 281:2750-6. 2006
  2. ncbi request reprint Quantitative proteomic analysis of chromatin-associated factors
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Soc Mass Spectrom 14:696-703. 2003
  3. pmc Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mol Cell Biol 26:1386-97. 2006
  4. pmc Quantitative proteomic analysis of Myc oncoprotein function
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    EMBO J 21:5088-96. 2002
  5. pmc Histone sumoylation is associated with transcriptional repression
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    Proc Natl Acad Sci U S A 100:13225-30. 2003
  6. ncbi request reprint Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:1112-22. 2005
  7. pmc Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry
    Frank Desiere
    Nestle Research Center, 1000 Lausanne 26, Switzerland
    Genome Biol 6:R9. 2005
  8. ncbi request reprint Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
    Yuzuru Shiio
    Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Nat Protoc 1:139-45. 2006

Research Grants

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4
    Yuzuru Shiio
    Institute for Systems Biology, Seattle, Washington 98103 8904, USA
    J Biol Chem 281:2750-6. 2006
    ..These results suggest that up-regulation of mtCLIC, together with a reduction in Bcl-2 and Bcl-xL, sensitizes Myc-expressing cells to the proapoptotic action of Bax...
  2. ncbi request reprint Quantitative proteomic analysis of chromatin-associated factors
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Soc Mass Spectrom 14:696-703. 2003
    ..The method will be widely applicable to various biological systems and reveal changes in chromatin-associated regulatory factors that underlie biological phenomena...
  3. pmc Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mol Cell Biol 26:1386-97. 2006
    ..These results suggest that SAP25 is a novel core component of the mSin3 corepressor complex whose subcellular location is regulated by PML...
  4. pmc Quantitative proteomic analysis of Myc oncoprotein function
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    EMBO J 21:5088-96. 2002
    ..These effects are dependent on the highly conserved Myc Box II region. Our results reveal a novel cytoskeletal function for Myc and indicate the feasibility of quantitative whole-proteome analysis in mammalian cells...
  5. pmc Histone sumoylation is associated with transcriptional repression
    Yuzuru Shiio
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    Proc Natl Acad Sci U S A 100:13225-30. 2003
    ..We present evidence suggesting that histone sumoylation mediates gene silencing through recruitment of histone deacetylase and heterochromatin protein 1...
  6. ncbi request reprint Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:1112-22. 2005
    ..The data suggest that in particular tumor types, such as those associated with CML, c-Myc contributes to tumorigenesis by inhibiting Ras antiproliferative activity...
  7. pmc Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry
    Frank Desiere
    Nestle Research Center, 1000 Lausanne 26, Switzerland
    Genome Biol 6:R9. 2005
    ..This resource could serve as an expandable repository for MS-derived proteome information...
  8. ncbi request reprint Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
    Yuzuru Shiio
    Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Nat Protoc 1:139-45. 2006
    ....

Research Grants6

  1. Quantitative Proteomic Analysis of the Secretory Pattern of Senescent Cells
    Yuzuru Shiio; Fiscal Year: 2007
    ....
  2. Analysis of the VHL-HIF hydroxylase pathway
    Yuzuru Shiio; Fiscal Year: 2007
    ..These studies should provide a better understanding of the biological functions of VHL and advance the nascent field of proteomics-based biology. ..
  3. Analysis of the VHL-HIF hydroxylase pathway
    Yuzuru Shiio; Fiscal Year: 2010
    ..These studies should provide a better understanding of the biological functions of VHL and advance the nascent field of proteomics-based biology. ..