Jean Shih

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Regulation of MAO-A and MAO-B gene expression
    J C Shih
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Science Center, University of Southern California, 1985 Zonal Ave Los Angeles, California 90033, USA
    Curr Med Chem 11:1995-2005. 2004
  2. ncbi request reprint Acquisition and extinction of a conditioned passive avoidance reflex in mice with genetic knockout of monoamine oxidase A
    N I Dubrovina
    State Science Research Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences
    Neurosci Behav Physiol 36:335-9. 2006
  3. pmc Transcriptional regulation and multiple functions of MAO genes
    Jean C Shih
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, Los Angeles, CA 90089, USA
    J Neural Transm 118:979-86. 2011
  4. ncbi request reprint Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B
    Jean Chen Shih
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Science Center, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA
    Neurotoxicology 25:21-30. 2004
  5. ncbi request reprint Monoamine oxidases: from tissue homogenates to transgenic mice
    Jean Chen Shih
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Neurochem Res 32:1757-61. 2007
  6. pmc Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B
    Kevin Chen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 518, Los Angeles, CA 90089, USA
    Mol Pharmacol 79:308-17. 2011
  7. pmc Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation
    Jason Boyang Wu
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    Mol Pharmacol 80:714-23. 2011
  8. pmc Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice
    Kevin Chen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 282:115-23. 2007
  9. ncbi request reprint Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males
    Ru Band Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Alcohol Clin Exp Res 27:889-93. 2003
  10. ncbi request reprint No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan
    Ru Band Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Prog Neuropsychopharmacol Biol Psychiatry 26:457-61. 2002

Research Grants

  1. PROTEIN(S) INVOLVED IN NEUROTRANSMISSION
    Jean Shih; Fiscal Year: 2001
  2. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
  3. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2007
  4. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2009
  5. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2010
  6. PROTEIN(S) INVOLVED IN NEUROTRANSMISSION
    Jean Shih; Fiscal Year: 1993
  7. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2011

Collaborators

  • Kevin Chen
  • Ru Band Lu
  • Jason Boyang Wu
  • N I Dubrovina
  • Rani Maurice Geha
  • R A Tomilenko
  • N K Popova
  • I Seif
  • M A Gilinskii
  • Johan Wouters
  • Frederic Ooms

Detail Information

Publications11

  1. ncbi request reprint Regulation of MAO-A and MAO-B gene expression
    J C Shih
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Science Center, University of Southern California, 1985 Zonal Ave Los Angeles, California 90033, USA
    Curr Med Chem 11:1995-2005. 2004
    ..The differences in MAO A and B gene regulation may explain the different tissue-specific expression and functions of these two important isoenzymes...
  2. ncbi request reprint Acquisition and extinction of a conditioned passive avoidance reflex in mice with genetic knockout of monoamine oxidase A
    N I Dubrovina
    State Science Research Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences
    Neurosci Behav Physiol 36:335-9. 2006
    ....
  3. pmc Transcriptional regulation and multiple functions of MAO genes
    Jean C Shih
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, Los Angeles, CA 90089, USA
    J Neural Transm 118:979-86. 2011
    ..This review discusses the recent progress in the transcriptional regulation and multiple functions of MAO A and MAO B genes...
  4. ncbi request reprint Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B
    Jean Chen Shih
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Science Center, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA
    Neurotoxicology 25:21-30. 2004
    ..In contrast, MAO B KO mice are resistant to MPTP, a toxin which induces Parkinson's syndromes. Studies of these mice suggest that MAO A and B have distinct biochemical and physiological functions...
  5. ncbi request reprint Monoamine oxidases: from tissue homogenates to transgenic mice
    Jean Chen Shih
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Neurochem Res 32:1757-61. 2007
    ....
  6. pmc Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B
    Kevin Chen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 518, Los Angeles, CA 90089, USA
    Mol Pharmacol 79:308-17. 2011
    ..Together, this study uncovers for the first time the molecular mechanisms for glucocorticoid activation of MAO B gene and provides new insights into the hormonal regulation of MAO...
  7. pmc Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation
    Jason Boyang Wu
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    Mol Pharmacol 80:714-23. 2011
    ..Taken together, these results demonstrate that MAO A is a novel target for VPA via Akt/FoxO1 signaling pathway. This information provides new insights into the pharmacological mechanisms and therapeutic implications of VPA action...
  8. pmc Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice
    Kevin Chen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 282:115-23. 2007
    ..Thus, the lack of MAO A in the forebrain of MAO A KO mice may underlie their phenotypes...
  9. ncbi request reprint Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males
    Ru Band Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Alcohol Clin Exp Res 27:889-93. 2003
    ..Therefore, association studies of alcoholism or antisocial personality disorder in Chinese may be more reliable if pure antisocial alcoholics, pure antisocial personality disorders, and normal controls as MAO-A gene are examined...
  10. ncbi request reprint No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan
    Ru Band Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Prog Neuropsychopharmacol Biol Psychiatry 26:457-61. 2002
    ..This finding suggests that no association exists between genetic variation at the MAOA locus and alcoholism in Chinese Han males...
  11. pmc Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling
    Rani Maurice Geha
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089 9121, USA
    J Biol Chem 277:17209-16. 2002
    ..Three-dimensional modeling of MAO A and B using polyamine oxidase as template suggests that the overall tertiary structure and the active sites of MAO A and B may be similar...

Research Grants25

  1. PROTEIN(S) INVOLVED IN NEUROTRANSMISSION
    Jean Shih; Fiscal Year: 2001
    ..The tissue distribution of factor b will be studied by Northern analysis. Factor b polypeptide(s) will also be expressed in resting Jurkat cells to see if it can stimulate IL-2 production. ..
  2. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
    ..These studies are important for both basic neuropharmacology and clinical research. ..
  3. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2007
    ..Co-regulators interacting with APJGR during agonist stimulated or basal state will be co-immuno-precipitated by AR or GR specific antibody. The validity and the function of identified protein(s) will be investigated. ..
  4. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2009
    ..It will also shed new light on preventive, diagnostic and therapeutic strategies for aggression and other mental disorders associated with abnormal monoamine neurotransmission. ..
  5. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2010
    ..It will also shed new light on preventive, diagnostic and therapeutic strategies for aggression and other mental disorders associated with abnormal monoamine neurotransmission. ..
  6. PROTEIN(S) INVOLVED IN NEUROTRANSMISSION
    Jean Shih; Fiscal Year: 1993
    ..Similar studies will be performed using activators of PKA such as forskolin and 8- bromodibutyryl cAMP. 6b. To investigate if antagonist induced 5-HT-2 receptor down regulation is at the transcriptional level...
  7. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2011
    ..It will also shed new light on preventive, diagnostic and therapeutic strategies for aggression and other mental disorders associated with abnormal monoamine neurotransmission. ..