J C Shih

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Room 528, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Brain Res 835:104-12. 1999
  2. pmc Monoamine oxidase: from genes to behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Annu Rev Neurosci 22:197-217. 1999
  3. ncbi Ginkgo biloba abolishes aggression in mice lacking MAO A
    J C Shih
    University of Southern California, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, Los Angeles 90089, USA
    Antioxid Redox Signal 2:467-71. 2000
  4. ncbi Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid
    R M Geha
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:9877-82. 2001
  5. ncbi Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice
    O U Scremin
    Department of Physiology, UCLA School of Medicine, Los Angeles, CA, USA
    Brain Res 824:36-44. 1999
  6. ncbi Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, LAC USC School of Medicine, 1200 North State St, CA 90033, Los Angeles, USA
    Neuroscience 101:869-77. 2000
  7. ncbi MAO-A and -B gene knock-out mice exhibit distinctly different behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, University of Southern California, School of Pharmacy, Los Angeles 90033, USA
    Neurobiology (Bp) 7:235-46. 1999
  8. pmc Human monoamine oxidase A and B genes exhibit identical exon-intron organization
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Proc Natl Acad Sci U S A 88:3637-41. 1991
  9. ncbi Effects of carboxyl-terminal truncations on the activity and solubility of human monoamine oxidase B
    I Rebrin
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:29499-506. 2001
  10. ncbi Cloning of a novel monoamine oxidase cDNA from trout liver
    K Chen
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Mol Pharmacol 46:1226-33. 1994

Collaborators

Detail Information

Publications35

  1. ncbi Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Room 528, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Brain Res 835:104-12. 1999
    ..This study suggests that ketanserin and TBZ may be developed as novel anti-aggressive agents...
  2. pmc Monoamine oxidase: from genes to behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Annu Rev Neurosci 22:197-217. 1999
    ..Both MAO A and B knock-out mice show increased reactivity to stress. These knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders...
  3. ncbi Ginkgo biloba abolishes aggression in mice lacking MAO A
    J C Shih
    University of Southern California, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, Los Angeles 90089, USA
    Antioxid Redox Signal 2:467-71. 2000
    ..This suggests that the antiaggressive effect of EGb may be mediated by 5-HT2A receptors and that EGb may be developed as a novel antiaggressive agent...
  4. ncbi Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid
    R M Geha
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:9877-82. 2001
    ..Our results indicate that Ile-335 in MAO A and Tyr-326 in MAO B play a critical role in determining substrate and inhibitor specificities in human MAO A and B...
  5. ncbi Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice
    O U Scremin
    Department of Physiology, UCLA School of Medicine, Los Angeles, CA, USA
    Brain Res 824:36-44. 1999
    ..It is concluded that MAOB may normally regulate CBF distribution and its response to blood PEA...
  6. ncbi Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, LAC USC School of Medicine, 1200 North State St, CA 90033, Los Angeles, USA
    Neuroscience 101:869-77. 2000
    ..Such a differential response may reflect neurodevelopmental abnormalities and/or effects of a chronic physiological adaptation on the regulation of cortical activation...
  7. ncbi MAO-A and -B gene knock-out mice exhibit distinctly different behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, University of Southern California, School of Pharmacy, Los Angeles 90033, USA
    Neurobiology (Bp) 7:235-46. 1999
    ..MAO KO mice are valuable models for investigating the role of monoamines in aggression and neurodegenerative and stress-related disorders...
  8. pmc Human monoamine oxidase A and B genes exhibit identical exon-intron organization
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Proc Natl Acad Sci U S A 88:3637-41. 1991
    ..9% peptide identity. These results suggest that MAOA and MAOB are derived from duplication of a common ancestral gene and provide insight on the structural/functional relationship of the enzyme products...
  9. ncbi Effects of carboxyl-terminal truncations on the activity and solubility of human monoamine oxidase B
    I Rebrin
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:29499-506. 2001
    ..Further, our results suggest that the carboxyl-terminal of MAO A and B plays different roles in mitochondrial attachment...
  10. ncbi Cloning of a novel monoamine oxidase cDNA from trout liver
    K Chen
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Mol Pharmacol 46:1226-33. 1994
    ..The structure of trout MAO will provide insights into the substrate and inhibitor selectivities of the MAOs...
  11. ncbi Increased stress response and beta-phenylethylamine in MAOB-deficient mice
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Nat Genet 17:206-10. 1997
    ..Indeed, MAOB-deficient mice showed an increased reactivity to stress. In addition, mutant mice were resistant to the neurodegenerative effects of MPTP, a toxin that induces a condition reminiscent of Parkinson's disease...
  12. ncbi Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease
    N C Lan
    Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033
    Genomics 4:552-9. 1989
    ..3)...
  13. ncbi Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, USC School of Medicine, Los Angeles, CA 90089, USA
    Brain Res Bull 56:453-62. 2001
    ..Differences are discussed in relation to the biochemical, behavioral, and physiologic changes investigated to date, as well as the role played by redundancy mechanisms, adaptational responses, and alterations in neurodevelopment...
  14. pmc Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
    J J Kim
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Proc Natl Acad Sci U S A 94:5929-33. 1997
    ..These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior...
  15. ncbi Heart rate dynamics in monoamine oxidase-A- and -B-deficient mice
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, University of Southern California, Keck School of Medicine, Los Angeles 90089, USA
    Am J Physiol Heart Circ Physiol 282:H1751-9. 2002
    ..Monoamine oxidase-deficient mice may represent a useful experimental model for studying compensatory mechanisms responsible for changes in HR dynamics in chronic states of high sympathetic tone...
  16. ncbi Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the Morris water maze
    D P Holschneider
    Dept of Psychiatry and the Behavioral Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Life Sci 65:1757-63. 1999
    ..Our results show that presence or absence of MAO-B does not appear to alter performance in the Morris water maze. Furthermore, presence or absence of MAO-B does not provide protection from the age-dependent deficits in spatial learning...
  17. ncbi Promoter organization and activity of human monoamine oxidase (MAO) A and B genes
    Q S Zhu
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    J Neurosci 12:4437-46. 1992
    ..2 kb for MAO B). Inclusion of these sequences decreased promoter activity. The different promoter organization of MAO A and B genes provides the basis for their different tissue- and cell-specific expression...
  18. ncbi Gene structure and expression of the mouse 5-HT2 receptor
    W Yang
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    J Neurosci Res 33:196-204. 1992
    ..Southern analysis of mouse liver genomic DNA shows a simple pattern of digestion by several restriction enzymes, which suggests that one copy of the 5-HT2 receptor gene may exist in the mouse genome...
  19. ncbi Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines
    H F Wu
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Mol Pharmacol 43:888-93. 1993
    ....
  20. ncbi Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product
    J W Voncken
    Division of Hematology Oncology, Childrens Hospital of Los Angeles Research Institute, University of Southern California, 90027, USA
    Int J Mol Med 2:577-83. 1998
    ..Combined biochemical and behavioral data indicate that bcr is involved in mediating the cellular effects of glucocorticoids, specifically down-regulation of the stress-activated hippocampal hypothalamic-pituitary-adrenal axis...
  21. ncbi The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical
    K Chen
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    J Neurochem 61:187-90. 1993
    ..These findings indicate the validity of using platelet MAO B mRNA as a marker for brain MAO B and provide a new approach to study the role of brain MAO B in humans...
  22. ncbi Regulation of human monoamine oxidase B gene by Sp1 and Sp3
    W K Wong
    Department of Cell and Neurobiology, School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Pharmacol 59:852-9. 2001
    ..These results suggest that the binding to the overlapping Sp1 sites by various members of Sp family is important for the regulation of the MAO B gene expression...
  23. ncbi Increased baroreceptor response in mice deficient in monoamine oxidase A and B
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, LAC USC Hosp, University of Southern California Los Angeles 90024, USA
    Am J Physiol Heart Circ Physiol 282:H964-72. 2002
    ..These data suggest that prevention of hypertension may occur in chronic states of catecholaminergic/indoleaminergic excess by increased gain of the baroreflex...
  24. ncbi Lack of protection from ischemic injury of monoamine oxidase B-deficient mice following middle cerebral artery occlusion
    D P Holschneider
    Department of Psychiatry, USC School of Medicine, West Los Angeles, VA Medical Center, CA, USA
    Neurosci Lett 259:161-4. 1999
    ..Our results suggest that absence of the MAO-B gene or inhibition of the enzyme with L-deprenyl are not protective or detrimental in an animal model of acute cortical infarction...
  25. ncbi Regulation of MAO-A and MAO-B gene expression
    J C Shih
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Science Center, University of Southern California, 1985 Zonal Ave Los Angeles, California 90033, USA
    Curr Med Chem 11:1995-2005. 2004
    ..The differences in MAO A and B gene regulation may explain the different tissue-specific expression and functions of these two important isoenzymes...
  26. ncbi 2-Naphthylamine, a compound found in cigarette smoke, decreases both monoamine oxidase A and B catalytic activity
    N Hauptmann
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, USA
    Life Sci 68:1231-41. 2001
    ..The inhibitory effect of 2-naphthylamine on both MAO A and B catalytic activity, supports the hypothesis that smoking decreases MAO activity in vivo, instead that smokers with lower MAO activity are more prone to become a smoker...
  27. ncbi The human 5-HT2 receptor is encoded by a multiple intron-exon gene
    K Chen
    Department of Molecular Pharmacology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Brain Res Mol Brain Res 14:20-6. 1992
    ..The deduced amino acid sequence of the human, mouse and rat 5-HT2 receptors are highly conserved and all three share a 90% sequence similarity...
  28. ncbi MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake
    M Lee
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA
    Genes Brain Behav 3:216-27. 2004
    ..The data suggest that the absence of MAO-B impairs the ability of mice to habituate in the inescapable environment, but does not alter their nicotine intake...
  29. pmc Localization of monoamine oxidase A and B genes on the mouse X chromosome
    J M Derry
    MRC Molecular Neurobiology Unit, Medical Research Council Centre, Cambridge, UK
    Nucleic Acids Res 17:8403. 1989
  30. pmc Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
    O Cases
    Centre National de la Recherche Scientifique CNRS, Unité de Recherche Associée URA, Institut Curie, Orsay, France
    Science 268:1763-6. 1995
    ..Adults manifested a distinct behavioral syndrome, including enhanced aggression in males...
  31. ncbi Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study
    F Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Italy
    J Neurochem 73:2434-40. 1999
    ..This is in contrast to the rat, where DA is always metabolized by MAO A regardless of concentration...
  32. pmc cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties
    A W Bach
    Center for Molecular Biology, University of Heidelberg, F R G
    Proc Natl Acad Sci U S A 85:4934-8. 1988
    ..Based on differences in primary amino acid sequences and RNA gel blot analysis of mRNAs, the A and B forms of monoamine oxidase appear to be derived from separate genes...
  33. ncbi Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia
    J Erdmann
    Institute of Human Genetics, University of Bonn, Germany
    Hum Genet 97:614-9. 1996
    ..However, the reported association of the non-coding polymorphism 102T/C with the disease has also been detected in our sample (P=0.041, odds ratio=1.28, 95% confidence interval 1.012-1.623)...
  34. ncbi Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human chromosome 13q14-q21 and mouse chromosome 14
    R S Sparkes
    Department of Medicine, UCLA School of Medicine
    Genomics 9:461-5. 1991
    ..A gene for serotonin 5HT-2 receptor (HTR2) is assigned to human chromosome 13 by somatic cell hybrids and to region 13q14-q21 by in situ hybridization. It is assigned to mouse chromosome 14 by somatic cell hybrid analysis...
  35. ncbi Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry
    J Saura
    E Hoffmann La Roche Ltd, Basel, Switzerland
    Neuroscience 70:755-74. 1996
    ..The combination of quantitative enzyme radioautography with in situ hybridization histochemistry is a useful approach to study, with high resolution, both the physiology and pathophysiology of monoamine oxidases in human brain...