Research Topics
| W D ShieldsSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Management of epilepsy in mentally retarded children using the newer antiepileptic drugs, vagus nerve stimulation, and surgeryW Donald Shields
Department of Pediatric Neurology, UCLA Medical Center, 10833 LeConte Avenue, Los Angeles, CA 90095 1752, USA
J Child Neurol 19:S58-64. 2004..In carefully selected children with specific epilepsy syndromes, epilepsy surgery can provide partial or complete relief from seizures...
Benign epilepsy with centrotemporal spikesW Donald Shields
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Epilepsia 50:10-5. 2009..Future research may lead to changes in the recommendations...- Catastrophic epilepsy in childhoodW D Shields
Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, Los Angeles, California, USA
Epilepsia 41:S2-6. 2000..In such patients, control of the seizures may lead to more normal intellectual development. Thus, every effort should be made to control seizures in children with catastrophic epilepsy... - Effects of epilepsy surgery on psychiatric and behavioral comorbidities in children and adolescentsW Donald Shields
Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
Epilepsy Behav 5:S18-24. 2004..Psychiatric and behavioral outcomes in older children with complex partial epilepsy are less clear; many patients improve, but there does appear to be a small risk of developing new psychiatric or behavioral disorders postoperatively... - Diagnosis of infantile spasms, Lennox-Gastaut syndrome, and progressive myoclonic epilepsyW Donald Shields
Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, U S A
Epilepsia 45:2-4. 2004..Accurate diagnosis of both the syndrome and the etiology is very important for treatment purposes, as well as for family education, since many of the disorders have a significant genetic component... - Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasmsR Jonas
Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA
Neurology 64:746-50. 2005..In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy... 
Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complexJ Y Wu
Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, CA 90095 1752, USA
Neurology 74:392-8. 2010..We assessed whether magnetic source imaging (MSI) and coregistration of (18)fluorodeoxyglucose PET (FDG-PET) with MRI could improve the identification of the epileptogenic regions noninvasively in children with TSC...- FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsyN Salamon
Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
Neurology 71:1594-601. 2008..This study determined whether fluorodeoxyglucose (FDG)-PET/MRI coregistration enhanced the recognition of CD in epilepsy surgery patients... - Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986-2008M Hemb
Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
Neurology 74:1768-75. 2010..Epilepsy neurosurgery is a treatment option for children with refractory epilepsy. Our aim was to determine if outcomes improved over time... - Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997G W Mathern
Division of Neurosurgery, The Mental Retardation Research Center, University of California, Los Angeles, USA
Epilepsia 40:1740-9. 1999..Stopping the seizures may prevent these disabilities, but it is unclear whether resective surgery is associated with adequate long-term seizure control... - Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complexJ Y Wu
Division of Pediatric Neurology, The Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Neurology 66:1270-2. 2006..02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy... - Blink rate in pediatric complex partial seizure disorderR Caplan
UCLA, Los Angeles, CA, USA
J Child Psychol Psychiatry 39:1145-52. 1998..Given previously reported low blink rates in schizophrenic children, these findings suggest that children with complex partial epilepsy or schizophrenia might have similar biological features... - Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomesR Jonas
Division of Pediatric Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
Neurology 62:1712-21. 2004..Furthermore, shorter seizure durations, seizure control, and greater presurgery developmental quotients predicted better postsurgery developmental quotients in all patients, irrespective of pathology... - Conversational repair in pediatric epilepsyR Caplan
Department of Psychiatry, University of California, Los Angeles 90024, USA
Brain Lang 78:82-93. 2001..The CPS and PGE patients with frontal lobe involvement underused fillers compared to the normal children. These findings provide additional evidence that both CPS and PGE impact the ongoing development of children's communication skills... - Favorable longitudinal outcome in a patient with Parry-Romberg syndromeM F Waters
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
Acta Neurol Scand 112:192-3. 2005 - Incidence of death in patients with intractable epilepsy during nitrazepam treatmentP J Rintahaka
UCLA School of Medicine, Los Angeles, California 90095 1752, USA
Epilepsia 40:492-6. 1999..Increased risk of death has been reported in patients with intractable epilepsy (IE) taking nitrazepam (NZP)... - Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absenceD Ott
Neuropsychiatric Institute, Los Angeles, CA, 90024, USA
J Am Acad Child Adolesc Psychiatry 40:907-14. 2001.... - Children with ESES: variability in the syndromeMichele Van Hirtum-Das
Department of Pediatrics and Neurology, David Geffen School of Medicine at UCLA, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA
Epilepsy Res 70:S248-58. 2006..However, the prognosis of LKS is substantially better than CSWS and these two disorders could be classified in a dichotomous manner rather than be seen as two points along a continuum... - Hippocampal volume in childhood complex partial seizuresMelita Daley
UCLA Department of Psychiatry, Psychiatry and Biobehavioral Sciences, UCLA, Semel Institute, Rm 48 253B, 760 Westwood Plaza, Los Angeles, CA 90095 1759, USA
Epilepsy Res 72:57-66. 2006..g., age, gender, ethnicity, socioeconomic status). It also examined the relationship between hippocampal volumes and seizure variables in the patients... - Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemiaPeter F Morrison
Department of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Pediatr Neurol 35:356-8. 2006.... - Frontal and temporal volumes in children with epilepsyMelita Daley
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1759, USA
Epilepsy Behav 10:470-6. 2007..These findings highlight the need to control for seizure, cognitive, psychiatric, and demographic variables in studies of frontotemporal volumes in pediatric CPS... - Amygdala volume and psychopathology in childhood complex partial seizuresMelita Daley
Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90095 1759, USA
Epilepsy Behav 13:212-7. 2008..The relationship of amygdala volume to seizure variables and presence of psychopathology was also examined in these patients... - Children get their due: A study of pediatric epilepsy patients before drug approvalW Donald Shields
Neurology 70:1946-7. 2008 - Special issues in the management of young children, older adults, and the developmentally disabledR Eugene Ramsay
International Center for Epilepsy, University of Miami, Miami, Florida 33136, USA
J Child Neurol 22:53S-60S. 2007..It is important to have a plan for management of prolonged and repetitive seizures. Long-term therapy should be managed in a manner that will eliminate the need for rescue therapies and visits to the emergency department... - Medical versus surgical treatment: which treatment whenW Donald Shields
Division of Pediatric Neurology, Mattel Children's Hospital, University of California, Los Angeles, California 90095, USA
Int Rev Neurobiol 49:253-67. 2002 - Behavioral disorders in pediatric epilepsy: unmet psychiatric needDerek Ott
Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
Epilepsia 44:591-7. 2003..This study examined the relation between psychiatric diagnosis and mental health services in children with epilepsy and the associated demographic, cognitive, linguistic, behavioral, and seizure-related variables... - Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patientsShon W Cook
Division of Neurosurgery, Department of Anesthesiology, The Brain Research Institute, The Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
J Neurosurg 100:125-41. 2004.... - Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomySusan Koh
Department of Pediatric Neurology, University of California, Los Angeles, California, USA
Epilepsia 45:527-33. 2004..Thus the number of APOSs was a predictor of postsurgery seizure control and can be used to counsel patients and families about prognosis after hemispherectomy... - Efficacy and safety of levetiracetam in children with partial seizures: an open-label trialTracy A Glauser
Department of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Epilepsia 43:518-24. 2002..To assess the efficacy and safety of levetiracetam (LEV) as adjunctive therapy in children with treatment-resistant partial-onset seizures... - West's syndromeW Donald Shields
Division of Pediatric Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1752, USA
J Child Neurol 17:S76-9. 2002..This article reviews the etiologies associated with West's syndrome, antiepilepsy drug therapies currently being used to treat the syndrome, and other treatment options available to clinicians... - Psychopathology and pediatric complex partial seizures: seizure-related, cognitive, and linguistic variablesRochelle Caplan
Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
Epilepsia 45:1273-81. 2004..This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence... - Social communication in children with epilepsyRochelle Caplan
UCLA, USA
J Child Psychol Psychiatry 43:245-53. 2002..1-16.9 years... - Depression and anxiety disorders in pediatric epilepsyRochelle Caplan
Department of Psychiatry, University of California at Los Angeles, 90024, USA
Epilepsia 46:720-30. 2005..This study examined affective disorders, anxiety disorders, and suicidality in children with epilepsy and their association with seizure-related, cognitive, linguistic, family history, social competence, and demographic variables... - Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patientsSusan Koh
Division of Pediatric Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
Epilepsia 46:1950-4. 2005..However, this concept is based on case reports, and the incidence and clinical characteristics of these patients have not been systematically assessed... - Developmental outcome with and without successful interventionRochelle Caplan
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Int Rev Neurobiol 49:269-84. 2002..Finally, the underlying pathology of the resected brain, rather than ongoing seizures and seizure type, plays an important role in development of the remaining brain tissue and the outcome of early onset symptomatic IS and non-IS... - Recurrent de novo mutations of SCN1A in severe myoclonic epilepsy of infancyJennifer A Kearney
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
Pediatr Neurol 34:116-20. 2006..Review of the literature indicates that recurrent mutations account for 25% of SCN1A mutations in severe myoclonic epilepsy of infancy, including six sites of deamination at CpG dinucleotides...