W D Shields

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Management of epilepsy in mentally retarded children using the newer antiepileptic drugs, vagus nerve stimulation, and surgery
    W Donald Shields
    Department of Pediatric Neurology, UCLA Medical Center, 10833 LeConte Avenue, Los Angeles, CA 90095 1752, USA
    J Child Neurol 19:S58-64. 2004
  2. doi request reprint Benign epilepsy with centrotemporal spikes
    W Donald Shields
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 50:10-5. 2009
  3. ncbi request reprint Catastrophic epilepsy in childhood
    W D Shields
    Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, Los Angeles, California, USA
    Epilepsia 41:S2-6. 2000
  4. ncbi request reprint Effects of epilepsy surgery on psychiatric and behavioral comorbidities in children and adolescents
    W Donald Shields
    Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 5:S18-24. 2004
  5. ncbi request reprint Diagnosis of infantile spasms, Lennox-Gastaut syndrome, and progressive myoclonic epilepsy
    W Donald Shields
    Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, U S A
    Epilepsia 45:2-4. 2004
  6. ncbi request reprint Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms
    R Jonas
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA
    Neurology 64:746-50. 2005
  7. pmc Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex
    J Y Wu
    Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, CA 90095 1752, USA
    Neurology 74:392-8. 2010
  8. pmc FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy
    N Salamon
    Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
    Neurology 71:1594-601. 2008
  9. pmc Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986-2008
    M Hemb
    Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
    Neurology 74:1768-75. 2010
  10. ncbi request reprint Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997
    G W Mathern
    Division of Neurosurgery, The Mental Retardation Research Center, University of California, Los Angeles, USA
    Epilepsia 40:1740-9. 1999

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Management of epilepsy in mentally retarded children using the newer antiepileptic drugs, vagus nerve stimulation, and surgery
    W Donald Shields
    Department of Pediatric Neurology, UCLA Medical Center, 10833 LeConte Avenue, Los Angeles, CA 90095 1752, USA
    J Child Neurol 19:S58-64. 2004
    ..In carefully selected children with specific epilepsy syndromes, epilepsy surgery can provide partial or complete relief from seizures...
  2. doi request reprint Benign epilepsy with centrotemporal spikes
    W Donald Shields
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 50:10-5. 2009
    ..Future research may lead to changes in the recommendations...
  3. ncbi request reprint Catastrophic epilepsy in childhood
    W D Shields
    Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, Los Angeles, California, USA
    Epilepsia 41:S2-6. 2000
    ..In such patients, control of the seizures may lead to more normal intellectual development. Thus, every effort should be made to control seizures in children with catastrophic epilepsy...
  4. ncbi request reprint Effects of epilepsy surgery on psychiatric and behavioral comorbidities in children and adolescents
    W Donald Shields
    Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 5:S18-24. 2004
    ..Psychiatric and behavioral outcomes in older children with complex partial epilepsy are less clear; many patients improve, but there does appear to be a small risk of developing new psychiatric or behavioral disorders postoperatively...
  5. ncbi request reprint Diagnosis of infantile spasms, Lennox-Gastaut syndrome, and progressive myoclonic epilepsy
    W Donald Shields
    Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, U S A
    Epilepsia 45:2-4. 2004
    ..Accurate diagnosis of both the syndrome and the etiology is very important for treatment purposes, as well as for family education, since many of the disorders have a significant genetic component...
  6. ncbi request reprint Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms
    R Jonas
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA
    Neurology 64:746-50. 2005
    ..In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy...
  7. pmc Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex
    J Y Wu
    Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, CA 90095 1752, USA
    Neurology 74:392-8. 2010
    ..We assessed whether magnetic source imaging (MSI) and coregistration of (18)fluorodeoxyglucose PET (FDG-PET) with MRI could improve the identification of the epileptogenic regions noninvasively in children with TSC...
  8. pmc FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy
    N Salamon
    Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
    Neurology 71:1594-601. 2008
    ..This study determined whether fluorodeoxyglucose (FDG)-PET/MRI coregistration enhanced the recognition of CD in epilepsy surgery patients...
  9. pmc Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986-2008
    M Hemb
    Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
    Neurology 74:1768-75. 2010
    ..Epilepsy neurosurgery is a treatment option for children with refractory epilepsy. Our aim was to determine if outcomes improved over time...
  10. ncbi request reprint Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997
    G W Mathern
    Division of Neurosurgery, The Mental Retardation Research Center, University of California, Los Angeles, USA
    Epilepsia 40:1740-9. 1999
    ..Stopping the seizures may prevent these disabilities, but it is unclear whether resective surgery is associated with adequate long-term seizure control...
  11. ncbi request reprint Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex
    J Y Wu
    Division of Pediatric Neurology, The Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurology 66:1270-2. 2006
    ..02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy...
  12. ncbi request reprint Blink rate in pediatric complex partial seizure disorder
    R Caplan
    UCLA, Los Angeles, CA, USA
    J Child Psychol Psychiatry 39:1145-52. 1998
    ..Given previously reported low blink rates in schizophrenic children, these findings suggest that children with complex partial epilepsy or schizophrenia might have similar biological features...
  13. ncbi request reprint Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes
    R Jonas
    Division of Pediatric Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Neurology 62:1712-21. 2004
    ..To compare hemispherectomy patients with different pathologic substrates for hospital course, seizure, developmental, language, and motor outcomes...
  14. ncbi request reprint Conversational repair in pediatric epilepsy
    R Caplan
    Department of Psychiatry, University of California, Los Angeles 90024, USA
    Brain Lang 78:82-93. 2001
    ..The CPS and PGE patients with frontal lobe involvement underused fillers compared to the normal children. These findings provide additional evidence that both CPS and PGE impact the ongoing development of children's communication skills...
  15. ncbi request reprint Favorable longitudinal outcome in a patient with Parry-Romberg syndrome
    M F Waters
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    Acta Neurol Scand 112:192-3. 2005
  16. ncbi request reprint Incidence of death in patients with intractable epilepsy during nitrazepam treatment
    P J Rintahaka
    UCLA School of Medicine, Los Angeles, California 90095 1752, USA
    Epilepsia 40:492-6. 1999
    ..Increased risk of death has been reported in patients with intractable epilepsy (IE) taking nitrazepam (NZP)...
  17. ncbi request reprint Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence
    D Ott
    Neuropsychiatric Institute, Los Angeles, CA, 90024, USA
    J Am Acad Child Adolesc Psychiatry 40:907-14. 2001
    ....
  18. ncbi request reprint Children with ESES: variability in the syndrome
    Michele Van Hirtum-Das
    Department of Pediatrics and Neurology, David Geffen School of Medicine at UCLA, Mattel Children s Hospital at UCLA, Los Angeles, CA, USA
    Epilepsy Res 70:S248-58. 2006
    ..We undertook a retrospective study of children who present with significant activation of paroxysmal discharges during sleep to examine the clinical spectrum of disorders that present with such an EEG abnormality...
  19. ncbi request reprint Hippocampal volume in childhood complex partial seizures
    Melita Daley
    UCLA Department of Psychiatry, Psychiatry and Biobehavioral Sciences, UCLA, Semel Institute, Rm 48 253B, 760 Westwood Plaza, Los Angeles, CA 90095 1759, USA
    Epilepsy Res 72:57-66. 2006
    ..g., age, gender, ethnicity, socioeconomic status). It also examined the relationship between hippocampal volumes and seizure variables in the patients...
  20. ncbi request reprint Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia
    Peter F Morrison
    Department of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pediatr Neurol 35:356-8. 2006
    ....
  21. ncbi request reprint Frontal and temporal volumes in children with epilepsy
    Melita Daley
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1759, USA
    Epilepsy Behav 10:470-6. 2007
    ..These findings highlight the need to control for seizure, cognitive, psychiatric, and demographic variables in studies of frontotemporal volumes in pediatric CPS...
  22. pmc Amygdala volume and psychopathology in childhood complex partial seizures
    Melita Daley
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90095 1759, USA
    Epilepsy Behav 13:212-7. 2008
    ..The relationship of amygdala volume to seizure variables and presence of psychopathology was also examined in these patients...
  23. doi request reprint Children get their due: A study of pediatric epilepsy patients before drug approval
    W Donald Shields
    Neurology 70:1946-7. 2008
  24. ncbi request reprint Special issues in the management of young children, older adults, and the developmentally disabled
    R Eugene Ramsay
    International Center for Epilepsy, University of Miami, Miami, Florida 33136, USA
    J Child Neurol 22:53S-60S. 2007
    ..It is important to have a plan for management of prolonged and repetitive seizures. Long-term therapy should be managed in a manner that will eliminate the need for rescue therapies and visits to the emergency department...
  25. ncbi request reprint Medical versus surgical treatment: which treatment when
    W Donald Shields
    Division of Pediatric Neurology, Mattel Children s Hospital, University of California, Los Angeles, California 90095, USA
    Int Rev Neurobiol 49:253-67. 2002
  26. ncbi request reprint Behavioral disorders in pediatric epilepsy: unmet psychiatric need
    Derek Ott
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
    Epilepsia 44:591-7. 2003
    ..This study examined the relation between psychiatric diagnosis and mental health services in children with epilepsy and the associated demographic, cognitive, linguistic, behavioral, and seizure-related variables...
  27. ncbi request reprint Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients
    Shon W Cook
    Division of Neurosurgery, Department of Anesthesiology, The Brain Research Institute, The Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    J Neurosurg 100:125-41. 2004
    ..Few studies have been conducted to compare whether there are perioperative differences based on hemispherectomy technique and/or pathological substrate in pediatric patients with epilepsy...
  28. ncbi request reprint Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy
    Susan Koh
    Department of Pediatric Neurology, University of California, Los Angeles, California, USA
    Epilepsia 45:527-33. 2004
    ..It is unknown whether APOSs also predict seizure outcome or hospital course after hemispherectomy...
  29. ncbi request reprint Efficacy and safety of levetiracetam in children with partial seizures: an open-label trial
    Tracy A Glauser
    Department of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Epilepsia 43:518-24. 2002
    ..To assess the efficacy and safety of levetiracetam (LEV) as adjunctive therapy in children with treatment-resistant partial-onset seizures...
  30. ncbi request reprint West's syndrome
    W Donald Shields
    Division of Pediatric Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1752, USA
    J Child Neurol 17:S76-9. 2002
    ..This article reviews the etiologies associated with West's syndrome, antiepilepsy drug therapies currently being used to treat the syndrome, and other treatment options available to clinicians...
  31. ncbi request reprint Psychopathology and pediatric complex partial seizures: seizure-related, cognitive, and linguistic variables
    Rochelle Caplan
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
    Epilepsia 45:1273-81. 2004
    ..This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence...
  32. ncbi request reprint Social communication in children with epilepsy
    Rochelle Caplan
    UCLA, USA
    J Child Psychol Psychiatry 43:245-53. 2002
    ..1-16.9 years...
  33. ncbi request reprint Depression and anxiety disorders in pediatric epilepsy
    Rochelle Caplan
    Department of Psychiatry, University of California at Los Angeles, 90024, USA
    Epilepsia 46:720-30. 2005
    ..This study examined affective disorders, anxiety disorders, and suicidality in children with epilepsy and their association with seizure-related, cognitive, linguistic, family history, social competence, and demographic variables...
  34. ncbi request reprint Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients
    Susan Koh
    Division of Pediatric Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Epilepsia 46:1950-4. 2005
    ..However, this concept is based on case reports, and the incidence and clinical characteristics of these patients have not been systematically assessed...
  35. ncbi request reprint Developmental outcome with and without successful intervention
    Rochelle Caplan
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Int Rev Neurobiol 49:269-84. 2002
    ..Finally, the underlying pathology of the resected brain, rather than ongoing seizures and seizure type, plays an important role in development of the remaining brain tissue and the outcome of early onset symptomatic IS and non-IS...
  36. ncbi request reprint Recurrent de novo mutations of SCN1A in severe myoclonic epilepsy of infancy
    Jennifer A Kearney
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Pediatr Neurol 34:116-20. 2006
    ..Review of the literature indicates that recurrent mutations account for 25% of SCN1A mutations in severe myoclonic epilepsy of infancy, including six sites of deamination at CpG dinucleotides...