Wei Shi

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
    Wei Shi
    Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L293-300. 2004
  2. doi request reprint Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma
    Nehad M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Clin Cancer Res 14:4891-7. 2008
  3. doi request reprint Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer
    Wenming Zhang
    Developmental Biology and Regenerative Medicine Program, Department of Surgery, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    BMC Biol 11:111. 2013
  4. pmc TACE in perinatal mouse lung epithelial cells promotes lung saccular formation
    Wei Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop 35, Los Angeles, CA 90027
    Am J Physiol Lung Cell Mol Physiol 305:L953-63. 2013
  5. pmc Development, repair and fibrosis: what is common and why it matters
    Wei Shi
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Respirology 14:656-65. 2009
  6. pmc Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development
    Bing Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Development 138:925-35. 2011
  7. ncbi request reprint Smad1 expression and function during mouse embryonic lung branching morphogenesis
    Cheng Chen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1033-9. 2005
  8. pmc Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation
    Jianping Sun
    Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Pathol 172:571-82. 2008
  9. pmc Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice
    Bing Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 303:L89-96. 2012
  10. pmc Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells
    Ling Lu
    Division of Rheumatology, Department of Medicine, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 184:4295-306. 2010

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
    Wei Shi
    Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L293-300. 2004
    ..Thus overexpression of Smurf1 specifically promotes Smad1 and Smad5 ubiquitination and degradation in embryonic lung epithelium, thereby modulating the effects of BMP4 on embryonic lung growth...
  2. doi request reprint Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma
    Nehad M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Clin Cancer Res 14:4891-7. 2008
    ..We evaluated the therapeutic potential of a mutant vesicular stomatitis virus (VSVDelta51) as single treatment modality or in combination with ionizing radiation (RT) in NPC...
  3. doi request reprint Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer
    Wenming Zhang
    Developmental Biology and Regenerative Medicine Program, Department of Surgery, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    BMC Biol 11:111. 2013
    ....
  4. pmc TACE in perinatal mouse lung epithelial cells promotes lung saccular formation
    Wei Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop 35, Los Angeles, CA 90027
    Am J Physiol Lung Cell Mol Physiol 305:L953-63. 2013
    ....
  5. pmc Development, repair and fibrosis: what is common and why it matters
    Wei Shi
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Respirology 14:656-65. 2009
    ..This leads us to propose the 'Goldilocks' hypothesis of regulatory signaling in lung development and injury repair that everything must be done just right!..
  6. pmc Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development
    Bing Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Development 138:925-35. 2011
    ..This suggests a novel regulatory loop of Bmp4-Smad1-Wif1-Wnt/β-catenin in coordinating BMP and Wnt pathways to control fetal lung development...
  7. ncbi request reprint Smad1 expression and function during mouse embryonic lung branching morphogenesis
    Cheng Chen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1033-9. 2005
    ..Therefore, these data indicate that Smad1, acting as an intracellular BMP signaling pathway component, positively regulates early mouse embryonic lung branching morphogenesis...
  8. pmc Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation
    Jianping Sun
    Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Pathol 172:571-82. 2008
    ..Therefore, our data suggest that deficiency of appropriate BMP signaling in lung epithelial cells results in prenatal lung malformation, neonatal atelectasis, and respiratory failure...
  9. pmc Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice
    Bing Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 303:L89-96. 2012
    ..Subsequently, increased bindings of transcription factors including NF-κB and Pea3 to MMP9 promoter significantly upregulate MMP9 transcription, contributing to emphysema pathogenesis...
  10. pmc Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells
    Ling Lu
    Division of Rheumatology, Department of Medicine, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 184:4295-306. 2010
    ..Therefore, selective targeting of these intracellular TGF-beta signaling pathways during iTreg and Th17 cell development might lead to the development of therapies in treating autoimmune and other chronic inflammatory diseases...
  11. ncbi request reprint VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis
    Pierre Marie del Moral
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatric Surgery, USC Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Dev Biol 290:177-88. 2006
    ..These results demonstrate that the VEGF pathway is involved in driving epithelial to endothelial crosstalk in embryonic mouse lung morphogenesis...
  12. ncbi request reprint Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema
    Hui Chen
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Am J Physiol Lung Cell Mol Physiol 288:L683-91. 2005
    ..Therefore, these results indicate that Smad3 not only has a positive regulatory impact on neonatal lung alveolarization but also potentially plays a protective role against the occurrence of centrilobular emphysema later on in life...
  13. pmc Lung organogenesis
    David Warburton
    The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, USA
    Curr Top Dev Biol 90:73-158. 2010
    ....
  14. ncbi request reprint A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis
    Denise Tefft
    Developmental Biology Program, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 282:422-31. 2005
    ..Our results show that the protein tyrosine phosphatase Shp2 plays an essential role in modulating growth factor mediated tyrosine kinase receptor activation in early embryonic lung branching morphogenesis...
  15. pmc Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation
    Wei Xu
    Developmental Biology and Regenerative Medicine Program, Department of Surgery, Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e40314. 2012
    ..Therefore, adoptive transfer of in vitro induced Treg cells may be a promising therapeutic approach to prevent and treat severe asthma...
  16. ncbi request reprint Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells
    Wei Ding
    Developmental Biology Program, Childrens Hospital Los Angeles Saban Research Institute, Los Angeles, CA 90027, USA
    J Cell Physiol 212:796-806. 2007
    ..Together, the combined operation of transcriptional and post-translational mechanisms suggests that regulation of Spry2 is a crucial event and emphasizes the important role that Spry2 plays in controlling cell behaviors...
  17. doi request reprint Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance
    Ning Kong
    University of Southern California, Los Angeles, CA 90033, USA
    Arthritis Rheum 64:2548-58. 2012
    ....
  18. pmc The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors
    Susan Buckley
    Developmental Biology and Regenerative Medicine, Saban Research Institute, Childrens Hospital Los Angeles, California, USA
    Am J Respir Cell Mol Biol 45:1212-21. 2011
    ..Thus, the microenvironment created by AEC2 damage not only promotes autocrine repair but also can attract uncommitted stem cells, which further augment healing through cytokine secretion and differentiation...
  19. ncbi request reprint Molecular mechanisms of early lung specification and branching morphogenesis
    David Warburton
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Pediatr Res 57:26R-37R. 2005
    ....
  20. pmc Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice
    Jooeun Lee
    Saban Inst for Research, Childrens Hospital Los Angeles, MS 35, 4661 Sunset Blvd, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 296:L57-70. 2009
    ..9631). Thus lung alveolar integrity, particularly in the distal epithelial compartment, depends on proper telomere maintenance...
  21. pmc miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution
    Gianni Carraro
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and School of Dentistry, Los Angeles, CA 90027, USA
    Dev Biol 333:238-50. 2009
    ....
  22. pmc All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus
    Ling Lu
    Division of Rheumatology, Department of Medicine, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e24590. 2011
    ..Our objective, therefore, was to determine how atRA promotes the differentiation of iTregs...
  23. ncbi request reprint Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
    Jingsong Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Lung Cell Mol Physiol 282:L585-93. 2002
    ..These results show that Smad3 contributes to bleomycin-induced lung injury and that Smad3 may serve as a novel target for potential therapeutic treatment of lung fibrosis...
  24. ncbi request reprint Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis
    Wei Ding
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, and Department of Pediatric Surgery, University of Southern California Keck School of Medicine and School of Dentistry, 90027, USA
    Am J Physiol Lung Cell Mol Physiol 287:L52-9. 2004
    ..Homology analysis further showed that the core promoter region of the hSpry4 gene exhibits significant similarity to the 5'-flanking region of the mouse gene...
  25. pmc TGFβ signaling plays a critical role in promoting alternative macrophage activation
    Dapeng Gong
    Division of Hematology Oncology, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    BMC Immunol 13:31. 2012
    ..Whereas it is well-established that IL-4 can drive alternative activation, if lack of TGFβ signaling at physiological levels affects M2 polarization has not been addressed...
  26. doi request reprint TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?
    David Warburton
    Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd MS35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 304:L83-5. 2013
    ....
  27. ncbi request reprint TACE is required for fetal murine cardiac development and modeling
    Wei Shi
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 261:371-80. 2003
    ..The data suggest that TACE-mediated cell surface protein ectodomain shedding plays an essential and a novel regulatory role during cardiac development and modeling...
  28. ncbi request reprint BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction
    Jianping Sun
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    J Biol Chem 281:29349-56. 2006
    ..Similar regulatory mechanisms may be utilized by other DAN family proteins...
  29. pmc Stem/progenitor cells in lung development, injury repair, and regeneration
    David Warburton
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, 4661 Sunset Boulevard, Los Angeles CA 90027, USA
    Proc Am Thorac Soc 5:703-6. 2008
    ..Further work will be needed to translate stem/progenitor cell therapy for the lung...
  30. pmc Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect
    Jianping Sun
    Developmental Biology Program, Department of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS 35, Los Angeles, CA 90027, USA
    Biochem Biophys Res Commun 360:238-43. 2007
    ....
  31. pmc Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot
    Xiaohui Zhou
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Los Angeles, CA, USA
    J Mol Cell Biol 2:164-9. 2010
    ..This method provides a valuable tool for the study of the T regulatory cell biology and their therapeutic manipulation...
  32. ncbi request reprint Lung development and susceptibility to chronic obstructive pulmonary disease
    David Warburton
    Saban Research Institute Children s Hospital Los Angeles, 4650 Sunset Blvd 35, Los Angeles, CA 90027, USA
    Proc Am Thorac Soc 3:668-72. 2006
    ..The hope is that providing the correct exogenous signals can coax them into doing so...
  33. ncbi request reprint Lung development and adult lung diseases
    Wei Shi
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd MS35, Los Angeles, CA 90027, USA
    Chest 132:651-6. 2007
    ..Subtle abnormalities of lung structure and function are found in clinically asymptomatic CF infants. Finally, airway remodeling due to chronic inflammation is important in infants who later acquire asthma...
  34. ncbi request reprint Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence
    Chun Peng Liao
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Res 67:7525-33. 2007
    ..These refined models should be useful in the elucidation of mechanisms of prostate cancer progression, and for the development of approaches to preclinical intervention...
  35. pmc Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity
    David Warburton
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Am J Pathol 167:921-2. 2005
  36. doi request reprint Lung mesenchymal expression of Sox9 plays a critical role in tracheal development
    Gianluca Turcatel
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    BMC Biol 11:117. 2013
    ..Sox9 is expressed in both distal lung epithelium and proximal lung mesenchyme. Here, we investigated the effect of lung mesenchyme-specific inducible deletion of Sox9 during murine lung development...
  37. pmc Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
    David Warburton
    Developmental Biology Program, Childrens Hospital Los Angeles Research Institute and the Center for Craniofacial Molecular Biology, Keck School of Medicine and School of Dentistry, University of Southern California, USA
    Respir Res 4:5. 2003
    ....
  38. pmc Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg
    Ling Lu
    Division of Rheumatology, Department of Medicine, Keck School of Medicine, University of Southern California, and Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, Los Angeles, CA 90033, USA
    Eur J Immunol 40:142-52. 2010
    ..In addition, the synergistic effect of BMP-2/4 and TGF-beta indicates that the simultaneous manipulation of TGF-beta and BMP signaling might have considerable effects in the clinical setting for the enhancement of Treg purity and yield...
  39. ncbi request reprint Functional analysis of the human Sprouty2 gene promoter
    Wei Ding
    Childrens Hospital Los Angeles Research Institute, Department of Pediatric Surgery, USC Keck School of Medicine, Los Angeles, CA 90027, USA
    Gene 322:175-85. 2003
    ..To our knowledge, this is the first promoter study of any mammalian Sprouty gene. We propose that the high-level basal expression of hSpry2 is controlled by multiple transcription factors binding to its proximal promoter...
  40. ncbi request reprint Protein phosphatase 1alpha is required for murine lung growth and morphogenesis
    Kadija Kathy Hormi-Carver
    Division of Hematology Oncology, Department of Pediatrics, Childrens Hospital Los Angeles, University of Southern California School of Medicine, Los Angeles, California, USA
    Dev Dyn 229:791-801. 2004
    ..These data suggest that PP1alpha is required for branching morphogenesis and differentiation...
  41. pmc Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor
    Feng Chi
    Department of Pediatrics, Saban Research Institute, University of Southern California, Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e25016. 2011
    ..Taken together, our data suggest that α7 nAChR plays a detrimental role in the host defense against meningitic infection by modulation of pathogen invasion, PMN recruitment, calcium signaling and neuronal inflammation...
  42. ncbi request reprint Laminin, VEGF, and bone matrix protein expression in uroepithelial bone induction--a canine model
    Yin Xiao
    AOSpine Reference Centre, School of Engineering Systems, Queensland University of Technology, Brisbane, Australia
    Connect Tissue Res 47:102-9. 2006
    ..The sequential expression of bone matrix proteins by differentiated osteogenetic cells indicates a subsequent sequence of bone autoinduction...
  43. ncbi request reprint [Construction of eukaryotic expression vector of mouse alpha-fetoprotein cDNA and its expression in dendritic cells and in vitro antitumor effect on hepatoma]
    Bin Zeng
    Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China
    Ai Zheng 24:1332-7. 2005
    ....
  44. ncbi request reprint Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos
    Wei Shi
    Department of Molecular Animal Breeding and Biotechnology, University of Munich, D 85764 Munich, Germany
    Biol Reprod 69:301-9. 2003
    ..The beneficial effect of NaBu on the developmental potential of cloned embryos reconstructed from BFF merits further studies...
  45. pmc The pineapple eye gene is required for survival of Drosophila imaginal disc cells
    Wei Shi
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genetics 165:1869-79. 2003
    ..The pineapple eye gene was identified and predicted to encode a novel 582-amino-acid protein. The protein contains a novel, cysteine-rich domain of 270 amino acids also found in predicted proteins of unknown function from other animals...
  46. ncbi request reprint Heterochromatin and tri-methylated lysine 20 of histone H4 in animals
    Niki Kourmouli
    Nuclear Reprogramming Laboratory, Division of Gene Expression and Development, Roslin Institute, Edinburgh, EH25 9PS, UK
    J Cell Sci 117:2491-501. 2004
    ..We also present evidence that Me(3)K20H4 is dependent upon H3-specific Suv(3)9 histone methyltransferase activity, suggesting that there may be 'epigenetic cross-talk' between histones H3 and H4...
  47. ncbi request reprint [The role of HOXB4 gene in the regulation of proliferation and differentiation of hematopietic stem cell]
    Wei Shi
    Sheng Li Ke Xue Jin Zhan 35:60-2. 2004
  48. ncbi request reprint [The maintenance of cord blood CD34+ progenitor cells with plant lectin FRIL in vitro and the expression of related cell cycle modulator HTm4 and HTm4S]
    Xiao Yan Xie
    Department of Stem Cell Biology, Beijing Institute of Transfusion Medicine, Beijing 100850, China
    Sheng Li Xue Bao 56:306-12. 2004
    ..In other words, HTm4 and HTm4S may play a crucial role in the cell cycle modulation of CD34(+) progenitor cells maintained with FRIL in vitro...
  49. ncbi request reprint Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals
    Ian G Cowell
    Division of Gene Expression and Development, The Roslin Institute Edinburgh, Midlothian, UK
    Chromosoma 111:22-36. 2002
    ..Finally, we provide evidence that Me9H3 is neither necessary nor sufficient for localisation of heterochromatin protein 1 (HP1) to chromosomal DNA...
  50. ncbi request reprint A conditionally replicating adenovirus for nasopharyngeal carcinoma gene therapy
    Marie C Chia
    Division of Experimental Therapeutics, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Ther 9:804-17. 2004
    ..We have successfully established a conditionally replicating adenovirus for EBV-positive NPC, which is both safe and efficacious, indicating a strategy that may be therapeutically applicable...
  51. ncbi request reprint [Polymorphism of the HLA-DMA in Han nationality in Hunan Province]
    Wen Cheng
    Hunan Yi Ke Da Xue Xue Bao 27:91, 93. 2002
  52. ncbi request reprint Efficacy of targeted FasL in nasopharyngeal carcinoma
    Jian Hua Li
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario MS 1A1, Canada
    Mol Ther 8:964-73. 2003
    ..These results demonstrate the efficacy of our EBV-specific targeting strategy, which allows the potentially safe and effective utilization of a highly potent membrane-based apoptotic gene...
  53. ncbi request reprint Scavenger receptor class B type I reduces cholesterol absorption in cultured enterocyte CaCo-2 cells
    Lei Cai
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 45:253-62. 2004
    ..Our data argue against a direct role for SR-BI in micellar cholesterol uptake. However, SR-BI might be involved in cholesterol absorption by facilitating cholesterol efflux to micelles...
  54. pmc Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene
    Valery Bliskovsky
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Proc Natl Acad Sci U S A 100:14982-7. 2003
    ..By analogy, human cancer may also result from the combined effects of several inefficient alleles...
  55. ncbi request reprint Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues
    Wei Shi
    Max Planck Institute for Molecular Genetics, Berlin Dahlem, Germany
    Dev Biol 272:53-65. 2004
    ..spretus X-chromosome rather than a modifier effect. Our results demonstrate that Chm is essential for diploid trophoblast development and plays a role in the vascularization in placenta and yolk sac...
  56. ncbi request reprint DJ-1, a novel regulator of the tumor suppressor PTEN
    Raymond H Kim
    Advanced Medical Discovery Institute, The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada M5G 2C1
    Cancer Cell 7:263-73. 2005
    ..DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer...
  57. ncbi request reprint Fetal loss in homozygous mutant Norrie disease mice: a new role of Norrin in reproduction
    Ulrich F O Luhmann
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Genesis 42:253-62. 2005
    ..Taken together, these data provide strong evidence for Norrin playing an important role in female reproductive tissues...
  58. ncbi request reprint Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling
    Wei Shi
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Int J Cancer 119:2467-75. 2006
    ..The role of survivin in resisting apoptosis in NPC was confirmed by RNA interference. Our data provide novel insights into the development and progression of NPC, and suggest survivin as a novel therapeutic target for NPC...
  59. ncbi request reprint Highly efficient photoactivation of Mn-depleted photosystem II by imidazole-liganded manganese complexes
    Bin Liu
    State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China
    J Biol Inorg Chem 11:626-32. 2006
    ....
  60. ncbi request reprint [A distinct whole nucleus stain pattern of gamma H2AX induced by N-methyl-No-nitro-N-nitrosoguanidine]
    Yan ke Yu
    Department of Public Health, Center for Environmental Genomics, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 35:635-41. 2006
    ..To characterize the DNA damage property represented by the distinct whole nucleus stain pattern of gammaH2AX induced by N-methyl-No-nitro-N-nitrosoguanidine (MNNG)...
  61. ncbi request reprint Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy
    Joseph D Mocanu
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Ther 15:921-9. 2007
    ..This study reports the favorable modulation by STI571 of the biodistribution of adenoviral vectors, providing a potential approach to improving therapeutic outcome...
  62. ncbi request reprint Synthesis of daunorubicin analogues containing truncated aromatic cores and unnatural monosaccharide residues
    Eric Fan
    Alberta Ingenuity Centre for Carbohydrate Science and Department of Chemistry, University of Alberta, Gunning Lemieux Chemistry Centre, Edmonton, AB T6G 2G2, Canada
    J Org Chem 72:2917-28. 2007
    ..The IC50 values for the latter group of compounds were in the range of 94-134 microM, compared to 17 microM for doxorubicin and 5 microM for daunorubicin...
  63. ncbi request reprint Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  64. ncbi request reprint Role of impaired peritubular capillary and hypoxia in progressive interstitial fibrosis after 56 subtotal nephrectomy of rats
    Bin Zhang
    Department of Nephrology, Guangdong Provincial People s Hospital, Guangzhou, PR China
    Nephrology (Carlton) 10:351-7. 2005
    ..To investigate the potential role of peritubular capillary (PTC) loss and subsequent hypoxia as a pathogenic factor in interstitial fibrosis after renal ablation in rats...
  65. ncbi request reprint Identifying cis-regulatory elements by statistical analysis and phylogenetic footprinting and analyzing their coexistence and related gene ontology
    Wei Shi
    Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Physiol Genomics 31:374-84. 2007
    ..This exploration verifies the putative cis-regulatory elements that have been found from this study and also gives new insight on the regulation mechanisms of gene expression...
  66. ncbi request reprint Imaging and modulating antisense microdistribution in solid human xenograft tumor models
    Joseph D Mocanu
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Canada
    Clin Cancer Res 13:5935-41. 2007
    ..Antisense oligodeoxynucleotides (ASO) are a class of therapeutics where limited information is available about their distribution within a solid tumor environment...
  67. ncbi request reprint Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression
    Mindy A Maynard
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 6:2810-6. 2007
    ....
  68. ncbi request reprint Intensive management affects composition of betaproteobacterial ammonia oxidizers in turfgrass systems
    Emily A Dell
    Department of Soil Science, North Carolina State University, Campus Box 7619, Raleigh, NC 27695, USA
    Microb Ecol 56:178-90. 2008
    ..e., 23 and 95 years old); fine-scale differences within Nitrosospira cluster 3 were seen between native pines and turf. Further investigations are needed to elucidate the ecological implications of the compositional differences...
  69. ncbi request reprint [Effects of CD147 on the production of matrix metalloproteinase-9 by fibroblasts and the invasion of melanoma cells]
    Xiang Chen
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008 China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:249-52. 2005
    ..To investigate a possible role of CD147 in the production of matrix metalloproteinase-9 (MMP-9) by fibroblasts and the invasion of melanoma cells...
  70. doi request reprint A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs
    Xiancheng Chen
    Department of Gynecology and Obstetrics, West China Medical School, Second West China Hospital, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Mol Ther 16:749-56. 2008
    ..05). These data indicate the potential of cytokine-engineered MSCs to be considered as an integrated therapeutic weapon for targeting advanced malignancies...
  71. ncbi request reprint Impact of erythrocyte Duffy antigen genetic polymorphism on the distribution of GroBeta-T, a novel human CXC chemokine
    Timothy W Hepburn
    Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    J Pharm Pharm Sci 10:486-95. 2007
    ..We used a combination of in vitro studies of Grobeta-DARC interaction and pharmacokinetic simulation to anticipate the potential impact of this polymorphism on the pharmacokinetics of Grobeta-T...
  72. doi request reprint Peritubular capillary loss is ameliorated by ramipril or valsartan treatment
    Bin Zhang
    Department of Nephrology, Guangdong Provincial People s Hospital, Nanfang Medical University, Guangzhou, China
    Microcirculation 15:337-48. 2008
    ..To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection...
  73. ncbi request reprint IL-12p40 is not required for islet allograft rejection
    En Guang Bi
    Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Acta Pharmacol Sin 27:1065-70. 2006
    ..To investigate whether IL-12p40 plays a crucial role in regulating islet allograft rejection in a streptozotocin (STZ)-induced diabetes mouse model...

Research Grants11

  1. Molecular Mechanisms of Lung Branching Morphogenesis
    Wei Shi; Fiscal Year: 2007
    ..This basic information may aid in the future design of novel therapeutic strategies to prevent and treat developmental pulmonary diseases. ..
  2. Molecular Mechanisms of Lung Branching Morphogenesis
    Wei Shi; Fiscal Year: 2005
    ..This basic information may aid in the future design of novel therapeutic strategies to prevent and treat such serious pulmonary diseases as lung hypoplasia, bronchopulmonary dysplasia and emphysema. ..
  3. SMAD MEDIATED SIGNALING DURING LUNG MORPHOGENESIS
    Wei Shi; Fiscal Year: 2002
    ..The results of this project will provide new rationales for novel therapeutic strategies to modulate TGF-beta signaling during lung development, injury, repair, and disease. ..
  4. Molecular Mechanisms of Lung Branching Morphogenesis
    Wei Shi; Fiscal Year: 2010
    ..This basic information may aid in the future design of novel therapeutic strategies to prevent and treat developmental pulmonary diseases. ..