Wei Shi


Affiliation: University of Southern California
Country: USA


  1. request reprint
    Shi W, Chen H, Sun J, Chen C, Zhao J, Wang Y, et al. Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol. 2004;286:L293-300 pubmed
    ..Thus overexpression of Smurf1 specifically promotes Smad1 and Smad5 ubiquitination and degradation in embryonic lung epithelium, thereby modulating the effects of BMP4 on embryonic lung growth. ..
  2. Zhang W, Menke D, Jiang M, Chen H, Warburton D, Turcatel G, et al. Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol. 2013;11:111 pubmed publisher
  3. Jiang Y, Luo Y, Tang Y, Moats R, Warburton D, Zhou S, et al. Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. Sci Rep. 2019;9:5296 pubmed publisher
    ..This provides a new direction to study the molecular and cellular mechanisms of CPAM pathogenesis in human. ..
  4. Luo Y, Li N, Chen H, Fernandez G, Warburton D, Moats R, et al. Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development. Sci Rep. 2018;8:8334 pubmed publisher
    ..Thus, the previous concept that deposition of elastin at alveolar tips drives septal inward growth may potentially be conceptually challenged by our data. ..
  5. Luo Y, El Agha E, Turcatel G, Chen H, Chiu J, Warburton D, et al. Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. BMC Biol. 2015;13:42 pubmed publisher
  6. Gong D, Shi W, Yi S, Chen H, Groffen J, Heisterkamp N. TGF? signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol. 2012;13:31 pubmed publisher
    ..This would cause defects in the ability of the M2 macrophages to negatively regulate other immune cells such as T-cells in the lung, possibly explaining the systemic inflammation observed in Vav1-Cre x T?RIIfx/fx mice. ..
  7. Turcatel G, Rubin N, Menke D, Martin G, Shi W, Warburton D. Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013;11:117 pubmed publisher
    ..Sox9 is expressed in both distal lung epithelium and proximal lung mesenchyme. Here, we investigated the effect of lung mesenchyme-specific inducible deletion of Sox9 during murine lung development...
  8. Xu W, Liu C, Kaartinen V, Chen H, Lu C, Zhang W, et al. TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol. 2013;305:L953-63 pubmed publisher
  9. Luo Y, Chen H, Ren S, Li N, Mishina Y, Shi W. BMP signaling is essential in neonatal surfactant production during respiratory adaptation. Am J Physiol Lung Cell Mol Physiol. 2016;311:L29-38 pubmed publisher

More Information


  1. Ren S, Luo Y, Chen H, Warburton D, Lam H, Wang L, et al. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016;186:3261-3272 pubmed publisher
    ..Therefore, Tsc2-mTOR signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization. ..