Shey Shing Sheu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Targeting antioxidants to mitochondria: a new therapeutic direction
    Shey Shing Sheu
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Biochim Biophys Acta 1762:256-65. 2006
  2. ncbi request reprint Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine
    Weike Mao
    University of Rochester Medical Center, Department of Medicine, Cardiology Division, Box 679, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 293:H1636-45. 2007
  3. ncbi request reprint Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells
    Seigo Itoh
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:26383-96. 2005
  4. ncbi request reprint Calcium, ATP, and ROS: a mitochondrial love-hate triangle
    Paul S Brookes
    University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 287:C817-33. 2004
  5. pmc Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes
    Jennifer Hom
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochim Biophys Acta 1797:913-21. 2010
  6. ncbi request reprint Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179
    Tetsu Watanabe
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circulation 112:1798-805. 2005
  7. pmc Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress
    Jiahao Liu
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Mol Cell Cardiol 44:304-14. 2008
  8. pmc Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts
    Shin Young Ryu
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 286:21324-9. 2011
  9. pmc Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease
    Lan Wei
    University of Rochester Medical Center, Department of Pharmacology and Physiology, Rochester, NY 14642, USA
    FASEB J 25:3068-78. 2011
  10. pmc ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes
    Xiangrong He
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 163:243-51. 2003

Research Grants

  1. Ca2+ and ROS Crosstalk Signaling in Cardiac Mitochondria
    Shey Shing Sheu; Fiscal Year: 2010
  2. MYOCARDIAL CA2+ TRANSPORT AND METABOLISM
    Shey Shing Sheu; Fiscal Year: 1993
  3. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2002
  4. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2003
  5. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2004
  6. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2006
  7. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2007
  8. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2009
  9. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2010
  10. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Targeting antioxidants to mitochondria: a new therapeutic direction
    Shey Shing Sheu
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Biochim Biophys Acta 1762:256-65. 2006
    ....
  2. ncbi request reprint Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine
    Weike Mao
    University of Rochester Medical Center, Department of Medicine, Cardiology Division, Box 679, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 293:H1636-45. 2007
    ..Thus ER stress occurs in autoimmune cardiomyopathy induced by beta(1)-EC(II) peptide, and this is enhanced by increased NE and caused by activation of the beta(1)-adrenergic receptor-coupled CaMKII, p38 MAPK, and ATF6 pathway...
  3. ncbi request reprint Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells
    Seigo Itoh
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:26383-96. 2005
    ..These data suggest a role for mitochondrial Dok-4 as an anchoring molecule for the tyrosine kinase c-Src, and in turn as a regulator of TNF-alpha-mediated ROS production and NF-kappaB activation...
  4. ncbi request reprint Calcium, ATP, and ROS: a mitochondrial love-hate triangle
    Paul S Brookes
    University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 287:C817-33. 2004
    ..Overall, a "two-hit" hypothesis is developed, in which Ca(2+) plus another pathological stimulus can bring about mitochondrial dysfunction...
  5. pmc Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes
    Jennifer Hom
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochim Biophys Acta 1797:913-21. 2010
    ..These results suggest that Ca2+, an important regulator of muscle contraction and energy generation, also dynamically regulates mitochondrial morphology and ROS generation in cardiac myocytes...
  6. ncbi request reprint Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179
    Tetsu Watanabe
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circulation 112:1798-805. 2005
    ....
  7. pmc Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress
    Jiahao Liu
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Mol Cell Cardiol 44:304-14. 2008
    ..Thus, we conclude that ER stress plays an important role in cell death and cardiac dysfunction in beta(1)-EC(II) IgG cardiomyopathy, and the effects of beta(1)-EC(II) IgG are mediated via the beta(1)-adrenergic receptor...
  8. pmc Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts
    Shin Young Ryu
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 286:21324-9. 2011
    ....
  9. pmc Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease
    Lan Wei
    University of Rochester Medical Center, Department of Pharmacology and Physiology, Rochester, NY 14642, USA
    FASEB J 25:3068-78. 2011
    ..Together, these results demonstrate that mSOF activity is a highly sensitive biomarker of mitochondrial respiration and the cellular metabolic state of muscle during physiological activity and pathological oxidative stress..
  10. pmc ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes
    Xiangrong He
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 163:243-51. 2003
    ..We conclude that ASK1 plays an important role in regulation of cardiac contractile function by phosphorylating cTnT and may participate in cytokine/ROS-induced pathogenesis of cardiomyopathy and heart failure...
  11. pmc Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels
    Shin Young Ryu
    Department of Pharmacology and Physiology, and Mitochondrial Research Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 584:1948-55. 2010
    ..Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca(2+) channels...
  12. ncbi request reprint Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury
    Naoya Maekawa
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA
    Circulation 113:2516-23. 2006
    ..Therefore, we hypothesized that inhibiting RSK in cardiomyocytes would prevent NHE1 activation and decrease I/R-mediated injury...
  13. ncbi request reprint Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling
    Gisela Beutner
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Biochim Biophys Acta 1717:1-10. 2005
    ..Thus, the mRyR functions as a transducer for excitation-metabolism coupling...
  14. pmc Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity
    Lan Wei-Lapierre
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 288:10567-77. 2013
    ..Furthermore, flash activity depends strongly on a combination of mitochondrial oxidation and pH gradient...
  15. ncbi request reprint Molecular and functional identification of a mitochondrial ryanodine receptor in neurons
    Regina Jakob
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, United States
    Neurosci Lett 575:7-12. 2014
    ....
  16. pmc Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity
    Yuntao Duan
    Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Physiol 585:741-58. 2007
    ..More importantly, the increase of mitochondrial ROS serves as a signal for PARP-1 activation, suggesting that concomitant mitochondrial Ca(2+) uptake and PARP-1 activation constitute a unified mechanism for excitotoxic neuronal death...
  17. ncbi request reprint Mechanisms of reduced mitochondrial Ca2+ accumulation in failing hamster heart
    Lin Lin
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Pflugers Arch 454:395-402. 2007
    ..In addition to other known impairments of ion transport in sarcoplasmic reticulum and plasma membrane, results from this paper on mitochondrial dysfunctions expand our understanding of the molecular mechanisms leading to heart failure...
  18. ncbi request reprint Mitochondria: new drug targets for oxidative stress-induced diseases
    M W Anders
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Expert Opin Drug Metab Toxicol 2:71-9. 2006
    ..Future studies will undoubtedly exploit the unique biophysical and biochemical properties of mitochondria, including mitochondrial activation of prodrugs, for the targeted delivery of cytoprotective agents...
  19. pmc NDUFS4: creation of a mouse model mimicking a Complex I disorder
    Christopher A Ingraham
    Department of Biomedical Genetics, Univ of Rochester Medical Center, Rochester, NY, USA
    Mitochondrion 9:204-10. 2009
    ..Decreased Complex I activity with unaltered Complex II activity, along with an accumulation of lactate, were consistent with Complex I disorders in this mouse model...
  20. ncbi request reprint Synergistic effects of low level stressors in an oxidative damage model of spinal motor neuron degeneration
    Elizabeth Kriscenski-Perry
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 673, Rochester, NY 14642, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:151-7. 2002
    ..An increase in reactive oxygen species (ROS) burden and subsequent oxidative damage to nucleic acids, proteins, and lipids, occurs during the normal aging process of cells, including neurons...
  21. pmc Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species
    Tianzheng Yu
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cardiovasc Res 79:341-51. 2008
    ..We investigated the role of mitochondrial fission in high glucose-induced cardiovascular cell injury...
  22. ncbi request reprint Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis
    Jennifer R Hom
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Physiol 212:498-508. 2007
    ..These results suggest that Ca(2+) is involved in controlling mitochondrial morphology via intra-mitochondrial Ca(2+) signaling as well as the apoptotic process...
  23. pmc Crosstalk signaling between mitochondrial Ca2+ and ROS
    Robert F Feissner
    Mitochondrial Research and Innovation Group and Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Front Biosci (Landmark Ed) 14:1197-218. 2009
    ..We present a model for crosstalk between Ca2+ and ROS signaling pathways within mitochondrial microdomains...
  24. pmc Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways
    Weike Mao
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Mol Cell Cardiol 45:250-60. 2008
    ..Thus, we conclude that darbepoetin alfa improves cardiac function and prevents progression of dilated cardiomyopathy probably by activating the PI3K/Akt and STAT3 pathways and reducing ER stress...
  25. ncbi request reprint Mitochondrial contact sites: their role in energy metabolism and apoptosis
    Dieter G Brdiczka
    Department of Pharmacology and Physiology, Box 711, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1762:148-63. 2006
    ..Furthermore, we describe experiments involving the complex-stabilizing conditions in vitro and in intact cells. At the end, we discuss unsolved problems and opportunities for clinical application of the complex-stabilizing factors...
  26. pmc The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation
    Jennifer R Hom
    Department of Pediatrics Division of Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Cell 21:469-78. 2011
    ..Furthermore, myocyte differentiation was inhibited and enhanced with oxidant and antioxidant treatment, respectively, suggesting that redox-signaling pathways lie downstream of mitochondria to regulate cardiac myocyte differentiation...
  27. pmc Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition
    Karthik Venkatesh
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Cell Biol 177:393-9. 2007
    ..In the presence of VCN, however, NgR1(-/-) RGCs exhibit enhanced neurite growth. Collectively, our experiments reveal distinct and cell type-specific mechanisms for MAG-elicited growth inhibition...
  28. pmc Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells
    Jennifer Hom
    Department of Pharmacology and Physiology, Mitochondrial Research and Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Mol Cell Cardiol 46:811-20. 2009
    ..In this review we will cover the recent field of mitochondrial dynamics and its physiological and pathological implications, with a particular emphasis on the experimental and theoretical basis of mitochondrial dynamics in the heart...
  29. pmc Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms
    Thomas E Gunter
    Department of Biochemistry and Biophysics and Mitochondrial Research and Innovation Group, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1787:1291-308. 2009
    ..The characteristics of these mechanisms of Ca(2+) transport and a discussion of how they might function are described in this paper...
  30. ncbi request reprint Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation
    Conrad C Alano
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Neurochem 80:531-8. 2002
    ..The presented results indicate that MPT can be detected in living neurons using fluorescent Ca2+ indicators, which would allow the study of the physiological role of MPT in cell death...
  31. pmc Superoxide flashes in single mitochondria
    Wang Wang
    Laboratories of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell 134:279-90. 2008
    ..We propose that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases...

Research Grants28

  1. Ca2+ and ROS Crosstalk Signaling in Cardiac Mitochondria
    Shey Shing Sheu; Fiscal Year: 2010
    ..It is our objective, not only to make a scientific contribution to oxidative stress-mediated disease mechanisms, but also to develop possible therapeutic means for treating these debilitating disorders. ..
  2. MYOCARDIAL CA2+ TRANSPORT AND METABOLISM
    Shey Shing Sheu; Fiscal Year: 1993
    ..Because Ca2+ is a key regulator for cardiac function in physiological and pathological states, these studies will broaden our understanding on the fundamental principles of normal and abnormal cardiac excitation and contraction...
  3. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2002
    ..This information is critical for our understanding of mitochondria-related cardiovascular diseases such as ischemic heart disease, cardiac arrhythmia, cardiomyopathy, and heart failure. ..
  4. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2003
    ..This information is critical for our understanding of mitochondria-related cardiovascular diseases such as ischemic heart disease, cardiac arrhythmia, cardiomyopathy, and heart failure. ..
  5. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2004
    ..This information is critical for our understanding of mitochondria-related cardiovascular diseases such as ischemic heart disease, cardiac arrhythmia, cardiomyopathy, and heart failure. ..
  6. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2006
    ....
  7. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2007
    ....
  8. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2009
    ..abstract_text> ..
  9. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2010
    ..abstract_text> ..
  10. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2001
    ..This information is critical for our understanding of mitochondria-related cardiovascular diseases such as ischemic heart disease, cardiac arrhythmia, cardiomyopathy, and heart failure. ..
  11. MYOCARDIAL CA2+ TRANSPORT AND METABOLISM
    Shey Shing Sheu; Fiscal Year: 1990
    ..Because Ca2+ is a key regulator for cardiac function in physiological and pathological states, these studies will broaden our understanding on the fundamental principles of normal and abnormal cardiac excitation and contraction...
  12. MYOCARDIAL CA2+ TRANSPORT AND METABOLISM
    Shey Shing Sheu; Fiscal Year: 1991
    ..Because Ca2+ is a key regulator for cardiac function in physiological and pathological states, these studies will broaden our understanding on the fundamental principles of normal and abnormal cardiac excitation and contraction...
  13. MYOCARDIAL CA2+ TRANSPORT AND METABOLISM
    Shey Shing Sheu; Fiscal Year: 1992
    ..Because Ca2+ is a key regulator for cardiac function in physiological and pathological states, these studies will broaden our understanding on the fundamental principles of normal and abnormal cardiac excitation and contraction...
  14. MITOCHONDRIAL CALCIUM REGULATION IN SINGLE HEART CELLS
    Shey Shing Sheu; Fiscal Year: 1999
    ....
  15. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2009
    ..abstract_text> ..