Sreerama Shetty

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Urokinase expression by tumor suppressor protein p53: a novel role in mRNA turnover
    Praveenkumar Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Cell Mol Biol 39:364-72. 2008
  2. pmc Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury
    Shwetha K Shetty
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Lab C 6, Tyler, TX, 75708, USA
    Am J Respir Cell Mol Biol 47:474-83. 2012
  3. ncbi request reprint Regulation of urokinase receptor expression by protein tyrosine phosphatases
    Sreerama Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L414-21. 2007
  4. pmc Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53
    Sreerama Shetty
    Texas Lung Injury Institute, University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 283:19570-80. 2008
  5. ncbi request reprint Urokinase induces activation of STAT3 in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 291:L772-80. 2006
  6. ncbi request reprint Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biochem 272:107-18. 2005
  7. ncbi request reprint Regulation of urokinase receptor expression by phosphoglycerate kinase is independent of its catalytic activity
    Sreerama Shetty
    Department of Medicine, University of Texas Health Center, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 289:L591-8. 2005
  8. ncbi request reprint Induction of p53 by urokinase in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 280:28133-41. 2005
  9. ncbi request reprint Protein synthesis and urokinase mRNA metabolism
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
    Mol Cell Biochem 271:13-22. 2005
  10. ncbi request reprint Regulation of urokinase receptor expression by phosphoglycerate kinase
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 31:100-6. 2004

Research Grants

  1. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2002
  2. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2004
  3. Regulation of Lung Epithelial Fibrinolysis by Urokinase
    Sreerama Shetty; Fiscal Year: 2005

Collaborators

Detail Information

Publications33

  1. pmc Urokinase expression by tumor suppressor protein p53: a novel role in mRNA turnover
    Praveenkumar Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Cell Mol Biol 39:364-72. 2008
    ..These observations confirm a new role for p53 as a uPA mRNA binding protein that down-regulates uPA mRNA stability and decreases cellular uPA expression...
  2. pmc Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury
    Shwetha K Shetty
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Lab C 6, Tyler, TX, 75708, USA
    Am J Respir Cell Mol Biol 47:474-83. 2012
    ..These observations demonstrate that inhibition of p53 binding to PAI-1 mRNA 3'UTR attenuates CS-induced ATII cell apoptosis. This presents a novel link between p53-mediated PAI-1 expression and CS-induced ATII cell apoptosis...
  3. ncbi request reprint Regulation of urokinase receptor expression by protein tyrosine phosphatases
    Sreerama Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L414-21. 2007
    ....
  4. pmc Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53
    Sreerama Shetty
    Texas Lung Injury Institute, University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 283:19570-80. 2008
    ..These observations demonstrate a novel role for p53 as an mRNA-binding protein that regulates increased PAI-1 expression and stabilization of PAI-1 mRNA in human lung epithelial and carcinoma cells...
  5. ncbi request reprint Urokinase induces activation of STAT3 in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 291:L772-80. 2006
    ....
  6. ncbi request reprint Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biochem 272:107-18. 2005
    ..These observations indicate a novel mechanism of uPAR gene regulation in lung epithelial cells in which cis elements within a 110 nt uPAR mRNA 3'UTR sequence interact with hnRNPC to regulate uPAR mRNA stability...
  7. ncbi request reprint Regulation of urokinase receptor expression by phosphoglycerate kinase is independent of its catalytic activity
    Sreerama Shetty
    Department of Medicine, University of Texas Health Center, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 289:L591-8. 2005
    ..These results demonstrate that uPAR mRNA binding activity as well as PGK-mediated regulation of uPAR mRNA are independent of PGK enzymatic activity...
  8. ncbi request reprint Induction of p53 by urokinase in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 280:28133-41. 2005
    ..This pathway could regulate pathophysiologic alterations of p53 expression in the setting of lung inflammation or neoplasia...
  9. ncbi request reprint Protein synthesis and urokinase mRNA metabolism
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
    Mol Cell Biochem 271:13-22. 2005
    ..This pathway may regulate uPA-mediated functions of the lung epithelium in the context of inflammation or neoplasia...
  10. ncbi request reprint Regulation of urokinase receptor expression by phosphoglycerate kinase
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 31:100-6. 2004
    ..Decline in 3H-thymidine incorporation and migration occurred in H157 cells transfected with PGK cDNA. These results demonstrate that PGK regulates uPAR expression at the post-transcriptional level...
  11. ncbi request reprint Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cells
    Sreerama Shetty
    Associate Professor of Medicine, University of Texas Health Center at Tyler, Tyler, TX, 75708, USA
    Am J Respir Cell Mol Biol 30:69-75. 2004
    ....
  12. doi request reprint The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability
    Sreerama Shetty
    Lab C 6, Biomedical Research Bldg, The Univ of Texas Health Science Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 295:L967-75. 2008
    ....
  13. pmc Post-transcriptional regulation of plasminogen activator inhibitor type-1 expression in human pleural mesothelial cells
    Sreerama Shetty
    Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 75708, USA
    Am J Respir Cell Mol Biol 43:358-67. 2010
    ..This newly recognized pathway could influence expression of PAI-1 by mesothelial or mesothelioma cells at the level of mRNA stability in the context of pleural inflammation or malignancy...
  14. ncbi request reprint Urokinase induces its own expression in Beas2B lung epithelial cells
    Sreerama Shetty
    Department of Medical Specialties, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 283:L319-28. 2002
    ....
  15. pmc Induction of tissue factor by urokinase in lung epithelial cells and in the lungs
    Sreerama Shetty
    Department of Specialty Care Services, The Texas Lung Injury Institute, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Am J Respir Crit Care Med 181:1355-66. 2010
    ..Urokinase-type plasminogen activator (uPA) regulates extracellular proteolysis in lung injury and repair. Although alveolar expression of uPA increases, procoagulant activity predominates...
  16. ncbi request reprint Urokinase induces expression of its own receptor in Beas2B lung epithelial cells
    S Shetty
    Department of Medical Specialties, The University of Texas Health Center at Tyler, Biomedical Research Bldg, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Biol Chem 276:24549-56. 2001
    ..Induction of uPAR by uPA represents a novel pathway by which epithelial cells can regulate uPAR-dependent cellular responses that may contribute to stromal remodeling in lung injury or neoplasia...
  17. pmc Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA
    Sreerama Shetty
    Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biol 27:5607-18. 2007
    ....
  18. ncbi request reprint Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 278:18124-31. 2003
    ..Induction of PAI-1 by exposure of lung epithelial cells to uPA is a newly recognized pathway by which PAI-1 could regulate local fibrinolysis and urokinase-dependent cellular responses in the setting of lung inflammation or neoplasia...
  19. doi request reprint Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C
    Thirunavukkarasu Velusamy
    Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, Texas 75708, USA
    Biochemistry 47:6508-17. 2008
    ..Increased hnRNPC interaction with the uPAR mRNA 3'-UTR through phosphorylation of Y57 represents a novel mechanism by which uPA regulates posttranscriptional uPAR mRNA turnover and cell surface uPAR expression...
  20. pmc Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury
    Yashodhar P Bhandary
    The Texas Lung Injury Institute, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Crit Care Med 179:288-98. 2009
    ..uPA induces its own expression in lung epithelial cells, which involves its interaction with cell surface uPAR. Regulation of uPAR expression is therefore crucial for uPA-mediated signaling in infectious acute lung injury (ALI)...
  21. pmc Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1
    Yashodhar P Bhandary
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Pathol 183:131-43. 2013
    ..Our findings indicate that disruption of p53-fibrinolytic system cross talk may serve as a novel intervention strategy to prevent lung injury and pulmonary fibrosis...
  22. pmc Regulation of urokinase expression at the posttranscription level by lung epithelial cells
    Shwetha K Shetty
    Texas Lung Injury Institute, The University of Texas Health Science Center, Tyler, Texas 75708, United States
    Biochemistry 51:205-13. 2012
    ..This newly recognized pathway could influence uPA expression and a broad range of uPA-dependent functions in lung epithelial cells in the context of lung inflammation and repair...
  23. pmc Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system
    Yashodhar P Bhandary
    Texas Lung Injury Institute, Department of Medicine, The University of Texas Health Science Center, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 302:L463-73. 2012
    ..We show that CSP, an intervention targeting this pathway, protects the lung epithelium from apoptosis and prevents PF in BLM-induced lung injury via uPA-mediated inhibition of p53 and PAI-1...
  24. ncbi request reprint Cytoplasmic-nuclear shuttling of the urokinase mRNA binding protein regulates message stability
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, 75708, USA
    Mol Cell Biochem 237:55-67. 2002
    ..This newly identified pathway may have evolved to regulate uPA-mediated functions of the lung epithelium in inflamation or neoplasia...
  25. pmc Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells
    Krishna K Midde
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Shock 36:128-37. 2011
    ....
  26. doi request reprint Urokinase receptor expression involves tyrosine phosphorylation of phosphoglycerate kinase
    Praveenkumar Shetty
    Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Lab C 6, Tyler, TX 75708, USA
    Mol Cell Biochem 335:235-47. 2010
    ..This region can effectively mimic the function of a whole PGK molecule in inhibiting tumor cell growth...
  27. ncbi request reprint Asbestos upregulates expression of the urokinase-type plasminogen activator receptor on mesothelial cells
    R C Perkins
    Department of Specialty Care, The University of Texas Health Center at Tyler, Tyler, Texas 75710, USA
    Am J Respir Cell Mol Biol 21:637-46. 1999
    ..We found that asbestos increases uPAR at the surface of rabbit and human mesothelial cells, suggesting that altered expression of this receptor could be involved in asbestos-induced remodeling of the pleural mesothelium...
  28. ncbi request reprint Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in culture
    A O Azghani
    The University of Texas Health Center, Department of Specialty Care Services, 119 37 US Highway 271, Tyler, TX 75708, USA
    Inflamm Res 51:506-10. 2002
    ..We sought to determine if Pseudomonas elastase (PE) induces mitogen-activated protein (MAP) kinase activity in association with interleukin-8 (IL-8) production by alveolar epithelial cells...
  29. pmc δ ENaC: a novel divergent amiloride-inhibitable sodium channel
    Hong Long Ji
    Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1013-26. 2012
    ..Here, we review the progress of research on δ ENaC in genomics, biophysics, proteomics, physiology, pharmacology, and clinical medicine...
  30. ncbi request reprint Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor
    Ankita Garg
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Immunol 177:6192-8. 2006
    ..ELISA and Far Western blotting showed that recombinant vimentin bound to a NKp46 fusion protein. These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes...
  31. ncbi request reprint Post-transcriptional regulation of urokinase mRNA. Identification of a novel urokinase mRNA-binding protein in human lung epithelial cells in vitro
    S Shetty
    Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 275:13771-9. 2000
    ..The mechanism involves an interaction between a 66-nucleotide sequence of the urokinase mRNA 3'-untranslated region with a newly recognized urokinase mRNA-binding protein to regulate urokinase mRNA stability...
  32. ncbi request reprint Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
    ....
  33. ncbi request reprint IL-2-mediated upregulation of uPA and uPAR in natural killer cells
    Gheath Al-Atrash
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Biochem Biophys Res Commun 292:184-9. 2002
    ..These data suggest that IL-2 upregulates both uPA and uPAR in NK cells through posttranscriptional as well as transcriptional mechanisms, partially explaining increases in NK cell invasiveness following IL-2 stimulation...

Research Grants9

  1. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2002
    ..This work may suggest new therapeutic approaches to a variety of inflammatory or neoplastic lung diseases for which current therapy is often unsatisfactory. ..
  2. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2004
    ..abstract_text> ..
  3. Regulation of Lung Epithelial Fibrinolysis by Urokinase
    Sreerama Shetty; Fiscal Year: 2005
    ..This information could hasten the development of new, mechanism-based interventions for lung disorders, including acute lung injury or lung neoplasia. ..