Research Topics
Genomes and Genes | Sreerama ShettySummaryAffiliation: University of Texas Health Center Country: USA Publications
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Publications
Urokinase expression by tumor suppressor protein p53: a novel role in mRNA turnoverPraveenkumar Shetty
The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
Am J Respir Cell Mol Biol 39:364-72. 2008..These observations confirm a new role for p53 as a uPA mRNA binding protein that down-regulates uPA mRNA stability and decreases cellular uPA expression...- Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injuryShwetha K Shetty
The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Lab C 6, Tyler, TX, 75708, USA
Am J Respir Cell Mol Biol 47:474-83. 2012..These observations demonstrate that inhibition of p53 binding to PAI-1 mRNA 3'UTR attenuates CS-induced ATII cell apoptosis. This presents a novel link between p53-mediated PAI-1 expression and CS-induced ATII cell apoptosis... 
Regulation of urokinase receptor expression by protein tyrosine phosphatasesSreerama Shetty
The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
Am J Physiol Lung Cell Mol Physiol 292:L414-21. 2007....- Regulation of urokinase receptor expression by phosphoglycerate kinase is independent of its catalytic activitySreerama Shetty
Department of Medicine, University of Texas Health Center, Tyler, TX 75708, USA
Am J Physiol Lung Cell Mol Physiol 289:L591-8. 2005..These results demonstrate that uPAR mRNA binding activity as well as PGK-mediated regulation of uPAR mRNA are independent of PGK enzymatic activity... - Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cellsSreerama Shetty
Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
Mol Cell Biochem 272:107-18. 2005..These observations indicate a novel mechanism of uPAR gene regulation in lung epithelial cells in which cis elements within a 110 nt uPAR mRNA 3'UTR sequence interact with hnRNPC to regulate uPAR mRNA stability... - Urokinase induces activation of STAT3 in lung epithelial cellsSreerama Shetty
Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
Am J Physiol Lung Cell Mol Physiol 291:L772-80. 2006.... - Induction of tissue factor by urokinase in lung epithelial cells and in the lungsSreerama Shetty
Department of Specialty Care Services, The Texas Lung Injury Institute, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
Am J Respir Crit Care Med 181:1355-66. 2010..Urokinase-type plasminogen activator (uPA) regulates extracellular proteolysis in lung injury and repair. Although alveolar expression of uPA increases, procoagulant activity predominates... - Post-transcriptional regulation of plasminogen activator inhibitor type-1 expression in human pleural mesothelial cellsSreerama Shetty
Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 75708, USA
Am J Respir Cell Mol Biol 43:358-67. 2010..This newly recognized pathway could influence expression of PAI-1 by mesothelial or mesothelioma cells at the level of mRNA stability in the context of pleural inflammation or malignancy... - Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNASreerama Shetty
Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
Mol Cell Biol 27:5607-18. 2007.... - Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53Sreerama Shetty
Texas Lung Injury Institute, University of Texas Health Center, Tyler, Texas 75708, USA
J Biol Chem 283:19570-80. 2008..These observations demonstrate a novel role for p53 as an mRNA-binding protein that regulates increased PAI-1 expression and stabilization of PAI-1 mRNA in human lung epithelial and carcinoma cells... 
The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viabilitySreerama Shetty
Lab C 6, Biomedical Research Bldg, The Univ of Texas Health Science Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708, USA
Am J Physiol Lung Cell Mol Physiol 295:L967-75. 2008....- Induction of p53 by urokinase in lung epithelial cellsSreerama Shetty
Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
J Biol Chem 280:28133-41. 2005..This pathway could regulate pathophysiologic alterations of p53 expression in the setting of lung inflammation or neoplasia... - Protein synthesis and urokinase mRNA metabolismSreerama Shetty
Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
Mol Cell Biochem 271:13-22. 2005..This pathway may regulate uPA-mediated functions of the lung epithelium in the context of inflammation or neoplasia... - Regulation of urokinase receptor expression by phosphoglycerate kinaseSreerama Shetty
Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
Am J Respir Cell Mol Biol 31:100-6. 2004..Decline in 3H-thymidine incorporation and migration occurred in H157 cells transfected with PGK cDNA. These results demonstrate that PGK regulates uPAR expression at the post-transcriptional level... - Urokinase induces expression of its own receptor in Beas2B lung epithelial cellsS Shetty
Department of Medical Specialties, The University of Texas Health Center at Tyler, Biomedical Research Bldg, 11937 U S Highway 271, Tyler, TX 75708, USA
J Biol Chem 276:24549-56. 2001..Induction of uPAR by uPA represents a novel pathway by which epithelial cells can regulate uPAR-dependent cellular responses that may contribute to stromal remodeling in lung injury or neoplasia... - Urokinase induces its own expression in Beas2B lung epithelial cellsSreerama Shetty
Department of Medical Specialties, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
Am J Physiol Lung Cell Mol Physiol 283:L319-28. 2002.... - Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cellsSreerama Shetty
Associate Professor of Medicine, University of Texas Health Center at Tyler, Tyler, TX, 75708, USA
Am J Respir Cell Mol Biol 30:69-75. 2004.... - Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cellsSreerama Shetty
Department of Specialty Care Services, University of Texas Health Center, Tyler, Texas 75708, USA
J Biol Chem 278:18124-31. 2003..Induction of PAI-1 by exposure of lung epithelial cells to uPA is a newly recognized pathway by which PAI-1 could regulate local fibrinolysis and urokinase-dependent cellular responses in the setting of lung inflammation or neoplasia... - Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein CThirunavukkarasu Velusamy
Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, Texas 75708, USA
Biochemistry 47:6508-17. 2008..Increased hnRNPC interaction with the uPAR mRNA 3'-UTR through phosphorylation of Y57 represents a novel mechanism by which uPA regulates posttranscriptional uPAR mRNA turnover and cell surface uPAR expression... - Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injuryYashodhar P Bhandary
The Texas Lung Injury Institute, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
Am J Respir Crit Care Med 179:288-98. 2009..uPA induces its own expression in lung epithelial cells, which involves its interaction with cell surface uPAR. Regulation of uPAR expression is therefore crucial for uPA-mediated signaling in infectious acute lung injury (ALI)... - Regulation of urokinase expression at the posttranscription level by lung epithelial cellsShwetha K Shetty
Texas Lung Injury Institute, The University of Texas Health Science Center, Tyler, Texas 75708, United States
Biochemistry 51:205-13. 2012..This newly recognized pathway could influence uPA expression and a broad range of uPA-dependent functions in lung epithelial cells in the context of lung inflammation and repair... - Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic systemYashodhar P Bhandary
Texas Lung Injury Institute, Department of Medicine, The University of Texas Health Science Center, Tyler, Texas 75708, USA
Am J Physiol Lung Cell Mol Physiol 302:L463-73. 2012..We show that CSP, an intervention targeting this pathway, protects the lung epithelium from apoptosis and prevents PF in BLM-induced lung injury via uPA-mediated inhibition of p53 and PAI-1... - Cytoplasmic-nuclear shuttling of the urokinase mRNA binding protein regulates message stabilitySreerama Shetty
Department of Specialty Care Services, The University of Texas Health Center at Tyler, 75708, USA
Mol Cell Biochem 237:55-67. 2002..This newly identified pathway may have evolved to regulate uPA-mediated functions of the lung epithelium in inflamation or neoplasia... - Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cellsKrishna K Midde
The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
Shock 36:128-37. 2011.... - Urokinase receptor expression involves tyrosine phosphorylation of phosphoglycerate kinasePraveenkumar Shetty
Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Lab C 6, Tyler, TX 75708, USA
Mol Cell Biochem 335:235-47. 2010..This region can effectively mimic the function of a whole PGK molecule in inhibiting tumor cell growth... - Asbestos upregulates expression of the urokinase-type plasminogen activator receptor on mesothelial cellsR C Perkins
Department of Specialty Care, The University of Texas Health Center at Tyler, Tyler, Texas 75710, USA
Am J Respir Cell Mol Biol 21:637-46. 1999..We found that asbestos increases uPAR at the surface of rabbit and human mesothelial cells, suggesting that altered expression of this receptor could be involved in asbestos-induced remodeling of the pleural mesothelium... - Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in cultureA O Azghani
The University of Texas Health Center, Department of Specialty Care Services, 119 37 US Highway 271, Tyler, TX 75708, USA
Inflamm Res 51:506-10. 2002..We sought to determine if Pseudomonas elastase (PE) induces mitogen-activated protein (MAP) kinase activity in association with interleukin-8 (IL-8) production by alveolar epithelial cells... - δ ENaC: a novel divergent amiloride-inhibitable sodium channelHong Long Ji
Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA
Am J Physiol Lung Cell Mol Physiol 303:L1013-26. 2012..Here, we review the progress of research on δ ENaC in genomics, biophysics, proteomics, physiology, pharmacology, and clinical medicine... - Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptorAnkita Garg
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
J Immunol 177:6192-8. 2006..ELISA and Far Western blotting showed that recombinant vimentin bound to a NKp46 fusion protein. These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes... - Post-transcriptional regulation of urokinase mRNA. Identification of a novel urokinase mRNA-binding protein in human lung epithelial cells in vitroS Shetty
Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
J Biol Chem 275:13771-9. 2000..The mechanism involves an interaction between a 66-nucleotide sequence of the urokinase mRNA 3'-untranslated region with a newly recognized urokinase mRNA-binding protein to regulate urokinase mRNA stability... - Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activationEdward Abraham
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 170:5644-51. 2003.... - IL-2-mediated upregulation of uPA and uPAR in natural killer cellsGheath Al-Atrash
Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA
Biochem Biophys Res Commun 292:184-9. 2002..These data suggest that IL-2 upregulates both uPA and uPAR in NK cells through posttranscriptional as well as transcriptional mechanisms, partially explaining increases in NK cell invasiveness following IL-2 stimulation...
Research Grants
- CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASESreerama Shetty; Fiscal Year: 2002..This work may suggest new therapeutic approaches to a variety of inflammatory or neoplastic lung diseases for which current therapy is often unsatisfactory. ..
- CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASESreerama Shetty; Fiscal Year: 2004..abstract_text> ..
- Regulation of Lung Epithelial Fibrinolysis by UrokinaseSreerama Shetty; Fiscal Year: 2005..This information could hasten the development of new, mechanism-based interventions for lung disorders, including acute lung injury or lung neoplasia. ..