Research Topics
| A Dean SherrySummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
The importance of water exchange rates in the design of responsive agents for MRIA Dean Sherry
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, United States Electronic address
Curr Opin Chem Biol 17:167-74. 2013....
Primer on gadolinium chemistryA Dean Sherry
Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA
J Magn Reson Imaging 30:1240-8. 2009..J. Magn. Reson. Imaging 2009;30:1240-1248. (c) 2009 Wiley-Liss, Inc...- Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groupsAzhar Pasha
Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, TX 75083, USA
J Biol Inorg Chem 14:421-38. 2009..The data indicate that these nontraditional contrast agents exhibit in vivo stability comparable to that of agents with much higher log K (ML) values, demonstrating the important contribution of kinetic inertness... - Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMRNatasha Hausler
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235-9085, USA
Biochem J 394:465-73. 2006..The tight correlation of these two pathways under multiple conditions suggest that interventions which increase or decrease hepatic tricarboxylic-acid-cycle flux will have a concomitant effect on gluconeogenesis and vice versa... - A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexesJeff Vipond
Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75083 0688, USA
Inorg Chem 46:2584-95. 2007.... - Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agentsFederico A Rojas-Quijano
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Chemistry 15:13188-200. 2009..The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PARACEST) agents... - Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liverShawn C Burgess
The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
Cell Metab 5:313-20. 2007..However, PEPCK flux correlated tightly with TCA cycle activity, suggesting that under some conditions in mice, PEPCK expression must coordinate with hepatic energy metabolism to control gluconeogenesis... - Strategies for labeling proteins with PARACEST agentsOlga Vasalatiy
Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083, USA
Bioorg Med Chem 19:1106-14. 2011.... - Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micellesChalermchai Khemtong
Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8807, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4095-7. 2009..The ability to turn "ON" and "OFF" ORS contrast of SPPM solutions permits for an accurate image subtraction and a contrast enhancement to visualize SPPM probes for in vivo imaging of cancer... - Effect of the regiochemistry of butyl amide substituents on the solution-state structures of lanthanide(III) DOTA-tetraamide complexesTomoyasu Mani
Department of Chemistry, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 75080, USA
Inorg Chem 48:10338-45. 2009..Unlike chiral complexes with larger amide substituents there is no "locking" effect of the orientation of the pendant arms in these complexes and up to four diastereoisomeric coordination isomers can be observed... 
Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucoseEunsook S Jin
The Mary Nell and Ralph B Rogers Magnetic Resonance Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
Am J Physiol Endocrinol Metab 288:E654-62. 2005..The differing mechanisms of excess glucose production in these models were easily distinguished by integrated 2H and 13C NMR analysis of plasma glucose...- Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonanceEunsook S Jin
Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
Magn Reson Med 53:1479-83. 2005.... - Off-resonance saturation MRI of superparamagnetic nanoprobes: theoretical models and experimental validationsChalermchai Khemtong
Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States
J Magn Reson 209:53-60. 2011.... - Polymeric PARACEST agents for enhancing MRI contrast sensitivityYunkou Wu
Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75083, USA
J Am Chem Soc 130:13854-5. 2008..This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging... - The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solventKyle J Miller
Department of Chemistry, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 7080, USA
Inorg Chem 49:8662-4. 2010..In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors... - (S)-5-(p-nitrobenzyl)-PCTA, a promising bifunctional ligand with advantageous metal ion complexation kineticsGyula Tircsó
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
Bioconjug Chem 20:565-75. 2009.... - Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopyKimberly A Stowe
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
FEBS Lett 580:4282-7. 2006..24 micromol/g dry wt/min, similar to the rate of oxidation of long-chain fatty acids, 0.16 micromol/g dry wt/min. Isoproterenol decreased the rate of de novo triglyceride synthesis and increased the rate of fatty acid oxidation... - Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonanceMatthew E Merritt
Advanced Imaging Research Center, Department of Molecular Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
Proc Natl Acad Sci U S A 108:19084-9. 2011..We conclude that MR detection of hyperpolarized TCA intermediates and bicarbonate is diagnostic of pyruvate carboxylase and PEPCK flux in the liver... - Synthesis and characterization of a hypoxia-sensitive MRI probeFederico A Rojas-Quijano
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Chemistry 18:9669-76. 2012..These results suggest that the nitroimidazole derivative might serve as a molecular reporter for discriminating hypoxic versus normoxic tissues by MRI... - Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexesMark Woods
Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75080, USA
Angew Chem Int Ed Engl 42:5889-92. 2003 - Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fastingShawn C Burgess
Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
Am J Physiol Endocrinol Metab 289:E53-61. 2005..The techniques used here are amenable to use as a secondary or tertiary tool for studying mouse models with disruptions of intermediary metabolism... - Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinaseShawn C Burgess
The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
J Biol Chem 279:48941-9. 2004..Inhibition of the TCA cycle and fatty acid oxidation due to increased TCA cycle intermediate concentrations and reduced mitochondrial red-ox state lead to the development of steatosis... - Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophyBrian C Weis
The Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9085, USA
Magn Reson Med 51:649-54. 2004..42 +/- 0.12 (P < 0.05) among subjects with lipoatrophy, and the TCA cycle contribution was reduced. Lipoatrophy was associated with an abnormal profile of glucose production as assessed by (13)C and (2)H NMR of plasma and urine... - Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effectsS James Ratnakar
Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
J Am Chem Soc 130:6-7. 2008..These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction... - The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivativesMark Woods
Macrocyclics, Dallas, TX, USA
Invest Radiol 43:861-70. 2008..The purpose of this study was to examine how the nature of the amide substituent, and in particular its charge, affected the fate of these chelates postinjection... - Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl)DOTA complexesMark Woods
Department of Chemistry, University of Texas at Dallas, P.O. Box 830660, Richardson, Texas 75083, USA
Inorg Chem 43:2845-51. 2004..The kinetic and thermodynamic stabilities of the Ln(p-NO2-Bn-DOTA)- complexes are also slightly lower than the corresponding LnDOTA- complexes but appear to be sufficiently high for in vivo use... - Investigations into whole water, prototropic and amide proton exchange in lanthanide(III) DOTA-tetraamide chelatesMark Woods
Department of Chemistry, Portland State University, 1719 SW 10th Ave, Portland, OR 97201, USA
Dalton Trans 40:6759-64. 2011..The extent of prototropic exchange increases as the pH increases above 8, leading to higher relaxivities at high pH. However, amide protons are found to contribute only a small amount to the relaxivity at high pH... - Towards the rational design of MRI contrast agents: δ-substitution of lanthanide(III) NB-DOTA-tetraamide chelates influences but does not control coordination geometryChristiane E Carney
Department of Chemistry, Portland State University, 1719 SW 10th Ave, Portland, OR 97201, USA
Chemistry 17:10372-8. 2011.... - Imaging the tissue distribution of glucose in livers using a PARACEST sensorJimin Ren
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 60:1047-55. 2008..CEST images of livers perfused in the magnet responded to changes in glucose concentrations demonstrating that the method has potential for imaging the tissue distribution of glucose in vivo... - Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-Matthew E Merritt
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 60:1029-36. 2008..Using this multinuclear NMR approach, we established that during the first 90 s of reperfusion PDH flux is essentially zero and recovers within 20 min in reversibly-injured myocardium... - Hyperpolarized 89Y complexes as pH sensitive NMR probesAshish K Jindal
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
J Am Chem Soc 132:1784-5. 2010..Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH... - DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signalLloyd Lumata
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
J Am Chem Soc 133:8673-80. 2011..This methodology may be applicable for the optimization of DNP of other low-γ(n) nuclei... - The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituentAna Christina L Opina
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083 0688, USA
Contrast Media Mol Imaging 6:459-64. 2011..3 to 7.4. This demonstrates a potential advantage of using mixtures of lanthanide(III) DOTA-tetraamides for mapping tissue pH by use of ratiometric CEST imaging... - Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pHFerenc K Kalman
Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, Texas 75083, USA
Inorg Chem 46:5260-70. 2007.... - Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvateKarlos X Moreno
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Am J Physiol Heart Circ Physiol 298:H1556-64. 2010..In conclusion, studies of cardiac metabolism using hyperpolarized [1-(13)C]pyruvate are sensitive to the effects of competing substrates on pyruvate oxidation... - T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxationTodd C Soesbe
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8568, USA
Magn Reson Med 66:1697-703. 2011..These experimental results were verified by Bloch simulations for two site exchange. This new class of T(2exch) agent could prove useful in the design of responsive MRI contrast agents for molecular imaging of biological processes... - Europium(III) DOTA-tetraamide complexes as redox-active MRI sensorsS James Ratnakar
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
J Am Chem Soc 134:5798-800. 2012..The CEST effect of the Eu(3+) complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range... - Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) ratsEunsook S Jin
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8568, USA
Diabetes 56:777-85. 2007..The distribution of (2)H in skeletal muscle glycogen suggested that at least a fraction of glucose molecules entering glycogen pass through phosphomannose isomerase... - Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8Karlos X Moreno
Advanced Imaging Research Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, United States
J Magn Reson 213:187-91. 2011..We demonstrate that FLOPSY-8 allows a direct readout of isotopomer populations in butyrate and glutamate in vitro... - Paramagnetic lanthanide complexes as PARACEST agents for medical imagingMark Woods
Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235, USA
Chem Soc Rev 35:500-11. 2006..It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents... - Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMRMatthew E Merritt
Advanced Imaging Research Center, Department of Radiology, and Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:19773-7. 2007..Thus, the rate of appearance of (13)CO(2) and H(13)CO(3)(-) from [1-(13)C(1)]pyruvate does not reflect production of CO(2) in the TCA cycle but rather reflects flux through pyruvate dehydrogenase exclusively... - Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formateMatthew E Merritt
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
J Magn Reson 189:280-5. 2007..The Solomon equations were used to model the proton signal as a function of time after polarization and to estimate (13)C polarization from the (1)H NMR spectra... - Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant armMark Woods
Macrocyclics, 2110 Research Row, Suite 425, Dallas, Texas 75235, USA
J Am Chem Soc 126:9248-56. 2004.... - Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applicationsChristopher Adair
Macrocyclics, 2110 Research Row, STE 425, Dallas, TX 75235, USA
Contrast Media Mol Imaging 2:55-8. 2007.... - TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive LipoCEST agentsAna Christina L Opina
Department of Chemistry, University of Texas at Dallas, Richardson, Texas, United States of America
PLoS ONE 6:e27370. 2011..Such pH sensitive nano-probes could prove useful for pH mapping of liposomes targeted to tumors... - Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agentsTomoyasu Mani
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
Contrast Media Mol Imaging 4:183-91. 2009.... - Albumin-binding PARACEST agentsM Meser Ali
Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, TX 75083 0688, USA
J Biol Inorg Chem 12:855-65. 2007..Water proton relaxation enhancements of 135 and 171% were observed upon binding of Gd2 and Gd3 to HSA, respectively, at 298 K and pH 7.4... - Catalytic effects of apoferritin interior surface residues on water proton exchange in lanthanide complexesOlga Vasalatiy
Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083-0688, USA
Contrast Media Mol Imaging 1:10-4. 2006 - In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticlesChalermchai Khemtong
Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 35790, USA
Cancer Res 69:1651-8. 2009..This combination of ORS imaging with a tumor vasculature-targeted, ultrasensitive SPPM design offers new opportunities in molecular imaging of cancer... - Advantages of macromolecular to nanosized chemical-exchange saturation transfer agents for MRI applicationsYunkou Wu
Department of Chemistry, University of Texas, Richardson, TX 75080, USA
Future Med Chem 2:351-66. 2010..By addressing these issues, it is anticipated that CEST agents will find useful applications in the detection of specific biomarkers of disease... - In vivo determination of human breast fat composition by ¹H magnetic resonance spectroscopy at 7 TIvan E Dimitrov
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 67:20-6. 2012..In conclusion, we have shown that a chemical analysis of lipids in breast tissue can be determined quite simply, quickly, and noninvasively by proton MRS at 7 T... - Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRIDonald E Woessner
Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 53:790-9. 2005.... - The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomainKenjiro Hanaoka
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9185, USA
Magn Reson Imaging 26:608-17. 2008..4 T. These experimental and extrapolated DLs are both well below current literature estimates and suggests that detection of low MW molecularly targeted T(1) agents is not an unrealistic goal... - Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient miceShawn C Burgess
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
J Biol Chem 281:19000-8. 2006.... - Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPOLloyd Lumata
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
J Phys Chem A 116:5129-38. 2012..These results are discussed qualitatively in terms of the spin temperature model of DNP... - SWIFT-CEST: a new MRI method to overcome T₂ shortening caused by PARACEST contrast agentsTodd C Soesbe
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Magn Reson Med 68:816-21. 2012..The results show that the negative contrast caused by T(2ex) can be overcome using the ultrashort echo time achieved with sweep imaging with Fourier transform, thereby enabling fast and sensitive in vivo PARACEST imaging... - Evidence for reverse flux through pyruvate kinase in skeletal muscleEunsook S Jin
Advanced Imaging Research Center, Departmnet of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd NE4 2, Dallas, TX 75390 8568, USA
Am J Physiol Endocrinol Metab 296:E748-57. 2009..Lactate serves as a substrate for glyconeogenesis in vivo without exchange into symmetric intermediates of the TCA cycle... - PARACEST agents: modulating MRI contrast via water proton exchangeShanrong Zhang
Department of Chemistry, University of Texas at Dallas, P.O. Box 830688, Richardson, Texas 75083-0688, USA
Acc Chem Res 36:783-90. 2003.... - Polymeric PARACEST MRI contrast agents as potential reporters for gene therapyYunkou Wu
Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75083, USA
Org Biomol Chem 8:5333-8. 2010..These observations provide support for the radical, new idea of creating a combined transfection/imaging agent for monitoring gene delivery in real time by MRI... - Labeling of adenovirus particles with PARACEST agentsOlga Vasalatiy
Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083, USA
Bioconjug Chem 19:598-606. 2008..A 12% decrease in bulk water signal intensity was observed relative to controls. This demonstrates that viral particles labeled with PARACEST-type imaging agents can potentially serve as targeted agents for molecular imaging... - Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRIRobert Trokowski
Department of Chemistry, The University of Texas at Dallas, P.O. Box 830688, Richardson, Texas 75083-0688, USA
Bioconjug Chem 15:1431-40. 2004..Thus, Eu(4) represents a new class of metabolite-specific imaging agents that may allow mapping of metabolites by MRI of the bulk water signal... - A responsive europium(III) chelate that provides a direct readout of pH by MRIYunkou Wu
Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75083, USA
J Am Chem Soc 132:14002-3. 2010..Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker... - Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agentM Meser Ali
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083, USA
Chemistry 14:7250-8. 2008..8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer... - Selective sensing of zinc ions with a PARACEST contrast agentRobert Trokowski
Department of Chemistry, The University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75080, USA
Angew Chem Int Ed Engl 44:6920-3. 2005 - Solid-phase synthesis of DOTA-peptidesLuis M De León-Rodríguez
Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, TX 75083, USA
Chemistry 10:1149-55. 2004..This provides a potential method for the screening of libraries of DOTA-linked peptides for optimal targeting properties... - Equilibrium and formation/dissociation kinetics of some Ln(III)PCTA complexesGyula Tircsó
Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75080, USA
Inorg Chem 45:9269-80. 2006..The acid-catalyzed dissociation rates (k1) varied with the cation from 9.61 x 10(-4), 5.08 x 10(-4), 1.07 x 10(-3), and 2.80 x 10(-4) M(-1) s(-1) for Ce(PCTA), Eu(PCTA), Y(PCTA), and Yb(PCTA), respectively... - Could 13C MRI assist clinical decision-making for patients with heart disease?Craig R Malloy
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
NMR Biomed 24:973-9. 2011..The ability to monitor directly specific metabolic pathways may lead to an improvement in the selection of patients who will benefit from interventions, pharmacologic or otherwise... - Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectraMatthew Merritt
Department of Radiology, The Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
Magn Reson Med 50:659-63. 2003..The combined MCMC Bayesian methodology is operationally simple and requires little intervention from the operator... - Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometryShawn C Burgess
The Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235-9085, USA
Anal Biochem 318:321-4. 2003 - Activation of a PARACEST agent for MRI through selective outersphere interactions with phosphate diestersChing Hui Huang
Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
Inorg Chem 49:5963-70. 2010..Further, DEP interacts only with the nonionized form of the complex, Ln(S-THP)(OH(2))(3+) contributing to the pH dependence of the PARACEST effect... - Compartmentation of glycolysis and glycogenolysis in the perfused rat heartNick Anousis
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083-0688, USA
NMR Biomed 17:51-9. 2004..These combined observations are consistent with functional compartmentation of glycolytic and glycogenolytic enzymes that allows pyruvate generated by these two processes to be distinguished at the level of lactate and acetyl-CoA... - Concurrent 31P nuclear magnetic resonance spectroscopy and fiber-optic oxygen consumption measurements in perfused rat heartsPiyu Zhao
Department of Chemistry, University of Texas at Dallas, Richardson 75083, USA
Methods Enzymol 381:735-46. 2004 - Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRSJimin Ren
University of Texas Southwestern Medical Center, Dallas, Texas 75390 8568, USA
Magn Reson Med 69:7-17. 2013..The TMA signal provides a simple and direct measure of the relative amounts of carnitine and acetylcarnitine... - Chemical exchange saturation transfer contrast agents for magnetic resonance imagingA Dean Sherry
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
Annu Rev Biomed Eng 10:391-411. 2008..This has opened the door for the discovery of new classes of responsive agents ranging from MR gene reporter molecules to small molecules that sense their tissue environment and respond to biological events... - Analytical solutions for (13)C isotopomer analysis of complex metabolic conditions: substrate oxidation, multiple pyruvate cycles, and gluconeogenesisA Dean Sherry
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083-0688, USA
Metab Eng 6:12-24. 2004 - pH-sensitive modulation of the second hydration sphere in lanthanide(III) tetraamide-DOTA complexes: a novel approach to smart MR contrast mediaMark Woods
Department of Chemistry, University of Texas at Dallas, P.O. Box 803066, Richardson, Texas 75083, USA
Chemistry 9:4634-40. 2003..The water relaxivity of the Gd(3+)-hydroxypyridyl complex is further enhanced upon binding to serum albumin... - Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexesShanrong Zhang
Department of Chemistry, University of Texas at Dallas, P.O. Box 830688, Richardson, Texas 75083, USA
J Am Chem Soc 124:4226-7. 2002..This demonstrates that water exchange is exquisitely fine-tuned in this macrocyclic tetraamide system and that a variety of Ln3+ complexes meet with the exchange requirement, Deltaomega*tauM >/= 1, necessary for an efficient MT agent... - Synthesis and luminescence studies of aryl substituted tetraamide complexes of europium(III): a new approach to pH responsive luminescent europium probesMark Woods
Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, and Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, Texas 75235, USA
Inorg Chem 42:4401-8. 2003..This offers the potential for developing pH responsive probes for in vivo imaging that are independent of probe concentration... - Magnetic resonance imaging detects a specific peptide-protein binding eventLuis M De León-Rodríguez
Department of Chemistry, The University of Texas at Dallas, P O Box 830688, Richardson, Texas 75083, USA
J Am Chem Soc 124:3514-5. 2002..8 +/- 1.7 mM-1 s-1) allowed detection of Gal-80 at muM levels using a standard magnetic resonance imaging protocol. This novel peptide-based, binding-activated MRI method could potentially be used to screen a wide variety of biomolecules...