A Dean Sherry

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc The importance of water exchange rates in the design of responsive agents for MRI
    A Dean Sherry
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States
    Curr Opin Chem Biol 17:167-74. 2013
  2. pmc Primer on gadolinium chemistry
    A Dean Sherry
    Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA
    J Magn Reson Imaging 30:1240-8. 2009
  3. pmc Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups
    Azhar Pasha
    Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, TX 75083, USA
    J Biol Inorg Chem 14:421-38. 2009
  4. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
  5. pmc A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes
    Jeff Vipond
    Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75083 0688, USA
    Inorg Chem 46:2584-95. 2007
  6. pmc Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents
    Federico A Rojas-Quijano
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Chemistry 15:13188-200. 2009
  7. pmc Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    Shawn C Burgess
    The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Cell Metab 5:313-20. 2007
  8. pmc The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent
    Kyle J Miller
    Department of Chemistry, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 7080, USA
    Inorg Chem 49:8662-4. 2010
  9. pmc (S)-5-(p-nitrobenzyl)-PCTA, a promising bifunctional ligand with advantageous metal ion complexation kinetics
    Gyula Tircsó
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
    Bioconjug Chem 20:565-75. 2009
  10. pmc Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles
    Chalermchai Khemtong
    Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8807, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4095-7. 2009

Collaborators

Detail Information

Publications86

  1. pmc The importance of water exchange rates in the design of responsive agents for MRI
    A Dean Sherry
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States
    Curr Opin Chem Biol 17:167-74. 2013
    ....
  2. pmc Primer on gadolinium chemistry
    A Dean Sherry
    Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA
    J Magn Reson Imaging 30:1240-8. 2009
    ..J. Magn. Reson. Imaging 2009;30:1240-1248. (c) 2009 Wiley-Liss, Inc...
  3. pmc Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups
    Azhar Pasha
    Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, TX 75083, USA
    J Biol Inorg Chem 14:421-38. 2009
    ..The data indicate that these nontraditional contrast agents exhibit in vivo stability comparable to that of agents with much higher log K (ML) values, demonstrating the important contribution of kinetic inertness...
  4. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
    ..The tight correlation of these two pathways under multiple conditions suggest that interventions which increase or decrease hepatic tricarboxylic-acid-cycle flux will have a concomitant effect on gluconeogenesis and vice versa...
  5. pmc A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes
    Jeff Vipond
    Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75083 0688, USA
    Inorg Chem 46:2584-95. 2007
    ....
  6. pmc Lanthanide(III) complexes of tris(amide) PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents
    Federico A Rojas-Quijano
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Chemistry 15:13188-200. 2009
    ..The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PARACEST) agents...
  7. pmc Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    Shawn C Burgess
    The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Cell Metab 5:313-20. 2007
    ..However, PEPCK flux correlated tightly with TCA cycle activity, suggesting that under some conditions in mice, PEPCK expression must coordinate with hepatic energy metabolism to control gluconeogenesis...
  8. pmc The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent
    Kyle J Miller
    Department of Chemistry, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 7080, USA
    Inorg Chem 49:8662-4. 2010
    ..In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors...
  9. pmc (S)-5-(p-nitrobenzyl)-PCTA, a promising bifunctional ligand with advantageous metal ion complexation kinetics
    Gyula Tircsó
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
    Bioconjug Chem 20:565-75. 2009
    ....
  10. pmc Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles
    Chalermchai Khemtong
    Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8807, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4095-7. 2009
    ..The ability to turn "ON" and "OFF" ORS contrast of SPPM solutions permits for an accurate image subtraction and a contrast enhancement to visualize SPPM probes for in vivo imaging of cancer...
  11. pmc Strategies for labeling proteins with PARACEST agents
    Olga Vasalatiy
    Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083, USA
    Bioorg Med Chem 19:1106-14. 2011
    ....
  12. pmc Effect of the regiochemistry of butyl amide substituents on the solution-state structures of lanthanide(III) DOTA-tetraamide complexes
    Tomoyasu Mani
    Department of Chemistry, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 75080, USA
    Inorg Chem 48:10338-45. 2009
    ..Unlike chiral complexes with larger amide substituents there is no "locking" effect of the orientation of the pendant arms in these complexes and up to four diastereoisomeric coordination isomers can be observed...
  13. ncbi request reprint pH-sensitive modulation of the second hydration sphere in lanthanide(III) tetraamide-DOTA complexes: a novel approach to smart MR contrast media
    Mark Woods
    Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, Texas 75083, USA
    Chemistry 9:4634-40. 2003
    ..The water relaxivity of the Gd(3+)-hydroxypyridyl complex is further enhanced upon binding to serum albumin...
  14. pmc Polymeric PARACEST agents for enhancing MRI contrast sensitivity
    Yunkou Wu
    Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75083, USA
    J Am Chem Soc 130:13854-5. 2008
    ..This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging...
  15. ncbi request reprint Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 288:E654-62. 2005
    ..The differing mechanisms of excess glucose production in these models were easily distinguished by integrated 2H and 13C NMR analysis of plasma glucose...
  16. pmc Off-resonance saturation MRI of superparamagnetic nanoprobes: theoretical models and experimental validations
    Chalermchai Khemtong
    Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States
    J Magn Reson 209:53-60. 2011
    ....
  17. ncbi request reprint Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance
    Eunsook S Jin
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 53:1479-83. 2005
    ....
  18. pmc Characterization of lung cancer by amide proton transfer (APT) imaging: an in-vivo study in an orthotopic mouse model
    Osamu Togao
    Advanced Imaging Research Center, Harold C Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e77019. 2013
    ....
  19. ncbi request reprint Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy
    Brian C Weis
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 51:649-54. 2004
    ..42 +/- 0.12 (P < 0.05) among subjects with lipoatrophy, and the TCA cycle contribution was reduced. Lipoatrophy was associated with an abnormal profile of glucose production as assessed by (13)C and (2)H NMR of plasma and urine...
  20. pmc Synthesis and characterization of a hypoxia-sensitive MRI probe
    Federico A Rojas-Quijano
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Chemistry 18:9669-76. 2012
    ..These results suggest that the nitroimidazole derivative might serve as a molecular reporter for discriminating hypoxic versus normoxic tissues by MRI...
  21. ncbi request reprint Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy
    Kimberly A Stowe
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    FEBS Lett 580:4282-7. 2006
    ..24 micromol/g dry wt/min, similar to the rate of oxidation of long-chain fatty acids, 0.16 micromol/g dry wt/min. Isoproterenol decreased the rate of de novo triglyceride synthesis and increased the rate of fatty acid oxidation...
  22. pmc Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
    Matthew E Merritt
    Advanced Imaging Research Center, Department of Molecular Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    Proc Natl Acad Sci U S A 108:19084-9. 2011
    ..We conclude that MR detection of hyperpolarized TCA intermediates and bicarbonate is diagnostic of pyruvate carboxylase and PEPCK flux in the liver...
  23. ncbi request reprint Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes
    Mark Woods
    Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75080, USA
    Angew Chem Int Ed Engl 42:5889-92. 2003
  24. pmc Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP
    Lloyd Lumata
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Phys Chem Chem Phys 15:9800-7. 2013
    ..5 GHz to 95 GHz, but becomes faster at 240 GHz and 336 GHz. The ESR properties of trityl OX063 reported here may provide insights into the efficiency of DNP of low-γ nuclei performed at various magnetic fields, from 0.35 T to 12 T...
  25. pmc Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH
    Ferenc K Kalman
    Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, Texas 75083, USA
    Inorg Chem 46:5260-70. 2007
    ....
  26. ncbi request reprint PARACEST agents: modulating MRI contrast via water proton exchange
    Shanrong Zhang
    Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, Texas 75083 0688, USA
    Acc Chem Res 36:783-90. 2003
    ....
  27. pmc Metabolism of glycerol, glucose, and lactate in the citric acid cycle prior to incorporation into hepatic acylglycerols
    Eunsook S Jin
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 288:14488-96. 2013
    ..Thus, a substantial fraction from both substrate sources passed through the cycle prior to incorporation into the glycerol moiety of acylglycerols in the liver...
  28. ncbi request reprint Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 279:48941-9. 2004
    ..Inhibition of the TCA cycle and fatty acid oxidation due to increased TCA cycle intermediate concentrations and reduced mitochondrial red-ox state lead to the development of steatosis...
  29. ncbi request reprint Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
    Shawn C Burgess
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 289:E53-61. 2005
    ..The techniques used here are amenable to use as a secondary or tertiary tool for studying mouse models with disruptions of intermediary metabolism...
  30. pmc Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects
    S James Ratnakar
    Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Am Chem Soc 130:6-7. 2008
    ..These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction...
  31. pmc The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivatives
    Mark Woods
    Macrocyclics, Dallas, TX, USA
    Invest Radiol 43:861-70. 2008
    ..The purpose of this study was to examine how the nature of the amide substituent, and in particular its charge, affected the fate of these chelates postinjection...
  32. pmc Investigations into whole water, prototropic and amide proton exchange in lanthanide(III) DOTA-tetraamide chelates
    Mark Woods
    Department of Chemistry, Portland State University, 1719 SW 10th Ave, Portland, OR 97201, USA
    Dalton Trans 40:6759-64. 2011
    ..The extent of prototropic exchange increases as the pH increases above 8, leading to higher relaxivities at high pH. However, amide protons are found to contribute only a small amount to the relaxivity at high pH...
  33. ncbi request reprint Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl)DOTA complexes
    Mark Woods
    Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75083, USA
    Inorg Chem 43:2845-51. 2004
    ..The kinetic and thermodynamic stabilities of the Ln(p-NO2-Bn-DOTA)- complexes are also slightly lower than the corresponding LnDOTA- complexes but appear to be sufficiently high for in vivo use...
  34. pmc Towards the rational design of MRI contrast agents: δ-substitution of lanthanide(III) NB-DOTA-tetraamide chelates influences but does not control coordination geometry
    Christiane E Carney
    Department of Chemistry, Portland State University, 1719 SW 10th Ave, Portland, OR 97201, USA
    Chemistry 17:10372-8. 2011
    ....
  35. pmc In vivo imaging of paraCEST agents using frequency labeled exchange transfer MRI
    Chien Yuan Lin
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA
    Magn Reson Med 71:286-93. 2014
    ..The suitability of excitation-based frequency labeled exchange transfer (FLEX) to separate out such MTC effects in vivo was tested...
  36. pmc Modulation of CEST images in vivo by T1 relaxation: a new approach in the design of responsive PARACEST agents
    S James Ratnakar
    Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States
    J Am Chem Soc 135:14904-7. 2013
    ..Reduction of paramagnetic nitroxide moieties to a diamagnetic species resulted in the appearance of CEST. The modulation of CEST by T1 relaxation provides a new platform for designing biologically responsive MRI agents. ..
  37. ncbi request reprint Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Anal Biochem 327:149-55. 2004
    ..6), and TCA cycle flux (49.1+/-16.8). In a separate group of rats, glucose production was not different in the absence of (2)H(2)O and [U-(13)C]propionate, demonstrating that these tracers do not alter the measurement of glucose turnover...
  38. pmc DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal
    Lloyd Lumata
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Am Chem Soc 133:8673-80. 2011
    ..This methodology may be applicable for the optimization of DNP of other low-γ(n) nuclei...
  39. pmc Imaging the tissue distribution of glucose in livers using a PARACEST sensor
    Jimin Ren
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 60:1047-55. 2008
    ..CEST images of livers perfused in the magnet responded to changes in glucose concentrations demonstrating that the method has potential for imaging the tissue distribution of glucose in vivo...
  40. pmc Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-
    Matthew E Merritt
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 60:1029-36. 2008
    ..Using this multinuclear NMR approach, we established that during the first 90 s of reperfusion PDH flux is essentially zero and recovers within 20 min in reversibly-injured myocardium...
  41. pmc Hyperpolarized 89Y complexes as pH sensitive NMR probes
    Ashish K Jindal
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Am Chem Soc 132:1784-5. 2010
    ..Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH...
  42. pmc The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent
    Ana Christina L Opina
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Contrast Media Mol Imaging 6:459-64. 2011
    ..3 to 7.4. This demonstrates a potential advantage of using mixtures of lanthanide(III) DOTA-tetraamides for mapping tissue pH by use of ratiometric CEST imaging...
  43. pmc Labeling of adenovirus particles with PARACEST agents
    Olga Vasalatiy
    Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083, USA
    Bioconjug Chem 19:598-606. 2008
    ..A 12% decrease in bulk water signal intensity was observed relative to controls. This demonstrates that viral particles labeled with PARACEST-type imaging agents can potentially serve as targeted agents for molecular imaging...
  44. pmc In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticles
    Chalermchai Khemtong
    Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 35790, USA
    Cancer Res 69:1651-8. 2009
    ..This combination of ORS imaging with a tumor vasculature-targeted, ultrasensitive SPPM design offers new opportunities in molecular imaging of cancer...
  45. pmc Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate
    Karlos X Moreno
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Am J Physiol Heart Circ Physiol 298:H1556-64. 2010
    ..In conclusion, studies of cardiac metabolism using hyperpolarized [1-(13)C]pyruvate are sensitive to the effects of competing substrates on pyruvate oxidation...
  46. pmc T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation
    Todd C Soesbe
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8568, USA
    Magn Reson Med 66:1697-703. 2011
    ..These experimental results were verified by Bloch simulations for two site exchange. This new class of T(2exch) agent could prove useful in the design of responsive MRI contrast agents for molecular imaging of biological processes...
  47. pmc Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8
    Karlos X Moreno
    Advanced Imaging Research Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, United States
    J Magn Reson 213:187-91. 2011
    ..We demonstrate that FLOPSY-8 allows a direct readout of isotopomer populations in butyrate and glutamate in vitro...
  48. pmc Paramagnetic lanthanide complexes as PARACEST agents for medical imaging
    Mark Woods
    Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235, USA
    Chem Soc Rev 35:500-11. 2006
    ..It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents...
  49. ncbi request reprint Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications
    Christopher Adair
    Macrocyclics, 2110 Research Row, STE 425, Dallas, TX 75235, USA
    Contrast Media Mol Imaging 2:55-8. 2007
    ....
  50. pmc Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm
    Mark Woods
    Macrocyclics, 2110 Research Row, Suite 425, Dallas, Texas 75235, USA
    J Am Chem Soc 126:9248-56. 2004
    ....
  51. ncbi request reprint Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats
    Eunsook S Jin
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8568, USA
    Diabetes 56:777-85. 2007
    ..The distribution of (2)H in skeletal muscle glycogen suggested that at least a fraction of glucose molecules entering glycogen pass through phosphomannose isomerase...
  52. pmc Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate
    Matthew E Merritt
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    J Magn Reson 189:280-5. 2007
    ..The Solomon equations were used to model the proton signal as a function of time after polarization and to estimate (13)C polarization from the (1)H NMR spectra...
  53. pmc Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
    Matthew E Merritt
    Advanced Imaging Research Center, Department of Radiology, and Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:19773-7. 2007
    ..Thus, the rate of appearance of (13)CO(2) and H(13)CO(3)(-) from [1-(13)C(1)]pyruvate does not reflect production of CO(2) in the TCA cycle but rather reflects flux through pyruvate dehydrogenase exclusively...
  54. pmc Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors
    S James Ratnakar
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Am Chem Soc 134:5798-800. 2012
    ..The CEST effect of the Eu(3+) complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range...
  55. pmc TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive LipoCEST agents
    Ana Christina L Opina
    Department of Chemistry, University of Texas at Dallas, Richardson, Texas, United States of America
    PLoS ONE 6:e27370. 2011
    ..Such pH sensitive nano-probes could prove useful for pH mapping of liposomes targeted to tumors...
  56. ncbi request reprint Catalytic effects of apoferritin interior surface residues on water proton exchange in lanthanide complexes
    Olga Vasalatiy
    Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083 0688, USA
    Contrast Media Mol Imaging 1:10-4. 2006
  57. pmc Albumin-binding PARACEST agents
    M Meser Ali
    Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, TX 75083 0688, USA
    J Biol Inorg Chem 12:855-65. 2007
    ..Water proton relaxation enhancements of 135 and 171% were observed upon binding of Gd2 and Gd3 to HSA, respectively, at 298 K and pH 7.4...
  58. pmc Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agents
    Tomoyasu Mani
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
    Contrast Media Mol Imaging 4:183-91. 2009
    ....
  59. pmc CEST: from basic principles to applications, challenges and opportunities
    Elena Vinogradov
    Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Magn Reson 229:155-72. 2013
    ..Some emerging clinical applications of CEST are described and the challenges and opportunities associated with translation of these methods to the clinical environment are discussed...
  60. pmc SWIFT-CEST: a new MRI method to overcome T₂ shortening caused by PARACEST contrast agents
    Todd C Soesbe
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    Magn Reson Med 68:816-21. 2012
    ..The results show that the negative contrast caused by T(2ex) can be overcome using the ultrashort echo time achieved with sweep imaging with Fourier transform, thereby enabling fast and sensitive in vivo PARACEST imaging...
  61. pmc Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO
    Lloyd Lumata
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Phys Chem A 116:5129-38. 2012
    ..These results are discussed qualitatively in terms of the spin temperature model of DNP...
  62. pmc In vivo determination of human breast fat composition by ¹H magnetic resonance spectroscopy at 7 T
    Ivan E Dimitrov
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 67:20-6. 2012
    ..In conclusion, we have shown that a chemical analysis of lipids in breast tissue can be determined quite simply, quickly, and noninvasively by proton MRS at 7 T...
  63. pmc Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    Shawn C Burgess
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 281:19000-8. 2006
    ....
  64. pmc Evidence for reverse flux through pyruvate kinase in skeletal muscle
    Eunsook S Jin
    Advanced Imaging Research Center, Departmnet of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd NE4 2, Dallas, TX 75390 8568, USA
    Am J Physiol Endocrinol Metab 296:E748-57. 2009
    ..Lactate serves as a substrate for glyconeogenesis in vivo without exchange into symmetric intermediates of the TCA cycle...
  65. doi request reprint Advantages of macromolecular to nanosized chemical-exchange saturation transfer agents for MRI applications
    Yunkou Wu
    Department of Chemistry, University of Texas, Richardson, TX 75080, USA
    Future Med Chem 2:351-66. 2010
    ..By addressing these issues, it is anticipated that CEST agents will find useful applications in the detection of specific biomarkers of disease...
  66. pmc The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain
    Kenjiro Hanaoka
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9185, USA
    Magn Reson Imaging 26:608-17. 2008
    ..4 T. These experimental and extrapolated DLs are both well below current literature estimates and suggests that detection of low MW molecularly targeted T(1) agents is not an unrealistic goal...
  67. ncbi request reprint Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI
    Donald E Woessner
    Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 53:790-9. 2005
    ....
  68. pmc Polymeric PARACEST MRI contrast agents as potential reporters for gene therapy
    Yunkou Wu
    Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75083, USA
    Org Biomol Chem 8:5333-8. 2010
    ..These observations provide support for the radical, new idea of creating a combined transfection/imaging agent for monitoring gene delivery in real time by MRI...
  69. ncbi request reprint Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRI
    Robert Trokowski
    Department of Chemistry, The University of Texas at Dallas, P O Box 830688, Richardson, Texas 75083 0688, USA
    Bioconjug Chem 15:1431-40. 2004
    ..Thus, Eu(4) represents a new class of metabolite-specific imaging agents that may allow mapping of metabolites by MRI of the bulk water signal...
  70. ncbi request reprint Selective sensing of zinc ions with a PARACEST contrast agent
    Robert Trokowski
    Department of Chemistry, The University of Texas at Dallas, P O Box 830688, Richardson, TX 75080, USA
    Angew Chem Int Ed Engl 44:6920-3. 2005
  71. pmc Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent
    M Meser Ali
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083, USA
    Chemistry 14:7250-8. 2008
    ..8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer...
  72. pmc A responsive europium(III) chelate that provides a direct readout of pH by MRI
    Yunkou Wu
    Department of Chemistry, University of Texas at Dallas, P O Box 830668, Richardson, Texas 75083, USA
    J Am Chem Soc 132:14002-3. 2010
    ..Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker...
  73. ncbi request reprint Solid-phase synthesis of DOTA-peptides
    Luis M De León-Rodríguez
    Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, TX 75083, USA
    Chemistry 10:1149-55. 2004
    ..This provides a potential method for the screening of libraries of DOTA-linked peptides for optimal targeting properties...
  74. pmc Equilibrium and formation/dissociation kinetics of some Ln(III)PCTA complexes
    Gyula Tircsó
    Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75080, USA
    Inorg Chem 45:9269-80. 2006
    ..The acid-catalyzed dissociation rates (k1) varied with the cation from 9.61 x 10(-4), 5.08 x 10(-4), 1.07 x 10(-3), and 2.80 x 10(-4) M(-1) s(-1) for Ce(PCTA), Eu(PCTA), Y(PCTA), and Yb(PCTA), respectively...
  75. ncbi request reprint Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra
    Matthew Merritt
    Department of Radiology, The Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 50:659-63. 2003
    ..The combined MCMC Bayesian methodology is operationally simple and requires little intervention from the operator...
  76. ncbi request reprint Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Anal Biochem 318:321-4. 2003
  77. pmc Could 13C MRI assist clinical decision-making for patients with heart disease?
    Craig R Malloy
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    NMR Biomed 24:973-9. 2011
    ..The ability to monitor directly specific metabolic pathways may lead to an improvement in the selection of patients who will benefit from interventions, pharmacologic or otherwise...
  78. ncbi request reprint Concurrent 31P nuclear magnetic resonance spectroscopy and fiber-optic oxygen consumption measurements in perfused rat hearts
    Piyu Zhao
    Department of Chemistry, University of Texas at Dallas, Richardson 75083, USA
    Methods Enzymol 381:735-46. 2004
  79. ncbi request reprint Compartmentation of glycolysis and glycogenolysis in the perfused rat heart
    Nick Anousis
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    NMR Biomed 17:51-9. 2004
    ..These combined observations are consistent with functional compartmentation of glycolytic and glycogenolytic enzymes that allows pyruvate generated by these two processes to be distinguished at the level of lactate and acetyl-CoA...
  80. pmc Activation of a PARACEST agent for MRI through selective outersphere interactions with phosphate diesters
    Ching Hui Huang
    Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    Inorg Chem 49:5963-70. 2010
    ..Further, DEP interacts only with the nonionized form of the complex, Ln(S-THP)(OH(2))(3+) contributing to the pH dependence of the PARACEST effect...
  81. pmc Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS
    Jimin Ren
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8568, USA
    Magn Reson Med 69:7-17. 2013
    ..The TMA signal provides a simple and direct measure of the relative amounts of carnitine and acetylcarnitine...
  82. pmc Chemical exchange saturation transfer contrast agents for magnetic resonance imaging
    A Dean Sherry
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA
    Annu Rev Biomed Eng 10:391-411. 2008
    ..This has opened the door for the discovery of new classes of responsive agents ranging from MR gene reporter molecules to small molecules that sense their tissue environment and respond to biological events...
  83. ncbi request reprint Analytical solutions for (13)C isotopomer analysis of complex metabolic conditions: substrate oxidation, multiple pyruvate cycles, and gluconeogenesis
    A Dean Sherry
    Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Metab Eng 6:12-24. 2004
  84. ncbi request reprint Synthesis and luminescence studies of aryl substituted tetraamide complexes of europium(III): a new approach to pH responsive luminescent europium probes
    Mark Woods
    Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, and Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, Texas 75235, USA
    Inorg Chem 42:4401-8. 2003
    ..This offers the potential for developing pH responsive probes for in vivo imaging that are independent of probe concentration...
  85. ncbi request reprint Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexes
    Shanrong Zhang
    Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, Texas 75083, USA
    J Am Chem Soc 124:4226-7. 2002
    ..This demonstrates that water exchange is exquisitely fine-tuned in this macrocyclic tetraamide system and that a variety of Ln3+ complexes meet with the exchange requirement, Deltaomega*tauM >/= 1, necessary for an efficient MT agent...
  86. ncbi request reprint Magnetic resonance imaging detects a specific peptide-protein binding event
    Luis M De León-Rodríguez
    Department of Chemistry, The University of Texas at Dallas, P O Box 830688, Richardson, Texas 75083, USA
    J Am Chem Soc 124:3514-5. 2002
    ..8 +/- 1.7 mM-1 s-1) allowed detection of Gal-80 at muM levels using a standard magnetic resonance imaging protocol. This novel peptide-based, binding-activated MRI method could potentially be used to screen a wide variety of biomolecules...